Dano de DNA/Reparo de DNA
Os inibidores de dano/ reparo do DNA são compostos que interferem nos processos envolvidos na detecção e reparo de danos ao DNA. Esses inibidores são fundamentais para estudar os mecanismos de estabilidade genômica, mutagênese e resposta ao dano ao DNA. Eles também são importantes na pesquisa do câncer, pois muitos tumores dependem de vias específicas de reparo de DNA para sobreviver. Ao inibir essas vias, os inibidores de dano/reparo de DNA podem aumentar a eficácia da quimioterapia e da radioterapia. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade de dano/reparo de DNA para apoiar sua pesquisa em biologia molecular, oncologia e farmacologia.
Subcategorias de "Dano de DNA/Reparo de DNA"
- ATM/ATR(71 produtos)
- Alquilação de DNA(11 produtos)
- DNA Metiltransferase(422 produtos)
- DNA girase(11 produtos)
- DNA-PK(51 produtos)
- MTH1(1 produtos)
- Nucleosídeo Antimetabólito/Análogo(1.388 produtos)
- Transcriptase reversa(43 produtos)
- Sirtuína(88 produtos)
- Telomerase(33 produtos)
- Topoisomerase(136 produtos)
Exibir 3 mais subcategorias
Foram encontrados 958 produtos de "Dano de DNA/Reparo de DNA"
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L67
CAS:<p>L67 (DNA Ligase Inhibitor) is a competitive human DNA ligase inhibitor, inhibits DNA ligases I and III (IC50: 10 μM).</p>Fórmula:C16H14Br2N4O4Pureza:98.34% - 99.56%Cor e Forma:SolidPeso molecular:486.11KCC-07
CAS:<p>KCC-07: Selective, potent, brain-penetrant MBD2 inhibitor with anticancer effects, blocking MBD2-DNA binding and activating BAI1 signaling.</p>Fórmula:C14H11N3OSPureza:98.86% - 99.01%Cor e Forma:SolidPeso molecular:269.32Tasquinimod
CAS:<p>Tasquinimod (ABR-215050) is an oral antiangiogenic agent and S100A9 inhibitor that binds to the HDAC4Zn2+ binding structural domain with Kd values ranging from 10 to 30 nM.Cost-effective and quality-assured.</p>Fórmula:C20H17F3N2O4Pureza:99.22% - >99.99%Cor e Forma:SolidPeso molecular:406.36SRT 1720
CAS:<p>SRT 1720 is a selective activator of human SIRT1 (EC1.5: 0.16 μM) and is >230-fold less potent for SIRT2 and SIRT3.</p>Fórmula:C25H23N7OSPureza:98.84%Cor e Forma:SolidPeso molecular:469.56Ceralasertib
CAS:<p>Ceralasertib (AZD6738) is an ATR kinase inhibitor (IC50=1 nM) with selective and oral activity. Ceralasertib has antitumor activity. Cost effective and quality assured.</p>Fórmula:C20H24N6O2SPureza:98% - 99.99%Cor e Forma:SolidPeso molecular:412.51Pyridostatin TFA
CAS:<p>Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes including c-</p>Fórmula:C37H35F9N8O11Pureza:97.09% - 99.84%Cor e Forma:SolidPeso molecular:938.71ME0328
CAS:<p>ME0328 is a potent and selective PARP inhibitor with IC50 of 0.89 μM for PARP3, about 7-fold selectivity over PARP1.</p>Fórmula:C19H19N3O2Pureza:99.22%Cor e Forma:SolidPeso molecular:321.37Razoxane
CAS:<p>Razoxane is used as an antimitotic agent with immunosuppressive properties.</p>Fórmula:C11H16N4O4Pureza:99.75%Cor e Forma:SolidPeso molecular:268.27Darglitazone Sodium
CAS:<p>Darglitazone Sodium, an oral PPAR-γ agonist, aids type II diabetes study by regulating glucose and lipids.</p>Fórmula:C23H21N2NaO4SCor e Forma:SolidPeso molecular:444.48BGP-15
CAS:<p>BGP-15 (BGP-15 2HCl) is a PARP inhibitor with protecting effect after ischemia-reperfusion injury.</p>Fórmula:C14H24Cl2N4O2Pureza:98.17% - 99.89%Cor e Forma:SolidPeso molecular:351.27KU60019
CAS:<p>Ku-60019 is a potent, reversible inhibitor of ATM kinase (IC50: 6.3 nM). It is much less effective or without effect against a panel of 229 other kinases.</p>Fórmula:C30H33N3O5SPureza:95.9% - 99.36%Cor e Forma:SolidPeso molecular:547.67GW9662
CAS:<p>GW9662 (TIMTEC-BB SBB006523) is a PPARγ antagonist (IC50=3.3 nM) with selectivity. GW9662 has anti-tumor effect. High-Quality, Low-Cost!</p>Fórmula:C13H9ClN2O3Pureza:98% - 99.95%Cor e Forma:Off-White SolidPeso molecular:276.68RHPS4
CAS:<p>RHPS4 (RHPS 4 methosulfate) is a potent inhibitor of Telomerase at submicromolar.</p>Fórmula:C22H17F2N2·CH3O4SPureza:99.72%Cor e Forma:SolidPeso molecular:458.48AZ20
CAS:<p>AZ20 is an effective and specific inhibitor of ATR kinase (IC50: 5 nM, in a cell-free assay), 8-fold selectivity over mTOR.</p>Fórmula:C21H24N4O3SPureza:98% - 99.69%Cor e Forma:SolidPeso molecular:412.51Rabdosiin
CAS:<p>Rabdosiin ((+)-Rabdosiin) is a natural product, and has anti-allergic activity, anti-HIV activity and inhibition on DNA topoisomerase.</p>Fórmula:C36H30O16Pureza:98.64% - 99.49%Cor e Forma:SolidPeso molecular:718.61PIK-75 hydrochloride
CAS:<p>PIK-75 hydrochloride (PIK-75 HCl) is a p110α inhibitor, isoform-specific mutants at Ser773, and potently inhibits DNA-PK with IC50 of 2 nM in cell-free assay.</p>Fórmula:C16H14BrN5O4S·HClPureza:97.82%Cor e Forma:SolidPeso molecular:488.74Topovale
CAS:<p>Topovale (ARC111) is a potent inhibitor of topoisomerase I.</p>Fórmula:C23H23N3O5Pureza:99.94%Cor e Forma:SolidPeso molecular:421.45JW 55
CAS:<p>JW 55 (JW55) is an effective and selective β-catenin signaling pathway inhibitor, works by inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2</p>Fórmula:C25H26N2O5Pureza:99.31% - 99.76%Cor e Forma:SolidPeso molecular:434.48Pixantrone hydrochloride
CAS:<p>Pixantrone hydrochloride is a topoisomerase II inhibitor and DNA intercalator with anti-tumor properties.</p>Fórmula:C17H20ClN5O2Cor e Forma:SolidPeso molecular:361.83Tretazicar
CAS:<p>CB1954, an anticancer prodrug, turns into a potent alkylating agent when activated by NQO2 and EP-0152R.</p>Fórmula:C9H8N4O5Pureza:99.41% - 99.7%Cor e Forma:SolidPeso molecular:252.18Coralyne chloride
CAS:<p>Coralyne chloride is a protoberberine with strong anticancer activity.</p>Fórmula:C22H22ClNO4Pureza:98.88%Cor e Forma:SolidPeso molecular:399.87NU6027
CAS:<p>NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-</p>Fórmula:C11H17N5O2Pureza:98.36%Cor e Forma:SolidPeso molecular:251.29Gatifloxacin hydrochloride
CAS:<p>Gatifloxacin hydrochloride, a fourth-gen fluoroquinolone antibiotic, blocks bacterial DNA rotase and topoisomerase IV.</p>Fórmula:C19H23ClFN3O4Pureza:99.85% - 99.89%Cor e Forma:SolidPeso molecular:411.86NPC 15199
CAS:<p>NPC 15199 (FMOC-L-Leucine) is an anti-inflammatory agent.</p>Fórmula:C21H23NO4Pureza:99.93% - 99.94%Cor e Forma:White Crystalline PowderPeso molecular:353.41Thiomyristoyl
CAS:<p>Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM.</p>Fórmula:C34H51N3O3SPureza:99.16%Cor e Forma:SolidPeso molecular:581.85Genz-644282
CAS:<p>Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment.</p>Fórmula:C22H21N3O5Pureza:97.49%Cor e Forma:SolidPeso molecular:407.42Pentamidine
CAS:<p>Pentamidine is an antifungal and antiprotozoal agent, interacting directly with the pathogen genome by binding to AT-rich regions of duplex DNA and the minor</p>Fórmula:C19H24N4O2Pureza:98.64% - 99.67%Cor e Forma:Crystallizes As Colorless Plates From Water SolidPeso molecular:340.42TIQ-A
CAS:<p>TIQ-A blocks PARP1 to prevent excessive DNA damage response, implicated in ischemia, asthma, and atherosclerosis.</p>Fórmula:C11H7NOSPureza:99.75%Cor e Forma:SolidPeso molecular:201.24AZD-2461
CAS:<p>AZD2461 is a novel PARP inhibitor.</p>Fórmula:C22H22FN3O3Pureza:98% - 99.87%Cor e Forma:SolidPeso molecular:395.43Clomesone
CAS:<p>Clomesone, a synthetic drug, treats female infertility by blocking brain estrogen, inducing ovulation.</p>Fórmula:C4H9ClO5S2Pureza:99%Cor e Forma:SolidPeso molecular:236.69Pyridostatin
CAS:<p>Pyridostatin (RR82) is a synthetic small-molecule stabilizer of G-quadruplexes, a secondary structure of DNA that usually exists in the end of the chromosome or</p>Fórmula:C31H32N8O5Pureza:98%Cor e Forma:SolidPeso molecular:596.64TMPyP4 tosylate
CAS:<p>TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand and is a telomerase inhibitor with antitumor effects in osteosarcoma cell lines.</p>Fórmula:C72H66N8O12S4Pureza:98.61% - 99.85%Cor e Forma:SolidPeso molecular:1363.6UPF 1069
CAS:<p>UPF 1069 is a specific PARP2 inhibitor ( IC50: 0.3 μM). It is ~27-fold selective against PARP1.</p>Fórmula:C17H13NO3Pureza:98.80% - 99.88%Cor e Forma:SolidPeso molecular:279.29SRT1720 hydrochloride
CAS:<p>SRT1720 hydrochloride (SRT1720 HCl) is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2/SIRT3 (EC1.5s: 37 μM/300 μM).</p>Fórmula:C25H24ClN7OSPureza:98% - 99.93%Cor e Forma:SolidPeso molecular:506.22KU-57788
CAS:<p>NU7441 (KU-57788 (NU7441)) is a highly effective and specific DNA-PK inhibitor (IC50: 14 nM).</p>Fórmula:C25H19NO3SPureza:98% - >99.99%Cor e Forma:SolidPeso molecular:413.49EDO-S101
CAS:<p>EDO-S101 (Tinostamustine) is a pan HDAC inhibitor with IC50 values of 9, 9 and 25 nM for HDAC1, HDAC2 and HDAC3 , respectively.</p>Fórmula:C19H28Cl2N4O2Pureza:98.02% - 99.44%Cor e Forma:SolidPeso molecular:415.36SCR130
CAS:<p>SCR130 (1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo-) 是基于 SCR7 的 DNA 非同源末端连接抑制剂，可诱导细胞凋亡并，具有抗癌活性。 它特异性依赖连接酶 IV，抑制 DNA 的末端连接。</p>Fórmula:C19H13Cl2N3O2SPureza:98.9%Cor e Forma:SolidPeso molecular:418.3PARP1-IN-5 dihydrochloride
CAS:<p>PARP1-IN-5 dihydrochloride: oral, potent PARP-1 inhibitor (IC50=14.7 nM), for cancer research.</p>Fórmula:C25H26Cl2N2O5SPureza:98.01%Cor e Forma:SolidPeso molecular:537.46Furegrelate
CAS:<p>FUREGRELATE, a thromboxane A2 (TxA2) synthase inhibitor, blunts the development of pulmonary arterial hypertension in neonatal piglets.</p>Fórmula:C15H11NO3Pureza:99.71%Cor e Forma:SolidPeso molecular:253.25AZ32
CAS:<p>AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell.</p>Fórmula:C20H16N4OPureza:98.68% - 99.68%Cor e Forma:SolidPeso molecular:328.37AZ9482
CAS:<p>AZ9482, a potent PARP inhibitor with 2-piperazinyl-3-cyano-pyridine linkage, causes centrosome declustering in HeLa cells with an EC50 < 18 nM.</p>Fórmula:C26H22N6O2Pureza:99.18% - 99.86%Cor e Forma:SolidPeso molecular:450.49DR2313
CAS:<p>DR2313 is a competitive inhibitor of poly(ADP-ribose) polymerase (IC50: 0.20 and 0.24 μM for PARP-1 and PARP-2 respectively). It also has neuroprotective.</p>Fórmula:C8H10N2OSPureza:98.65%Cor e Forma:SolidPeso molecular:182.24Bendamustine
CAS:<p>Bendamustine (SDX105) for the treatment of Non-Hodgkin Lymphomas and Chronic Lymphocytic Leukemia</p>Fórmula:C16H21Cl2N3O2Pureza:≥98%Cor e Forma:SolidPeso molecular:358.26γ-Oryzanol
CAS:<p>γ-Oryzanol (Gamma-Oryzanol) is a natural nutrient extract isolated from rice bran oil that contains a mixture of sterols and ferulic acids, which may aid in the</p>Fórmula:C40H58O4Pureza:mixture - mixtureCor e Forma:White Or White Crystalline Powder OdourlessPeso molecular:602.9VE-821
CAS:<p>VE-821 (ATR Inhibitor IV) is a selective ATP competitive inhibitor of ATR( Ki/IC50: 13/26 nM in cell-free assays).</p>Fórmula:C18H16N4O3SPureza:97.19% - 99.97%Cor e Forma:SolidPeso molecular:368.41Prulifloxacin
CAS:<p>Prulifloxacin (NM441) is a broad-spectrum fluoroquinolone that inhibits bacterial DNA synthesis by blocking topoisomerase II and IV.</p>Fórmula:C21H20FN3O6SPureza:99.47%Cor e Forma:Yellow Or Slightly Yellow PowerPeso molecular:461.46Senaparib
CAS:<p>Senaparib (IMP4297) is a novel highly potent and selective oral PARP1/2 inhibitor with strong antitumor activity.</p>Fórmula:C24H20F2N6O3Pureza:99.8%Cor e Forma:SolidPeso molecular:478.45Levofloxacin hydrochloride
CAS:<p>Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity.</p>Fórmula:C18H21ClFN3O4Pureza:99.78% - 99.98%Cor e Forma:SolidPeso molecular:397.8Pirarubicin
CAS:<p>Pirarubicin (Theprubicin), an anthracycline antibiotic, inhibits DNA/RNA synthesis and is used as an antineoplastic.</p>Fórmula:C32H37NO12Pureza:97.80% - 99.15%Cor e Forma:Red Crystalline PowderPeso molecular:627.64Ganciclovir sodium
CAS:<p>Ganciclovir sodium, a sodium salt with anti-CMV and HSV-1 antiviral properties.</p>Fórmula:C9H13N5NaO4Pureza:99.93%Cor e Forma:SolidPeso molecular:278.22
