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Imunologia e Inflamação

Imunologia e Inflamação

Os inibidores de imunologia e inflamação são compostos que modulam a resposta imunológica e os processos inflamatórios. Esses inibidores são cruciais para estudar os mecanismos de regulação imunológica, autoimunidade e inflamação crônica, bem como para desenvolver tratamentos para doenças inflamatórias, alergias e distúrbios relacionados ao sistema imunológico. Ao direcionar vias-chave no sistema imunológico, esses inibidores podem ajudar a reduzir respostas imunológicas excessivas ou inadequadas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de alta qualidade para apoiar sua pesquisa em imunologia, inflamação e desenvolvimento terapêutico.

Subcategorias de "Imunologia e Inflamação"

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Foram encontrados 3045 produtos de "Imunologia e Inflamação"

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  • STING agonist-21
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    STING agonist-21

    CAS:
    <p>STING agonist-21 (compound 1), possessing an EC 50 of 592.8 nM, functions as a STING agonist. It is applicable in cancer research [1].</p>
    Fórmula:C17H11F6N5O2
    Cor e Forma:Solid
    Peso molecular:431.29

    Ref: TM-T87445

  • ALR-27
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    ALR-27

    CAS:
    <p>ALR-27 serves as an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP and exhibits anti-inflammatory properties. It effectively inhibits 5-LOX product formation (&gt;80%) in pro-inflammatory M1-MDM without significantly inhibiting 5-LOX directly. Additionally, ALR-27 decreases prostaglandin and leukotriene (LT) production in neutrophils and enhances the production of specialized prolytic mediators in certain human macrophage phenotypes [1].</p>
    Fórmula:C19H22O3
    Cor e Forma:Solid
    Peso molecular:298.38

    Ref: TM-T85637

  • TE-11
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    TE-11

    CAS:
    <p>TE-11 is a MIF tautomerase inhibitor with an IC50 of 5.63 μM. This compound can alleviate Crohn's-like colitis, reduce MIF-induced migration of eosinophils and neutrophils, and prevent M1 polarization and associated metabolic reprogramming.</p>
    Fórmula:C16H13NO
    Cor e Forma:Solid
    Peso molecular:235.28

    Ref: TM-T207303

  • SB24011
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    SB24011

    CAS:
    <p>SB24011, a STING-TRIM29 interaction inhibitor, has an IC₅₀ value of 3.85 μM. It boosts STING immunity by upregulating STING protein levels, thereby enhancing the immunotherapeutic effects of STING agonists and anti-PD-1 antibodies through systemic anticancer immunity [1].</p>
    Fórmula:C34H38N4O7
    Cor e Forma:Solid
    Peso molecular:614.69

    Ref: TM-T87367

  • IKZF1-degrader-2
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    IKZF1-degrader-2

    CAS:
    <p>IKZF1-degrader-2 (Compound 3), an IKZF1 degrader, exhibits anticancer activity and low toxicity [1].</p>
    Fórmula:C33H30FN5O5
    Cor e Forma:Solid
    Peso molecular:595.62

    Ref: TM-T86708

  • IRAK4 modulator-1
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    IRAK4 modulator-1

    CAS:
    <p>IRAK4 Modulator-1 (example 161), an IRAK4 modulator with an IC50 of 4.647 μM, is employed in the investigation of IRAK-mediated disorders [1].</p>
    Fórmula:C19H13ClN4O2
    Cor e Forma:Solid
    Peso molecular:364.79

    Ref: TM-T86740

  • NIK-IN-2
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    NIK-IN-2

    CAS:
    <p>NIK-IN-2 (compound 1) is an effective inhibitor of NF-κB inducing kinase (NIK), exhibiting a pIC50 of 7.4. It plays a crucial role in cancer research.</p>
    Fórmula:C20H22N4O3
    Cor e Forma:Solid
    Peso molecular:366.41

    Ref: TM-T201462

  • NLRP3-IN-57
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    NLRP3-IN-57

    <p>NLRP3-IN-57 (compound 5) inhibits the NLRP3 inflammasome, consequently downregulating IL-1β levels in THP-1 macrophages induced by LPS+Nigericin.</p>
    Fórmula:C44H60O7
    Cor e Forma:Solid
    Peso molecular:700.94

    Ref: TM-T201467

  • Factor B-IN-3
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    Factor B-IN-3

    CAS:
    <p>Factor B-IN-3 is a potent inhibitor of complement factor B. Factor B-IN-3 can be used to study inflammatory and immune-related diseases.</p>
    Fórmula:C24H29N3O4
    Cor e Forma:Solid
    Peso molecular:423.5

    Ref: TM-T62276

  • TBK1/IKKε-IN-1
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    TBK1/IKKε-IN-1

    CAS:
    <p>TBK1/IKKε-IN-1 is a dual inhibitor of TBK1 and IKKε (IC50s of &lt;100 nM).</p>
    Fórmula:C28H26N4O5
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:498.53

    Ref: TM-T13097

  • DEG-35
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    DEG-35

    CAS:
    <p>DEG-35 is a CRBN-dependent bifunctional degrader targeting IKZF2 and CK1α, with DC50 values of 1.4 nM and 4.4 nM for CK1α and IKZF2, respectively. It activates the p53 apoptotic pathway and is applicable for research related to acute myeloid leukemia (AML).</p>
    Fórmula:C25H21N3O5
    Cor e Forma:Solid
    Peso molecular:443.45

    Ref: TM-T207249

  • IRAK4-IN-31
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    IRAK4-IN-31

    CAS:
    <p>IRAK4-IN-31 is a crystalline inhibitor of IRAK4. It is applicable in research related to myelodysplastic syndromes (MDS).</p>
    Fórmula:C27H33N5O5
    Cor e Forma:Solid
    Peso molecular:507.58

    Ref: TM-T207192

  • Factor B-IN-4
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    Factor B-IN-4

    CAS:
    <p>Factor B-IN-4 is a potent inhibitor (IC50: 1 μM) of complement factor B. Factor B-IN-4 can be used to study inflammatory and immune-related diseases.</p>
    Fórmula:C27H32N2O4
    Cor e Forma:Solid
    Peso molecular:448.55

    Ref: TM-T62688

  • TMC353121
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    TMC353121

    CAS:
    <p>TMC353121 is an effective inhibitor of respiratory syncytial virus fusion (pEC50: 9.9).</p>
    Fórmula:C32H42N6O3
    Pureza:≥98%
    Cor e Forma:Solid
    Peso molecular:558.71

    Ref: TM-T17107

  • Logotipo do CymitQuimica
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    COX-2/PI3K-IN-2

    <p>COX-2/PI3K-IN-2 (5f): anti-inflammatory &amp; anti-cancer, selectively inhibits COX-2 (Ki=3.02nM), potently blocks PI3K (IC50=2.78nM).</p>
    Fórmula:C16H17N5O2
    Cor e Forma:Solid
    Peso molecular:311.34

    Ref: TM-T60769

  • Numidargistat
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    Numidargistat

    CAS:
    <p>CB-1158 is a potent and orally bioavailable inhibitor of arginase (IC50s: 86 and 296 nM for recombinant human arginase 1 and 2).</p>
    Fórmula:C11H22BN3O5
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:287.12

    Ref: TM-T10692L

  • Logotipo do CymitQuimica
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    COX-2-IN-7

    <p>COX-2-IN-7: potent, orally active COX-2 inhibitor with higher selectivity than Celecoxib, IC50 6.585 uM, anti-inflammatory, low ulcer risk.</p>
    Fórmula:C15H13N3O2S2
    Cor e Forma:Solid
    Peso molecular:331.41

    Ref: TM-T60978

  • meso-Zeaxanthin
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    meso-Zeaxanthin

    CAS:
    <p>meso-Zeaxanthin accumulates in the central retina and, together with lutein and zeaxanthin, forms the macular pigment, which functions as a light filter. meso-Zeaxanthin can quench reactive oxygen species (ROS), thereby exhibiting antioxidant properties.</p>
    Fórmula:C40H56O2
    Cor e Forma:Solid
    Peso molecular:568.871

    Ref: TM-T204572

  • Logotipo do CymitQuimica
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    XO/COX/LOX-IN-1

    <p>XO/COX/LOX-IN-1 targets XO/COX/LOX, used in research of inflammation, cancer, and metabolic disorders.</p>
    Fórmula:C24H20N4O2S
    Cor e Forma:Solid
    Peso molecular:428.51

    Ref: TM-T62350

  • Logotipo do CymitQuimica
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    Anti-inflammatory agent 10

    <p>Tilomisole-derived benzimidazole-thiazole, orally active, favors COX-2 inhibition over COX-1.</p>
    Fórmula:C17H13BrN4O3S2
    Cor e Forma:Solid
    Peso molecular:465.34

    Ref: TM-T62967