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Dano de DNA/Reparo de DNA

Dano de DNA/Reparo de DNA

Os inibidores de dano/ reparo do DNA são compostos que interferem nos processos envolvidos na detecção e reparo de danos ao DNA. Esses inibidores são fundamentais para estudar os mecanismos de estabilidade genômica, mutagênese e resposta ao dano ao DNA. Eles também são importantes na pesquisa do câncer, pois muitos tumores dependem de vias específicas de reparo de DNA para sobreviver. Ao inibir essas vias, os inibidores de dano/reparo de DNA podem aumentar a eficácia da quimioterapia e da radioterapia. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade de dano/reparo de DNA para apoiar sua pesquisa em biologia molecular, oncologia e farmacologia.

Subcategorias de "Dano de DNA/Reparo de DNA"

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Foram encontrados 959 produtos de "Dano de DNA/Reparo de DNA"

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  • Antibacterial agent 236
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    Antibacterial agent 236

    CAS:
    <p>Anti bacterial agent 236 (Compound 4l), an orally effective inhibitor of DNA gyrase and topoisomerase IV (with IC50 values of 3.2 and 300 nM in Staphylococcus aureus, respectively), exhibits broad-spectrum antibacterial activity. It also demonstrates favorable pharmacokinetic properties in mice.</p>
    Fórmula:C26H27N5O2S
    Cor e Forma:Solid
    Peso molecular:473.59

    Ref: TM-T200041

  • Carbacyclin
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    Carbacyclin

    CAS:
    <p>Carbacyclin, a PGI2 analog, is a prostacyclin (PGI2) receptor agonist and vasodilator with potent inhibitory platelet aggregation.</p>
    Fórmula:C21H34O4
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:350.49

    Ref: TM-T10673

  • ATR kinase-IN-3
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    ATR kinase-IN-3

    CAS:
    <p>ATRkinase-IN-3 (Compound I-G-28) is an inhibitor of the ATR protein kinase, exhibiting a Ki value ranging from 0.01 to 1 μM, and is utilized in cancer research.</p>
    Fórmula:C24H27F2N9O2
    Cor e Forma:Solid
    Peso molecular:511.53

    Ref: TM-T201805

  • PARP1/2-IN-4
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    PARP1/2-IN-4

    CAS:
    <p>PARP1/2-IN-4 (compound 3) is an inhibitor of PARP1/2.</p>
    Fórmula:C23H30FN5O6
    Cor e Forma:Solid
    Peso molecular:491.51

    Ref: TM-T201607

  • Sirtuin-IN-2
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    Sirtuin-IN-2

    <p>Sirtuin-IN-2 (compound 20) is an inhibitor of Sirtuin5, a key target in leukemia and breast cancer.</p>
    Fórmula:C28H46N8O6S
    Cor e Forma:Solid
    Peso molecular:622.78

    Ref: TM-T201797

  • SIRT6 activator 2
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    SIRT6 activator 2

    CAS:
    <p>SIRT6 activator2 (compound 31) is a sirtuin6 activator known for its anti-lipid accumulation properties. It significantly downregulates LXR, SREBP-1c, and their target genes, making it valuable for research into lipid metabolism-related diseases.</p>
    Fórmula:C23H23N3O6
    Cor e Forma:Solid
    Peso molecular:437.45

    Ref: TM-T200625

  • Bizelesin
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    Bizelesin

    CAS:
    <p>Bizelesin, a synthetic antineoplastic agent, binds DNA, disrupts replication, triggers cell-cycle arrest, and induces senescence.</p>
    Fórmula:C43H36Cl2N8O5
    Cor e Forma:Solid
    Peso molecular:815.7

    Ref: TM-T71034

  • Logotipo do CymitQuimica
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    ATR-IN-11

    <p>ATR-IN-11, a potent ATR kinase inhibitor, shows promise as a lead for DNA damage response-targeted cancer drugs.</p>
    Fórmula:C25H30N6O2
    Cor e Forma:Solid
    Peso molecular:446.54

    Ref: TM-T62651

  • Topoisomerase I inhibitor 8
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    Topoisomerase I inhibitor 8

    CAS:
    <p>Topoisomerase I inhibitor 8, a hexacyclic analogue of camptothecin, is also a potent inhibitor of topoisomerase I and is toxic to tumour cells.</p>
    Fórmula:C24H21FN2O4
    Cor e Forma:Solid
    Peso molecular:420.43

    Ref: TM-T62225

  • ATR kinase-IN-2
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    ATR kinase-IN-2

    CAS:
    <p>ATRkinase-IN-2 (Compound I-G-27) is an inhibitor of the ATR protein kinase, with a Ki value ranging from 0.01 to 1 μΜ. It is utilized in tumor research.</p>
    Fórmula:C24H29F2N9O2
    Cor e Forma:Solid
    Peso molecular:513.54

    Ref: TM-T201634

  • PPARα/δ agonist 3
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    PPARα/δ agonist 3

    CAS:
    <p>PPARα/δ agonist 3 (Compound 8) is an orally active PPAR agonist capable of activating PPARα, PPARδ, and PPARγ, with EC50 values of 5.6 nM, 3.4 nM, and 1278 nM, respectively. It exhibits anti-cholestatic activity in mouse models of cholestatic liver disease induced by ANIT or CDCA.</p>
    Fórmula:C23H25F3N2O4
    Cor e Forma:Solid
    Peso molecular:450.451

    Ref: TM-T205373

  • PPARγ-IN-5
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    PPARγ-IN-5

    CAS:
    <p>PPARγ-IN-5 (Compound A3) is an inhibitor of PPARγ. In liver cells, it reduces lipid accumulation and shows no significant cytotoxicity in HepG2 cells at a concentration of 400 µM. PPARγ-IN-5 is applicable for research on non-alcoholic fatty liver disease.</p>
    Fórmula:C22H23ClO7
    Cor e Forma:Solid
    Peso molecular:434.867

    Ref: TM-T205246

  • O6BTG-C8-αGlu
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    O6BTG-C8-αGlu

    CAS:
    <p>O6BTG-C8-αGlu is an O6-methylguanine-DNA methyltransferase (MGMT) inhibitor with an IC50 of 0.45 μM. At a concentration of 0.1 μM, it fully inhibits MGMT in HeLaS3 cells and demonstrates no cytotoxicity even at prolonged high doses (up to 20 μM). This compound is suitable for research on MGMT-related cancers.</p>
    Fórmula:C24H34BrN5O7S
    Cor e Forma:Solid
    Peso molecular:616.525

    Ref: TM-T205643

  • Logotipo do CymitQuimica
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    ATR-IN-12

    <p>ATR-IN-12, a potent ATR kinase inhibitor with IC50 of 0.007 μM, shows promise for drug development.</p>
    Fórmula:C22H27N5O3S
    Cor e Forma:Solid
    Peso molecular:441.55

    Ref: TM-T62563

  • RU-0415529
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    RU-0415529

    CAS:
    <p>RU-0415529 is an orally active inhibitor of SARS-CoV-2 non-structural protein 14 (NSP14), with an IC50 of 356 nM. It inhibits viral RNA methylation and replication by stabilizing the cap-binding pocket through SAH binding. Additionally, RU-0415529 exhibits anti-infective activity in mouse models.</p>
    Fórmula:C21H29N3O4S
    Cor e Forma:Solid
    Peso molecular:419.538

    Ref: TM-T204295

  • ATR-IN-19
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    ATR-IN-19

    CAS:
    <p>ATR-IN-19 (Compound 15 R-configure) is an ATR inhibitor [1].</p>
    Fórmula:C18H19N7OS
    Cor e Forma:Solid
    Peso molecular:381.45

    Ref: TM-T61636

  • Amezalpat
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    Amezalpat

    CAS:
    <p>Amezalpat is a PPARα antagonist with an IC50 of 58 nM [nanomolar]. Amezalpat also exhibits antitumor activity.</p>
    Fórmula:C34H41N3O4
    Cor e Forma:Solid
    Peso molecular:555.707

    Ref: TM-T205015

  • (1R,2S,7R)-Sitafloxacin
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    (1R,2S,7R)-Sitafloxacin

    CAS:
    <p>(R)-Sitafloxacin (DU-6857) is an enantiomer of Sitafloxacin (DU-6859a) and functions as a topoisomerase inhibitor, demonstrating an IC50 of 0.18 μg/mL against DNA gyrase.</p>
    Fórmula:C19H18ClF2N3O3
    Cor e Forma:Solid
    Peso molecular:409.814

    Ref: TM-T206262

  • Camptothecin-20(S)-O-propionate
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    Camptothecin-20(S)-O-propionate

    CAS:
    <p>CZ-48 is a DNA topoisomerase inhibitor.</p>
    Fórmula:C23H20N2O5
    Cor e Forma:Solid
    Peso molecular:404.42

    Ref: TM-T27113

  • Logotipo do CymitQuimica
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    Pparδ agonist 5

    <p>Pparδ agonist 5 is a selective, orally active PPARδ agonist with an EC50 of 0.335 μM and better selectivity than GW0742.</p>
    Fórmula:C23H21F3N2O2S
    Cor e Forma:Solid
    Peso molecular:446.49

    Ref: TM-T62646