Dano de DNA/Reparo de DNA
Os inibidores de dano/ reparo do DNA são compostos que interferem nos processos envolvidos na detecção e reparo de danos ao DNA. Esses inibidores são fundamentais para estudar os mecanismos de estabilidade genômica, mutagênese e resposta ao dano ao DNA. Eles também são importantes na pesquisa do câncer, pois muitos tumores dependem de vias específicas de reparo de DNA para sobreviver. Ao inibir essas vias, os inibidores de dano/reparo de DNA podem aumentar a eficácia da quimioterapia e da radioterapia. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade de dano/reparo de DNA para apoiar sua pesquisa em biologia molecular, oncologia e farmacologia.
Subcategorias de "Dano de DNA/Reparo de DNA"
- ATM/ATR(71 produtos)
- Alquilação de DNA(11 produtos)
- DNA Metiltransferase(422 produtos)
- DNA girase(11 produtos)
- DNA-PK(51 produtos)
- MTH1(1 produtos)
- Nucleosídeo Antimetabólito/Análogo(1.388 produtos)
- Transcriptase reversa(43 produtos)
- Sirtuína(88 produtos)
- Telomerase(33 produtos)
- Topoisomerase(136 produtos)
Exibir 3 mais subcategorias
Foram encontrados 959 produtos de "Dano de DNA/Reparo de DNA"
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Methotrexate disodium
CAS:<p>Methotrexate disodium is an tetrahydrofolate dehydrogenase inhibitor</p>Fórmula:C20H20N8Na2O5Pureza:99.77% - 99.96%Cor e Forma:SolidPeso molecular:498.49-Hydroxycamptothecin
CAS:<p>9-Hydroxycampothecin is a camptothecin derivative with anticancer activity.</p>Fórmula:C20H16N2O5Pureza:98.28%Cor e Forma:SolidPeso molecular:364.35Levofloxacin hydrochloride
CAS:<p>Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity.</p>Fórmula:C18H21ClFN3O4Pureza:99.78% - 99.98%Cor e Forma:SolidPeso molecular:397.8PIK-93
CAS:PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.Fórmula:C14H16ClN3O4S2Pureza:97.72%Cor e Forma:SolidPeso molecular:389.88Xanthosine 5'-monophosphate sodium salt
CAS:<p>Xanthosine 5'-monophosphate sodium salt (L-XMP Sodium) is an intermediate in purine metabolism.</p>Fórmula:C10H11N4Na2O9PPureza:99% - 99.77%Cor e Forma:SolidPeso molecular:408.17Ganciclovir sodium
CAS:<p>Ganciclovir sodium, a sodium salt with anti-CMV and HSV-1 antiviral properties.</p>Fórmula:C9H13N5NaO4Pureza:99.93%Cor e Forma:SolidPeso molecular:278.22Silver sulfadiazine
CAS:<p>Silver sulfadiazine (Dermazin) is a sulfonamide-based topical agent with antibacterial and antifungal activity.</p>Fórmula:C10H9AgN4O2SPureza:99.04% - 99.58%Cor e Forma:SolidPeso molecular:357.14AZD-7648
CAS:<p>AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.</p>Fórmula:C18H20N8O2Pureza:99.03% - 99.85%Cor e Forma:SolidPeso molecular:380.4AZD 6482
CAS:<p>AZD 6482 (KIN-193) is a potent and selective inhibitor of p110β and PI3Kβ with IC50 values of 0.69nM and 10nM.Cost-effective and quality-assured.</p>Fórmula:C22H24N4O4Pureza:99.79% - 99.95%Cor e Forma:SolidPeso molecular:408.451-Oleoyl lysophosphatidic acid sodium
CAS:<p>1-Oleoyl lysophosphatidic acid sodium (1-Oleoyl lysophosphatidic acid sodium salt) salt is an Endogenous agonist of LPA1 and LPA2</p>Fórmula:C21H40O7P·NaPureza:98.75% - 99.24%Cor e Forma:SolidPeso molecular:458.51LMK-235
CAS:<p>LMK-235 is a potent HDAC inhibitor, and is used in cancer research.</p>Fórmula:C15H22N2O4Pureza:98.18% - 99.68%Cor e Forma:SolidPeso molecular:294.35MK-4827 Racemate
CAS:<p>MK-4827 Racemate (Niraparib Racemate) is a selective PARP1 and PARP2 inhibitor with IC50s of 3.8 nM and 2.1 nM, respectively, over 330-fold selectivity for</p>Fórmula:C19H20N4OPureza:99.86%Cor e Forma:SolidPeso molecular:320.39Altretamine hydrochloride
CAS:<p>Altretamine hydrochloride is an alkylating antineoplastic agent.</p>Fórmula:C9H19ClN6Cor e Forma:SolidPeso molecular:246.74Ensulizole
CAS:<p>Ensulizole, a water-soluble UV absorber, damages DNA by generating ROS under UV light, and absorbs UVB and some UVA.</p>Fórmula:C13H10N2O3SPureza:99.79%Cor e Forma:White To Pale Beige Solid PowderPeso molecular:274.30Gatifloxacin hydrochloride
CAS:<p>Gatifloxacin hydrochloride, a fourth-gen fluoroquinolone antibiotic, blocks bacterial DNA rotase and topoisomerase IV.</p>Fórmula:C19H23ClFN3O4Pureza:99.85% - 99.89%Cor e Forma:SolidPeso molecular:411.86EIDD-1931
CAS:<p>EIDD-1931 (Beta-d-N4-hydroxycytidine) is a ribonucleoside analog with antiviral activity. It inhibits replication of SARS-CoV, MERS-CoV, and SARS-CoV-2.</p>Fórmula:C9H13N3O6Pureza:99.14% - 99.73%Cor e Forma:SolidPeso molecular:259.22Rubitecan
CAS:<p>Rubitecan: a semisynthetic DNA topoisomerase I inhibitor with antitumor and antiviral effects.</p>Fórmula:C20H15N3O6Pureza:97.54%Cor e Forma:Yellow Amorphous PowderPeso molecular:393.352',3',5'-triacetyl-5-Azacytidine
CAS:<p>2',3',5'-triacetyl-5-Azacytidine (Nsc291930) is a prodrug form of 5-azacytidine that may be rapidly absorbed orally.</p>Fórmula:C14H18N4O8Pureza:98.34%Cor e Forma:SolidPeso molecular:370.31CXD101
CAS:<p>CXD101 is a novel class I-selective HDACi (HDAC1 (IC50 : 63nM), HDAC2 (IC50 :570nM), HDAC3 (IC50 :550nM)). CXD101(CXD-101) has no activity against HDAC class II</p>Fórmula:C24H29N5OPureza:99.82%Cor e Forma:SolidPeso molecular:403.52SRT 1720
CAS:<p>SRT 1720 is a selective activator of human SIRT1 (EC1.5: 0.16 μM) and is >230-fold less potent for SIRT2 and SIRT3.</p>Fórmula:C25H23N7OSPureza:98.84%Cor e Forma:SolidPeso molecular:469.56GW9662
CAS:<p>GW9662 (TIMTEC-BB SBB006523) is a PPARγ antagonist (IC50=3.3 nM) with selectivity. GW9662 has anti-tumor effect. High-Quality, Low-Cost!</p>Fórmula:C13H9ClN2O3Pureza:98% - 99.95%Cor e Forma:Off-White SolidPeso molecular:276.68M344
CAS:<p>M344 (Histone Deacetylase Inhibitor III) is a potent HDAC inhibitor with IC50 of 100 nM and able to induce cell differentiation.</p>Fórmula:C16H25N3O3Pureza:98.18%Cor e Forma:SolidPeso molecular:307.39NU1025
CAS:<p>NU1025 (NSC-696807) is a potent PARP inhibitor with IC50 of 400 nM.</p>Fórmula:C9H8N2O2Pureza:99.86%Cor e Forma:SolidPeso molecular:176.17AG14361
CAS:<p>AG14361 is an effective inhibitor of PARP1 (Ki<5 nM).</p>Fórmula:C19H20N4OPureza:98.7% - 99.93%Cor e Forma:SolidPeso molecular:320.391,4-Naphthoquinone
CAS:<p>1,4-Naphthoquinone used as inhibitor for monoamine oxidase, DNA topoisomerase, and acetyltransferase.</p>Fórmula:C10H6O2Pureza:99.24% - 99.56%Cor e Forma:SolidPeso molecular:158.15CM-579 trihydrochloride
<p>CM-579 trihydrochloride: reversible G9a/DNMT inhibitor with IC50s 16 nM (G9a) & 32 nM (DNMT); potent against various cancer cells.</p>Fórmula:C29H43Cl3N4O3Cor e Forma:SolidPeso molecular:602.04NU 7026
CAS:<p>NU 7026 (DNA-PK Inhibitor II) is an effective DNA-PK inhibitor (IC50: 0.23 μM, in cell-free assays), 60-fold selective for DNA-PK than PI3K and no inhibition</p>Fórmula:C17H15NO3Pureza:99.51% - >99.99%Cor e Forma:SolidPeso molecular:281.31SirReal2
CAS:<p>SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.</p>Fórmula:C22H20N4OS2Pureza:98.96% - 99.75%Cor e Forma:SolidPeso molecular:420.55PI-3065
CAS:<p>PI-3065 is a novel potent and selective PI3K p110δ inhibitor.</p>Fórmula:C27H31FN6OSPureza:99.84% - ≥95%Cor e Forma:SolidPeso molecular:506.64ML216
CAS:<p>ML216 (CID-49852229) inhibits BLM helicase (IC50: 1.8 μM), 28-fold selective over RECQ1, RECQ5, and UvrD (IC50s > 50 μM).</p>Fórmula:C15H9F4N5OSPureza:98.12%Cor e Forma:SolidPeso molecular:383.32Palifosfamide tromethamine
CAS:<p>Palifosfamide, a less toxic ifosfamide metabolite, is a DNA-alkylating anticancer agent.</p>Fórmula:C8H22Cl2N3O5PCor e Forma:SolidPeso molecular:342.16Azemiglitazone
CAS:<p>Azemiglitazone (MSDC 0602) is an insulin sensitizer potentially for the treatment of diabetes.</p>Fórmula:C19H17NO5SPureza:98.29% - 99.6%Cor e Forma:SolidPeso molecular:371.41NMS-P118
CAS:<p>NMS-P118 is a potent, selective and orally available Inhibitor of PARP-1 for cancer therapy.</p>Fórmula:C20H24F3N3O2Pureza:98.79%Cor e Forma:SolidPeso molecular:395.42Zebularine
CAS:<p>Zebularine (4-Deoxyuridine) is a DNA methylation inhibitor.</p>Fórmula:C9H12N2O5Pureza:99.04% - >99.99%Cor e Forma:SolidPeso molecular:228.2Thymidine
CAS:<p>Thymidine (DThyd) is a cell synchronizing agent and a precursor of deoxyribonucleic acid. Thymidine inhibits DNA synthesis. Cost-effective and quality-assured.</p>Fórmula:C10H14N2O5Pureza:99.64% - 99.86%Cor e Forma:White To Off-White Solid CrystallinePeso molecular:242.23T0070907
CAS:<p>T0070907(IC50=1 nM) , an effective and specific PPARγ inhibitor, with the >800-fold selectivity over PPARα and PPARδ.</p>Fórmula:C12H8ClN3O3Pureza:98.25% - 99.98%Cor e Forma:SolidPeso molecular:277.66SW-100
CAS:<p>SW-100 is a potent HDAC6 inhibitor with 2.3 nM IC50, highly selective (>1000-fold), can cross blood-brain-barrier.</p>Fórmula:C17H17ClN2O2Pureza:98.34% - 98.47%Cor e Forma:SolidPeso molecular:316.78Pirarubicin
CAS:<p>Pirarubicin (Theprubicin), an anthracycline antibiotic, inhibits DNA/RNA synthesis and is used as an antineoplastic.</p>Fórmula:C32H37NO12Pureza:97.80% - 99.15%Cor e Forma:Red Crystalline PowderPeso molecular:627.64GSK3685032
CAS:<p>GSK3685032 is a non-covalent and selective DNMT1 inhibitor(IC50 = 36 nM).</p>Fórmula:C22H24N6OSPureza:98.56% - 99.49%Cor e Forma:SolidPeso molecular:420.53Senaparib
CAS:<p>Senaparib (IMP4297) is a novel highly potent and selective oral PARP1/2 inhibitor with strong antitumor activity.</p>Fórmula:C24H20F2N6O3Pureza:99.8%Cor e Forma:SolidPeso molecular:478.45L-778123 hydrochloride
CAS:<p>The L-778123 hydrochloride is an inhibitor of FPTase (IC50: 2 nM) and GGPTase-I (IC50: 98 nM) in enzyme inhibition determination.</p>Fórmula:C22H21Cl2N5OPureza:93.93% - 98.51%Cor e Forma:SolidPeso molecular:442.34Prulifloxacin
CAS:<p>Prulifloxacin (NM441) is a broad-spectrum fluoroquinolone that inhibits bacterial DNA synthesis by blocking topoisomerase II and IV.</p>Fórmula:C21H20FN3O6SPureza:99.47%Cor e Forma:Yellow Or Slightly Yellow PowerPeso molecular:461.46Ceralasertib
CAS:<p>Ceralasertib (AZD6738) is an ATR kinase inhibitor (IC50=1 nM) with selective and oral activity. Ceralasertib has antitumor activity. Cost effective and quality assured.</p>Fórmula:C20H24N6O2SPureza:98% - 99.99%Cor e Forma:SolidPeso molecular:412.51VE-821
CAS:<p>VE-821 (ATR Inhibitor IV) is a selective ATP competitive inhibitor of ATR( Ki/IC50: 13/26 nM in cell-free assays).</p>Fórmula:C18H16N4O3SPureza:97.19% - 99.97%Cor e Forma:SolidPeso molecular:368.41Indotecan
CAS:<p>Indotecan (LMP-400) is an effective inhibitor of topoisomerase 1(Top1) (IC50: 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively).</p>Fórmula:C26H26N2O7Pureza:97% - 98%Cor e Forma:SolidPeso molecular:478.49γ-Oryzanol
CAS:<p>γ-Oryzanol (Gamma-Oryzanol) is a natural nutrient extract isolated from rice bran oil that contains a mixture of sterols and ferulic acids, which may aid in the</p>Fórmula:C40H58O4Pureza:mixture - mixtureCor e Forma:White Or White Crystalline Powder OdourlessPeso molecular:602.9Thiomyristoyl
CAS:<p>Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM.</p>Fórmula:C34H51N3O3SPureza:99.16%Cor e Forma:SolidPeso molecular:581.85AGK7
CAS:<p>AGK7 is an AGK2 control; it's a less selective SIRT2 inhibitor, with IC50s >5 μM for SIRT3, and >50 μM for SIRT1/2.</p>Fórmula:C23H13Cl2N3O2Pureza:98.31%Cor e Forma:SolidPeso molecular:434.27Hinokitiol
CAS:<p>Hinokitiol prevents UVB-caused cell death, boosts antioxidant activity, and hinders breast cancer growth.</p>Fórmula:C10H12O2Pureza:99.49% - 99.67%Cor e Forma:SolidPeso molecular:164.2UBCS039
CAS:<p>UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM)</p>Fórmula:C16H13N3Pureza:98.31%Cor e Forma:SolidPeso molecular:247.29
