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Ciclo celular/Ponto de verificação

Ciclo celular/Ponto de verificação

Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.

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Foram encontrados 3756 produtos de "Ciclo celular/Ponto de verificação"

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  • CDK6/9-IN-1
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    CDK6/9-IN-1

    CAS:
    <p>CDK6/9-IN-1, an oral dual inhibitor of CDK6/9, has IC50s of 40.5nM (CDK6) and 39.5nM (CDK9).</p>
    Fórmula:C22H25ClN8O
    Cor e Forma:Solid
    Peso molecular:452.95

    Ref: TM-T40047

  • Logotipo do CymitQuimica
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    PD-1/PD-L1-IN-52

    PD-1/PD-L1-IN-52 (Compound Ⅲ-5) is an orally active inhibitor of PD-1/PD-L1 interaction, exhibiting an IC50 of 109.9 nM. It demonstrates antitumor activity in a C57BL/6 mouse model of MC38 colon carcinoma cells expressing human PD-1, achieving a tumor growth inhibition (TGI) rate of 49.6%.
    Cor e Forma:Odour Solid

    Ref: TM-T200724

  • Dihydro-5-azacytidine
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    Dihydro-5-azacytidine

    CAS:
    Dihydro-5-azacytidine (DHAC) is a nucleoside analog that interrupts DNA methylation by integrating into DNA. It also exhibits notable antitumor properties.
    Fórmula:C8H14N4O5
    Pureza:>99.99%
    Cor e Forma:Solid
    Peso molecular:246.22

    Ref: TM-T40713

  • 5'-O-DMT-ibu-dC
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    5'-O-DMT-ibu-dC

    CAS:
    5'-O-DMT-ibu-dC can be used in the synthesis of oligodeoxyribonucleotides.
    Fórmula:C34H37N3O7
    Cor e Forma:Solid
    Peso molecular:599.67

    Ref: TM-T38405

  • Carboxy-pyridostatin
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    Carboxy-pyridostatin

    CAS:
    <p>Carboxy-pyridostatin, as a fluorescent probe, can target G-quadruplex structures and trap cytoplasmic RNA G-quadruplex structures in cells.</p>
    Fórmula:C35H34N10O7
    Cor e Forma:Solid
    Peso molecular:706.71

    Ref: TM-T30745

  • Isocytosine
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    Isocytosine

    CAS:
    Compound PDK0016, with CAS No. 108-53-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0016 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.
    Fórmula:C4H5N3O
    Cor e Forma:White To Off-White Solid
    Peso molecular:111.1

    Ref: TM-PDK0016

  • Logotipo do CymitQuimica
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    Biotin-PEG7-C2-S-Vidarabine

    Biotin-PEG7-C2-S-Vidarabine: PEG linker with antiviral adenosine analog effective against herpes and zoster.
    Fórmula:C36H60N8O12S2
    Cor e Forma:Solid
    Peso molecular:861.04

    Ref: TM-T74385

  • Logotipo do CymitQuimica
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    PP-C8

    PP-C8: PROTAC CDK12-Cyclin K degrader with DC50s 416/412 nM; synergizes with PARP inhibitor against TNBC.
    Fórmula:C43H51FN12O7
    Cor e Forma:Solid
    Peso molecular:866.94

    Ref: TM-T74359

  • Uridine triphosphate 13C9,15N2 sodium
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    Uridine triphosphate 13C9,15N2 sodium

    CAS:
    Uridine triphosphate 13C9,15N2 sodium is an isotopically labeled.UTP is a key in RNA synthesis molecule a substrate for RNA polymerase.
    Fórmula:C9H1415N2NaO15P3
    Cor e Forma:Solid
    Peso molecular:517.04

    Ref: TM-T36299

  • PLK1-IN-2
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    PLK1-IN-2

    CAS:
    PLK1-IN-2 is a PLK1 kinase inhibitor with an IC 50 value of 0.384 μM.
    Fórmula:C24H27FN8OS
    Cor e Forma:Solid
    Peso molecular:494.59

    Ref: TM-T40265

  • Garenoxacin
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    Garenoxacin

    CAS:
    <p>Garenoxacin (BMS284756) is a novel oral des-fluoro(6) quinolone for the treatment of Gram-positive and Gram-negative bacterial infections.</p>
    Fórmula:C23H20F2N2O4
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:426.41

    Ref: TM-T7179

  • Xylocytidine
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    Xylocytidine

    CAS:
    Xylocytidine is a biochemical.
    Fórmula:C9H13N3O5
    Cor e Forma:Solid
    Peso molecular:243.22

    Ref: TM-T35201

  • Logotipo do CymitQuimica
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    Nocarnickelamides B

    <p>Nocarnickelamides B (Compound 2) is a linear peptide and an inhibitor of ROCK1/2. It exhibits dual inhibitory activity against ROCK1 and ROCK2, with IC50 values of 14.9 μM and 21.9 μM, respectively. This compound binds to the ATP binding site and inhibits ROCK-mediated cytoskeletal contraction markers, such as myosin light chain activation. Nocarnickelamides B can be utilized in glaucoma research.</p>
    Fórmula:C29H42N6O9
    Cor e Forma:Odour Solid
    Peso molecular:618.68

    Ref: TM-TN9153

  • Ficellomycin
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    Ficellomycin

    CAS:
    Ficellomycin is an aziridine antibiotic produced by Streptomyces ficellus. Which shows high in vitro activity against Gram-positive bacteria.
    Fórmula:C13H24N6O3
    Cor e Forma:Solid
    Peso molecular:312.37

    Ref: TM-T24063

  • Logotipo do CymitQuimica
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    Anti-MRSA agent 7

    Compound 12: a potent anti-MRSA, inhibits S. aureus/E. coli DNA gyrases/topo IV; IC50: 0.185-0.365/0.341-0.059 μM.
    Fórmula:C22H20BrF2N3O4
    Cor e Forma:Solid
    Peso molecular:508.31

    Ref: TM-T74810

  • Logotipo do CymitQuimica
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    Endo-1,4-β-xylanase

    CAS:
    Endo-1,4-β-xylanase (CtXyn11A) is a type of xylan hydrolase that hydrolyzes the β-1,4-glycosidic bond of the xylan molecule.
    Cor e Forma:Solid

    Ref: TM-T76179

  • Eesperamicin A1
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    Eesperamicin A1

    CAS:
    Esperamicin A1, a powerful antitumor drug, comes from Actinomadura verrucosospora.
    Fórmula:C59H80N4O22S4
    Cor e Forma:Solid
    Peso molecular:1325.54

    Ref: TM-T41140

  • Logotipo do CymitQuimica
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    CD532 hydrochloride

    CD532 hydrochloride, potent Aurora A inhibitor (IC50=45 nM), hampers MYCN protein, changes AURKA's shape, aids cancer research.
    Cor e Forma:Solid

    Ref: TM-T36932

  • RA-V
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    RA-V

    RA-V is a natural product that can be used as a reference standard.
    Fórmula:C160H202N24O41
    Cor e Forma:Solid
    Peso molecular:3117.5

    Ref: TM-T124482

  • BSJ-03-204
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    BSJ-03-204

    CAS:
    BSJ-03-204 is a selective Cdk4/6 degrader.
    Fórmula:C43H48N10O8
    Cor e Forma:Solid
    Peso molecular:832.9

    Ref: TM-T30600