Imunologia e Inflamação
Os inibidores de imunologia e inflamação são compostos que modulam a resposta imunológica e os processos inflamatórios. Esses inibidores são cruciais para estudar os mecanismos de regulação imunológica, autoimunidade e inflamação crônica, bem como para desenvolver tratamentos para doenças inflamatórias, alergias e distúrbios relacionados ao sistema imunológico. Ao direcionar vias-chave no sistema imunológico, esses inibidores podem ajudar a reduzir respostas imunológicas excessivas ou inadequadas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de alta qualidade para apoiar sua pesquisa em imunologia, inflamação e desenvolvimento terapêutico.
Subcategorias de "Imunologia e Inflamação"
- CCR(136 produtos)
- CXCR(148 produtos)
- Parede celular(5 produtos)
- Receptor IL(112 produtos)
- IκB/IKK(60 produtos)
- LTR(3 produtos)
- MALT(23 produtos)
- MRP(6 produtos)
- NADPH-oxidase(1 produtos)
- NF-κB(444 produtos)
- NOD(17 produtos)
- NOS(63 produtos)
- Nrf2(79 produtos)
- PGE Sintase(31 produtos)
- ROS(69 produtos)
- TGF-beta/Smad(58 produtos)
- TLR(66 produtos)
- Tiorredoxina(12 produtos)
- gp120/CD4(4 produtos)
Exibir 11 mais subcategorias
Foram encontrados 3045 produtos de "Imunologia e Inflamação"
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4-hydroperoxy 2-Nonenal
CAS:<p>4-HNE, a marker of oxidative stress, arises from oxidized ω-6 fats like linoleic acid and shows cytotoxic and genotoxic effects.</p>Fórmula:C9H16O3Cor e Forma:SolidPeso molecular:172.224Moxilubant HCl
CAS:<p>Moxilubant HCl: small molecule LTB4R antagonist for immune, skin, musculoskeletal disorders, and research in psoriasis, arthritis.</p>Fórmula:C26H38ClN3O4Pureza:99.94%Cor e Forma:SoildPeso molecular:492.05Eftilagimod alfa
CAS:<p>Eftilagimod alfa (IMP321), a recombinant LAG-3Ig fusion protein, binds to MHC class II and mediates the activation of antigen-presenting cells (APCs), which in</p>Cor e Forma:LiquidArginase inhibitor 7
CAS:<p>Arginase Inhibitor 7 (compound A17), an inhibitor of arginase (ARG1), exhibits an IC 50 value of 0.16 μM and possesses high oral bioavailability [1].</p>Fórmula:C14H29BN6O5Cor e Forma:SolidPeso molecular:372.23HNGF6A
CAS:<p>increases glucose stimulated insulin secretion and glucose metabolism</p>Fórmula:C112H198N34O31S2Pureza:98%Cor e Forma:SolidPeso molecular:2581.11Withangulatin A
CAS:<p>Withangulatin A, a COX-2 inhibitor from Physalis angulata, has anti-tumor and anti-inflammatory effects.</p>Fórmula:C30H38O8Cor e Forma:SolidPeso molecular:526.62Nrf2 degrader 1
CAS:<p>Nrf2 degrader 1 (compound 1), a PROTAC Nrf2 degrader, exhibits anticancer properties by inhibiting the growth of cancer cells. It demonstrates IC 50 values of 100 nM for A549 cells and 40 nM for LK-2 cells, indicating potent efficacy [1].</p>Fórmula:C45H42N6O8SCor e Forma:SolidPeso molecular:826.92TLR8 agonist 2
CAS:<p>TLR8 agonist 2 activates human TLR8 (EC50=3nM), less effective on TLR7 (EC50=33.33μM).</p>Fórmula:C16H22N8Cor e Forma:SolidPeso molecular:326.408CK3 peptide
CAS:<p>CK3 peptide is an NRP-1-targeting peptide with the amino acid sequence CLKADKAKC. It specifically binds to NRP-1 to target breast cancer cells. Single-photon emission computed tomography (SPECT) and near-infrared fluorescence (NIRF) imaging demonstrate that CK3 peptide significantly accumulates in xenograft tumors in nude mice. CK3 peptide is applicable for molecular imaging studies of breast cancer.</p>Fórmula:C40H72N12O12S2Cor e Forma:SolidPeso molecular:977.2033-O-(2'E,4'Z-Decadienoyl)ingenol
<p>3-O-(2'E,4'Z-Decadienoyl)ingenol is a useful organic compound for research related to life sciences and the catalog number is T124104.</p>Fórmula:C30H42O6Cor e Forma:SolidPeso molecular:498.66Se-DOPE
Se-DOPE is a selenium-containing phospholipid molecule utilized for the synthesis of bifunctional Janus lipase. It facilitates the production of ROS under light induction and scavenges ROS in the presence of glutathione. Se-DOPE plays a role in regulating redox and immune homeostasis, aiding in the healing of infectious diabetic wounds.Fórmula:C43H80NO12PSePeso molecular:913.45834Antitumor agent-185
<p>Antitumor agent-185 (compound 3) exhibits significant antitumor effects, effectively inhibiting tumor growth and extending the survival period of mice in vivo.</p>Fórmula:C109H199N5O36P2Cor e Forma:SolidPeso molecular:2217.71AChE-IN-3
CAS:<p>AChE-IN-3 had inhibitory effect on AChE and stronger inhibitory effect on NO, with EC50 of 0.57 μM.</p>Fórmula:C25H21N3O4Pureza:98.59%Cor e Forma:SolidPeso molecular:427.45Cannabigerolic acid
CAS:<p>Cannabigerolic acid has antiviral activity and inhibits the TRPM7 ion channel, and is used in the study of acute respiratory syndrome.</p>Fórmula:C22H32O4Cor e Forma:SolidPeso molecular:360.49Phthalazine
CAS:<p>Compound PDK0135, with CAS No. 253-52-1, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0135 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>Fórmula:C8H6N2Cor e Forma:Yellow SolidPeso molecular:130.14CAY10614
CAS:<p>CAY10614 is a TLR4 antagonist.</p>Fórmula:C42H78INO2Cor e Forma:SolidPeso molecular:755.995Tempone
CAS:<p>Tempone, an aminooxyalkane, scavenges free radicals and lowers arterial pressure in hypertensive rats.</p>Fórmula:C9H16NO2Pureza:98.18%Cor e Forma:Dark Red Munsell 10 R 3/6 LiquidPeso molecular:170.23RH-EDA
<p>RH-EDA, a rhodamine-based turn-on fluorescent probe, detects hydroxyl radicals ([OH]) in living systems.</p>Fórmula:C28H25N3O4Cor e Forma:SolidPeso molecular:467.52STING agonist-13
CAS:<p>STING agonist-13 boosts cancer immunity by activating STING pathway, reducing tumors, and enhancing immune memory.</p>Fórmula:C45H53N15O7Cor e Forma:SolidPeso molecular:916BQ0413
CAS:<p>BQ0413 exhibits high affinity for PSMA, with a dissociation constant (KD) of 89 pM. It demonstrates effective uptake and internalization, with an internalization rate of 44% in PC3-pip cells. After being labeled with [99mTc], BQ0413 can serve as an imaging agent for tumors.</p>Fórmula:C69H96N12O24SCor e Forma:SolidPeso molecular:1509.63APF
CAS:<p>APF, a low-fluorescence probe, turns bright (490/515 nm) when oxidized by specific radicals; not affected by NO or H2O2.</p>Fórmula:C26H17NO5Cor e Forma:SolidPeso molecular:423.42Avatrombopag hydrochloride
CAS:<p>Avatrombopag (AKR-501) - oral, nonpeptide TPO receptor agonist, EC50 3.3 nM, boosts platelet production, CYP2C9 and CYP3A substrate.</p>Cor e Forma:Solid6Lac[6]Met
CAS:<p>6Lac[6]Met is a galectin-4 inhibitor with an IC50 value of 5 μM [1].</p>Fórmula:C126H180N12O66S6Cor e Forma:SolidPeso molecular:3111.21STING agonist-8 dihydrochloride
<p>STING Agonist-8 Dihydrochloride (Compound 5-AB) is a highly effective STING agonist, exhibiting an EC50 value of 27 nM in THP1-Dual KI-hSTING-R232 cells.</p>Fórmula:C41H48Cl2N14O4Cor e Forma:SolidPeso molecular:871.82GHN105
<p>GHN105 is an orally active STING inhibitor that suppresses STING-dependent IFN-β secretion in THP-1 human monocytes with an IC50 of 4.4 μM. In mice, GHN105 reduces serum levels of IFN-β, IL-6, and CXCL10, and alleviates colitis in a DSS-induced acute colitis mouse model. Additionally, GHN105 demonstrates favorable pharmacokinetic properties in mice, with an oral bioavailability of 43% and a half-life of 1.1 hours.</p>Fórmula:C41H56N2O14Cor e Forma:SolidPeso molecular:800.89Ac-LDEETGEFL-NH2
CAS:<p>Ac-LDEETGEFL-NH2 is a fluorescent molecule designed to target the interaction between the Kelch-like ECH-associated protein 1 (Keap1) and nuclear factor</p>Fórmula:C48H72N10O19Cor e Forma:SolidPeso molecular:1093.14COX-1/2-IN-9
COX-1/2-IN-9 (Compound 3n) serves as a selective and potent inhibitor of both COX-1 and COX-2, demonstrating IC 50 values of 0.031 µM for COX-1 and 0.01 µM for COX-2. This compound exhibits antibacterial and anti-inflammatory properties, effectively targeting MRSA 1478 (MIC=50 μg/mL) and multidrug-resistant S. lentus (MIC=50 μg/mL). Furthermore, COX-1/2-IN-9 shows promise in relieving MRSA-induced pneumonia in conditions of compromised immunity.Fórmula:C30H20IN9O13S2Cor e Forma:SolidPeso molecular:905.57PSB-12379 disodium
<p>PSB-12379 disodium is a nucleotide analogue acting as a potent inhibitor of Ecto-5'-Nucleotidase (CD73), demonstrating inhibitory constants (Ki) of 9.03 nM in</p>Fórmula:C18H21N5Na2O9P2Cor e Forma:SolidPeso molecular:559.31NLRP3-IN-73
<p>NLRP3-IN-73 (W16) is an orally bioavailable inhibitor that disrupts the assembly of the NLRP3 inflammasome, exhibiting an IC50 value of 0.18 μM for the NLRP3/IL-1β pathway.</p>Cor e Forma:Odour SolidSTING agonist-28
CAS:<p>STING agonist-28 (CF510), a non-nucleotide, boosts STING, TBK1, IRF3 phosphorylation, and cytokines; active against SARS-CoV.</p>Fórmula:C39H46N14O6Cor e Forma:SolidPeso molecular:806.87PROTAC IRAK4 degrader-4
CAS:<p>PROTAC IRAK4 degrader-4 is a targeted Cereblon-based molecule for degrading IRAK4.</p>Fórmula:C41H38F3N11O10Cor e Forma:SolidPeso molecular:901.817KD014
<p>KD014 (DX-2400) is a human monoclonal antibody (mAb) that targets MMP14, with a Ki of 0.9 nM. It inhibits TGFβ and SMAD2/3 signaling, increases macrophage count and iNOS expression, and shifts macrophage phenotype towards an antitumor M1-like type. KD014 exhibits antitumor activity in three tumor models (MDA-MB-231, MDA-MB-435, and PC3) and is applicable in breast cancer research.</p>Cor e Forma:Odour LiquidTorudokimab
<p>Torudokimab (ZB-880) is a monoclonal antibody that neutralizes interleukin 33 and can be used to study immune system diseases.</p>Pureza:95.8% (SDS-PAGE); 96.2% (SEC-HPLC) - 95.8% (SDS-PAGE); 96.2% (SEC-HPLC)Cor e Forma:Odour LiquidNLRP3-IN-12
<p>NLRP3-IN-12 inhibits NLRP3 inflammasome, curbing IL-1β release with 0.45 μM IC50, for inflammatory bowel disease research.</p>Fórmula:C27H32ClNO7Cor e Forma:SolidPeso molecular:518Anti-Mesothelin Antibody (YP218)
Anti-Mesothelin Antibody (YP218) is a chimeric rabbit IgG antibody that targets human Mesothelin.P2X7-IN-2 TFA
P2X7-IN-2 TFA inhibits IL-Iβ release (IC50=0.01nM), used in autoimmunity, inflammation & cardiovascular research.Fórmula:C24H22F7N3O4Cor e Forma:SolidPeso molecular:549.44Spirohexenolide A
CAS:<p>Spirohexenolide A is an inhibitor of human macrophage migration inhibitory factor (hMIF) with a dissociation constant (Kd) of 35.9 μM. It is employed in the study of cellular transport.</p>Cor e Forma:Solid4-ACETAMIDOANTIPYRINE
CAS:<p>4-ACETAMIDOANTIPYRINE, with CAS No. 83-15-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 4-ACETAMIDOANTIPYRINE provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>Fórmula:C13H15N3O2Cor e Forma:SolidPeso molecular:245.28Galectin-8N-IN-2
<p>Galectin-8N-IN-2 (compound 2) is an effective selective inhibitor of Galectin-8N, with a Ki value of 74 μM.</p>Cor e Forma:Odour SolidDZ-837
<p>DZ-837 is a PROTAC that targets the BCL6 protein. The composition of DZ-837 includes the BCL6 ligand-2, the E3 ubiquitin ligase ligand Thalidomide-4-OH, and a PROTAC Linker. The configuration notably features a conjugate of the E3 ubiquitin ligase ligand and the Linker, designated as 2-(2,6-Dioxopiperidin-3-yl)-4-((2-(2-hydroxyethoxy)ethyl)amino)isoindoline-1,3-dione.</p>Fórmula:C42H44FN9O7SCor e Forma:SolidPeso molecular:837.92Tri(TLR4-IN-C34-PEG2-amide-PEG1)-amide-C3-COOH
<p>Tri(TLR4-IN-C34-PEG2/PEG1)-amide-C3-COOH is a TLR4 inhibiting linker, reducing inflammation in endotoxemia and enterocolitis mouse models.</p>Fórmula:C78H125N7O42Cor e Forma:SolidPeso molecular:1832.85Pegaldesleukin
CAS:<p>Pegaldesleukin, a PEG-IL2 conjugate, exhibits antiviral properties, potentially slowing HIV progression, preserving immune function.</p>Cor e Forma:LiquidKTX-497
CAS:<p>KTX-497, an IRAK4 degrader, demonstrates a potent DC50 value of 3 nM. It is utilized in oncology research[1].</p>Fórmula:C45H49F3N8O6Cor e Forma:SolidPeso molecular:854.92IFN-γ Antagonist 1 acetate
<p>IFN-γ Antagonist 1 (AYCRDGKIGPPKLDIRKEEKQI) acetate, an interferon γ (IFN γ) antagonist, effectively inhibits the expression of HLR/DR antigen in Colon 205</p>Fórmula:C117H198N34O36SCor e Forma:SolidPeso molecular:2689.1ADU-S100 disodium salt
CAS:<p>ADU-S100 (MIW815) disodium salt is an activator of stimulator of interferon genes (STING).</p>Fórmula:C20H22N10Na2O10P2S2Pureza:98%Cor e Forma:SolidPeso molecular:734.51Galectin-3-IN-5
<p>Galectin-3-IN-5 (Compound 20) is an orally active inhibitor of galectin-3 (Gal-3), exhibiting an IC50 value of 9.2 nM against hGal-3.</p>Fórmula:C24H19BrClF5N6O4SCor e Forma:SoildPeso molecular:697.86Zuberitamab
CAS:<p>Zuberitamab (HS006) is a monoclonal antibody targeting CD20, utilized in cancer research, notably in diffuse large B-cell lymphoma [1].</p>Cor e Forma:LiquidPU23
CAS:<p>PU 23 is an inhibitor of multidrug-resistant protein 4 (MRP4).</p>Fórmula:C21H19N3O3S2Pureza:99.52%Cor e Forma:SolidPeso molecular:425.52Diprovocim-X
<p>Diprovocim-X, a potent TLR1/2 agonist, has EC50s of 0.14nM (hTLR) and 0.75nM (mTLR), enhances mice's adaptive immunity.</p>Fórmula:C66H83N7O10Cor e Forma:SolidPeso molecular:1134.41PROTAC STING Degrader-2
CAS:<p>PROTAC STING Degrader-2 is a protein degrader targeting the Stimulator of interferon genes (STING) with a DC50 of 0.53 μM. It induces STING protein degradation by covalently binding to both the STING protein and an E3 ubiquitin ligase. This compound is useful for studying the role of STING in autoinflammatory and autoimmune diseases.</p>Fórmula:C74H79FN10O15S3Cor e Forma:SolidPeso molecular:1463.67Anti-CD200R1 Antibody
<p>Anti-CD200R1 Antibody is an antibody that targets CD200R1 and can be used to study protein immunoblotting.</p>Pureza:97.9% (SDS-PAGE); 98.6% (SEC-HPLC) - 97.9% (SDS-PAGE); 98.6% (SEC-HPLC)Cor e Forma:Odour LiquidMitoquinol
CAS:<p>Mitoquinol is a mitochondria-targeted antioxidant used in the study of cardiovascular disease by modulating the mitochondrial antioxidant defense system.</p>Fórmula:C38H49O7PSPureza:98%Cor e Forma:SolidPeso molecular:680.83Mifamurtide TFA
<p>Mifamurtide TFA: muramyl dipeptide analog, boosts immunity, activates macrophages/monocytes, potential osteosarcoma research.</p>Fórmula:C61H110F3N6O21PCor e Forma:SolidPeso molecular:1351.52Human Immunoglobulin M
<p>Human Immunoglobulin M (IgM) is an antibody secreted by the adaptive immune system in response to foreign antigens. It is a primary type of immunoglobulin released into circulation during the early stages of the primary antibody response. Human Immunoglobulin M forms a pentamer comprising five IgG equivalents, with 10 Fab fragments, allowing for 10 antigen binding sites. Additionally, Human Immunoglobulin M acts as a complement (complement) activator.</p>Cor e Forma:Odour Solidcyclo(RLsKDK) TFA
<p>Cyclo(RLsKDK) TFA (BK-1361 TFA) is a cyclic peptide and selective ADAM8 metalloproteinase inhibitor, used in research on inflammation and cancer.</p>Fórmula:C33H58F3N11O11Pureza:98.54%Cor e Forma:SolidPeso molecular:841.88Dazostinag
CAS:<p>Dazostinag (TAK-676) is a STING agonist with anti-cancer properties, used in making ADCs.</p>Fórmula:C21H22F2N8O10P2S2Cor e Forma:SolidPeso molecular:710.52Y13g dihydrochloride
<p>Y13g dihydrochloride is a potent inhibitor of interleukin 6 (IL-6) and acetylcholinesterase (AChE) (both targets of Alzheimer's disease (AD) progression are</p>Fórmula:C16H25ClN2O4Pureza:97.81%Cor e Forma:SoildPeso molecular:344.83Mifamurtide
CAS:<p>Mifamurtide is a drug against osteosarcoma, is an immunomodulator with antitumor effects.</p>Fórmula:C59H109N6O19PPureza:98%Cor e Forma:SolidPeso molecular:1237.5FITC-labeled ODN 1826 sodium
<p>FITC-labeled ODN 1826 (sodium), a class B CpG ODN (oligodeoxynucleotide) and TLR9 agonist, facilitates the assessment of CpG ODN cellular uptake and</p>Cor e Forma:Odour SolidTLR8 agonist 2 hydrochloride
CAS:<p>TLR8 agonist 2 hydrochloride: potent for human TLR8 (EC50 3 nM), weak for TLR7 (EC50 33.33 μM).</p>Fórmula:C16H22N8·xHClCor e Forma:SolidDectrekumab
CAS:<p>Dectrekumab (QAX576) is a humanized monoclonal antibody targeting IL-13.</p>Pureza:96.5% (SDS-PAGE); 97.1% (SEC-HPLC) - 96.5% (SDS-PAGE); 97.1% (SEC-HPLC)Cor e Forma:LiquidPSMA-DA1
CAS:PSMA–DA1 may be a useful PSMA-targeting radiotheranostic agent.Fórmula:C50H76IN9O20Cor e Forma:SolidPeso molecular:1250.105Ginger extract
CAS:<p>Ginger extract demonstrates (exhibits) anti-cancer, anti-inflammatory, and chemotherapeutic properties in living organisms (in vivo).</p>Cor e Forma:SolidBMX-010
CAS:<p>BMX-010, also known as AEOL-10113, is Porphyrin-Based SOD Mimic.</p>Fórmula:C48H44Cl5MnN8Cor e Forma:SolidPeso molecular:965.12PSMA-IN-2
CAS:<p>PSMA-IN-2, an inhibitor of PSMA with a K i value of 1.07 nM, exhibits favorable in vivo NIR imaging (λ EM = 1088 nm, λ ex = 808 nm) and is useful for NIRII image-guided tumor resection surgery in PSMA-positive tumor-bearing mice [1].</p>Fórmula:C54H60N14O18S2Cor e Forma:SolidPeso molecular:1257.27IFN-α Receptor Recognition Peptide 1
CAS:<p>IFN-α Receptor Recognition Peptide 1, associated with receptor interactions, is a peptide of IFN-α.</p>Fórmula:C35H59N13O12SPureza:98%Cor e Forma:SolidPeso molecular:885.99TLR7/8 agonist 4 TFA
CAS:<p>TLR7/8 agonist 4 TFA (compound 41) is a highly potent TLR7/8 agonist that exhibits significant anti-cancer activity.</p>Fórmula:C20H25F3N6O2Cor e Forma:SolidPeso molecular:438.45OATD-02 hydrochloride
<p>OATD-02 hydrochloride is the hydrochloride salt form of OATD-02. It is an orally effective, competitive, reversible, and non-covalent dual inhibitor of Arginase1 and Arginase2. OATD-02 hydrochloride serves as a sustained-release inhibitor that efficiently blocks the activity of intracellular arginases, with IC50 values of 20 nM (hARG1), 39 nM (hARG2), 39 nM (mARG1), and 28 nM (rARG1). It effectively eliminates tumor-induced immunosuppression caused by both types of arginases. This compound is utilized in research studies on melanoma.</p>Cor e Forma:Odour SolidWAY-605471
CAS:<p>WAY-605471 is a AHR antagonist with IC50 of 0.5 - 1 μM.</p>Fórmula:C14H15NO3S2Pureza:99.62%Cor e Forma:SolidPeso molecular:309.4EC1169
CAS:<p>EC1169 is a targeted PSMA ligand that acts to inhibit the proliferation of cells expressing PSMA.</p>Fórmula:C78H112N14O28S3Cor e Forma:SolidPeso molecular:1790.00NC318
<p>NC318 is a humanized antibody targeting Siglec-15/CD33L3 for the study of non-small cell lung cancer.</p>Pureza:98.6% (SDS-PAGE); 99% (SEC-HPLC) - 98.6% (SDS-PAGE); 99% (SEC-HPLC)Cor e Forma:Odour LiquidVEN-02XX
<p>VEN-02XX is an orally active NLRP3 inhibitor capable of penetrating the brain. It effectively suppresses the release of IL-1β and IL-18, with IC50 values of 0.3 and 0.28 μM, respectively. In the 5XFAD/Rubicon KO mouse model, VEN-02XX aids in restoring memory and cognition, inhibits microgliosis, and alleviates neuroinflammation and tau protein pathology. This compound is valuable for Alzheimer's disease (AD) research.</p>Fórmula:C18H16ClF3N4OCor e Forma:SolidPeso molecular:396.79Anti-MRC2/CD280 Antibody
<p>Anti-MRC2/CD280 Antibody is a humanized anti-MRC2/CD280 antibody that can be used in immunoblotting (WB) and immunohistochemistry experiments.</p>Pureza:99.1% (SDS-PAGE); 98.7% (SEC-HPLC) - 99.1% (SDS-PAGE); 98.7% (SEC-HPLC)Cor e Forma:Odour LiquidDalutrafusp alfa
CAS:<p>Dalutrafusp alfa (AGEN-1423; GS-1423) is a bifunctional antibody targeting CD73 and TGF-β, components of the immunosuppressive pathway [1].</p>Cor e Forma:LiquidIKKγ NBD Inhibitory Peptide
CAS:<p>A cell-permeable synthetic peptide NEMO-binding domain peptide (NBD peptide) corresponding to the NEMO amino-terminal alpha-helical region is shown to block TNF</p>Fórmula:C170H259N49O42S1Pureza:98%Cor e Forma:SolidPeso molecular:3693.3Anticonvulsant agent 10
<p>Anticonvulsant agent 10 (Compound 6d) is an inhibitor targeting the Keap1-Nrf2 interaction, with a strong activity showing an ED50 of 0.04 mmol/kg. By inhibiting the Keap1-Nrf2 binding, it activates the Nrf2/ARE pathway, providing anticonvulsant and neuroprotective effects, making it useful for research in epilepsy and neuroprotection.</p>Cor e Forma:Odour SolidODN D-SL03
CAS:<p>ODN D-SL03, a C class CpG oligonucleotide, stimulates PBMCs, activating B cells, NK cells & monocytes, and can inhibit tumor growth.</p>Cor e Forma:SolidPeso molecular:9345Bavunalimab
CAS:<p>Bavunalimab: bispecific anti-CTLA-4/LAG-3 antibody, T-cell activator in NSG mice, for cancer research.</p>Cor e Forma:LiquidTP508
CAS:<p>TP508 (Chrysalin), a 23-amino-acid peptide from human prothrombin, aids in tissue repair, targeting thrombin receptors.</p>Fórmula:C97H146N28O36SPureza:98%Cor e Forma:SolidPeso molecular:2312.44DOPAL
CAS:<p>DOPAL, a neurotoxic aldehyde from dopamine metabolism, is linked to Parkinson's and can convert to DOPAC or DOPET.</p>Fórmula:C8H8O3Cor e Forma:SolidPeso molecular:152.15FITC-labeled Agatolimod sodium
<p>FITC-labeled Agatolimod (sodium), a class B CpG ODN (oligodeoxynucleotide) and TLR9 agonist, facilitates the assessment of CpG ODN cellular uptake and</p>Cor e Forma:Odour SolidMAPK-IN-4
<p>MAPK-IN-4 (Compound c1) is an orally active anti-inflammatory agent that inhibits the expression and release of pro-inflammatory cytokines IL-6 and TNF-α induced by LPS. It interacts with IRAK4 to exert its anti-inflammatory effects by inhibiting the MAPK pathway.</p>Cor e Forma:Odour SolidTLR7/8 agonist 12
<p>TLR7/8 agonist 12 (compound 9) is a human TLR7/8 agonist with EC50 values of 11 nM for hTLR7 and 150 nM for hTLR8, indicating its potential for immune modulation.</p>Fórmula:C29H38N6O3Cor e Forma:SolidPeso molecular:518.65NF-κB-IN-9
<p>NF-κB-IN-9, a nuclear factor kappa B (NF-κB) targeting sonosensitizer with excitation and emission wavelengths (λex/λem) of 489/628 nm, features dual</p>Fórmula:C62H50N4O4SCor e Forma:SolidPeso molecular:947.15ROS inducer 6
<p>ROS inducer 6 (compound 9) acts as a reactive oxygen species (ROS) inducer by depleting intracellular glutathione, thereby functioning as an antitumor agent.</p>Fórmula:C32H26N2O3Cor e Forma:SolidPeso molecular:486.56PROTAC IRAK4 degrader-5
CAS:<p>PROTAC IRAK4 degrader-5 is a Cereblon-based IRAK4 degrader.</p>Fórmula:C41H40F3N11O9Cor e Forma:SolidPeso molecular:887.834Varokibart
CAS:<p>Varokibart (TEV-53275) is a human IgG4λ antibody that targets interleukin-5 (IL-5) [1].</p>Cor e Forma:LiquidNeuroprotective agent 8
<p>Neuroprotective agent 8 (compound AA-9) is an orally active neuroprotective agent that functions through antioxidant stress reduction and anti-inflammatory mechanisms. In a rat model of MCAO ischemic stroke, it activates PGC-1α and inhibits the NLRP3 inflammasome.</p>Cor e Forma:Odour SolidRC529-MDP
<p>RC529-MDP is an immunological adjuvant that couples Toll-like receptors (TLR4a) and NOD-like receptors (NOD2a) to enhance the innate immune response through the TLR4 and NOD2 signaling pathways. In mouse models, RC529-MDP induces high levels of the cytokine interleukin-related factor (IL-6), highlighting its immunostimulatory activity. Additionally, when injected into mice models with ovalbumin (OVA), RC529-MDP elevates OVA-specific antibody responses, T cell responses, and the proportion of memory T cells.</p>Fórmula:C118H215N10O28PCor e Forma:SolidPeso molecular:2252.992'2'-cGAMP (sodium salt)
CAS:<p>2'2'-cGAMP, a synthetic CDN, binds STING in the immune response, inducing IFN-β; binds weaker than 2'3'-cGAMP but stronger than other CDNs.</p>Fórmula:C20H24N10O13P2Cor e Forma:SolidPeso molecular:674.417DA-E 5090
CAS:<p>DA-E 5090, an active metabolite of E 5090, inhibits IL-1 production in human monocytes.</p>Fórmula:C17H18O4Pureza:98%Cor e Forma:SolidPeso molecular:286.32Ripertamab
CAS:<p>Ripertamab (SCT-400) is a recombinant human-mouse chimeric monoclonal antibody that targets CD20 and is cytotoxic.</p>Pureza:97.8% (SEC-HPLC) - 97.8% (SEC-HPLC)Cor e Forma:LiquidGlutaminase C-IN-2
<p>Glutaminase C-IN-2 (compound 11), an allosteric inhibitor of glutaminase C (GAC), exhibits potent inhibitory activity with an IC50 of 10.64 nM.</p>Fórmula:C24H23N7O2SPureza:98%Cor e Forma:SolidPeso molecular:473.55Guignardone L
CAS:<p>Guignardone L, a metabolite extracted from the endophytic fungus Guignardia mangiferae, possesses toll-like receptor 3 (TLR3) regulating activity [1].</p>Fórmula:C17H24O4Cor e Forma:SolidPeso molecular:292.3717-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid
CAS:<p>DPA metabolite 17-oxo-DPA, found in fish oil, spurs antioxidant genes, modulates inflammation, and activates PPARγ (EC50 ≈ 200 nM).</p>Fórmula:C22H32O3Cor e Forma:SolidPeso molecular:344.495Biotinoyl tripeptide-1
CAS:<p>Biotinoyl tripeptide-1 can produce hair follicles by promoting scalp micro-circulation and reduce follicle atrophy and aging.</p>Fórmula:C24H38N8O6SPureza:98%Cor e Forma:SolidPeso molecular:566.67ODN 2395
CAS:<p>ODN 2395, a class C oligodeoxynucleotide and TLR9 agonist, serves as a vaccine adjuvant. Its sequence is 5'-tcgtcgttttcggcgc:gcgccg-3' [1].</p>Cor e Forma:SolidPeso molecular:7035Reslizumab
CAS:<p>Reslizumab (Sch 55700) is a humanized immunoglobulin G (IgG) 4 κ monoclonal antibody, thereby reducing eosinophil production and survival.</p>Pureza:98.1% (SDS-PAGE); 98.6% (SEC-HPLC) - 98.1% (SDS-PAGE); 98.6% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:N/ACDD-3290
<p>CDD-3290 (Compound 20) is an inhibitor of prostate-specific antigen (PSA) with a Ki value of 216 nM. This compound also exhibits inhibitory effects on α-chymotrypsin and elastase.</p>Cor e Forma:Odour SolidBivalirudin TFA
CAS:<p>Bivalirudin TFA, a 20-residue synthetic peptide, reversibly inhibits thrombin, affecting platelet aggregation and thrombin generation.</p>Fórmula:C98H138N24O33·C2HF3O2Cor e Forma:SolidPeso molecular:2294.34
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