Imunologia e Inflamação
Os inibidores de imunologia e inflamação são compostos que modulam a resposta imunológica e os processos inflamatórios. Esses inibidores são cruciais para estudar os mecanismos de regulação imunológica, autoimunidade e inflamação crônica, bem como para desenvolver tratamentos para doenças inflamatórias, alergias e distúrbios relacionados ao sistema imunológico. Ao direcionar vias-chave no sistema imunológico, esses inibidores podem ajudar a reduzir respostas imunológicas excessivas ou inadequadas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de alta qualidade para apoiar sua pesquisa em imunologia, inflamação e desenvolvimento terapêutico.
Subcategorias de "Imunologia e Inflamação"
- CCR(136 produtos)
- CXCR(149 produtos)
- Parede celular(5 produtos)
- Receptor IL(112 produtos)
- IκB/IKK(59 produtos)
- LTR(3 produtos)
- MALT(23 produtos)
- MRP(6 produtos)
- NADPH-oxidase(1 produtos)
- NF-κB(443 produtos)
- NOD(18 produtos)
- NOS(63 produtos)
- Nrf2(78 produtos)
- PGE Sintase(31 produtos)
- ROS(69 produtos)
- TGF-beta/Smad(58 produtos)
- TLR(66 produtos)
- Tiorredoxina(12 produtos)
- gp120/CD4(4 produtos)
Exibir 11 mais subcategorias
Foram encontrados 3054 produtos de "Imunologia e Inflamação"
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DZ-837
<p>DZ-837 is a PROTAC that targets the BCL6 protein. The composition of DZ-837 includes the BCL6 ligand-2, the E3 ubiquitin ligase ligand Thalidomide-4-OH, and a PROTAC Linker. The configuration notably features a conjugate of the E3 ubiquitin ligase ligand and the Linker, designated as 2-(2,6-Dioxopiperidin-3-yl)-4-((2-(2-hydroxyethoxy)ethyl)amino)isoindoline-1,3-dione.</p>Fórmula:C42H44FN9O7SCor e Forma:SolidPeso molecular:837.92Xanthine oxidase-IN-12
<p>Xanthine oxidase-IN-12 (Compound 11), an inhibitor of xanthine oxidase (XO), possesses an IC50 value of 91 nM and exhibits antioxidant properties, additionally</p>Pureza:98%Cor e Forma:Odour SolidGuretolimod hydrochloride
<p>Guretolimod hydrochloride acts as an agonist for Toll-like receptor 7 (TLR7) [1].</p>Fórmula:C24H35ClF3N5O4Cor e Forma:SolidPeso molecular:550.01MAPK Inhibitor Library
<p>A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;</p>Cor e Forma:Odour SolidEX-A5758
CAS:<p>EX-A5758: novel nNOS-NOS1AP inhibitor, reduces pain & enhances paclitaxel's anti-tumor effect.</p>Fórmula:C10H17NO5Pureza:99.67%Cor e Forma:SolidPeso molecular:231.25Prostaglandin D synthase
CAS:<p>Prostaglandin D synthase is a biomarker for meningioma cells and coronary artery disease. Lipocalin-type prostaglandin D synthase (L-PGDS) is found in human coronary atherosclerotic plaques and can be detected in human serum.</p>Cor e Forma:SolidCOX-2-IN-48
<p>COX-2-IN-48 (5-25) serves as an inhibitor of COX-2, exhibiting an IC50 of 51.7 nM against human COX-2. It displays anti-inflammatory and analgesic effects in various rodent models through inhibition of the NF-κB pathway. COX-2-IN-48 (5-25) inhibits the degradation of IκB, phosphorylation and nuclear translocation of NF-κB p65, and the expression of COX-2 and iNOS.</p>Cor e Forma:Odour SolidUlevostinag
CAS:<p>Ulevostinag (MK-1454) is a STING agonist.</p>Fórmula:C20H22F2N10O9P2S2Cor e Forma:SolidPeso molecular:710.52Perfluorododecanoic acid
CAS:<p>Perfluorododecanoic acid (PFDoA) is a PFAS pollutant causing ROS increase, mitochondrial damage, and neuronal cytotoxicity.</p>Fórmula:C12HF23O2Pureza:98.42%Cor e Forma:SolidPeso molecular:614.1PIC1 PA TFA
<p>PIC1 PATFA is the trifluoroacetate form of PIC1 PA. PIC1 PA TFA is a peptide composed of 15 amino acids and serves as an effective PIC1 analog capable of inhibiting complement activation mediated by the classical pathway.</p>Fórmula:C71H123N19O21S2·xC2HF3O2Cor e Forma:SolidPam3CSK4-Biotin
CAS:<p>Pam3CSK4-Biotin is a biotinylated derivative of Pam3CSK4, functioning as a Toll-like receptor 1/2 (TLR1/2) agonist.</p>Fórmula:C103H192N14O17S2Pureza:98%Cor e Forma:SolidPeso molecular:1962.85Nrf2 activator-8
<p>Nrf2 Activator-8 (Compound 10e), with an EC50 of 37.9 nM, is a potent Nrf2 activator that demonstrates significant antioxidant and anti-inflammatory properties</p>Fórmula:C13H11ClN2O3SCor e Forma:SolidPeso molecular:310.76SDH-IN-23
<p>SDH-IN-23 (Compound B21) is an SDH inhibitor with exceptional nematicidal activity. It can suppress nematode feeding, reproduction, and embryonic development while also inducing lethal effects through mechanisms such as oxidative stress, intestinal damage, and SDH inhibition.</p>Fórmula:C19H11ClF6N2O2Cor e Forma:SolidPeso molecular:448.75PROTAC IRAK4 degrader-3
CAS:PROTAC IRAK4 degrader-3 is a PROTAC-induced IRAK4 degrader based on von Hippel-Lindau.Fórmula:C57H68FN11O8SCor e Forma:SolidPeso molecular:1086.3NLRP3-IN-46
<p>NLRP3-IN-46 (Compound 3k) activates the cholinergic anti-inflammatory pathway involved in neuro-immune modulation, thereby inhibiting the activation of the NLRP3 inflammasome. Furthermore, NLRP3-IN-46 suppresses the production of IL-1β in THP-1 cells induced by Uric acid sodium, making it relevant for research in gouty arthritis.</p>Cor e Forma:Odour Solidβ-Aminoarteether
CAS:<p>β-Aminoarteether (SM934 free base), an orally active derivative of Artemisinin, serves a pivotal role in the research of inflammation and autoimmune disorders,</p>Fórmula:C17H29NO5Pureza:96.09% - 97.02%Cor e Forma:SolidPeso molecular:327.42Amfenac sodium
CAS:<p>Amfenac is a nonsteroidal anti-inflammatory drug. Amfenac also has acetic acid moiety.</p>Fórmula:C15H12NNaO3Pureza:98%Cor e Forma:SolidPeso molecular:277.26N(G)-Nitroarginine-4-nitroanilide
CAS:<p>N(G)-Nitroarginine-4-nitroanilide is an anti-nociceptive in mice.</p>Fórmula:C12H17N7O5Pureza:98%Cor e Forma:SolidPeso molecular:339.31Endoplasmic Reticulum Stress Compound Library
<p>A unique collection of 193 endoplasmic reticulum stress (ER stress) related compounds used for high throughput screening (HTS) and high content screening (HCS);</p>Cor e Forma:Odour Solid1-Heptadecanoyl-rac-glycerol
CAS:<p>1-Heptadecanoyl-rac-glycerol, a monoacylglycerol with heptadecanoic acid, combats various bacteria and is found in T. africana, I. sonorae, and wheat bran.</p>Fórmula:C20H40O4Cor e Forma:SolidPeso molecular:344.536Arginase inhibitor 9
<p>Arginase inhibitor9 (Compound 12a) is a type of arginase enzyme inhibitor with IC50 values of 9 μM for bovine and 55 μM for human arginase I. It also exhibits antioxidant activity by scavenging free radicals. Moreover, Arginase inhibitor9 effectively regulates collagen and procollagen levels, thereby exerting an anti-fibrotic effect.</p>Fórmula:C13H11NO4SCor e Forma:SolidPeso molecular:277.3(±)11(12)-EET
CAS:<p>(±)11(12)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes.[1][2][3[]A higher</p>Fórmula:C20H32O3Cor e Forma:SolidPeso molecular:320.47Nuclear Receptor Compound Library
<p>A unique collection of 531 nuclear receptor signaling targeted compounds for high throughput and high content screening;</p>Cor e Forma:Odour Solid3-Hydroxykynurenamine
CAS:<p>3-Hydroxykynurenamine (3-HKA) is a tryptophan metabolite with anti-inflammatory effects, reducing cytokines and aiding in models of psoriasis and nephritis.</p>Fórmula:C9H12N2O2Cor e Forma:SolidPeso molecular:180.2Aβ-IN-6
<p>Aβ-IN-6 is an orally active compound exhibiting anti-inflammatory, antioxidant, and anti-oligomeric activities, with significant implications for Alzheimer's</p>Fórmula:C28H31N3O4Cor e Forma:SolidPeso molecular:473.56Kinase Inhibitor Library
<p>A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;</p>Cor e Forma:Odour SolidFITC-labeled ODN 2088 sodium
<p>FITC-labeled ODN 2088 (sodium) serves as a potent inhibitor of TLR3, TLR7, and TLR9, and is utilized to assess CpG ODN cellular uptake and localization</p>Cor e Forma:Odour SolidPROTAC IRAK4 degrader-4
CAS:<p>PROTAC IRAK4 degrader-4 is a targeted Cereblon-based molecule for degrading IRAK4.</p>Fórmula:C41H38F3N11O10Cor e Forma:SolidPeso molecular:901.817DA-E 5090
CAS:<p>DA-E 5090, an active metabolite of E 5090, inhibits IL-1 production in human monocytes.</p>Fórmula:C17H18O4Pureza:98%Cor e Forma:SolidPeso molecular:286.32Antitumor agent-185
<p>Antitumor agent-185 (compound 3) exhibits significant antitumor effects, effectively inhibiting tumor growth and extending the survival period of mice in vivo.</p>Fórmula:C109H199N5O36P2Cor e Forma:SolidPeso molecular:2217.71Antiparasitic agent-26
<p>Antiparasitic agent-26 (Compound 8) is an antiparasitic compound that effectively inhibits the growth of Naegleria fowleri, with an IC50 of 22.87 μM (trophozoite stage) and 25.16 μM (cyst stage). It exerts its antiparasitic effects by inducing programmed cell death, which includes cytosolic calcium accumulation, mitochondrial membrane potential collapse, ATP synthesis inhibition, ROS accumulation, and chromatin condensation. Antiparasitic agent-26 can be utilized in research on primary amoebic meningoencephalitis (PAM).</p>Cor e Forma:Odour SolidAntibacterial agent 119
<p>Antibacterialagent 119 (Compound 21 g) is a potential antibacterial agent effective against methicillin-resistant Staphylococcus aureus, with a minimum inhibitory concentration (MIC) of less than 1 μg/mL against tested strains. It induces reactive oxygen species (ROS) generation and disrupts bacterial cell membranes, causing their rupture. Antibacterialagent 119 exhibits strong antimicrobial activity, low cytotoxicity, rapid bactericidal action, and favorable in vivo antibacterial efficacy.</p>Fórmula:C42H54BrClN2O4Cor e Forma:SolidPeso molecular:766.246TGF-β/Smad Compound Library
<p>A unique collection of xnum TGF-beta/Smad signaling targeted compounds for high throughput and high content screening;</p>Cor e Forma:Odour SolidNω-allyl-L-arginine
CAS:<p>Nω-allyl-L-arginine is a competitive and reversible inhibitor of bovine brain nitric oxide synthase (nNOS), efficiently inactivating nNOS in a time-dependent</p>Fórmula:C9H18N4O2Cor e Forma:SolidPeso molecular:214.26Sacituzumab MMAE
<p>Sacituzumab-MMAE (CHB295) Anti-TROP2 Reference Antibody is produced in CHO cells and consists of a huIgG1 heavy chain and a hukappa light chain. This compound has a predicted molecular weight (MW) of 146.06 kDa.</p>Cor e Forma:LiquidPeso molecular:150 kDaE7766 diammonium salt
CAS:<p>E7766 diammonium salt, a macrocycle-bridged STING agonist, exhibits a dissociation constant (Kd) of 40 nM, demonstrating potent pan-genotypic and antitumor</p>Fórmula:C24H32F2N12O8P2S2Cor e Forma:SolidPeso molecular:780.66iE-DAP dihydrochloride
<p>iE-DAP dihydrochloride is a Nod1 agonist that activates the NF-κB pathway through recognition by Nod1, leading to an inflammatory cytokine response. This compound is useful for studying maternal-fetal inflammation and preterm birth.</p>Fórmula:C12H23Cl2N3O7Cor e Forma:SolidPeso molecular:391.09131Topramezone
CAS:<p>Topramezone is a 4-HPPD inhibitor herbicide for post-emergence weed control in corn.</p>Fórmula:C16H17N3O5SCor e Forma:SolidPeso molecular:363.39Anti-Human MSLN Antibody (Clone HN1)
<p>Anti-Human MSLN Antibody (Clone HN1) is a humanised monoclonal antibody targeting MSLN (Mesothelin), , blocks the interaction between MSLN and CA125, cancer .</p>Pureza:95%Cor e Forma:Odour Liquid19-epi-Scholaricine
CAS:<p>19-epi-Scholaricine: indole alkaloid, taken orally, reduces collagen fibrosis, boosts SOD.</p>Fórmula:C20H24N2O4Cor e Forma:SolidPeso molecular:356.42PNT2001
CAS:<p>PNT2001 (LY4181530) is an effective prostate-specific membrane antigen (PSMA) ligand with an IC50 of 3.1 nM. It enhances cellular internalization and, when labeled with 177Lu and 225Ac, is applicable for prostate cancer research.</p>Fórmula:C85H107N15O32Cor e Forma:SolidPeso molecular:1850.84Inbakicept
CAS:<p>Inbakicept (ALT 803) is a fusion protein of the IL-15 receptor 伪-sushi binding domain IL-15R伪Su and immunoglobulin G1 (human Fc fragment).</p>Pureza:98.94%Cor e Forma:LiquidNLRP3-IN-51
<p>NLRP3-IN-51 (Compound 3q) is an effective activator of the cholinergic anti-inflammatory pathway (CAP). This compound demonstrates potential for treating gouty arthritis as it inhibits the production of IL-1β in THP-1 cells induced by monosodium urate (MSU). Furthermore, NLRP3-IN-51 suppresses the phosphorylation of NF-κBp65 triggered by MSU without impacting the self-cleavage and activation of NLRP3, pro-caspase 1, or the second messenger caspase-1. Therefore, the initial stage of NLRP3 inhibition by NLRP3-IN-51 occurs through the activation of CAP.</p>Cor e Forma:Odour SolidAllyl methyl trisulfide
CAS:<p>Allyl methyl trisulfide: a garlic oil compound with antibacterial, antioxidant, and antitumor properties.</p>Fórmula:C4H8S3Cor e Forma:SolidPeso molecular:152.3Polyinosinic acid
CAS:<p>Polyinosinic acid: single-strand, TLR3 agonist, boosts immune response, has immune regulation uses.</p>Fórmula:(C10H13N4O8P)xCor e Forma:SolidInflexuside B
CAS:<p>Inflexuside B, an abietane diterpenoid derived from the aerial parts of Isodon inflexus, effectively inhibits lipopolysaccharide (LPS)-activated NO Synthase in</p>Fórmula:C35H48O11Cor e Forma:SolidPeso molecular:644.75KYN-101
CAS:<p>KYN-101 is an and aryl hydrocarbon receptor (AHR) inhibitor with anticancer activity. KYN-101 is used for the study of breast cancer and acute myeloid leukemia.</p>Fórmula:C22H19FN6Pureza:98.35%Cor e Forma:SolidPeso molecular:386.43TLR4-IN-C34-C2-amide-C6-OH
<p>TLR4-IN-C34-C2-amide-C6-OH: a linker with TLR4-IN-C34 that curbs TLR4 and inflammation in mice.</p>Fórmula:C25H42N2O11Cor e Forma:SolidPeso molecular:546.61cGAMP disodium
CAS:<p>cGAMP disodium, a bacterial CDN, boosts interferon production and activates STING, enhancing immune responses as a sublingual adjuvant.</p>Fórmula:C20H24N10O13P2·2NaCor e Forma:SoildPeso molecular:720.39Schisanchinin D
CAS:<p>Schisanchinin D is a useful organic compound for research related to life sciences. The catalog number is T125682 and the CAS number is 1614245-13-4.</p>Fórmula:C23H30O6Cor e Forma:SolidPeso molecular:402.487
