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Imunologia e Inflamação

Imunologia e Inflamação

Os inibidores de imunologia e inflamação são compostos que modulam a resposta imunológica e os processos inflamatórios. Esses inibidores são cruciais para estudar os mecanismos de regulação imunológica, autoimunidade e inflamação crônica, bem como para desenvolver tratamentos para doenças inflamatórias, alergias e distúrbios relacionados ao sistema imunológico. Ao direcionar vias-chave no sistema imunológico, esses inibidores podem ajudar a reduzir respostas imunológicas excessivas ou inadequadas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de alta qualidade para apoiar sua pesquisa em imunologia, inflamação e desenvolvimento terapêutico.

Subcategorias de "Imunologia e Inflamação"

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Foram encontrados 3054 produtos de "Imunologia e Inflamação"

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  • RGT-068A
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    RGT-068A

    CAS:
    <p>RGT-068A is a potent, selective and oral bioavailable MALT1 inhibitor .</p>
    Fórmula:C17H16ClN9O2
    Cor e Forma:Solid
    Peso molecular:413.82

    Ref: TM-T73389

  • NOTA-FAPI
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    NOTA-FAPI

    CAS:
    <p>NOTA-FAPI is a FAP inhibitor and FAPI-4 analogue used in PET imaging and targeted therapy for FAP-overexpressing pathological conditions.</p>
    Fórmula:C36H47F2N9O8
    Pureza:99.748%
    Cor e Forma:Solid
    Peso molecular:771.81

    Ref: TM-T69660

  • Logotipo do CymitQuimica
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    ABZI

    CAS:
    <p>(S)-2-(1-Ethyl-3-methyl-1H-pyrazole-5-carboxamido)-1-(2-hydroxy-2-phenylethyl)-1H-benzo[d]imidazole-5-carboxamide (compound 4) is a STING agonist containing the crucial amide benzimidazole (ABZI) component. It consistently inhibits the binding of 3 H-cGAMP to STING, with an apparent inhibition constant (IC50) of 14 μM. This compound is applicable in tumor research.</p>
    Fórmula:C23H24N6O3
    Peso molecular:432.48

    Ref: TM-T207188

  • TLR4/NF-κB/MAPK-IN-1
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    TLR4/NF-κB/MAPK-IN-1

    CAS:
    <p>TLR4/NF-κB/MAPK-IN-1 is a novel antineuroinflammatory agent that functions by inhibiting the TLR4/NF-κB/MAPK pathways.</p>
    Fórmula:C19H25BrO6
    Cor e Forma:Solid
    Peso molecular:429.3

    Ref: TM-T62359

  • AMC-04
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    AMC-04

    CAS:
    AMC-04 is a protein response (UPR) activator that initiates the UPR pathway via ROS and p38 MAPK signaling, leading to apoptotic cell death. It is used in cancer research [1].
    Fórmula:C26H28N2O3
    Cor e Forma:Solid
    Peso molecular:416.51

    Ref: TM-T85643

  • AhR agonist 8
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    AhR agonist 8

    CAS:
    <p>Compound 9, also known as AhR agonist 8, effectively activates the Aryl Hydrocarbon Receptor (AhR) with an EC50 of 0.154 nM. This compound is utilized in researching psoriasis and atopic dermatitis.</p>
    Fórmula:C17H15FN4O
    Cor e Forma:Solid
    Peso molecular:310.33

    Ref: TM-T89981

  • TNFα activity modulator 3
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    TNFα activity modulator 3

    CAS:
    <p>TNFα Activity Modulator 3 (example 6) is a molecule that regulates TNF activity by inhibiting TNFα-induced NF-κB activation, making it applicable for related research.</p>
    Fórmula:C27H24F2N6O2
    Cor e Forma:Solid
    Peso molecular:502.52

    Ref: TM-T89932

  • NLRP3-IN-44
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    NLRP3-IN-44

    CAS:
    <p>NLRP3-IN-44 (compound P33), an orally active (approximately 62%) and potent inhibitor of NLRP3, exhibits a dissociation constant (K D) of 17.5 nM. This compound is crucial in the research of diseases mediated by the NLRP3 inflammasome.</p>
    Fórmula:C25H30N4O3
    Cor e Forma:Solid
    Peso molecular:434.53

    Ref: TM-T89953

  • GTCpFE
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    GTCpFE

    CAS:
    GTCpFE, a compound synthesized from Dimethyl fumarate (DMF) and Aspirin (ASA), inhibits IKKα/β in the NF-κB pathway, exhibiting anti-inflammatory activity by preventing p65 from entering the nucleus. It selectively inhibits cancer stem cell (CSC) activity by reducing the growth of mammospheres and the expression of the CD44+CD24- immune phenotype. Furthermore, GTCpFE targets breast cancer stem cells, crucial in aggressive cancer phenotypes that depend on NFκB and PGE2.
    Fórmula:C22H20O8
    Cor e Forma:Solid
    Peso molecular:412.39

    Ref: TM-T200141

  • Panaxcerol B
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    Panaxcerol B

    CAS:
    <p>Panaxcerol B, a monogalactosyl monoacylglycerol, exhibits an IC50 value of 59.4 μM against NO production in LPS-stimulated RAW264.7 cells.</p>
    Fórmula:C27H46O9
    Cor e Forma:Solid
    Peso molecular:514.65

    Ref: TM-T89969

  • SBI-0640726
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    SBI-0640726

    CAS:
    <p>SBI-0640726, an eIF4G1 inhibitor, exhibits antiproliferative activity against melanoma. It disrupts the eIF4F translation initiation complex by inhibiting the AKT and NF-kB signaling pathways. Additionally, SBI-0640726 inhibits the growth of melanoma with NRAS and BRAF mutations in vitro.</p>
    Fórmula:C23H15ClN2O2
    Cor e Forma:Solid
    Peso molecular:386.83

    Ref: TM-T89836

  • C5aR-IN-3
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    C5aR-IN-3

    CAS:
    <p>C5aR-IN-3, a potent C5aR inhibitor, may treat autoimmune and inflammatory diseases.</p>
    Fórmula:C36H40FN5O3
    Cor e Forma:Solid
    Peso molecular:609.73

    Ref: TM-T73262

  • Logotipo do CymitQuimica
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    TLR7/8 antagonist 1

    <p>Compound 16c, an imidazoquinoline, is a TLR7/8 agonist; IC50: 3.91 μM (TLR7), 2.19 μM (TLR8); targets TLR-2050 for disease treatment.</p>
    Fórmula:C24H27N5O2
    Cor e Forma:Solid
    Peso molecular:417.5

    Ref: TM-T62178

  • STING agonist-20
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    STING agonist-20

    CAS:
    <p>STING agonist-20: potent, aids in XMT-2056 synthesis, used as a cancer vaccine adjuvant.</p>
    Fórmula:C36H39N11O8
    Cor e Forma:Solid
    Peso molecular:753.76

    Ref: TM-T72688

  • STING agonist-42
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    STING agonist-42

    CAS:
    <p>STINGagonist-42 (compound 8a) is a potent STING agonist. It activates STING in THP1 and RAW 264.7 cells, with EC50 values of 0.06 μM and 14.15 μM, respectively.</p>
    Fórmula:C17H8F2LiN5O3
    Cor e Forma:Solid
    Peso molecular:375.22

    Ref: TM-T207376

  • SMW139
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    SMW139

    CAS:
    <p>SMW139 is a selective allosteric antagonist of the P2X7 receptor, exhibiting a Ki value of 32 nM for human P2X7R. In rat liver microsomes, its half-life is 47 minutes. SMW139 is applicable in research related to inflammation, Alzheimer's disease, and multiple sclerosis.</p>
    Fórmula:C19H21ClF3NO2
    Cor e Forma:Solid
    Peso molecular:387.824

    Ref: TM-T206318

  • IRAK4-IN-15
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    IRAK4-IN-15

    CAS:
    <p>IRAK4-IN-15: selective IRAK4 inhibitor, IC50 0.002 μM, good PK, low clearance, synergizes with Acalabrutinib in MyD88/CD79 mutant ABC-DLBCL.</p>
    Fórmula:C25H29FN10
    Cor e Forma:Solid
    Peso molecular:488.56

    Ref: TM-T63262

  • Creatine ethyl ester
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    Creatine ethyl ester

    CAS:
    <p>Creatine ethyl ester (CEE) is a readily available form of creatine commonly used in supplements. It can upregulate TLRs (TLR2, 3, 4, and TLR7) over a short period.</p>
    Fórmula:C6H13N3O2
    Cor e Forma:Solid
    Peso molecular:159.186

    Ref: TM-T206807

  • EGR-1-IN-3
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    EGR-1-IN-3

    CAS:
    <p>EGR-1-IN-3 (Compound 36) is an inhibitor of early growth response 1 (EGR-1) binding to DNA. It effectively suppresses the binding of EGR-1 to DNA and the expression of inflammation-related genes (such as TSLP, IL-31, IL-6, and CCL2) induced by TNFα. This compound is applicable to the study of inflammatory diseases.</p>
    Fórmula:C31H31N3O6S
    Cor e Forma:Solid
    Peso molecular:573.659

    Ref: TM-T204527

  • Gardiquimod hydrochloride
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    Gardiquimod hydrochloride

    CAS:
    <p>Gardiquimod (hydrochloride) is an imidazoquinoline class TLR7/8 agonist. It can inhibit HIV-1 infection in macrophages and activated peripheral blood mononuclear cells (PBMCs). At concentrations below 10 μM, Gardiquimod (hydrochloride) specifically activates TLR7.</p>
    Fórmula:C17H24ClN5O
    Cor e Forma:Solid
    Peso molecular:349.858

    Ref: TM-T204751