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Ciclo celular/Ponto de verificação

Ciclo celular/Ponto de verificação

Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.

Subcategorias de "Ciclo celular/Ponto de verificação"

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Foram encontrados 3675 produtos de "Ciclo celular/Ponto de verificação"

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  • USP7-IN-10
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    USP7-IN-10

    CAS:
    <p>USP7-IN-10 is a potent inhibitor of ubiquitin-specific protease 7 (USP7), exhibiting an inhibition concentration half-maximal (IC50) value of 13.39 nM.</p>
    Fórmula:C26H29ClN4O3S
    Cor e Forma:Solid
    Peso molecular:513.05

    Ref: TM-T73136

  • L-2'-Fd4C
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    L-2'-Fd4C

    CAS:
    L-2'-Fd4C is an L-nucleoside analogue with both anti-human immunodeficiency virus (HIV) and anti-hepatitis B virus (HBV) activity [1].
    Fórmula:C9H10FN3O3
    Cor e Forma:Solid
    Peso molecular:227.19

    Ref: TM-T60285

  • 12(S)-HETE
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    12(S)-HETE

    CAS:
    <p>Enpatoran hydrochloride (M5049 hydrochloride) is a TLR7/8 inhibitor with antiviral activity that is used in the study of autoimmune diseases.</p>
    Fórmula:C20H32O3
    Cor e Forma:Solid
    Peso molecular:320.47

    Ref: TM-T37047

  • 2′-O-MOE-CMP
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    2′-O-MOE-CMP

    CAS:
    <p>2′-O-MOE-CMP is a nucleotide analogue utilized in the synthesis of oligonucleotides.</p>
    Fórmula:C12H20N3O9P
    Cor e Forma:Solid
    Peso molecular:381.28

    Ref: TM-TSW-00960

  • Logotipo do CymitQuimica
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    Pol I-IN-1

    Pol I-IN-1 is a powerful inhibitor of RNA polymerase I (Pol I), specifically targeting the large catalytic subunit RPA194, demonstrating an inhibition
    Fórmula:C23H22N4O2
    Cor e Forma:Solid
    Peso molecular:386.45

    Ref: TM-T61720

  • YKL-1-116
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    YKL-1-116

    CAS:
    YKL-1-116 is an effective, selective, and covalent CDK7 inhibitor.
    Fórmula:C34H38N8O3
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:606.72

    Ref: TM-T24643

  • Antifolate agent 1
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    Antifolate agent 1

    CAS:
    Antifolateagent 1 (Compound 1) is an antifolate agent featuring a single-carbon bridge. It lacks RFC transport, shows no affinity for FRα and FRβ, and exhibits no GARFTase inhibition activity. Antifolateagent 1 serves as a negative control in the development of folate receptor-targeted antifolate agents.
    Fórmula:C19H19N5O6
    Cor e Forma:Solid
    Peso molecular:413.38

    Ref: TM-T212452

  • Logotipo do CymitQuimica
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    IRE1α kinase-IN-5

    <p>IRE1α kinase-IN-5 (compound 7) is a potent inhibitor of IRE1α (Ki: 98 nM) and is an ATP-competitive ligand for IRE1α.</p>
    Fórmula:C28H30N6O3S
    Cor e Forma:Solid
    Peso molecular:530.64

    Ref: TM-T63734

  • 3'-NH-Tr-2',3'-ddG(iBu)-5'-CE-Phosphoramidite
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    3'-NH-Tr-2',3'-ddG(iBu)-5'-CE-Phosphoramidite

    CAS:
    3'-NH-Tr-2',3'-ddG(iBu)-5'-CE-Phosphoramidite is a nucleoside phosphoramidite monomer featuring protective group modifications, suitable for RNA oligonucleotide synthesis.
    Fórmula:C42H51N8O5P
    Cor e Forma:Solid
    Peso molecular:778.88

    Ref: TM-TSW-01143

  • Deoxythymidine-5'-triphosphate-d15
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    Deoxythymidine-5'-triphosphate-d15

    CAS:
    Deoxythymidine-5'-triphosphate-d15 (dTTP-d15) dilithium is a deuterium-labeled form of deoxythymidine-5'-triphosphate. Deoxythymidine-5'-triphosphate (dTTP) is a triphosphate nucleotide utilized in DNA synthesis.
    Fórmula:C10H15Li2N2O14P3
    Cor e Forma:Solid
    Peso molecular:509.13

    Ref: TM-T211806

  • SCH-1473759
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    SCH-1473759

    CAS:
    SCH-1473759 is an inhibitor of the aurora (IC50s: 4 and 13 nM for Aurora A and B, respectively).
    Fórmula:C20H26N8OS
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:426.54

    Ref: TM-T16862

  • Morpholino U subunit
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    Morpholino U subunit

    CAS:
    Morpholino U subunit is one of the fundamental components of morpholino oligonucleotides, capable of pairing with adenine in target RNA.
    Fórmula:C30H32ClN4O5P
    Cor e Forma:Solid
    Peso molecular:595.03

    Ref: TM-TSW-01102

  • CDK4/6-IN-3
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    CDK4/6-IN-3

    CAS:
    <p>CDK4/6-IN-3 is a brain-penetrant CDK4/CDK6 inhibitor (Kis: &lt;0.3 nM and 2.2 nM) used for the treatment of glioblastoma. It inhibits CDK1 with a Ki of 110 nM.</p>
    Fórmula:C25H31FN8
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:462.57

    Ref: TM-T10737

  • Logotipo do CymitQuimica
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    Hesperadin hydrochloride

    <p>Hesperadin hydrochloride is an ATP-competitive indolone inhibitor of Aurora A and B, with an IC50 value of 250 nM for Aurora B.</p>
    Fórmula:C29H33ClN4O3S
    Cor e Forma:Solid
    Peso molecular:553.12

    Ref: TM-T63905

  • Logotipo do CymitQuimica
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    MtTMPK-IN-8

    <p>MtTMPK-IN-8 inhibits MtbTMPK, has low cytotoxicity, shows 0.78-9.4 μM activity against Mycobacterium, useful for tuberculosis research.</p>
    Fórmula:C24H24N6O7
    Cor e Forma:Solid
    Peso molecular:508.48

    Ref: TM-T63491

  • N-Isobutyryl-2', 3'-acetyl-guanosine
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    N-Isobutyryl-2', 3'-acetyl-guanosine

    CAS:
    <p>N-Isobutyryl-2', 3'-acetyl-guanosine is a derivative of guanosine.</p>
    Fórmula:C18H23N5O8
    Cor e Forma:Solid
    Peso molecular:437.404

    Ref: TM-T206416

  • LIMK1 inhibitor 1
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    LIMK1 inhibitor 1

    CAS:
    <p>LIMK1 inhibitor1 (compound 24) is a LIMK1 inhibitor, potentially useful for cancer research.</p>
    Fórmula:C12H15N3S2
    Cor e Forma:Solid
    Peso molecular:265.398

    Ref: TM-T204784

  • CDK1-IN-7
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    CDK1-IN-7

    CAS:
    <p>CDK1-IN-7 (compound M7) is a potent CDK1 inhibitor. It effectively suppresses the proliferation and migration of HCT116 and Lovo cells, making it a valuable tool for colorectal cancer research.</p>
    Fórmula:C23H19ClN4O3
    Cor e Forma:Solid
    Peso molecular:434.88

    Ref: TM-T207488

  • RNAP-σ interaction inhibitor-2
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    RNAP-σ interaction inhibitor-2

    CAS:
    RNAP-σ interaction inhibitor-2 (compound 7d) is an inhibitor targeting the interaction between RNA polymerase and the sigma factor. It demonstrates inhibitory activity against S. aureus with a minimum inhibitory concentration (MIC) of 2 µg/mL.
    Fórmula:C27H19Cl3N2O6S2
    Cor e Forma:Solid
    Peso molecular:637.939

    Ref: TM-T206884

  • NVP-BQS481
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    NVP-BQS481

    CAS:
    NVP-BQS481 (Compound 1) is a selective inhibitor of spindle motor protein 5 (Eg5), with an IC50 of less than 0.5 nM. It demonstrates significant anti-mitotic and anti-tumor activities, exhibiting an IC50 of 0.09 nM against SK-OV-3ip cells. NVP-BQS481 is suitable for use as a cytotoxic payload in the synthesis of antibody-drug conjugates (ADCs).
    Fórmula:C27H33F3N4O2
    Cor e Forma:Solid
    Peso molecular:502.57

    Ref: TM-T212559