Sirtuína
As sirtuínas são uma família de desacetilases dependentes de NAD+ que desempenham um papel crucial na regulação de processos celulares como reparo de DNA, envelhecimento, metabolismo e resistência ao estresse. As sirtuínas influenciam o reparo do DNA ao desacetilar proteínas envolvidas nas vias de reparo, modulando assim sua atividade. Inibidores e ativadores de sirtuínas são ferramentas valiosas em pesquisas sobre envelhecimento, câncer e doenças metabólicas, onde a regulação do reparo do DNA e da longevidade celular é de interesse. Na CymitQuimica, oferecemos uma gama de moduladores de sirtuínas de alta qualidade para apoiar sua pesquisa em reparo de DNA, envelhecimento celular e regulação metabólica.
Foram encontrados 88 produtos de "Sirtuína"
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SIRT-IN-2
CAS:SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively).Fórmula:C15H21N5O3S2Pureza:98.26%Cor e Forma:SolidPeso molecular:383.49Ref: TM-T12919
1mg97,00€5mg227,00€10mg364,00€25mg620,00€50mg848,00€100mg1.159,00€200mg1.549,00€1mL*10mM (DMSO)250,00€Nicotinamide riboside
CAS:<p>Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-</p>Fórmula:C11H15N2O5Pureza:98.82% - 99.58%Cor e Forma:SolidPeso molecular:255.25Resveratrol
CAS:Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities.Fórmula:C14H12O3Pureza:99.82% - 99.96%Cor e Forma:Off-White To Tan PowderPeso molecular:228.24MC3482
CAS:MC3482 is a specific inhibitor of sirtuin5 (SIRT5).Fórmula:C33H38N4O8Pureza:98% - 99.90%Cor e Forma:SoildPeso molecular:618.68Ref: TM-T11962
1mg52,00€2mg74,00€5mg111,00€10mg180,00€25mg283,00€50mg445,00€100mg723,00€500mg1.454,00€MIND4-19
CAS:MIND4-19 is an inhibitor of SIRT2 with antitumor activity.Fórmula:C22H19N3OSPureza:99.9%Cor e Forma:SolidPeso molecular:373.47SIRT2-IN-16
SIRT2-IN-16 (compound 17) is a SIRT2 inhibitor targeted at prostate-specific membrane antigen (PSMA).Fórmula:C55H91N9O15SCor e Forma:SolidPeso molecular:1150.43SIRT5 inhibitor 8
CAS:SIRT5 inhibitor 8 (compound 10) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=5.38 μM, with potential anticancer effects.Fórmula:C22H25ClN8O2SPureza:99.56%Cor e Forma:SolidPeso molecular:501Et-29
CAS:<p>Et-29 is a selective inhibitor of SIRT5 inhibitor with a Ki of 40 nM.</p>Fórmula:C34H46N6O6SPureza:99.52%Cor e Forma:SolidPeso molecular:666.83Benzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl)
CAS:3-Methoxybenzamide derivative modulates sirtuins; may boost cell lifespan and treat diseases.Fórmula:C20H15N3O2SPureza:99.32%Cor e Forma:SolidPeso molecular:361.42WAY-323061
CAS:WAY-323061 is a SIRT2 inhibitor.Fórmula:C25H21N5O2SPureza:99.33%Cor e Forma:SolidPeso molecular:455.53BML-278
CAS:BML-278 is a SIRT1 activator with an EC150 of 1 μM.BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, andFórmula:C24H25NO4Pureza:99.98%Cor e Forma:SolidPeso molecular:391.46SIRT2-IN-17
SIRT2-IN-17 (compound Z18) is a potent inhibitor of SIRT2, effectively reducing the expression of α-SMA and p-Smad2/3.Fórmula:C24H15N3O2SCor e Forma:SolidPeso molecular:409.46SJ-106C
SJ-106C, a SIRT inhibitor, exhibits IC50 values of 0.59, 0.12, and 0.49 μM against SIRT1/2/3, respectively. This compound specifically targets mitochondria and inhibits the growth of DLBCL tumors.Cor e Forma:Odour SolidSIRT1-IN-1
CAS:<p>SIRT1-IN-1 is a selective inhibitor of SIRT1 with an IC50 of 205 nM.Cost-effective and quality-assured.</p>Fórmula:C14H16N2OPureza:99.58%Cor e Forma:SolidPeso molecular:228.29Sirtuin modulator 2
CAS:Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities.Fórmula:C19H15N3O2SPureza:99.67%Cor e Forma:SolidPeso molecular:349.41SIRT3 activator 2
SIRT3 activator2 (compound 2a) acts as an activator of SIRT3. It is presumed to bind directly with SIRT3 in SH-SY5Y cells, as inferred through thermal stability, facilitating the SIRT3-dependent clearance of α-Syn. Furthermore, SIRT3 activator2 enhances motor functions in Parkinsonian mice and dose-dependently prevents the loss of dopaminergic (DA) neurons in the substantia nigra.Fórmula:C22H24N2O9SCor e Forma:SolidPeso molecular:492.5SIRT-IN-5
SIRT-IN-5, a selective inhibitor of SIRT3 with an IC50 of 2.88 μM, facilitates the differentiation of multiple myeloma cells. This differentiation is associated with increased expression of the differentiation antigens CD49e and human immunoglobulin light chains λ and κ.Cor e Forma:Odour SolidZ26395438
CAS:Z26395438 is an inhibitor of Sirtuin-1 with IC50 of 1.6 μM.Fórmula:C17H15FN2OPureza:99.54%Cor e Forma:SolidPeso molecular:282.31Ref: TM-T77653
1mg57,00€2mg81,00€5mg120,00€10mg180,00€25mg329,00€50mg472,00€100mg700,00€500mg1.406,00€SIRT1 activator 1
SIRT1 Activator 1 (Compound 3), a marine-derived xyloallenoide A derivative from the Xylaria sp.Pureza:98%Cor e Forma:Odour SolidSirt1/2-IN-4
Sirt1/2-IN-4 (compound PS3) is a potent triple inhibitor of SIRT1, SIRT2, and SIRT3, exhibiting IC50 values of 1.2 μM (SIRT1), 1.9 μM (SIRT2), and 18.6 μM (Fórmula:C21H20N4O3S2Pureza:98%Cor e Forma:SolidPeso molecular:440.54
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