Imunologia e Inflamação
Os inibidores de imunologia e inflamação são compostos que modulam a resposta imunológica e os processos inflamatórios. Esses inibidores são cruciais para estudar os mecanismos de regulação imunológica, autoimunidade e inflamação crônica, bem como para desenvolver tratamentos para doenças inflamatórias, alergias e distúrbios relacionados ao sistema imunológico. Ao direcionar vias-chave no sistema imunológico, esses inibidores podem ajudar a reduzir respostas imunológicas excessivas ou inadequadas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de alta qualidade para apoiar sua pesquisa em imunologia, inflamação e desenvolvimento terapêutico.
Subcategorias de "Imunologia e Inflamação"
- CCR(136 produtos)
- CXCR(148 produtos)
- Parede celular(5 produtos)
- Receptor IL(112 produtos)
- IκB/IKK(60 produtos)
- LTR(3 produtos)
- MALT(23 produtos)
- MRP(6 produtos)
- NADPH-oxidase(1 produtos)
- NF-κB(444 produtos)
- NOD(17 produtos)
- NOS(63 produtos)
- Nrf2(79 produtos)
- PGE Sintase(31 produtos)
- ROS(69 produtos)
- TGF-beta/Smad(58 produtos)
- TLR(66 produtos)
- Tiorredoxina(12 produtos)
- gp120/CD4(4 produtos)
Exibir 11 mais subcategorias
Foram encontrados 3045 produtos de "Imunologia e Inflamação"
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Nepafenac-d5
CAS:<p>Nepafenac D5 is the deuterium labeled Nepafenac, which is a selective inhibitor of COX-2 .</p>Fórmula:C15H14N2O2Pureza:98%Cor e Forma:SolidPeso molecular:259.31Maresin 1
CAS:<p>Maresin 1 is biosynthesized by macrophages (MΦ) and possesses significant anti-inflammatory activity that attenuates LPS-induced lung injury in mice.</p>Fórmula:C22H32O4Cor e Forma:SolidPeso molecular:360.49Etokimab
CAS:<p>Etokimab (ANB-020) is a humanised monoclonal antibody targeting IL-33, neutrophil migration, atopic dermatitis, asthma, and sinusitis.</p>Pureza:95%Cor e Forma:LiquidAHR-10037
CAS:<p>AHR-10037, a NSAID, offers pain relief, fever reduction, safety, and low stomach risk, acting as a prodrug for COX inhibitors.</p>Fórmula:C15H13ClN2O2Pureza:98%Cor e Forma:SolidPeso molecular:288.73(9α,13α,14α)-4-Hydroxy-3,7-dimethoxy-7,8-didehydromorphinan-6-one
CAS:(9α,13α,14α)-4-Hydroxy-3,7-dimethoxy-7,8-didehydromorphinan-6-one is a major mechanism of Sinomenine.Fórmula:C18H21NO4Pureza:97.85%Cor e Forma:SoildPeso molecular:315.36TMV-IN-9
CAS:<p>TMV-IN-9 (compound A6) is an antiviral agent that exhibits exceptional inactivation effects against Tobacco Mosaic Virus (TMV), with an EC50 of 62.8 μg/mL. It demonstrates strong binding capabilities to the TMV capsid protein, with a binding affinity of 1.862 μM. Moreover, TMV-IN-9 significantly disrupts the integrity of TMV particles, thereby preventing the virus from infecting the host.</p>Fórmula:C20H20O8Cor e Forma:SolidPeso molecular:388.37D228
CAS:<p>D228 is an oral anti-inflammatory,inhibi B and T lymphocytes, down-regulation of MyD88/TRAF6/p38 and up-regulation of IL-10,inflammatory bowel disease (IBD).</p>Fórmula:C22H28O12Pureza:99.91%Cor e Forma:SolidPeso molecular:484.45FAPI-2
CAS:<p>FAPI-2 is a specific inhibitor of fibroblast-activated protein based on the radiotracer FAP labeling, and has anticancer activity.</p>Fórmula:C40H56N10O10Pureza:98.76%Cor e Forma:SolidPeso molecular:836.933,4-DAA
CAS:<p>3,4-DAA has anti-inflammatory activity and inhibits EOC20 cell-induced nitric oxide synthase (iNOS) induced by IFN-γ and lipopolysaccharide.</p>Fórmula:C18H17NO6Pureza:98%Cor e Forma:SolidPeso molecular:343.33Amfenac
CAS:<p>Amfenac promotes apoptosis in ARPE-19 cell culture.</p>Fórmula:C15H13NO3Cor e Forma:SolidPeso molecular:255.27AZD4144
CAS:<p>AZD4144 is a potent and selective NLRP3 inhibitor (IC50 = 54 nM) that reducs IL-1β and IL-18 production for immune disorders.</p>Fórmula:C18H16F3N3O3Pureza:99.02%Cor e Forma:SoildPeso molecular:379.33Azacyclonol hydrochloride
CAS:<p>Azacyclonol hydrochloride can be used in the treatment of chronic schizophrenia.</p>Fórmula:C18H22ClNOCor e Forma:Off White Crystalline PowderPeso molecular:303.83Vopikitug
CAS:<p>Vopikitug is a humanized monoclonal antibody targeting IL-2RA with antitumor activity. It can be used to study cancer.</p>Pureza:99.1% (SDS-PAGE); 96.5% (SEC-HPLC) - 99.1% (SDS-PAGE); 96.5% (SEC-HPLC)Cor e Forma:LiquidKamebakaurin
CAS:<p>Kamebakaurin combats liver toxicity, cancer, inflammation, and neuroinflammation by blocking NF-κB, HIF-1α, and key signaling pathways.</p>Fórmula:C20H30O5Pureza:98.05%Cor e Forma:SolidPeso molecular:350.45Avasopasem manganese
CAS:<p>Avasopasem manganese is a drug candidate of superoxide dismutase mimetic.</p>Fórmula:C21H35Cl2MnN5Pureza:98%Cor e Forma:SolidPeso molecular:483.38BMS-378806
CAS:BMS-378806 (BMS-806) selectively inhibits the binding of HIV-1 gp120 to the CD4 receptor with EC50 of 0.85-26.5 nM in virus.Fórmula:C22H22N4O4Pureza:99.93%Cor e Forma:SolidPeso molecular:406.43E3330
CAS:<p>E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.</p>Fórmula:C21H30O6Pureza:99.52%Cor e Forma:SolidPeso molecular:378.46Pelubiprofen
CAS:<p>Pelubiprofen is a non-steroidal anti-inflammatory agent and a COX-2 inhibitor, which effectively reduces PGE(2) production by inhibiting COX activity.</p>Fórmula:C16H18O3Pureza:99.69%Cor e Forma:SolidPeso molecular:258.31Catalase
CAS:<p>Catalase, an enzyme, metabolizes H2O2 and ROS; its expression and localization change significantly in tumors.</p>Pureza:≥98%Cor e Forma:Small Colorless Crystals Or Powder At Room Temperature Almost Odourless Small Colourless Crystals Or A White Crystalline PowderAllopurinol Sodium
CAS:<p>Allopurinol Sodium is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM.</p>Fórmula:C5H4N4NaOPureza:99.93%Cor e Forma:SolidPeso molecular:159.1TLR7 agonist 1
CAS:<p>TLR7 agonist 1 is a selective and oral TLR7 agonist (IC50: 90 nM).</p>Fórmula:C21H25N5OPureza:98%Cor e Forma:SolidPeso molecular:363.46M62812 free base
CAS:<p>M62812 (free base), a Toll-like receptor 4 (TLR4) signal transduction inhibitor, suppresses activation of endothelial cells and leukocytes and prevents lethal</p>Fórmula:C13H11N3OSCor e Forma:SolidPeso molecular:257.31BAY32-5915
CAS:<p>BAY32-5915 is a selective inhibitor of IKKalpha.</p>Fórmula:C10H7NO3Pureza:96.48% - 97%Cor e Forma:Yellow Crystalline PowderPeso molecular:189.17OXSI-2
CAS:<p>OXSI-2 (Syk Inhibitor) is an inhibitor of Syk with an EC50 of 313 nM and an IC50 of 14 nM.</p>Fórmula:C18H15N3O3SPureza:98%Cor e Forma:Dark Orange SolidPeso molecular:353.39UC-781
CAS:<p>UC-781, a potent NNRTI, inhibits HIV-1 with a C50 of 5 nM and is stable across pH and temperatures.</p>Fórmula:C17H18ClNO2SPureza:92.17%Cor e Forma:SolidPeso molecular:335.85MIF-IN-2
CAS:<p>MIF-IN-2 is a MIF inhibitor with anticancer activity for the study of cancer and autoimmune diseases.</p>Fórmula:C14H10ClN3O4Pureza:98.55%Cor e Forma:SolidPeso molecular:319.7TRAF-STOP inhibitor 6877002
CAS:<p>TRAF-STOP 6877002 inhibits CD40-TRAF6, curbing leukocyte recruitment and macrophage activation/proliferation in plaques.</p>Fórmula:C17H17NOPureza:99.76%Cor e Forma:SolidPeso molecular:251.32DDX3-IN-2
CAS:<p>DDX3-IN-2 is a potent DDX3 inhibitor with an IC50 of 0.3 μM and shows broad antiviral effects, including against HIV resistance.</p>Fórmula:C20H23N5OCor e Forma:SolidPeso molecular:349.43ARV-393
CAS:<p>ARV-393 is a PROTAC degrader targeting BCL6 orally available. ubiquitin proteasome for diffuse large b-cell lymphoma (DLBCL) and non-Hodgkin's lymphoma (NHL)</p>Fórmula:C46H53ClFN9O7Pureza:99.96%Cor e Forma:SoildPeso molecular:898.42KIN1400
CAS:<p>KIN1400 activates IRF3, boosts antiviral immunity, stimulates IFNbeta, and inhibits WNV, DV, and HCV.</p>Fórmula:C24H17F2N3O2SPureza:98%Cor e Forma:SolidPeso molecular:449.47SNAP 398299
CAS:<p>SNAP 398299 is a Glycopeptide Receptor Type 3 (Gal3) antagonist with anxiolytic and antidepressant-like effects and is used in the study of mood disorders.</p>Fórmula:C27H24F3N3O2Pureza:97.16%Cor e Forma:SolidPeso molecular:479.49GCPII-IN-1 TFA
CAS:<p>GCPII-IN-1 TFA (compound 2) is an inhibitor scaffold for glutamate carboxypeptidase II (GCPII, PSMA) with a Ki of 44.3±2.4 nM for use in prostate cancer.</p>Fórmula:C14H22F3N3O9Cor e Forma:SoildPeso molecular:433.34NLRP3-IN-13
CAS:<p>NLRP3-IN-13 is an NLRP3 inhibitor that inhibits NLRP3-associated inflammation.NLRP3-IN-13 can be used in the study of neurological disorders and inflammation.</p>Fórmula:C19H15N3O3SPureza:99.16%Cor e Forma:SolidPeso molecular:365.41MitoTEMPOL
CAS:<p>MitoTEMPOL is a mitochondria-targeted antioxidant that prevents septal dysfunction by reversing sepsis-induced decreases in mitochondrial function.</p>Fórmula:C32H42BrNO2PCor e Forma:SolidPeso molecular:583.56ADU-S100 ammonium salt
CAS:<p>ADU-S100 ammonium salt is an activator of stimulator of interferon genes (STING).Cost-effective and quality-assured.</p>Fórmula:C20H30N12O10P2S2Pureza:98%Cor e Forma:SolidPeso molecular:724.6LY 178002
CAS:<p>LY 178002 inhibits 5-LPO (IC50: 0.6 μM), PLA2, and LTB4 production; weak on cyclooxygenase.</p>Fórmula:C18H25NO2SPureza:98%Cor e Forma:SolidPeso molecular:319.46Oxyphenbutazone monohydrate
CAS:<p>Oxyphenbutazone monohydrate: Phenylbutazone derivative, anti-inflammatory, non-selective COX inhibitor, kills dormant M. tuberculosis.</p>Fórmula:C19H22N2O4Cor e Forma:SolidPeso molecular:342.39CU-76
CAS:<p>CU-76 inhibits cGAS (IC50 = 0.24 μM) affecting DNA-induced IFN-β production, not RIG-I-MAVS pathway, in THP-1 cells.</p>Fórmula:C11H8F2IN5O2Cor e Forma:SolidPeso molecular:407.11MSU38225
CAS:<p>MSU38225, an Nrf-2 inhibitor, elevates reactive oxygen species (ROS) levels and suppresses the proliferation of human lung cancer cells.</p>Fórmula:C21H19N3Cor e Forma:SolidPeso molecular:313.4Isofezolac
CAS:<p>Isofezolac (LM 22070), a NSAID, inhibits prostaglandin-synthetase, offering powerful anti-inflammatory and antipyretic effects.</p>Fórmula:C23H18N2O2Cor e Forma:SolidPeso molecular:354.4MIF-IN-1
CAS:<p>MIF-IN-1 (compound 14) inhibits MIF, a cytokine linked to diseases, with pIC50 of 6.87.</p>Fórmula:C15H13N3O5Cor e Forma:SolidPeso molecular:315.28Asperbisabolane L
<p>Asperbisabolane L, a sesquiterpenoid, combats inflammation by blocking NF-κB signaling and NO in BV-2 cells.</p>Fórmula:C12H14O3Cor e Forma:SolidPeso molecular:206.24NF-κB/PON1-IN-1
CAS:<p>NF-κB/PON1-IN-1 (Compound 16) is an NF-κB/PON1 pathway inhibitor with antioxidant activity (IC50: 45.76 μM) and hepatoprotective activity.</p>Fórmula:C20H16N6O4S2Cor e Forma:SolidPeso molecular:468.51TLR7/8 agonist 4
CAS:<p>TLR7/8 agonist 4 (compound 41) is a potent agonist of TLR7/8 with anti-cancer activity [1].</p>Fórmula:C18H24N6Cor e Forma:SolidPeso molecular:324.42RI-962
CAS:<p>RI-962 is a potent and selective inhibitor of RIPK1 that protects cells from necrotic apoptosis by inhibiting RIPK1, RIPK3, and MLKL phosphorylation.</p>Fórmula:C28H28N6O2Pureza:99.39%Cor e Forma:SoildPeso molecular:480.56S-Isopropylisothiourea hydrobromide
CAS:<p>S-Isopropylisothiourea hydrobromide is an iNOS inhibitor.</p>Fórmula:C4H11BrN2SPureza:98%Cor e Forma:SolidPeso molecular:199.11Antiviral agent 14
CAS:<p>Antiviral agent 14 is an antiviral agent that inhibits tobacco mosaic virus (TMV) (EC50: 135.5 μg/mL), and cucumber mosaic virus (CMV) (EC50: 178.6 μg/mL).</p>Fórmula:C24H26O7Cor e Forma:SolidPeso molecular:426.46Ophthalmic acid
CAS:<p>Ophthalmic acid is a glutathione analog in which cysteine is substituted by L-aminobutyrate.</p>Fórmula:C11H19N3O6Cor e Forma:SolidPeso molecular:289.29Ferric citrate
CAS:<p>Ferric citrate as a source of iron used in cell culture applications can provide iron with a less toxic form compared to free iron salts.</p>Fórmula:C6H8FeO7Cor e Forma:Limit Its Spread To The Environment It Is Used In Medicine In Making Blueprints And As A FeedPeso molecular:247.968Ro 106-9920
CAS:<p>Inhibitor of NF-κB activation</p>Fórmula:C10H7N5OSPureza:98%Cor e Forma:SolidPeso molecular:245.26Galectin-3-IN-1
CAS:<p>Galectin-3-IN-1 is a potent Gal-3 inhibitor, key in cancer-related metabolic processes.</p>Fórmula:C18H26O10SCor e Forma:SolidPeso molecular:434.46Imupedone
CAS:<p>Imupedone (LF 1695) is a synthetic immunomodulator that increases the proliferative response of lymphocytes to mitogens, antigens and allogeneic cells.</p>Fórmula:C19H21ClN2OPureza:99.53%Cor e Forma:SolidPeso molecular:328.84DPP-4 inhibitor 3
CAS:<p>DPP-4 inhibitor 3 is a powerful DPP-IV blocker with 0.75 nM IC50, boasting antioxidant and insulinotropic effects.</p>Fórmula:C19H22N6O2Cor e Forma:SolidPeso molecular:366.42NIC-0102
CAS:<p>NIC-0102 is an orally active proteasome inhibitor (pIC50:7.55) that exhibits specific inhibition of NLRP3 inflammatory vesicle activation. Inhibitory effect.</p>Fórmula:C21H25BF2N2O4Cor e Forma:SolidPeso molecular:418.24Naproxcinod
CAS:<p>Naproxcinod is a derivative of naproxen, analgesic and anti-inflammatory, a COX-inhibitory nitric oxide donor (CINOD), osteoarthritis and inflammatory.</p>Fórmula:C18H21NO6Cor e Forma:SolidPeso molecular:347.36MIP-1095
CAS:<p>MIP-1095 is the prostate-specific membrane antigen inhibitor.</p>Fórmula:C19H25IN4O8Pureza:98%Cor e Forma:SolidPeso molecular:564.33COX-2-IN-28
CAS:<p>COX-2-IN-28 is a potent and selective COX-2 inhibitor capable of acting on COX-2 (IC50: 0.054 μM), 15-LOX (IC50: 2.14 μM) and COX-1 (IC50: 13.21 μM).</p>Fórmula:C30H27N7S3Cor e Forma:SolidPeso molecular:581.78AP-1/NF-κB activation inhibitor 1
CAS:<p>AP-1/NF-κB activation inhibitor 1 is a potent inhibitor of AP-1 and NF-κB mediated transcriptional activation ( IC 50 =1 μM), does not blocking basal</p>Fórmula:C13H11F3N4O4Pureza:99.52% - 99.91%Cor e Forma:SolidPeso molecular:344.25BCX 1470
CAS:<p>BCX 1470 inhibits the esterolytic activity of factor D and C1s (IC50: 96 nM and 1.6 nM), 3.4- and 200-fold better than that of trypsin, respectively.</p>Fórmula:C14H10N2O2S2Pureza:98%Cor e Forma:SolidPeso molecular:302.37STING Agonist C11
CAS:<p>STING agonist C11 activates STING, induces type I IFN in cells, phosphorylates IRF3, and lowers various viral titers via STING/IFNAR pathway.</p>Fórmula:C19H18N4O3SCor e Forma:SolidPeso molecular:382.44CD73-IN-9
CAS:<p>CD73-IN-9, a potent inhibitor of CD73, may treat cancer by blocking adenosine production that aids tumor growth and spread.</p>Fórmula:C14H11F2N5O2Cor e Forma:SolidPeso molecular:319.27Heme Oxygenase-1-IN-1 hydrochloride
CAS:<p>HO-1-IN-1 hydrochloride is a heme oxygenase 1 (HO-1) inhibitor (IC50: 250 nM).</p>Fórmula:C13H16BrClN2Cor e Forma:SolidPeso molecular:315.64IACS-8803
CAS:<p>IACS-8803 is a potent cyclic dinucleotide STING agonist that exhibits strong systemic antitumor efficacy.</p>Fórmula:C20H23FN10O9P2S2Pureza:98%Cor e Forma:SolidPeso molecular:692.53L-Nabe
CAS:<p>L-Nabe (H-Arg(NO2)-Obzl) is a effective irreversible endothelium dependent relaxation inhibitor.</p>Fórmula:C13H19N5O4Pureza:98.03%Cor e Forma:SolidPeso molecular:309.32ML388
CAS:<p>ML388 is an inhibitor of human NAD(+)- dependent 15- hydroxyprostaglandin dehydrogenase.</p>Fórmula:C20H24N4Pureza:98%Cor e Forma:SolidPeso molecular:320.43BSP16
CAS:<p>BSP16: potent, oral STING agonist; boosts interferon genes; promising for cancer research.</p>Fórmula:C16H18O5SeCor e Forma:SolidPeso molecular:369.27TL8-506
CAS:<p>TL8-506 is a selective and potent TLR8 agonist that induces cytokine and chemokine production.TL8-506 alleviates inflammatory and autoimmune diseases.</p>Fórmula:C20H17N3O2Pureza:95% - 99.97%Cor e Forma:SolidPeso molecular:331.37Naproxen etemesil
CAS:<p>Naproxen, a COX-1/2 inhibitor, has IC50s of 8.72/5.15 μM. Its prodrug, naproxen etemesil, is lipophilic and converts to active form upon absorption.</p>Fórmula:C17H20O5SPureza:98%Cor e Forma:SolidPeso molecular:336.4IL-17A modulator-3
CAS:<p>IL-17A modulator-3 inhibits IL-17A/A, IC50 <10 μM, for inflammation, cancer, autoimmune research.</p>Fórmula:C34H50FN7O4Cor e Forma:SolidPeso molecular:639.86,2',4'-Trimethoxyflavone
CAS:<p>The compound is an Aryl hydrocarbon receptor antagonist (EC50 = 0.9 μM). It also has no short term agonist activity and no species or promoter dependence.</p>Fórmula:C18H16O5Pureza:98%Cor e Forma:SolidPeso molecular:312.32MIF degrader MD13
CAS:<p>MD13, a MIF-degrading PROTAC, disrupts vital protein interactions in cancer and inflammation, showing promise as a therapeutic research tool.</p>Fórmula:C35H35N5O8Cor e Forma:SolidPeso molecular:653.68TFC-007
CAS:<p>TFC-007 is an H-PGDS inhibitor, reducing inflammation, useful for studying guinea pig allergic rhinitis induced by cedar pollen.</p>Fórmula:C27H29N5O4Pureza:98.07%Cor e Forma:SolidPeso molecular:487.55PD 127443
CAS:<p>PD 127443 is a Leukotriene B4 antagonist, it is also a dual inhibitor of cyclooxygenase and 5-lipoxygenase.</p>Fórmula:C20H28N2OCor e Forma:SolidPeso molecular:312.45CU-32
CAS:<p>CU-32 is a cGAS inhibitor with IC50=0.45 μM, blocks DNA-stimulated IFN-β production, and is selective over RIG-I-MAVS and TLRs pathways.</p>Fórmula:C11H10IN5O2Cor e Forma:SolidPeso molecular:371.13ASP-6537
CAS:<p>ASP-6537 is a selective and reversible inhibitor of cyclooxygenase-1.</p>Fórmula:C17H17N3O3Pureza:98%Cor e Forma:SolidPeso molecular:311.34Carpro-AM1
CAS:<p>Carpro-AM1, dual FAAH/COX inhibitor, IC50: 94 nM.</p>Fórmula:C21H18ClN3OCor e Forma:SolidPeso molecular:363.84COX-2-IN-11
CAS:<p>COX-2-IN-11 (compound 7b2) is a potent and selective COX-2 inhibitor. COX-2-IN-11 has the potential in inflammation disease research[1].</p>Fórmula:C12H12OS3Cor e Forma:SolidPeso molecular:268.42MLT-747
CAS:MLT-747 is an effective and allosteric inhibitor of MALT1. It binds MALT1 in the allosteric Trp580 pocket (IC50: 14 nM).Fórmula:C20H21Cl2N7O3Cor e Forma:SolidPeso molecular:478.33Xanthine oxidase-IN-6
<p>Xanthine oxidase-IN-6: potent oral mixed-type XOD inhibitor, IC50 1.37 µM, anti-hyperuricemia, renal protection.</p>Fórmula:C29H34N2O15Cor e Forma:SolidPeso molecular:650.58NED-3238
CAS:<p>NED-3238 is a highly potent inhibitor of arginase I and II (IC50 of 1.3 nM and 8.1 nM, respectively).</p>Fórmula:C17H28BN3O4Pureza:98%Cor e Forma:SolidPeso molecular:349.23AR-C102222 hydrochloride
CAS:AR-C102222 hydrochloride: oral iNOS inhibitor, selective, IC50=37 nM, with anti-inflammatory and pain relief effects.Fórmula:C19H17ClF2N6OPureza:98%Cor e Forma:SolidPeso molecular:418.83Mivotilate
CAS:<p>Mivotilate, a potent, non-toxic aryl hydrocarbon receptor (AhR) activator, functions as a hepatoprotective agent.</p>Fórmula:C12H14N2O3S3Pureza:98%Cor e Forma:SolidPeso molecular:330.45AMT hydrochloride
CAS:<p>AMT hydrochloride is an iNOS inhibitor.</p>Fórmula:C5H11ClN2SPureza:98%Cor e Forma:SolidPeso molecular:166.67Cyclic-di-GMP
CAS:<p>Cyclic-di-GMP is a STING agonist and ubiquitous second messenger, which regulates the formation, motility and virulence of biofilms in various bacterial species</p>Fórmula:C20H24N10O14P2Pureza:98%Cor e Forma:SolidPeso molecular:690.41STING Agonist 12b
CAS:<p>STING agonist 12b activates human/mouse STING, binds with Kd 26.4 μM, prompts interferon, and induces TNF-a, IL-6, IP-10, IL-1b in THP-1 cells.</p>Fórmula:C16H15NO2Cor e Forma:SolidPeso molecular:253.3CD73-IN-8
CAS:<p>CD73-IN-8 blocks CD73, hindering adenosine production that supports tumor growth, flagged as compound 57 in WO2022052886A1.</p>Fórmula:C17H13ClN4O2Cor e Forma:SolidPeso molecular:340.76IRAK4-IN-16
CAS:<p>IRAK4-IN-16 inhibits IRAK4 at 2.5nM; cytotoxic to OCI-LY10, TMD8, Ramos, HT cells with IC50s of 0.2, 0.2, 0.6, 2.7μM.</p>Fórmula:C17H20F2N8OCor e Forma:SolidPeso molecular:390.39L-NIL hydrochloride
CAS:<p>selective inhibitor of inducible nitric oxide synthase</p>Fórmula:C8H18ClN3O2Pureza:98%Cor e Forma:White To Off-White SolidPeso molecular:223.7IRAK inhibitor 4
CAS:<p>IRAK inhibitor 4 is an interleukin-1 receptor associated kinase 4 inhibitor.</p>Fórmula:C33H35F3N6O3Pureza:98%Cor e Forma:SolidPeso molecular:620.66AL-8417
CAS:<p>AL-8417 is an enzyme inhibitor with antioxidant, anti-inflammatory, and cytostatic properties; prevents vitrectomy-induced lens alterations.</p>Fórmula:C29H34O5Pureza:98%Cor e Forma:SolidPeso molecular:462.58Mercaptoethylguanidine (MEG) (dihydrobromide)
CAS:<p>MEG dihydrobromide inhibits inducible nitric oxide synthase and scavenges peroxynitrite, potentially aiding in inflammatory bowel disease studies.</p>Fórmula:C3H11Br2N3SCor e Forma:SolidPeso molecular:281.01Sulfo-ara-F-NMN
CAS:<p>Sulfo-ara-F-NMN: cell-permeable, NMN analogue, activates SARM1, inhibits CD38 (IC50 ~10μM), induces cADPR, NAD loss, non-apoptotic death.</p>Fórmula:C11H14FN2O6PSPureza:98%Cor e Forma:SolidPeso molecular:352.28MD13
<p>MD13 is a macrophage migration inhibitor (MIF) oriented PROTAC (Ki value: 71 nM). MD13 can be used to study cancer.</p>Cor e Forma:LiquidCOX-2-IN-18
CAS:<p>COX-2-IN-18 is a potent COX-2 inhibitor similar to Celecoxib, showing promise in cancer research. IC50=0.775μM.</p>Fórmula:C18H19N3O3S2Cor e Forma:SolidPeso molecular:389.49(R)-MLT-985
CAS:<p>(R)-MLT-985 (compound 11) is a MALT1 protease inhibitor with IC50 of 3 nM, also blocking IL-2 in Jurkat cells and ABC-DLBCL cell growth.</p>Fórmula:C17H15Cl2N9O2Cor e Forma:SolidPeso molecular:448.27TPO agonist 1
CAS:<p>TPO agonist 1 is a thrombopoietin agonist. It would be useful as promoters of thrombopoiesis and megakaryocytopoiesis to treat thrombocytopenia.</p>Fórmula:C25H22N8O2Pureza:98%Cor e Forma:SolidPeso molecular:466.49Dihydrolipoic acid
CAS:<p>Dihydrolipoic acid (USAF XR-12), a dithiol carboxylic acid, is a potent antioxidant active against various reactive oxygen species at 0.01-0.5 mM.</p>Fórmula:C8H16O2S2Pureza:97.51%Cor e Forma:Yellow To Orange LiquidPeso molecular:208.34Methyl aminolevulinate
CAS:<p>Methyl aminolevulinate, a prodrug for protoporphyrin IX, sensitizes in PDT.</p>Fórmula:C6H11NO3Pureza:98%Cor e Forma:SolidPeso molecular:145.16NF-κB-IN-2
CAS:<p>NF-κB-IN-2 inhibits canonical NF-κB signaling induced by TNF-α in PC-3 cells.</p>Fórmula:C15H18O3Cor e Forma:SolidPeso molecular:246.3Clopirac
CAS:<p>Clopirac is a potent and orally active prostaglandin synthetase inhibitor that is an anti-inflammatory agent [1].</p>Fórmula:C14H14ClNO2Cor e Forma:SolidPeso molecular:263.72COX-2/15-LOX-IN-1
CAS:<p>COX-2/15-LOX-IN-1 is a dual inhibitor for COX-2/15-LOX with anti-inflammatory properties (IC50: COX-1 10.65μM, COX-2 0.075μM, 15-LOX 2.98μM).</p>Fórmula:C21H21N7S3Cor e Forma:SolidPeso molecular:467.63Ruzotolimod
CAS:<p>Ruzotolimod, an agonist of TLR7, exhibits promising potential for investigating HBV, COVID-19, and SARS-CoV-2 infections （WO2021130195A1）[1].</p>Fórmula:C14H18N4O5SCor e Forma:SolidPeso molecular:354.38Heterophdoid A
CAS:<p>Heterophdoid A is an anti-inflammatory agent that inhibits NO production in BV-2 cells (IC50: 5.93 μM).</p>Fórmula:C26H42O10Cor e Forma:SolidPeso molecular:514.61MitoB
CAS:<p>MitoB is a novel exon of mitochondrial hydrogen peroxide.</p>Fórmula:C25H23BBrO2PCor e Forma:SolidPeso molecular:477.14IRAK4-IN-21
CAS:<p>IRAK4-IN-21: Oral IRAK4 inhibitor, IC50: IRAK4 5 nM, TAK1 56 nM; curbs IL-23, aids autoimmune research.</p>Fórmula:C28H28FN7O2Cor e Forma:SolidPeso molecular:513.57MIND4-17
CAS:<p>MIND4-17 activates NRF2 by binding Keap1 C151, blocking Keap1-Nrf2, stabilizes Nrf2, and promotes its nuclear entry, with strong antioxidant effects.</p>Fórmula:C20H15N5O3SCor e Forma:SolidPeso molecular:405.43IKKβ-IN-1
CAS:<p>IKKβ-IN-1 is a potent, orally active inhibitor of IkappaB (IKK-β) (IC50: 0.20 μM).</p>Fórmula:C31H30N4O4SCor e Forma:SolidPeso molecular:554.66COX-2/5-LOX-IN-1
CAS:<p>COX-2/5-LOX-IN-1, a benzothiophen-2-yl pyrazole, inhibits COX-2 & 5-LOX with IC50: COX-1 (12.13μM), COX-2 (0.4μM), 5-LOX (4.96μM). Better than Celecoxib.</p>Fórmula:C14H10ClN3O4S2Cor e Forma:SolidPeso molecular:383.83Insulin levels modulator
CAS:<p>Insulin level regulators can be used to treat diabetes.</p>Fórmula:C21H23N7OSPureza:98%Cor e Forma:SolidPeso molecular:421.52MK-0703
CAS:<p>MK-0703 is a selective cyclooxygenase-2 inhibitor.</p>Fórmula:C17H22O5SPureza:98%Cor e Forma:SolidPeso molecular:338.42MALT1-IN-3
CAS:<p>MALT1-IN-3 is a potent inhibitor of MALT1 protease (IC50: 0.06 μM) with IC50 values of 0.14 and 0.13 μM for human IL6 and IL10, respectively, in OCI-LY3 cells.</p>Fórmula:C21H19F3N8O2Cor e Forma:SolidPeso molecular:472.42R110
CAS:<p>R110 shows the potential for cancer research that is a potent, competitive MIF2 tautomerase inhibitor (IC 50 = 15 μM) [1].</p>Fórmula:C15H17ClN2OSCor e Forma:SolidPeso molecular:308.837-NINA
CAS:<p>non-selective NOS inhibitor</p>Fórmula:C7H5N3NaO2Pureza:98%Cor e Forma:SolidPeso molecular:186.12Prostaglandin G/H synthase 1 inhibitor
CAS:<p>Prostaglandin G/H synthase 1 inhibitor (CP 74006) is a selective D5D inhibitor with an IC(50) value of 20 nM.</p>Fórmula:C13H11ClN2OPureza:99.76%Cor e Forma:SolidPeso molecular:246.69iNOS-IN-2
CAS:<p>iNOS-IN-2 (Compound 53) is a potent inducible nitric oxide synthase (iNOS) protein down-regulator.</p>Fórmula:C25H31NO7Cor e Forma:SolidPeso molecular:457.52Anti-inflammatory agent 8
CAS:<p>Anti-inflammatory agent 8 targets COX-2 over COX-1, IC50 of 0.09 nM, orally bioavailable.</p>Fórmula:C18H15N5OS2Cor e Forma:SolidPeso molecular:381.47STING ligand-1
CAS:<p>STING ligand-1 is a lead STING ligand(IC50 of 68 nM for HAQ STING).</p>Fórmula:C29H27ClFNO5Pureza:98%Cor e Forma:SolidPeso molecular:523.98NBC 6
CAS:<p>NLRP3-IN-NBC6: potent NLRP3 inflammasome inhibitor, IC50 574 nM, Ca2+ independent, inhibits inflammasome in THP-1 cells/BMDMs.</p>Fórmula:C18H16BCl3N2O2Cor e Forma:SolidPeso molecular:409.5YS-121
CAS:<p>YS121 inhibits mPGES-1 (IC50=3.4μM) & 5-LOX (IC50=6.5μM), and lowers PGE2 in A549 cells (EC50=12μM).</p>Fórmula:C20H26ClN3O2SCor e Forma:SolidPeso molecular:407.96UC-1V150
CAS:<p>UC-1V150: TLR7 agonist, triggers immune response, anti-tumor, precursor for ISAC synthesis.</p>Fórmula:C16H17N5O4Cor e Forma:SolidPeso molecular:343.34CHS-111
CAS:<p>CHS-111 is a benzyl indazole that inhibits O2- generation, fMLP-induced PLD activity (IC50 3.9μM), and disrupts PLD1/Arf6 and RhoA interactions.</p>Fórmula:C21H18N2OPureza:98%Cor e Forma:SolidPeso molecular:314.38IL-1β-IN-2
CAS:<p>IL-1β-IN-2, a cannabigerol derivative, serves as a potent inhibitor of IL-1β, exhibiting anti-inflammatory and pain-resolving properties [1].</p>Fórmula:C22H34O2Cor e Forma:SolidPeso molecular:330.5MALT1-IN-8
CAS:<p>MALT1-IN-8: potent MALT1 inhibitor, IC50=2 nM; hinders OCI-LY3 cells, IC50=1.16 μM; anticancer, from patent WO2018165385A1.</p>Fórmula:C20H15Cl2N7OCor e Forma:SolidPeso molecular:440.29(-)-Ibuprofenamide
CAS:<p>(-)-Ibuprofenamide is an amide prodrug of Ibuprofen with anti-inflammatory activity.</p>Fórmula:C13H19NOPureza:98%Cor e Forma:SolidPeso molecular:205.3Nrf2-Activator-12G
CAS:<p>Nrf2-Activator-12G is a potent Nrf-2 activator.</p>Fórmula:C15H13ClO3SPureza:98%Cor e Forma:SolidPeso molecular:308.78Ppc-1
CAS:<p>Ppc-1 inhibits Porphyromonas gingivalis, uncouples mitochondria, and blocks IL-2, with anti-obesity, antibacterial, anti-inflammatory effects.</p>Fórmula:C21H25NO4Pureza:98%Cor e Forma:SolidPeso molecular:355.43Hetrombopag
CAS:<p>Hetrombopag: potent thrombopoietin receptor agonist, well tolerated, safe, promising for immune thrombocytopenia research.</p>Fórmula:C25H22N4O5Cor e Forma:SolidPeso molecular:458.47COX-2-IN-14
CAS:<p>COX-2-IN-14 (2a) is a potent, selective COX-2 inhibitor with high affinity and notable anti-inflammatory effects in mice.</p>Fórmula:C18H18N4O6Cor e Forma:SolidPeso molecular:386.364N-α-Tosyl-L-lysine chloromethyl ketone hydrochloride
CAS:<p>N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride inhibits trypsin-like proteases and IFN-γ activities.</p>Fórmula:C14H22Cl2N2O3SPureza:97.44%Cor e Forma:PowderPeso molecular:369.31COX/5-LO-IN-1
CAS:<p>COX/5-LO-IN-1 is a cyclooxygenase and 5-lipoxygenase (5-LO) inhibitor, and used for inflammatory and allergic disease states.</p>Fórmula:C16H15FN2O2SPureza:98%Cor e Forma:SolidPeso molecular:318.37Thiazolinobutazone
CAS:<p>Thiazolinobutazone is the 2-amino-2-thiazoline salt of phenylbutazone.</p>Fórmula:C22H26N4O2SCor e Forma:SolidPeso molecular:410.53NRP1 antagonist 2
CAS:<p>NRP1 antagonist 2 (Compound 1) is an NRP1 antagonist.</p>Fórmula:C20H17ClN6OS2Cor e Forma:SolidPeso molecular:456.97TBK1/IKKε-IN-4
CAS:<p>TBK1/IKKε-IN-4, a 6-aminopyrazolopyrimidine derivative, serves as a potent, selective inhibitor for TBK1 and IKKε, demonstrating IC50 values of 13 nM and 59 nM</p>Fórmula:C28H35N7O4Cor e Forma:SolidPeso molecular:533.62Tilarginine
CAS:<p>Tilarginine is a nitric oxide synthetase competitive inhibitor.</p>Fórmula:C7H16N4O2Pureza:98%Cor e Forma:SolidPeso molecular:188.23AHR antagonist 5
CAS:<p>Potent, oral AHR blocker from WO2018195397; IC50 < 0.5μM; hinders tumor growth with anti-PD-1.</p>Fórmula:C25H27Cl3FN7Pureza:98%Cor e Forma:SolidPeso molecular:550.89NLRP3 antagonist 1
CAS:<p>Potential cancer research drug, NLRP3 antagonist 1, targets immune response in macrophages, neutrophils.</p>Fórmula:C16H18N6OCor e Forma:SolidPeso molecular:310.35Phortress
CAS:<p>Phortress (NSC-710305) is a potent AhR ligand with strong binding affinity, which subsequently triggers the transcription of CYP1A1 and induces antitumor</p>Fórmula:C20H25Cl2FN4OSPureza:99.89%Cor e Forma:SolidPeso molecular:459.41QD-394
CAS:<p>QD-394 promotes ROS, impairs GSH/GSSG ratio, and is cytotoxic to pancreatic cancer cells, with synergy with napabucasin.</p>Fórmula:C19H19N5O2Cor e Forma:SolidPeso molecular:349.39COX-2-IN-16
CAS:<p>COX-2-IN-16: potent, selective oral COX-2 blocker, IC50=102 μM, reduces NO, anti-inflammatory.</p>Fórmula:C19H12BrN3O2Cor e Forma:SolidPeso molecular:394.22(+)-DHMEQ
CAS:<p>(+)-DHMEQ is an antioxidant transcription factor Nrf2 activator. (+)-DHMEQ is the enantiomer of (-)-DHMEQ.</p>Fórmula:C13H11NO5Cor e Forma:SolidPeso molecular:261.23STING Agonist 1a
CAS:<p>STING agonist 1a activates STING, induces IRF-SEAP, IFN-β, IL-6, CXCL10 (EC50=16.77 µM); effects reversed by STING KO/inhibitor H-151.</p>Fórmula:C19H11Cl2N5OCor e Forma:SolidPeso molecular:396.23PHA-408
CAS:<p>PHA-408 is a novel potent, highly selective and ATP-competitive inhibitor of IKB kinase-2.</p>Fórmula:C29H27ClFN7O2Pureza:98%Cor e Forma:SolidPeso molecular:560.02AN-3485
CAS:<p>AN-3485 is a Toll-Like Receptor(TLR) inhibitor (IC50s: 18 to 580 nM).</p>Fórmula:C14H13BClNO3Cor e Forma:SolidPeso molecular:289.52Isoandrographolide
CAS:<p>Isoandrographolide induces cell differentiation, protects the liver, blocks NLRP3, and reduces silicosis in mice.</p>Fórmula:C20H30O5Cor e Forma:SolidPeso molecular:350.45NOS-IN-3
CAS:<p>NOS-IN-3: potent, selective iNOS inhibitor; IC50 of 4.6 µM; spares eNOS; low toxicity; potential for septic shock treatment.</p>Fórmula:C10H15N3OCor e Forma:SolidPeso molecular:193.25Tyrosinase-IN-12
CAS:<p>Tyrosinase-IN-12(Non-competitive tyrosinase inhibitor) is a potent non-competitive tyrosinase inhibitor with an IC50 of 49.33 ± 2.64 µM and a Ki of 31.25 ± 0.25</p>Fórmula:C16H12ClN3SPureza:99.2%Cor e Forma:SoildPeso molecular:313.8Cyclic-di-GMP diammonium
CAS:<p>C-di-GMP diammonium activates STING, regulates biofilms, motility, and virulence in bacteria.</p>Fórmula:C20H30N12O14P2Cor e Forma:SolidPeso molecular:724.47Eltrombopag methyl ester
CAS:<p>Eltrombopag methyl ester, a Tpo receptor agonist derivative, boosts platelet production for thrombocytopenia research.</p>Fórmula:C26H24N4O4Cor e Forma:SolidPeso molecular:456.49Nω-Propyl-L-arginine hydrochloride
CAS:<p>Highly selective and potent inhibitor of nNOS (Ki = 57 nM). Displays 3158-fold and 149-fold selectivity over iNOS and eNOS respectively. Hypotensive in vivo.</p>Fórmula:C9H21ClN4O2Cor e Forma:SolidPeso molecular:252.74T-5342126
CAS:<p>T-5342126: TLR4 antagonist, lowers LPS-induced NO in cells (IC50=27.8 μM) & cytokines in blood, cuts ethanol intake & Iba1 in mice.</p>Fórmula:C25H32ClN3O3Cor e Forma:SolidPeso molecular:457.99IRAK4-IN-17
CAS:<p>IRAK4-IN-17 is a potent IRAK4 inhibitor with a 1.3 nM IC50, key for DLBCL research.</p>Fórmula:C17H20F2N8OCor e Forma:SolidPeso molecular:390.39HPGDS inhibitor 3
CAS:<p>HPGDS inhibitor 3: oral, potent (IC50=9.4 nM; EC50=42 nM), selective, no CNS toxicity, good pharmacokinetics, anti-inflammatory.</p>Fórmula:C21H27N3O2Cor e Forma:SolidPeso molecular:353.46OPC-163493
CAS:<p>OPC-163493 is an orally active, liver-targeted mitochondrial uncoupling agent that diminishes Δψ (delta psi) and mitochondrial ROS (reactive oxygen species)</p>Fórmula:C14H8F3N5SPureza:98%Cor e Forma:SolidPeso molecular:335.31L-Kynurenine sulfate
CAS:<p>L-Kynurenine sulfate activates AHR, leading naive T cells to anti-inflammatory Treg phenotype.</p>Fórmula:C10H14N2O7SCor e Forma:SolidPeso molecular:306.29STING modulator-4
CAS:STING modulator-4: competitive, Ki=0.0933 μM (R232H STING), EC50 >10 μM (p-IRF3, THP-1 cells).Fórmula:C17H18N8OCor e Forma:SolidPeso molecular:350.38BC12-4
CAS:<p>BC12-4 is a novel potent inhibitor of IL-2 secretion, it has potent immunomodulatory activity.</p>Fórmula:C19H14N2O3Cor e Forma:SolidPeso molecular:318.33c-di-AMP
CAS:<p>c-di-AMP (Cyclic diadenylate) is a STING agonist. It binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway.</p>Fórmula:C20H24N10O12P2Pureza:98%Cor e Forma:SolidPeso molecular:658.41Keap1-Nrf2-IN-13
CAS:<p>Keap1-Nrf2-IN-13 is a PPI inhibitor (IC50: 0.15 μM) that binds Keap1 strongly, useful for oxidative stress and inflammation research.</p>Fórmula:C28H32N2O10S2Cor e Forma:SolidPeso molecular:620.69C5aR-IN-2
CAS:<p>C5aR-IN-2, a potent C5aR inhibitor, shows promise for researching inflammatory diseases.</p>Fórmula:C36H40FN5O2Cor e Forma:SolidPeso molecular:593.73COX-2-IN-20
CAS:<p>COX-2-IN-20 (Compound 5d) is a selective and orally active inhibitor of COX-2 (IC 50 = 17.9 nM) with anti-inflammatory activity [1].</p>Fórmula:C11H9ClFN3O2Cor e Forma:SolidPeso molecular:269.66APC-0576
CAS:<p>APC-0576, an (S,S)-isomer, blocks NF-kappaB gene activation and may reduce inflammation in human cells.</p>Fórmula:C23H27N3O3Cor e Forma:SolidPeso molecular:393.48TLR7/8 agonist 6
CAS:<p>Compound 4: Imidazoquinoline, potent TLR7/8 agonist, IC50: 0.18μM (TLR7), 5.34μM (TLR8).</p>Fórmula:C24H27N5O2Cor e Forma:SolidPeso molecular:417.5TMV-IN-1
CAS:<p>TMV-IN-1: a chalcone inhibits TMV with EC50s of 70.7 and 60.8 μg/mL, applicable in infection and tumor studies.</p>Fórmula:C28H26O4Cor e Forma:SolidPeso molecular:426.5PNRI-299
CAS:<p>PNRI-299 is a selective inhibitor of AP-1 transcription(IC50 of 20 uM ).</p>Fórmula:C21H15N5O4Pureza:98%Cor e Forma:SolidPeso molecular:401.37Veledimex (S enantiomer)
CAS:Veledimex S is the oral S enantiomer of a gene therapy promoter activator and CYP3A4/5 inhibitor.Fórmula:C27H38N2O3Pureza:98%Cor e Forma:SolidPeso molecular:438.6COX-2/sEH-IN-1
CAS:<p>COX-2/sEH-IN-1, oral dual inhibitor: COX-2 (IC50=1.24 μM), sEH (IC50=0.40 μM); boosts anti-inflammatory action, cuts heart risk.</p>Fórmula:C23H18F3N5O3SCor e Forma:SolidPeso molecular:501.48Keap1-Nrf2-IN-14
CAS:<p>Keap1-Nrf2-IN-14, a KEAP1-NRF2 inhibitor (IC50: 75 nM, Kd: 24 nM), boosts NRF2 gene expression, antioxidative and anti-inflammatory response.</p>Fórmula:C30H29NO8SCor e Forma:SolidPeso molecular:563.62β-Nor-lapachone
CAS:β-Nor-lapachone is an antibiofilm agent of Candida glabrata.Fórmula:C14H12O3Cor e Forma:SolidPeso molecular:228.24COX-1/2-IN-1
CAS:<p>"COX-1/2-IN-2: Strong dual inhibitor of COX-1 (IC50 = 13.9 μM) and COX-2 (IC50 = 6.4 μM)."</p>Fórmula:C15H10BrClN2OCor e Forma:SolidPeso molecular:349.61Z-VRPR-FMK
CAS:<p>Z-VRPR-FMK: irreversible MALT1 inhibitor, halts growth/invasion of diffused B-cell lymphoma by blocking NF-κB activation and MMP expression.</p>Fórmula:C31H49FN10O6Cor e Forma:SolidPeso molecular:676.78COX-1/2-IN-3
CAS:<p>COX-1/2-IN-3 (Compound 7a) is a dual inhibitor of COX-1 and COX-2. COX-1/2-IN-3 has anti-inflammatory activity with low toxicity [1].</p>Fórmula:C14H8N2O8Cor e Forma:SolidPeso molecular:332.22IFN α-IFNAR-IN-1
CAS:<p>Nonpeptidic IFN-α/IFNAR blocker, halts MVA-triggered BM-pDC IFN-α response; IC50: 2-8 μM.</p>Fórmula:C18H17NSPureza:98%Cor e Forma:SolidPeso molecular:279.4COX-2-IN-23
CAS:<p>COX-2-IN-23 selectively inhibits COX-2 (IC50=0.28μM), weakly affects COX-1 (IC50=20.14μM), and has anti-inflammatory and low ulcerogenic properties.</p>Fórmula:C24H25N5O3S2Cor e Forma:SolidPeso molecular:495.62IRAK4-IN-13
CAS:<p>IRAK4-IN-13 (compound 21) is a potent IRAK4 inhibitor, IC50 0.6 nM, with high HLM clearance at 96 μL/min/mg.</p>Fórmula:C24H27N9OCor e Forma:SolidPeso molecular:457.53PPM-18
CAS:<p>PPM-18 (NSC 73233), a potent anti-inflammatory, inhibits iNOS and NF-κB binding; also suppresses bladder cancer cell growth.</p>Fórmula:C17H11NO3Cor e Forma:SolidPeso molecular:277.27COX-2-IN-24
CAS:<p>COX-2-IN-24 is an orally active COX-2 inhibitor (IC50: 0.17 μM) with anti-inflammatory and hypo-ulcerogenic effects.</p>Fórmula:C24H24BrN5O3S2Cor e Forma:SolidPeso molecular:574.51COX-2-IN-19
CAS:<p>COX-2-IN-19, a potent COX-2 inhibitor, IC50 of 1.76 μM, has strong anti-inflammatory effects in vivo.</p>Fórmula:C18H18N4O2SCor e Forma:SolidPeso molecular:354.43CAY10589
CAS:<p>CAY10589 is an mPGES-1 inhibitor.</p>Fórmula:C25H28ClN3O2SCor e Forma:SolidPeso molecular:470.03DMX-129
CAS:<p>DMX-129 is a chemical compound acting as an inhibitor for both ΙΚΚε and TBK-1, demonstrating efficacy with IC50 values of below 30 nM for each [1].</p>Fórmula:C19H17FN8Cor e Forma:SolidPeso molecular:376.39COX-2/5-LOX-IN-2
CAS:<p>COX-2/5-LOX-IN-2, a benzothiophen derivative, inhibits COX-1, COX-2, 5-LOX with IC50s of 5.40, 0.01, 1.78 μM. More effective than Celecoxib, Indomethacin.</p>Fórmula:C18H13N3O4S2Cor e Forma:SolidPeso molecular:399.44PT4
CAS:<p>PT4: treats CL, disrupts parasite mitochondria, kills Leishmania spp., IC50- L. amazonensis 125.18 μM, L. braziliensis 233.18 μM, anti-inflammatory.</p>Fórmula:C18H14N4O2Cor e Forma:SolidPeso molecular:318.33P2X7-IN-2
CAS:<p>P2X7-IN-2 is a P2X7 receptor blocker, halts IL-Iβ release (IC50: 0.01 nM), researched for autoimmunity and heart issues.</p>Fórmula:C22H21F4N3O2Cor e Forma:SolidPeso molecular:435.41IT-901
CAS:<p>IT-901: Oral NF-κB c-Rel inhibitor, IC50 0.1 µM. Blocks c-Rel/DNA binding, IC50 3 µM. Antitumor naphthalene derivative for lymphoma/myeloma therapy.</p>Fórmula:C17H14N2O4SPureza:98.06%Cor e Forma:SolidPeso molecular:342.37Piroxicam cinnamate
CAS:<p>Cinnoxicam is a COX inhibitor used for bone/joint inflammation, rheumatic issues, and varicocele-related oligospermia.</p>Fórmula:C24H19N3O5SCor e Forma:SolidPeso molecular:461.49Keap1-Nrf2-IN-12
CAS:<p>eap1-Nrf2-IN-12 is a potent inhibitor of Keap1-Nrf2 (IC50: 2.30 μM). eap1-Nrf2-IN-12 is metabolically stable in human liver microsomes.</p>Fórmula:C26H28N2O10S2Cor e Forma:SolidPeso molecular:592.64APHS
CAS:<p>APHS is a cyclooxygenase-2 (COX-2) inhibitor with anti-inflammatory action. It also more potent than aspirin in the inhibition of COX-1.</p>Fórmula:C15H18O2SCor e Forma:SolidPeso molecular:262.37NXPZ-2
CAS:<p>NXPZ-2, an oral Keap1-Nrf2 PPI inhibitor (Ki: 95 nM, EC50: 120-170 nM), may improve cognition and neuron health in AD.</p>Fórmula:C27H27N5O7S2Cor e Forma:SolidPeso molecular:597.6610-Cl-BBQ
CAS:<p>10-Cl-BBQ is a ligand of aryl hydrocarbon receptor (AhR).</p>Fórmula:C18H9ClN2OCor e Forma:SolidPeso molecular:304.73Keap1-Nrf2-IN-11
CAS:<p>Keap1-Nrf2-IN-11 (6k) inhibits Keap1-Nrf2, KD 0.21 nM; reduces ROS, NO, TNF-α; aids anti-inflammatory research.</p>Fórmula:C36H43N7O8S2Cor e Forma:SolidPeso molecular:765.9iNOs-IN-3
CAS:<p>iNOs-IN-3: oral iNOS inhibitor, IC50 = 3.342 μM, anti-inflammatory, for LPS-induced ALI study.</p>Fórmula:C27H24N2O5SCor e Forma:SolidPeso molecular:488.55Antimicrobial agent-2
CAS:<p>Compound V-a: broad-spectrum, low-toxicity antimicrobial with no resistance, high bioavailability, damages membranes, targets MRSA (MIC 1μg/mL).</p>Fórmula:C16H14N2O4SCor e Forma:SolidPeso molecular:330.36Nrf2 activator-5
CAS:<p>Nrf2 activator-5 combats oxidative stress and inflammation in microglia, with potent antioxidant effects.</p>Fórmula:C25H30Cl2O6Cor e Forma:SolidPeso molecular:497.41AChE/Nrf2 modulator 1
CAS:<p>AChE/Nrf2 modulator 1: oral, targets AChE/Nrf2, IC50s: 0.07 μM (eeAChE), 0.38 μM (hAChE); for Alzheimer's research.</p>Fórmula:C27H27FN4O2Cor e Forma:SolidPeso molecular:458.53NF-κB-IN-3
CAS:<p>NF-κB-IN-3 (Compound 2) is an NF-κB inhibitor (IC50: 0.70 μM) and can be used as an anti-tumour agent.</p>Fórmula:C24H18ClF3N2O2Cor e Forma:SolidPeso molecular:458.86COX-2-IN-21
CAS:<p>COX-2-IN-21 (Compound 5c) is an orally active, selective COX-2 inhibitor (IC50: 0.039 μM). COX-2-IN-21 has good anti-inflammatory potential.</p>Fórmula:C21H22N6O4Cor e Forma:SolidPeso molecular:422.44HE 3286
CAS:<p>Triolex, an NF-kB inhibitor, is used potentially for the treatment of rheumatoid arthritis, ulcerative colitis.</p>Fórmula:C21H30O3Cor e Forma:SolidPeso molecular:330.46Tilarginine citrate
CAS:<p>Tilarginine citrate is a competitive nitric oxide synthetase inhibitor.</p>Fórmula:C13H24N4O9Pureza:98%Cor e Forma:SolidPeso molecular:380.354Enflicoxib
CAS:<p>Enflicoxib is an effective treatment for canine osteoarthritis pain and inflammation, with faster onset than mavacoxib, improving veterinary outcomes.</p>Fórmula:C16H12F5N3O2SPureza:99.88%Cor e Forma:SolidPeso molecular:405.34IRAK4-IN-22
CAS:<p>IRAK4-IN-22: oral IRAK4 inhibitor, IC50: IRAK4-3nM, TAK1-17nM, disrupts IL-23, targets autoimmune diseases.</p>Fórmula:C28H28FN7O2Cor e Forma:SolidPeso molecular:513.57CHD-5
CAS:<p>CHD-5 is a selective antagonist of the aryl hydrocarbon receptor (AhR).</p>Fórmula:C19H17N3O2Cor e Forma:SolidPeso molecular:319.36
