Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase(95 produtos)
- CDK(501 produtos)
- Ciclo celular/Parada(4 produtos)
- Chk(42 produtos)
- DYRK(48 produtos)
- Dinamina(23 produtos)
- Ferroptose(215 produtos)
- HSP(169 produtos)
- Integrinas(224 produtos)
- Cinesina(66 produtos)
- LIM Quinase(19 produtos)
- Microtúbulo associado(262 produtos)
- PKC(102 produtos)
- PLK(28 produtos)
- ROCK(69 produtos)
- Rho(2 produtos)
- Wee1(15 produtos)
- c-Myc(69 produtos)
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Foram encontrados 3485 produtos de "Ciclo celular/Ponto de verificação"
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Aurora inhibitor 1
CAS:<p>Aurora inhibitor 1 is a potent Aurora inhibitor (IC50: ≤ 4 nM and ≤13 nM for Aurora A and Aurora B kinase).</p>Fórmula:C23H25N9SPureza:98%Cor e Forma:SolidPeso molecular:459.57MY05
CAS:<p>MY05 selectively targets c-MYC within cells and disrupts the interaction between MYC and MAX. It binds to intracellular c-MYC, modulating its thermal stability, reducing the transcriptional targets of c-MYC, and exhibiting anticancer activity (TNBC, triple-negative breast cancer).</p>Fórmula:C19H11ClN4OCor e Forma:SolidPeso molecular:346.77LY309887
CAS:<p>LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (Ki: 6.5 nM). It also has antitumor activity.</p>Fórmula:C19H23N5O6SCor e Forma:SolidPeso molecular:449.48TA-316
CAS:<p>Agent induces megakaryocytes/platelets from stem cells to treat thrombopenia.</p>Fórmula:C28H25BrN4O5S2Pureza:98%Cor e Forma:SolidPeso molecular:641.562-Amino-2'-fluoro-2'-deoxyadenosine
CAS:<p>2-Amino-2'-fluoro-2'-deoxyadenosine is a component of nucleic acids.</p>Fórmula:C10H13FN6O3Cor e Forma:SolidPeso molecular:284.25Terpendole E
CAS:<p>Terpendole E is an atypical L5 site inhibitor.</p>Fórmula:C28H39NO3Cor e Forma:SolidPeso molecular:437.61RNAP-σ interaction inhibitor-1
CAS:<p>RNAP-σ interaction inhibitor-1 (compound 5d) acts as an inhibitor of the interaction between RNA polymerase and the sigma factor. It exhibits activity against Streptococci with a minimum inhibitory concentration (MIC) ranging from 1-2 µg/mL.</p>Fórmula:C19H11Cl3N2O6S2Cor e Forma:SolidPeso molecular:533.79MTH1 activator-1
CAS:<p>MTH1 activator-1 is an MTH1 activator that enhances endogenous MTH1 activity and significantly reduces 8-oxo-dG levels in cellular DNA. It is useful for investigating the upregulation of oxidative damage repair in nucleotide pools and examining biological effects, as well as for studies aiming to delay or prevent tumorigenesis.</p>Fórmula:C29H23F3N4O2Cor e Forma:SolidPeso molecular:516.514GFB-12811
CAS:<p>GFB-12811 is an orally active, selective, and potent CDK5 inhibitor, used in the study of autosomal dominant polycystic kidney disease.</p>Fórmula:C22H23F4N5OPureza:98.88%Cor e Forma:SolidPeso molecular:449.44CTPS1-IN-1
CAS:<p>CTPS1-IN-1 is a cytidine-5′ triphosphate synthase 1 (CTPS1) inhibitor with potential antitumor activity and can be used to study autoimmune diseases.</p>Fórmula:C21H22N6O4S2Pureza:99.46%Cor e Forma:SolidPeso molecular:486.57Elacytarabine
CAS:<p>Elacytarabine (M7594 0037), a lipid-conjugated derivative of the nucleoside analog cytarabine, is an antineoplastic drug. It has cytotoxicity in solid tumors.</p>Fórmula:C27H45N3O6Pureza:97.69%Cor e Forma:SolidPeso molecular:507.66HRO761
CAS:<p>HRO761 is a potent Werne r syndrome RecQ DNA deconjugase (WRN) inhibitor that can be used to study cancers such as colon and stomach cancer.</p>Fórmula:C31H31ClF3N9O5Pureza:98.74% - 99.62%Cor e Forma:SolidPeso molecular:702.08SR 11302
CAS:<p>SR 11302 is an inhibitor of activator protein-1 (AP-1).</p>Fórmula:C26H32O2Pureza:98.65%Cor e Forma:SolidPeso molecular:376.53LY3143921 hydrate
CAS:<p>LY3143921 ((S)-Example 2) hydrate is an orally active CDC7 kinase inhibitor with broad in vitro anticancer activity [1].</p>Fórmula:C16H14FN5O2Pureza:98.43%Cor e Forma:SolidPeso molecular:327.31INCB086550
CAS:<p>INCB086550 (PD-1/PD-L1-IN-8) (example 24) is a PD-1/PD-L1 inhibitor, with an IC50 <= 10 nM.</p>Fórmula:C41H39N7O4Pureza:98.49%Cor e Forma:SolidPeso molecular:693.79Bicyclomycin benzoate
CAS:<p>Bicyclomycin benzoate (BCM benzoate, FR2054) is a broad-spectrum antibiotic and selective Rho protein inhibitor active against Gram-negative bacteria.</p>Fórmula:C19H22N2O8Cor e Forma:SolidPeso molecular:406.39Troxacitabine
CAS:<p>Troxacitabine, a DNA polymerase inhibitor, is potentially used for the treatment of acute myeloid leukemia (AML). In comparison with gemcitabine, troxacitabine was equally active against MiaPaCa and was more efficacious against Panc-01.</p>Fórmula:C8H11N3O4Pureza:98%Cor e Forma:SolidPeso molecular:213.19Deoxypseudouridine
CAS:<p>Deoxypseudouridine is a nucleotide analog.</p>Fórmula:C9H12N2O5Cor e Forma:SolidPeso molecular:228.2PLK1-IN-6
<p>PLK1-IN-6: potent, selective PLK1 inhibitor, IC50 = 0.45 nM, hinders cancer cell growth.</p>Fórmula:C28H37N9O3Cor e Forma:SolidPeso molecular:547.655'-DMT-3'-TBDMS-ibu-rG
CAS:<p>5'-DMT-3'-TBDMS-ibu-rG is a modified nucleoside employed in deoxyribonucleic acid (DNA) synthesis.</p>Fórmula:C41H51N5O8SiCor e Forma:SolidPeso molecular:769.96NSC639828
CAS:<p>NSC639828 is an efficient inhibitor of DNA polymerase α, exhibiting a remarkable IC50 value of 70 μM. Additionally, NSC639828 demonstrates substantial antitumor activity, making it a promising candidate for cancer research.</p>Fórmula:C18H13BrClN5O3Cor e Forma:SolidPeso molecular:462.69Formycin A
CAS:<p>Formycin A shows antitumor and antiviral activities. Formycin A , a purine nucleoside antibiotic, is a potent human immunodeficiency virus type 1 (HIV-1) inhibitor with an EC50 of 10 μM.</p>Fórmula:C10H13N5O4Pureza:98%Cor e Forma:SolidPeso molecular:267.24Tanuxiciclib
CAS:<p>Tanuxiciclib is a cyclin dependent kinase (CDK) inhibitor, specifically designed to interfere with cell cycle progression by inhibiting the activity of CDKs, which are crucial regulators of cell division.</p>Fórmula:C15H13FN6OCor e Forma:SolidPeso molecular:312.3085'-O-DMT-N6-ibu-dA
CAS:<p>5'-O-DMT-N6-ibu-dA can be utilized in the synthesis of oligodeoxyribonucleotides.</p>Fórmula:C35H37N5O6Cor e Forma:SolidPeso molecular:623.71Ethynylcytidine
CAS:<p>Ethynylcytidine is a nucleoside antimetabolite.</p>Fórmula:C11H13N3O5Pureza:98%Cor e Forma:SolidPeso molecular:267.245'-O-TBDMS-dT
CAS:<p>5’-O-TBDMS-dT is a nucleoside with protective and modification effects.</p>Fórmula:C16H28N2O5SiCor e Forma:SolidPeso molecular:356.49GSK-3/CDK5/CDK2-IN-1
CAS:<p>GSK-3/CDK5/CDK2-IN-1 is an imidazole derivative compound that inhibits cdk5, cdk2, and GSK-3.it has demonstrated applications in cancer research and the study of neurodegenerative diseases [1].</p>Fórmula:C21H22N4O2Cor e Forma:SolidPeso molecular:362.4332'-Deoxy-2'-fluoro-5-iodouridine
CAS:<p>2'-Deoxy-2'-fluoro-5-iodouridine is a nucleoside, specifically a fluoro-modified and halo-nucleoside.</p>Fórmula:C9H10FIN2O5Cor e Forma:SolidPeso molecular:372.09N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine
CAS:<p>N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine, catalog number T66118 and CAS number 64325-78-6, is a valuable organic compound for life sciences research.</p>Fórmula:C38H35N5O6Cor e Forma:SolidPeso molecular:657.7276-Amino-5-nitropyridin-2-one
CAS:<p>6-Amino-5-nitropyridin-2-one, a pyridine derivative, serves as a nucleobase within hachimoji DNA, where it is specifically paired with 5-aza-7-deazaguanine.</p>Fórmula:C5H5N3O3Pureza:98%Cor e Forma:SolidPeso molecular:155.11MitoE10
CAS:<p>MitoE10 is an effective mitochondrial targeting antioxidant.</p>Fórmula:C42H55O5PSCor e Forma:SolidPeso molecular:702.92Ribocil-C
CAS:<p>Ribocil-C is a selective inhibitor of the bacterial riboflavin riboswitch, a synthetic analogue of flavin mononucleotide (FMN), inhibits bacterial cell growth.</p>Fórmula:C21H21N7OSPureza:98%Cor e Forma:SolidPeso molecular:419.5Tibremciclib
CAS:<p>Tibremciclib is a cyclin-dependent kinase 4 (CDK4) inhibitor that exhibits antineoplastic properties [1].</p>Fórmula:C28H32F2N8Pureza:98%Cor e Forma:SolidPeso molecular:518.6PHI-101
CAS:<p>PHI-101 is a checkpoint kinase 2 (Chk2) inhibitor that can be used for the study of refractory acute myeloid leukemia (AML) and ovarian cancer.</p>Fórmula:C19H19FN4O2SPureza:99.4%Cor e Forma:SolidPeso molecular:386.44YK-2168
CAS:<p>YK-2168 is a differentiated selective inhibitor of CDK9.</p>Fórmula:C16H18ClN5Cor e Forma:SolidPeso molecular:315.80Ref: TM-T200769
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