Imunologia e Inflamação
Os inibidores de imunologia e inflamação são compostos que modulam a resposta imunológica e os processos inflamatórios. Esses inibidores são cruciais para estudar os mecanismos de regulação imunológica, autoimunidade e inflamação crônica, bem como para desenvolver tratamentos para doenças inflamatórias, alergias e distúrbios relacionados ao sistema imunológico. Ao direcionar vias-chave no sistema imunológico, esses inibidores podem ajudar a reduzir respostas imunológicas excessivas ou inadequadas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de alta qualidade para apoiar sua pesquisa em imunologia, inflamação e desenvolvimento terapêutico.
Subcategorias de "Imunologia e Inflamação"
- CCR(140 produtos)
- CXCR(153 produtos)
- Parede celular(5 produtos)
- Receptor IL(108 produtos)
- IκB/IKK(59 produtos)
- LTR(3 produtos)
- MALT(24 produtos)
- MRP(6 produtos)
- NADPH-oxidase(1 produtos)
- NF-κB(445 produtos)
- NOD(17 produtos)
- NOS(62 produtos)
- Nrf2(82 produtos)
- PGE Sintase(31 produtos)
- ROS(70 produtos)
- TGF-beta/Smad(59 produtos)
- TLR(74 produtos)
- Tiorredoxina(12 produtos)
- gp120/CD4(4 produtos)
Exibir 11 mais subcategorias
Foram encontrados 3269 produtos de "Imunologia e Inflamação"
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AhR agonist 8
CAS:<p>Compound 9, also known as AhR agonist 8, effectively activates the Aryl Hydrocarbon Receptor (AhR) with an EC50 of 0.154 nM. This compound is utilized in researching psoriasis and atopic dermatitis.</p>Fórmula:C17H15FN4OCor e Forma:SolidPeso molecular:310.33DEG-35
CAS:DEG-35 is a CRBN-dependent bifunctional degrader targeting IKZF2 and CK1α, with DC50 values of 1.4 nM and 4.4 nM for CK1α and IKZF2, respectively. It activates the p53 apoptotic pathway and is applicable for research related to acute myeloid leukemia (AML).Fórmula:C25H21N3O5Cor e Forma:SolidPeso molecular:443.45PVTX-405
CAS:PVTX-405 is a selective oral IKZF2 molecular glue degrader with a DC50 of 0.7 nM and a maximum degradation (Dmax) of 91%. It enhances degradation efficiency, significantly reduces off-target degradation, and minimizes hERG inhibition with an IC50 of 48 µM. PVTX-405 effectively inhibits MC38 tumor growth in Crbn391VC57BL/6 mouse xenograft models and shows superior synergistic anticancer effects when combined with immune checkpoint therapies (ICTs) such as anti-PD1 or anti-LAG3 antibodies.Fórmula:C30H31N5O4Cor e Forma:SolidPeso molecular:525.60PSB-0963
CAS:PSB-0963 is a selective competitive extracellular 5'-nucleotidase (eN/CD73) inhibitor with a Ki value of 150 nM for rat extracellular 5'-nucleotidase. It exhibits greater selectivity compared to other extracellular nucleotidases (NTPDases 1-3) and P2Y receptors. PSB-0963 is applicable in cancer research.Fórmula:C28H17N2NaO5SCor e Forma:SolidPeso molecular:516.50Cyclic-di-GMP sodium
c-di-GMP sodium: STING activator, regulates bacteria biofilm, motility, virulence.Fórmula:C20H24N10NaO14P2Cor e Forma:SolidPeso molecular:713.08464Ocipumaltib
CAS:Ocipumaltib (Example 2) is an inhibitor of mucosa-associated lymphoid tissue protein 1 (MALT1). It functions as an antineoplastic agent and is utilized in the study of cancer, infections, neurological disorders, and hematological diseases.Fórmula:C20H16ClF3N8O2Cor e Forma:SolidPeso molecular:492.84Cbl-b-IN-1
CAS:Cbl-b-IN-1 is a potent Cbl-b inhibitor (IC50 <100 nM) with potential anticancer activity for the study of intestinal inflammation.Fórmula:C29H34N6O2Pureza:99.68%Cor e Forma:SolidPeso molecular:498.631Indeno[1,2,3-cd]pyrene
CAS:Indeno[1,2,3-cd]pyrene, a polycyclic aromatic hydrocarbon, exhibits moderate cytotoxicity to human alveolar epithelial cells (HPAEpiC). Additionally, it enhances allergic pulmonary inflammation responses through the activation of the aryl hydrocarbon receptor.Fórmula:C22H12Cor e Forma:SolidPeso molecular:276.33Anti-inflammatory agent 23
Anti-inflammatory agent 23 blocks LPS-induced NO (IC50: 0.449 μM) and binds p65 well.Fórmula:C34H49NO6Cor e Forma:SolidPeso molecular:567.76α-Hydroxy alprazolam
CAS:α-Hydroxy alprazolam (U 40125), the primary metabolite of α-Hydroxy alprazolam, possesses pharmacological activity accounting for 60% of that of Alprazolam.Fórmula:C17H13ClN4OCor e Forma:SolidPeso molecular:324.76HTS05585
CAS:HTS05585 (Compound Hit-1) is a selective inhibitor of macrophage migration inhibitory factor (MIF) with a Kd value of 0.29 μM determined by microscale thermophoresis (MST) and confirmed through isothermal titration calorimetry (ITC) at 0.32 μM. It suppresses the release of pro-inflammatory factors (TNF-α, IL-6, IL-1β) in macrophages induced by LPS, making it a promising candidate for the study of inflammatory diseases such as sepsis.Fórmula:C18H15N3OCor e Forma:SolidPeso molecular:289.33TNFα activity modulator 3
CAS:<p>TNFα Activity Modulator 3 (example 6) is a molecule that regulates TNF activity by inhibiting TNFα-induced NF-κB activation, making it applicable for related research.</p>Fórmula:C27H24F2N6O2Cor e Forma:SolidPeso molecular:502.52RGT-068A
CAS:RGT-068A is a potent, selective and oral bioavailable MALT1 inhibitor .Fórmula:C17H16ClN9O2Cor e Forma:SolidPeso molecular:413.82NLRP3-IN-44
CAS:<p>NLRP3-IN-44 (compound P33), an orally active (approximately 62%) and potent inhibitor of NLRP3, exhibits a dissociation constant (K D) of 17.5 nM. This compound is crucial in the research of diseases mediated by the NLRP3 inflammasome.</p>Fórmula:C25H30N4O3Cor e Forma:SolidPeso molecular:434.53IRAK4-IN-14
CAS:IRAK4-IN-14 is a selective, potent, orally active IRAK4 inhibitor (IC50: 0.003 μM) with favorable PK parameters in rats and mice. effect.Fórmula:C25H28FN9OCor e Forma:SolidPeso molecular:489.55cGAS-IN-4
CAS:<p>cGAS-IN-4 (Compound 36) is an orally active inhibitor of cyclic GMP-AMP synthase (cGAS) with IC50 values of 32 nM for human cGAS (h-cGAS) and 5.8 nM for mouse cGAS (m-cGAS). In THP-1 cells, cGAS-IN-4 inhibits cGAMP with an IC50 of 60 nM, enhancing cellular potency. Additionally, cGAS-IN-4 exhibits anti-inflammatory effects in a mouse model of Concanavalin A-induced acute liver injury.</p>Fórmula:C19H18Cl2N4O3Cor e Forma:SolidPeso molecular:421.277NLRP3-IN-6
<p>NLRP3-IN-6 (Compound 34) is a selective inhibitor of the NLRP3 inflammasome.</p>Fórmula:C18H15ClN2O4S3Cor e Forma:SolidPeso molecular:454.97NLRP3-IN-57
<p>NLRP3-IN-57 (compound 5) inhibits the NLRP3 inflammasome, consequently downregulating IL-1β levels in THP-1 macrophages induced by LPS+Nigericin.</p>Fórmula:C44H60O7Cor e Forma:SolidPeso molecular:700.94CYP1B1-IN-10
CAS:CYP1B1-IN-10 (Compound 15C) is a highly selective inhibitor of human cytochrome P450 1B1 (hCYP1B1) with an IC50 value of 0.11 μM. It shows promise for use in research focused on hormone-dependent tumors, including breast and ovarian cancers.Fórmula:C23H18N2Cor e Forma:SolidPeso molecular:322.40Itaconic acid prodrug-1
CAS:Itaconic acid prodrug-1 (Compound P2) is an orally active prodrug of Itaconic acid that efficiently delivers Itaconic acid to skin tissues upon oral administration. It exhibits immunomodulatory effects, significantly inhibiting Poly(I:C)/IFNγ-induced inflammatory cytokines in human epidermal keratinocytes. Itaconic acid prodrug-1 is useful for research into alopecia areata and other inflammatory skin conditions.Fórmula:C15H22O10Cor e Forma:SolidPeso molecular:362.329CD73-IN-13
CD73-IN-13, a potent CD73 inhibitor, may be developed for tumor-related disease treatment.Fórmula:C13H11F3N4O2Cor e Forma:SolidPeso molecular:312.25PB01
CAS:<p>PB01 is a DPP-4 inhibitor with an IC50 of 15.66 nM. It effectively suppresses high glucose-induced ROS generation and mitochondrial superoxide production while significantly reducing the cellular expression of DPP-4. Additionally, PB01 notably lowers blood glucose levels in diabetic mice. It demonstrates excellent safety, exhibiting almost no cytotoxicity at a concentration of 100 μM. PB01 holds promise for research in the diabetes field.</p>Fórmula:C18H21N5O3Cor e Forma:SolidPeso molecular:355.391STING agonist-43
CAS:STINGagonist-43 (Compound 67) is a selective STING agonist with an EC50 of 20.53 μM. It selectively enhances the cGAMP-dependent STING pathway activation by modulating STING oligomerization. STINGagonist-43 demonstrates antitumor activity in a B16.F10 mouse melanoma model and can be utilized in cancer immunotherapy research.Fórmula:C21H23NO4Cor e Forma:SolidPeso molecular:353.41NLRP3-IN-70
CAS:<p>NLRP3-IN-70 (Compound 5m) is an inhibitor of the NLRP3 inflammasome with low oral bioavailability. It binds directly to the NACHT domain of the NLRP3 protein, thereby blocking its interaction with ASC, which inhibits ASC oligomerization and the assembly of the NLRP3 inflammasome. NLRP3-IN-70 is applicable in studies on sepsis and non-alcoholic steatohepatitis.</p>Fórmula:C23H23NO5Cor e Forma:SolidPeso molecular:393.432GTCpFE
CAS:GTCpFE, a compound synthesized from Dimethyl fumarate (DMF) and Aspirin (ASA), inhibits IKKα/β in the NF-κB pathway, exhibiting anti-inflammatory activity by preventing p65 from entering the nucleus. It selectively inhibits cancer stem cell (CSC) activity by reducing the growth of mammospheres and the expression of the CD44+CD24- immune phenotype. Furthermore, GTCpFE targets breast cancer stem cells, crucial in aggressive cancer phenotypes that depend on NFκB and PGE2.Fórmula:C22H20O8Cor e Forma:SolidPeso molecular:412.39Panaxcerol B
CAS:<p>Panaxcerol B, a monogalactosyl monoacylglycerol, exhibits an IC50 value of 59.4 μM against NO production in LPS-stimulated RAW264.7 cells.</p>Fórmula:C27H46O9Cor e Forma:SolidPeso molecular:514.65BCL6 ligand-4
CAS:BCL6ligand-4 is a BCL6 ligand used in the synthesis of PROTACs, such as BCL6PROTAC 1.Fórmula:C21H25ClN6O3Cor e Forma:SolidPeso molecular:444.92NLRP3-IN-7
<p>NLRP3-IN-7 (Compound 36) is a selective inhibitor of the NLRP3 inflammasome and is able to assemble the NLRP3 inflammasome.</p>Fórmula:C18H15ClN2O4S3Cor e Forma:SolidPeso molecular:454.97HOIPIN-8 sodium
CAS:<p>HOIPIN-8 sodium is a LUBAC inhibitor for the study of inflammatory and immune diseases.</p>Fórmula:C23H15F2N4NaO3Pureza:97.34%Cor e Forma:SolidPeso molecular:456.38VVD-130037
CAS:VVD-130037 is a KEAP1 activator with potential antitumor activity.VVD-130037 inhibits tumor growth in advanced solid tumors by degrading NRF2.Fórmula:C17H17ClN4O2Pureza:99.01% - 99.92%Cor e Forma:SolidPeso molecular:344.8UBS109
CAS:<p>UBS109, a curcumin analog, is a DNA demethylating agent in pancreatic cancer that promotes osteoblast differentiation and mineralization.</p>Fórmula:C18H17N3OPureza:99.48%Cor e Forma:SolidPeso molecular:291.35KI696
CAS:KI696 is a high-affinity probe that potently inhibits the interaction of Keap1 and NRF2.Fórmula:C28H30N4O6SPureza:99.74%Cor e Forma:SolidPeso molecular:550.63Evixapodlin
CAS:Evixapodlin (PD-1/PD-L1-IN 7) is a human PD-1/PD-L1 protein/protein interaction inhibitor (IC50: 0.213).Evixapodlin has anticancer and antiviral activities.Fórmula:C34H36Cl2N8O4Pureza:99.07%Cor e Forma:SolidPeso molecular:691.61AM103
CAS:AM103 is an effective and selective inhibitor of FLAP (IC50 = 4.2 nM).Fórmula:C36H38N3NaO4SPureza:99.75%Cor e Forma:SolidPeso molecular:631.76Antiproliferative agent-22
CAS:<p>Antiproliferative agent-22 is an anticancer compound that shows antiproliferative activity on MCF-7, MDA-MB-231 and MDA-MB-468 cells.</p>Fórmula:C17H13N3O3Pureza:99.20% - 99.27%Cor e Forma:SolidPeso molecular:307.3Dazostinag disodium
CAS:<p>Dazostinag disodium (TAK-676) is a synthetic novel interferon gene (STING) agonist.Cost-effective and quality-assured.</p>Fórmula:C21H20F2N8Na2O10P2S2Pureza:98.84% - 99.96%Cor e Forma:SolidPeso molecular:754.482-Selenouracil
CAS:2-Selenouracil is a specialized photosensitizer for photodynamical therapy.Fórmula:C4H4N2OSeCor e Forma:SolidPeso molecular:175.05NSC23925
CAS:NSC23925 is a selective and effective inhibitor of P-glycoprotein (Pgp).Fórmula:C22H26Cl2N2O2Pureza:98%Cor e Forma:SolidPeso molecular:421.36PSB-12379
CAS:PSB-12379 is a potent inhibitor of Ecto-5'-Nucleotidase (CD73)(Kis of 9.03 nM (rat) and 2.21 nM (human)).Fórmula:C18H23N5O9P2Pureza:98%Cor e Forma:SolidPeso molecular:515.35Veledimex
CAS:Veledimex is an oral activator ligand for a proprietary gene therapy promoter system. It is also a moderate inhibitor of and substrate for CYP3A4/5.Fórmula:C27H38N2O3Pureza:98%Cor e Forma:SolidPeso molecular:438.69a-Fluoro-11b,17a,21-trihydroxy-16b-methylpregna-1,4-diene-3,20-dione
CAS:Fórmula:C22H29FO5Pureza:99%Cor e Forma:SolidPeso molecular:392.461111β,17α,21-Trihydroxypregn-4-ene-3,20-dione
CAS:Fórmula:C21H30O5Pureza:98%Cor e Forma:SolidPeso molecular:362.4599Ref: IN-DA003AAY
Produto descontinuadoRef: IN-DA0034OW
Produto descontinuadoα-Terpineol
CAS:<p>Terpineol possesses antifungal activity against Trichophyton mentagrophytes, it also exhibits strong antimicrobial activity against periodontopathic and cariogenic bacteria. α-Terpineol (Terpineol) shows anticonvulsant, and anti-inflammatory activities, it inhibits the gene expression of the IL-6 receptor.</p>Fórmula:C10H18OPureza:97.55%Cor e Forma:Colorless LiquidPeso molecular:154.25(11β,16α)-9-Fluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione
CAS:Fórmula:C24H31FO6Pureza:99%Cor e Forma:SolidPeso molecular:434.4977Ref: IN-DA0039HQ
Produto descontinuado11β,17α,21-Trihydroxypregna-1,4-diene-3,20-dione
CAS:Fórmula:C21H28O5Pureza:98%Cor e Forma:SolidPeso molecular:360.4440Tacalcitol
CAS:Tacalcitol (1,24(R)-Dihydroxyvitamin D3; 1.alpha.,24R-Dihydroxyvitamin D3) promotes normal bone development by regulating calcium and modulates immunological and inflammatory processes.Fórmula:C27H44O3Pureza:98%Cor e Forma:SolidPeso molecular:416.64TLR7/8/9 antagonist 2
CAS:<p>TLR7/8/9 antagonist 2 is an orally active and highly bioavailable vTLR7/8/9 antagonist. It inhibits HEK/hTLR7, HEK/hTLR8, and HEK/hTLR9 with IC50s of 0.011 μM, 0.029 μM, and 0.052 μM, respectively. TLR7/8/9 antagonist 2 can be used to study auto-inflammatory diseases such as systemic lupus erythematosus or lupus nephritis.</p>Fórmula:C23H31N7Pureza:98%Cor e Forma:SoildPeso molecular:405.54Pam2CSK4 TFA
<p>Pam2CSK4 TFA (PUL-042 TFA) is a potent dual agonist of TLR2 and TLR6, a peptide that mimics bacterial lipoproteins.Pam2CSK4 TFA promotes platelet aggregation, and can be used to study the effects of lipoproteins on the periodontium.</p>Fórmula:C67H127F3N10O14SPureza:99.90%Cor e Forma:SoildPeso molecular:1385.84Aurothioglucose
CAS:Aurothioglucose is a active-site TrxR1 inhibitor.Fórmula:C6H11AuO5SPureza:98%Cor e Forma:Yellow Crystals SolidPeso molecular:392.18Tripeptide-41
CAS:<p>Tripeptide-41 (CG-Lipoxyn) is a bioactive peptide known for its ability to reduce fat accumulation.</p>Fórmula:C29H30N4O5Pureza:98%Cor e Forma:SolidPeso molecular:514.57Icatolimab
<p>Icatolimab (JS-004) is a humanized antibody targeting BTLA/CD272 for the study of lymphomas and solid tumors.</p>Pureza:98.7% (SDS-PAGE); 95.6% (SEC-HPLC) - 98.7% (SDS-PAGE); 95.6% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:145.5 kDaRef: TM-T77490
Produto descontinuadoSTING agonist-22
CAS:<p>STING agonist-22 (CF501) boosts vaccines by activating STING, inducing IFN-I and cytokines, aiding in SARS-CoV-2 research.</p>Fórmula:C40H48N14O6Cor e Forma:SolidPeso molecular:820.9gp91ds-tat
<p>gp91ds-tat is a useful organic compound for research related to life sciences and the catalog number is T35393.</p>Pureza:98%Cor e Forma:Solid2,3-Bis(3-indolylmethyl)indole
CAS:2,3-Bis(3-indolylmethyl)indole exhibits a concentration-dependent inhibition of RANKL-induced osteoclastogenesis, actin ring formation, and bone resorption.Fórmula:C26H21N3Cor e Forma:SolidPeso molecular:375.475Xibornol
CAS:Xibornol (Nanbacine) 具有广谱的抗菌和抗病毒活性，可用于研究革兰氏阳性菌感染和人呼吸道合胞病毒与人冠状病毒229E感染。Fórmula:C18H26OCor e Forma:SolidPeso molecular:258.4Elamipretide acetate
<p>Elamipretide acetate (MTP 131), a small tetrapeptide, targets mitochondria to reduce toxic species and stabilize cardiolipin.</p>Fórmula:C34H53N9O7Pureza:99.76%Cor e Forma:SoildPeso molecular:699.84TLQP-21 TFA
<p>TLQP-21 TFA is a VGF-derived peptide, C3aR1 agonist (mouse EC50: 10.3μM; human EC50: 68.8μM), that raises intracellular Ca2+ for nociception research.</p>Pureza:98%Cor e Forma:LiquidDi-O-methyldemethoxycurcumin
CAS:Di-O-methyldemethoxycurcumin is a Curcumin analog isolated from medicinal plant turmeric di-orthomethyldemethoxycurcumin, anti-inflammatory and antioxidant properties Inhibition of IL-6 production, EC50 is 16.20μg/mL.Fórmula:C22H22O5Pureza:98%Cor e Forma:SolidPeso molecular:366.41JH-X-119-01 hydrochloride
CAS:JH-X-119-01 hydrochloride is a potent, selective inhibitor of interleukin-1 receptor-associated kinase 1 (IRAK1) that effectively alleviates lipopolysaccharide (LPS)-induced sepsis in mice.Fórmula:C25H21ClN6O3Cor e Forma:SolidPeso molecular:488.93Racemic Naproxen
CAS:Racemic Naproxen is a biochemical substance.Fórmula:C14H14O3Pureza:98%Cor e Forma:Crystals From Acetone-Hexane White SolidPeso molecular:230.26Magnesium citrate
CAS:Magnesium citrate is a useful organic compound for research related to life sciences. The catalog number is T64455 and the CAS number is 3344-18-1.Fórmula:C12H10Mg3O14Cor e Forma:SolidPeso molecular:451.113RIDR-PI-103
CAS:<p>RIDR-PI-103 is a reactive oxygen species (ROS)-induced drug release prodrug featuring an autocyclized portion connected to the pan-PI3K inhibitor (PI-103). In MDA-MB-361 and MDA-MB-231 cells, Doxorubicin and RIDR-PI-103 exhibited synergistic inhibition of cancer cell proliferation.</p>Fórmula:C27H25N7O4Cor e Forma:SolidPeso molecular:511.53TLQP-21 TFA
<p>TLQP-21 TFA （TLQP-21 Trifluoroacetate） 是一种 VGF 衍生肽，可通过结合后折叠机制激活C3aR1 受体。</p>Pureza:98%ARGX-112
CAS:<p>Temtokibart is a humanized IgG1 λ2 antibody that specifically targets IL22RA1, and is expressed by cells that are deficient in the glutamine synthetase gene.</p>Cor e Forma:Odour LiquidL-NIO dihydrochloride
CAS:<p>L-NIO dihydrochloride, a potent and non-selective NADPH-dependent nitric oxide synthase (NOS) inhibitor, consistently induces focal ischemic infarct in rats. It exhibits inhibitory constants (Kis) of 1.7, 3.9, and 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS) forms, respectively.</p>Fórmula:C7H16ClN3O2Pureza:98%Cor e Forma:SolidPeso molecular:209.67ALPK1-IN-2
CAS:<p>ALPK1-IN-2 is a potent inhibitor of ALPK1 (α-kinase 1) (IC50: 95 nM). ALPK1-IN-2 inhibits NF-κB (IC50: 1.31 μM).</p>Fórmula:C20H18F2N4O2SCor e Forma:SolidPeso molecular:416.44Ref: TM-T62162
Produto descontinuadoALPK1-IN-1
CAS:<p>ALPK1-IN-1 (A001) strongly inhibits ALPK1, key for innate immunity & NF-κB signaling via TIFA/TRAF.</p>Fórmula:C25H32N6O2SCor e Forma:SolidPeso molecular:480.63ALPK1-IN-3
CAS:<p>ALPK1-IN-3,serves as an ALPK1 inhibitor that dampens proinflammatory gene expression in the kidney and enhances survival in animal models of sepsis-induced</p>Fórmula:C20H16F2N4OSPureza:98%Cor e Forma:SolidPeso molecular:398.43
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