Imunologia e Inflamação

MLT-748 is an effective, selective, and allosteric MALT1 inhibitor. It binds MALT1 in the allosteric Trp580 pocket (IC50: 5 nM).

Bromfenac sodium hydrate (Bromfenac monosodium salt sesquihydrate) is the sodium salt form of bromfenac, a NSAID with analgesic and anti-inflammatory effects.

Benzobicyclon is a 4-HPPD) inhibitor and herbicide that is spectrally active against annual grasses, sedges, and broadleaf weeds without toxicity to rice.

CORM-401 is an oxidant-sensitive CO-releasing molecule. It can be used in oxidative stress-mediated pathologies and the research of inflammatory.

<p>AMY-101 acetate (Cp40 acetate) is a peptide, an inhibitor of C3 Complement in gingivitis and periodontitis, reduces inflammation and lowers MMP-8 and MMP-9.</p>

<p>Glimepiride sulfonamide is an antiinflammatory agent.</p>

<p>Satralizumab (SA-237) is a humanized antibody targeting interleukin-6 (IL-6), used in research on neuromyelitis optica spectrum disorder (NMOSD).</p>

<p>Brazikumab (AMG 139) is a humanized antibody targeting IL-23 by binding to the P19 subunit, a selective IL-23p19 antagonist.</p>

RA-839 is a Keap1 conjugate and Nrf2 signaling activator, and an inhibitor of Keap1/Nrf2 interaction with anticancer activity.

<p>The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human CD248. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human CD248. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human CD248, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human CD248 in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>Tirilazad mesylate (U 74006F) is a lipid peroxidation inhibitor with antiviral activity.Tirilazad mesylate is used in the study of neurological disorders.</p>

MF63 is a selective mPGES-1 inhibitor (IC50: 0.9 nM and 1.3 nM for pig mPGES-1 and human mPGES-1 enzyme, respectively).

NF-κB/MAPK-IN-1 is an NF-κB and MAPK pathway inhibitor. NF-κB/MAPK-IN-1 is used to prevent rheumatoid arthritis (RA).

NLRP3-IN-11 is an NLRP3 protein inhibitor with potential anti-inflammatory activity.NLRP3-IN-11 can be used in the study of atherosclerosis and parkinsonism.

<p>The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human CD248. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human CD248. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human CD248, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human CD248 in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>Efaproxiral (RSR13) is a hemoglobin allosteric modulator, a potential radiation sensitizer and chemotherapy enhancer, improving tumor oxygenation.</p>

Imigliptin (KBP 3853) is a dipeptidyl peptidase-4 inhibitor used in the study of type 2 diabetes.

<p>CBR-470-1 is a glycolytic phosphoglycerate kinase 1 inhibitor and Nrf2 activator that exhibits neuroprotective activity by activating the Keap1-Nrf2 cascade.</p>

<p>MK-0159 is an orally available, highly potent CD38 inhibitor with myocardial injury protection for the study of cardiac ischemia and reperfusion injury.</p>

<p>L-Kynurenine-d4 is a deuterated isotope compound of L-Kynurenine. L-Kynurenine is a metabolite of tryptophan and an endogenous agonist of the AHR.</p>

<p>PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over other</p>

D-Ribose-L-cysteine is the antioxidant glutathione precursor.

<p>Gumokimab (AK 111) is an anti-IL-17A mAb that blocks pro-inflammatory signaling, a candidate for psoriasis and ankylosing spondylitis.</p>

<p>Divozilimab (BCD-132), a humanized monoclonal antibody targeting CD20 (CD20), is utilized in multiple sclerosis research [1].</p>

<p>Encelimab, an anti-LAG3 antibody, prevents LAG-3/MHC II binding, activating T-cells and reducing tumor burden in preclinical lymphoma models.</p>

<p>Fontolizumab (HuZAF) is a humanised IgG1 monoclonal anti-IFN-gamma (IFN-γ) antibody for the study of Crohn's disease.</p>

<p>Bempikibart (ADX-914) is a fully humanised monoclonal antibody targeting IL-7Rα, inhibiting IL-17 and TSLP (Thymic stromal lymphopoietin), inflammation.</p>

<p>Tirnovetmab (KIND-016) is a fully dog-derived monoclonal antibody targeting IL-31 with high affinity, suitable for investigating canine atopic dermatitis.</p>

<p>Dresbuxelimab (AK-119), an IgG-κ monoclonal antibody, selectively targets CD73 and is commonly produced using a Chinese Hamster Ovary (CHO) cell expression</p>

<p>Bapotulimab (BAY-1905254) is a human/mouse/monkey cross-reactive monoclonal antibody that targets and inhibits ILDR2, blocking its immunosuppressive activity.</p>

<p>Anti-Mouse IL-6R Antibody (15A7) is an antibody inhibitor targeting mouse IL-6R, derived from rats, widely used in research and experiments</p>

<p>Exlinkibart (LVGN-6051) is a humanised monoclonal antibody and agonist targeting CD137/TNFRSF9, inducing cytotoxic T lymphocyte (CTL) proliferation.</p>

<p>Ocaratuzumab, an Fc-engineered humanized IgG1 anti-CD20 antibody with ~100 pM affinity, enhances ADCC.</p>

<p>Ziralimumab（ABX-RB2） is a monoclonal antibody that targets and inhibits IL-2 receptor, thereby modulating the immune response.</p>

<p>Anti-Mouse IFN Gamma Antibody is a host Armenian Hamster-derived anti-mouse IFN gamma immunoglobulin G (IgG) inhibitor.</p>

<p>Tebotelimab is a human IgG4κ DART antibody targeting PD-1 and LAG-3 with EC50s of 1.65 nM and 0.41 nM, blocking their interactions and signaling.</p>

<p>Keliximab (SB-210396), a chimeric IgG1 anti-CD4 antibody, inhibits T cells and IL-2, for cancer research, K i 1.0 nM.</p>

<p>Depemokimab (GSK-3511294) is a long-acting monoclonal antibody targeting IL-15, utilized in asthma research [1] [2].</p>

<p>Camoteskimab (AVTX-007) is a human anti-IL-18 antibody for autoinflammatory diseases like AOSD research.</p>

<p>Samalizumab (anti-CD200 mAb) is an immune checkpoint inhibitor under investigation for treating myeloma and B-cell CLL.</p>

<p>Suciraslimab (SM03) is a human IgG1 monoclonal antibody against the B-cell restriction antigen CD22 for rheumatoid arthritis (RA) and B-cell related diseases.</p>

<p>Crovalimab (SKY59; RO7112689) is an humanised monoclonal antibody that binds to complement C5 , paroxysmal nocturnal haemoglobinuria (PNH).</p>

<p>Empasiprubart (anti-C2 mAb) inhibits classical &amp; lectin complement pathways upstream of C3, showing efficacy in autoimmune models.</p>

<p>Gatralimab (anti-CD52 mAb) shows successful lymphocyte depletion &amp; repopulation in Phase 1, supporting its study for relapsing MS.</p>

<p>CTX-471, a human monoclonal antibody, targets CD137 with Kd 50-748 nM, for immunomodulation and cancer research.</p>

<p>1,3-Dibenzyl-5-fluorouracil is a chemical inhibitor that suppresses the formation of osteoclasts, functioning by downregulating the signaling pathways of nuclear factor κB ligand receptor activator (Receptor activator of NF-κB ligand, RANKL) and macrophage colony-stimulating factor (M-CSF). This compound is used in the research of metabolic bone diseases.</p>

<p>Puxitatug (INT-016) is a humanised monoclonal antibody targeting VTCN1/B7H4, (ADC) Puxitatug samrotecan, delivering to cancer cells expressing B7-H4.</p>

<p>Casdozokitug is a human IgG1κ anti-IL-27 antibody that blocks immunosuppressive activity, relevant in tumor immunology and immune checkpoint therapy research.</p>

<p>Sofituzumab is a humanised monoclonal antibody targeting the MUC16 protein,in the synthetic ADC Sofituzumab vedotin, ovarian cancer and pancreatic cancer.</p>

<p>Surzebiclimab (BGB-A425), a humanized variant IgG1 monoclonal antibody, targets and binds with high affinity (K D = 0.36 nM) and specificity to the</p>

<p>Favezelimab (MK-4280) blocks LAG-3/MHC II interaction, restoring T-cell function, studied in colorectal cancer research and with PD-L1 inhibitors.</p>

<p>Dargistotug (M-6223), a human IgG1 antibody targeting TIGIT, enhances NK and T-cell activity, cytokine secretion, Treg function for immune checkpoint studies.</p>

<p>Manfidokimab is an anti-IL-4Rα mAb that blocks IL-4/IL-13 signaling, in trials for atopic dermatitis.</p>

<p>Tegoprubart (anti-CD40L mAb) inhibits the CD40-CD40L pathway, reducing immune responses and promoting tolerance in transplant models.</p>

<p>Avizakimab (BOS161721) is a humanized lgG1 monoclonal antibody IL-21, with potential for the treatment of systemic lupus erythematosus (SLE).</p>

<p>Dazukibart (anti-IFNB1 mAb) is a potential treatment for dermatomyositis, an autoimmune disorder with pronounced interferon overexpression.</p>

<p>Erzotabart is an IgG1κ antibody targeting CD38, modulating tumor cell metabolism and immune evasion, serving as an investigational oncology research candidate.</p>

Anti-IL-12 p70 Antibody (20C2), an IgG1 monoclonal, suppresses interferon-gamma, IL-12-mediated inflammation, paired with a Rat IgG1 kappa control.

<p>Tocopherol nicotinate is an antioxidant. It is used for skin conditioning.</p>

<p>Rademikibart (CBP-201) is a human monoclonal antibody selective for IL-4Rα, exhibiting strong affinity with a KD of 20.7 pM for human IL-4Rα epitopes, without</p>

<p>Imidazole Salicylate, a non-steroidal anti-inflammatory drug, has limited inhibitory effects on prostaglandin synthesis.</p>

<p>Ebdarokimab (anti-IL-12/23 p40 mAb) inhibits the IL-12/IL-23 pathway and is under clinical investigation for SLE and plaque psoriasis.</p>

<p>Tifcemalimab (JS004) is a humanized monoclonal antibody targeting BTLA to block HVEM-BTLA interaction and inhibit cancer signaling pathways.</p>

<p>Photosensitizer-1 (Compound CLB-13) hydrochloride is a photosensitizer [1] .</p>

<p>Faralimomab (64G12) is an immunomodulator, and a murine anti- IFNA1 IgG1 mAb [1] .</p>

<p>Anti-Mouse CD8α Antibody (2.43) is a mouse-derived IgG2b kappa antibody targeting CD8α in mice,,flow cytometry.</p>

<p>Trabikibart (CSL311) is a human βc-specific antibody inhibiting IL-3, GM-CSF and IL-5, regulating eosinophil survival in chronic inflammatory disease research.</p>

NSC 31156 is a bioactive chemical.

<p>Botensilimab (AGEN 1181) is a humanized anti-CTLA-4 antibody activating innate and adaptive immunity, under research for enhancing antitumor responses.</p>

<p>Anti-Mouse IL-1b Antibody is an IgG inhibitor specific to mouse IL-1b, derived from an Armenian Hamster host.</p>

<p>Tositumomab is a murine IgG2a lambda antibody targeting CD20 on B cells, used in B cell therapy, immunology studies, and radioimmunoconjugate development.</p>

<p>Argininosuccinic acid can be obtained during the urea cycle from citrulline, aspartate, and ATP by argininosuccinic acid synthetase.</p>

<p>Picankibart (IBI112) is a human recombinant monoclonal antibody targeting IL-23p19, indicated for psoriasis treatment.</p>

<p>Anti-Mouse IL-1R Antibody is an IgG2b subclass inhibitor targeting the mouse IL-1 receptor, sourced from Armenian hamsters.</p>

<p>Ifinatamab is a humanised monoclonal immunoglobulin,B7-H3 protein.ADC drug Ifinatamab deruxtecan,small cell lung cancer (SCLC).</p>

<p>Lulizumab: Humanized antibody selectively blocking CD28 to prevent T cell activation.</p>

<p>Lebrikizumab is a humanised monoclonal antibody that targets and inhibits interleukin 13 (IL-13), suppressing Th2 inflammation.asthma and atopic dermatitis.</p>

<p>Photosensitizer-1 (Compound CLB-13) is a photosensitizer [1] .</p>

<p>Lokivetmab: anti-IL31 monoclonal antibody for dog atopic dermatitis research.</p>

<p>Vamikibart is a chimeric, humanized IgG2κ antibody that targets IL6 [1].</p>

<p>Gefurulimab (ALXN-1720) is a bispecific antibody derived from humans, targeting complement C5 and albumin.</p>

<p>Riliprubart (SAR445088) is a humanized monoclonal antibody that acts as an anti-C1s inhibitor in the proximal part of the classical complement system. It selectively targets activated C1s, inhibiting its enzymatic activity on substrates C4 and C2, thereby preventing the formation of the classical pathway C3 convertase, C4b2a [1].</p>

<p>Duvortuxizumab (MGD 011) is a chimeric, humanized immunoglobulin (IG) antibody that specifically targets CD19 and CD3E receptors [1].</p>

<p>Bimekizumab is a humanised monoclonal antibody targeting IL17A/IL17F, blocking inflammation-driven osteoblast differentiation.</p>

<p>Aspirin DL-lysine: a water-soluble, injectable NSAID that may also hinder cancer growth.</p>

<p>Octaethylporphyrin is a stable porphyrin compound used for research.</p>

<p>Loncastuximab (RB4v1.2) is an anti-CD19 antibody with antitumor effects, used for treating NHL, including DLBCL.</p>

<p>Sonelokimab (ALX 0761; M 1095), a trivalent nanobody targeting IL-17A, IL-17F, and serum albumin, may aid in psoriasis research.</p>

<p>Anti-Mouse LAG-3 Antibody (C9B7W) is a monoclonal antibody inhibitor targeting the D2 domain of mouse LAG-3 (CD223), thereby enhancing antitumour effects.</p>

<p>Grisnilimab (WT1) is a monoclonal antibody targeting CD7. WT1) gene is overexpressed in leukaemia and various types of solid tumours</p>

<p>BMS-986449 is a CELMoD-type molecular gel that enhances anti-tumor by directing the E3 ubiquitin ligase, Cereblon, to degrade IKZF2 (Helios) and IKZF4 (Eos).</p>

<p>Minretumomab (CC-49) is a mouse monoclonal antibody targeting TAG-72 breast cancer, colon cancer, lung cancer, and pancreatic cancer.</p>

<p>Anti-Mouse TIM-3 Antibody (23C3.N) is an antibody that inhibits mouse TIM-3 (CD366), immune diseases such as experimental autoimmune encephalomyelitis (EAE).</p>

<p>Anrukinzumab (IMA-638) is an anti-IL-13 mAb with anti-inflammatory effects, in development for ulcerative colitis and asthma.</p>

<p>Gevokizumab (S-78989) is a humanised monoclonal antibody targeting IL-1β, allosteric regulation, diabetes, cancer, inflammation, and cardiovascular diseases.</p>

<p>Zanolimumab is a humanised monoclonal antibody targeting CD4, blocking TCR signalling, autoimmune diseases such as rheumatoid arthritisa.</p>

<p>Paridiprubart (NI-0101) is a humanised monoclonal antibody targeting TLR4, ameliorative effects in COVID-19 patients with ARDS and rheumatoid arthritis.</p>

<p>Afasevikumab (RG 7624) is a fully humanised monoclonal antibody that targets and neutralises IL-17A and IL-17F,autoimmune diseases and inflammation.</p>

<p>Imalumab (BAX69), a human IgG1 antibody, targets MIF for ovarian cancer, recurrent ascites, and cancer research.</p>

<p>Lutikizumab (ABT-981) is a dual-action antibody blocking IL-1α/β, potential osteoarthritis research drug.</p>