Imunologia e Inflamação

CD73-IN-11 is a potent inhibitor used to prepare medication for cancer by blocking adenosine production, which fosters tumor growth.

NLRP3-IN-18, also known as compound 13, is a potent inhibitor of NLRP3, demonstrating an IC50 value of ≤1.0 µM [1].

<p>Friluglanstat is an inhibitor of the enzyme prostaglandin E synthase (mPGES-1) and exhibits anti-inflammatory activity [1].</p>

<p>TLR9-IN-1: selective, potent human TLR9 inhibitor (IC50: 7 nM), useful for researching immune-related diseases.</p>

<p>NLRP3-IN-22 (Compound II-4) is an inhibitor of NLRP3, exhibiting a 67% inhibition rate at a concentration of 10 μM [1].</p>

<p>OATD-02 is an orally active, competitive, reversible, noncovalent inhibitor with slow offset kinetics that targets both Arginase1 and 2, exhibiting inhibitory</p>

MALT1-IN-6 is a MALT1 protease inhibitor (Ki: 9 nM) that exhibits anticancer activity.

(R)-MALT1-IN-7 (compound 142a) is a potent inhibitor of MALT1 protease and has potential for cancer research.

<p>TMV-IN-4, a TMV inhibitor, enhances plant defense and TMV resilience by interacting with helicase, increasing peroxidase and SOD activity.</p>

4-Thiouracil is a photoactivatable probe designated for site-specific applications in detecting RNA structures and nucleic acid-nucleic acid contacts. Upon illumination with ultraviolet light exceeding 300 nm and in the presence of oxygen, it serves as an energy donor, facilitating the generation of singlet oxygen through triplet-triplet energy transfer. This process enables the highly reactive oxygen species to interact with 4-thiouracil, leading to the formation of uracil and uracil-6-sulfonate; the latter exhibits fluorescence around a wavelength of approximately 390 nm. Additionally, 4-Thiouracil functions as a substrate for T. gondii uracil phosphoribosyltransferase, allowing the synthesis of 4-thiouridine monophosphate for subsequent integration into RNA.

JT002 is an orally active NLRP3 inflammasome inhibitor that decreases the production of NLRP3-dependent proinflammatory cytokines (such as IL-1β, IL-1α, IL-18)

BD-AcAc 2 (Ketone Ester) is a ketone monoester and can be used as a source of oral nutritional ketones.

<p>Nitric oxide production-IN-1 (Compound 1) is an inhibitor of nitric oxide (NO) production extracted from Tupistra chinensis.</p>

W-54011: potent non-peptide C5a receptor blocker; binds 125I-C5a (Ki=2.2nM); stops Ca2+ movement, chemotaxis, ROS in neutrophils (IC50=1.6-3.1nM).

<p>Caspase-3 activator 1 (compound 4b), a Ru(III) metal complex, effectively inhibits gastric tumor growth and metastasis by mediating caspase-3 cleavage.</p>

h-NTPDase-IN-3 is an h-NTPDase inhibitor that inhibits h-NTPDase1, h-NTPDase2, h-NTPDase3 and h-NTPDase8.

<p>5J-4 is a potent a blocker of calcium release-activated calcium (CRAC) channel and store-operated calcium entry (SOCE).</p>

<p>Cergutuzumab amunaleukin (CEA-IL2v) is a CEA-targeted IL-2 variant immunocytokine for combination cancer immunotherapy with anti-tumor activity.</p>

5-Androstenetriol, a steroid and active metabolite of dehydroepiandrosterone (DHEA), demonstrates significant therapeutic effects. Administered at 0.75 mg/25 g body weight, it mitigates radiation-induced mortality and facilitates hematopoietic recovery from surviving stem cells in mice. Moreover, a dosage of 40 mg/kg enhances survival rates in rats subjected to surgical trauma-induced sepsis. Additionally, elevated urinary levels of 5-androstenetriol are observed in women suffering from androgenic alopecia.

<p>FEN1-IN-5 (compound 12A) is a potent Flap endonuclease-1 (FEN1) inhibitor with an IC50 value of 12 nM, playing a role in DNA repair mechanisms [1].</p>