Imunologia e Inflamação
Os inibidores de imunologia e inflamação são compostos que modulam a resposta imunológica e os processos inflamatórios. Esses inibidores são cruciais para estudar os mecanismos de regulação imunológica, autoimunidade e inflamação crônica, bem como para desenvolver tratamentos para doenças inflamatórias, alergias e distúrbios relacionados ao sistema imunológico. Ao direcionar vias-chave no sistema imunológico, esses inibidores podem ajudar a reduzir respostas imunológicas excessivas ou inadequadas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de alta qualidade para apoiar sua pesquisa em imunologia, inflamação e desenvolvimento terapêutico.
Subcategorias de "Imunologia e Inflamação"
- CCR(136 produtos)
- CXCR(149 produtos)
- Parede celular(5 produtos)
- Receptor IL(112 produtos)
- IκB/IKK(59 produtos)
- LTR(3 produtos)
- MALT(23 produtos)
- MRP(6 produtos)
- NADPH-oxidase(1 produtos)
- NF-κB(443 produtos)
- NOD(18 produtos)
- NOS(62 produtos)
- Nrf2(78 produtos)
- PGE Sintase(31 produtos)
- ROS(69 produtos)
- TGF-beta/Smad(58 produtos)
- TLR(66 produtos)
- Tiorredoxina(12 produtos)
- gp120/CD4(4 produtos)
Exibir 11 mais subcategorias
Foram encontrados 3055 produtos de "Imunologia e Inflamação"
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D-NAME (hydrochloride)
CAS:<p>D-NAME, a less active NO synthase inhibitor enantiomer, has mild cardiovascular effects in rats; inactive in mouse nociception.</p>Fórmula:C7H16ClN5O4Cor e Forma:SolidPeso molecular:269.69MAPK-IN-4
<p>MAPK-IN-4 (Compound c1) is an orally active anti-inflammatory agent that inhibits the expression and release of pro-inflammatory cytokines IL-6 and TNF-α induced by LPS. It interacts with IRAK4 to exert its anti-inflammatory effects by inhibiting the MAPK pathway.</p>Cor e Forma:Odour SolidPROTAC IRAK4 degrader-11
PROTACIRAK4 degrader-11 (compound 15) is a PROTAC molecule utilizing a Cereblon ligand, achieving a maximal IRAK4 degradation rate of 96.25% in HEK293 cells, with a DC50 value of 2.29 nM.Fórmula:C41H41F3N8O6Peso molecular:798.31012Dithianon
CAS:Dithianon: broad-spectrum anthraquinone fungicide; sticks to leaves/fruits; controls various fungi in some produce.Fórmula:C14H4N2O2S2Pureza:98%Cor e Forma:SolidPeso molecular:296.32CP-447697
CAS:CP-447697, a lipophilic C5a receptor antagonist, exhibits an IC50 of 31 nM. It is utilized in inflammation research.Fórmula:C29H26ClF2N3O2SPureza:99.90%Cor e Forma:SoildPeso molecular:554.05M133 peptide
<p>The M133 peptide is a coronavirus-specific CD4 T cell epitope. In mice infected with the neurotropic coronavirus (strain JHM of mouse hepatitis virus), the M133 peptide demonstrates immunodominance. It activates CD4 T cells by forming an MHC/peptide complex through binding with MHC II molecules, which is recognized by specific TCRs.</p>Fórmula:C84H130N20O25Peso molecular:1818.9516SARS-CoV-2-IN-39
CAS:<p>SARS-CoV-2-IN-39 is a SARS-CoV-2 inhibitor with an EC50 of 1 μM.</p>Fórmula:C14H8ClF4NO3Pureza:99.86%Cor e Forma:SoildPeso molecular:349.66COX-2/NLRP3-IN-1
<p>COX-2/NLRP3-IN-1 (Compound 6k) is an inhibitor that targets COX-2 and NLRP3, exhibiting an IC50 value of 1.53 μM for COX-2. This compound exerts anti-inflammatory effects by inhibiting the NF-κB/NLRP3 signaling pathway.</p>Fórmula:C24H19Cl2N5OSPeso molecular:495.06874JH-FK-08
<p>JH-FK-08 is an inhibitor of the serine/threonine-specific phosphatase enzyme calcineurin (calcium-dependent phosphatase). It demonstrates antifungal activity, effectively inhibiting C. neoformans with a MIC80 of 0.8 µg/mL. Additionally, JH-FK-08 exhibits immunosuppressive properties by inhibiting IL-2 expression with an IC50 of 42.6 nM, and shows anti-infective activity in mouse models.</p>Fórmula:C45H73N3O13Cor e Forma:SolidPeso molecular:864.073Calcitriol Impurities D
CAS:Calcitriol Impurities D: Vitamin hormone, promotes cell differentiation, has bone activity, inhibits HIV, and aids in treating AIDS/viral infections.Fórmula:C28H46O3Pureza:98%Cor e Forma:SolidPeso molecular:430.66GB1908
<p>GB1908 is a selective oral inhibitor of galectin-1 (galectin-1), with Ki values of 57 nM for human galectin-1 and 72 nM for mouse galectin-1. It demonstrates over 50-fold selectivity for galectin-1 compared to galectin-3. GB1908 can be utilized in lung cancer research.</p>Fórmula:C18H18Cl2N4O5S2Peso molecular:504.00957dsVACV-70mer sodium
<p>dsVACV-70mer sodium is a 70 base pair double-stranded oligonucleotide that contains a viral DNA motif derived from vaccinia virus DNA. It effectively induces IFN-β through a STING-dependent mechanism.</p>Antiviral agent 61
<p>Antiviralagent 61 (compound Z40) serves as an effective antiviral agent with activity against Tomato Spotted Wilt Virus (TSWV), exhibiting an EC50 value of 252 µg/mL. It increases the RNA expression of Ndufb9, COX6B, 7.1.2.2, E, COX5B, Ndufs4, and SDHB, while reducing the expression of Ndufb7, Ndufa5, and G.</p>Fórmula:C22H23N5O4SCor e Forma:SolidPeso molecular:453.51Ezeprogind
CAS:<p>Ezeprogind, TLR9 inhibitor for Alzheimer's. Affordable Excellence: Reliable Quality You Can Trust</p>Fórmula:C25H44N6Pureza:99.28%Cor e Forma:SolidPeso molecular:428.66Glutaminase C-IN-2
<p>Glutaminase C-IN-2 (compound 11), an allosteric inhibitor of glutaminase C (GAC), exhibits potent inhibitory activity with an IC50 of 10.64 nM.</p>Fórmula:C24H23N7O2SPureza:98%Cor e Forma:SolidPeso molecular:473.55mPGES-1/5-LOX-IN-1
mPGES-1/5-LOX-IN-1 (compound 3j) is a potent, orally active dual inhibitor of mPGES-1 and 5-LOX, with IC50 values of 0.92 and 1.89 µM, respectively. Additionally, mPGES-1/5-LOX-IN-1 exhibits anti-inflammatory properties.Fórmula:C20H22N4O6SPeso molecular:446.12601TBK1/IKKε-IN-6
CAS:<p>TBK1/IKKε-IN-6 (example 110) is a potent inhibitor of TBK1 and IKKε, with IC50 values of less than 100 nM for both enzymes.</p>Fórmula:C31H36F2N8O4Cor e Forma:SolidPeso molecular:622.678UNC9036
<p>UNC9036 is a PROTAC degrader of STING, with a DC50 value of 227 nM. The degradation of STING mediated by UNC9036 is dependent on the proteasomal VHL pathway.</p>Fórmula:C73H95N17O11SPeso molecular:1417.71177Antibiofilm agent-8
<p>Antibiofilm agent-8 (compound Ru2) boosts antibacterial activity under visible light (400-700 nm, 10 J cm-2). It induces oxidative stress by promoting NADH oxidation and reactive oxygen species (ROS) generation, which disrupts the bacterial cell wall.</p>Fórmula:C35H23ClF6N7PRuPeso molecular:823.038876Lac[6]Met
CAS:<p>6Lac[6]Met is a galectin-4 inhibitor with an IC50 value of 5 μM [1].</p>Fórmula:C126H180N12O66S6Cor e Forma:SolidPeso molecular:3111.21PROTAC IRAK4 degrader-5
CAS:<p>PROTAC IRAK4 degrader-5 is a Cereblon-based IRAK4 degrader.</p>Fórmula:C41H40F3N11O9Cor e Forma:SolidPeso molecular:887.834HSV-60mer sodium
<p>HSV-60mer sodium is a 60 bp double-stranded oligonucleotide that includes viral DNA motifs from the herpes simplex virus 1 (HSV-1) genome. Transfection of HSV-60mer effectively induces IFN-β in a manner dependent on STING, TBK1, and IFN regulatory factor 3 (IRF3).</p>CAY10512
CAS:<p>CAY10512, a resveratrol analog, is 100x more potent, inhibiting NF-κB with an IC50 of 0.15 μM versus resveratrol's 20 μM.</p>Fórmula:C15H13FOCor e Forma:SolidPeso molecular:228.266Mipeginterferon alfa-2b
CAS:<p>Mipeginterferon alfa-2b, an IFNA2b analogue, has 5 modified amino groups out of 11 and weighs 40 kDa.</p>Cor e Forma:LiquidMC-ND-18
<p>MC-ND-18 is an ATTEC degrader that facilitates the degradation of NLRP3 via autophagy, exhibiting a DC50 of 125.5 nM in THP-1 cells. It is composed of an NLRP3 ligand, a linker, and an LC3 ligand.</p>Fórmula:C42H42Br2IN3O9SPeso molecular:1049.00532NOD1 antagonist-2
<p>NOD1antagonist-2 (compound 66) is an orally active and selective inhibitor that can suppress NOD1 in both humans and mice. It effectively blocks the NOD1-induced NF-κB and MAPK pathways.</p>Fórmula:C21H13Cl2F2N3O5S2Cor e Forma:SolidPeso molecular:560.378NLRP3-IN-55
NLRP3-IN-55 (Compound 19) is an effective inhibitor of NLRP3, exhibiting an inhibitory concentration (IC50) of 0.34 μM. It targets the NLRP3 protein directly with a dissociation constant (KD) of 0.45 μM, effectively blocking the assembly and activation of the NLRP3 inflammasome. This action results in anti-inflammatory effects and inhibits cell pyroptosis.Fórmula:C32H30ClFN2O4Cor e Forma:SolidPeso molecular:561.04STING agonist-31
CAS:<p>STING agonist-31, a potent STING agonist, exhibits EC50 values of 0.24 μM and 39.51 μM for human STING (h-STING) and murine STING (m-STING), respectively,</p>Fórmula:C43H51N15O6Cor e Forma:SolidPeso molecular:873.96Benz-AP
CAS:<p>Benz-AP: potent photosensitizer, creates singlet oxygen, more toxic in low hCES2 cancer cells, generates ROS via TPE to kill tumors.</p>Fórmula:C20H13NO2Cor e Forma:SolidPeso molecular:299.32OVA Peptide(257-264) acetate salt
<p>OVA Peptide(257-264) acetate salt is a Class I (Kb)-restricted epitope of OVA. This octamer peptide is presented by Class I MHC molecule H-2Kb derived from ovalbumin.</p>Fórmula:C47H78N10O15Peso molecular:1022.56481(-)-10,11-Dihydroxyfarnesol
CAS:<p>(-)-10,11-Dihydroxyfarnesol, from Cryptomarasmius aucubae, inhibits NO production.</p>Fórmula:C15H28O3Cor e Forma:SolidPeso molecular:256.38Suc-Tyr-Val-Ala-Asp-pNA
CAS:<p>Suc-YVAD-pNA, a chromogenic caspase-1 substrate.</p>Fórmula:C31H38N6O12Cor e Forma:SolidPeso molecular:686.675ZM640
ZM640 is an NLRP3 inhibitor that promotes IL-1β release mediated by NLRP3 inflammasome activation in THP-1 cells. It demonstrates low cytotoxicity.Fórmula:C28H36F3NO8SPeso molecular:603.21137WAY-605471
CAS:WAY-605471 is a AHR antagonist with IC50 of 0.5 - 1 μM.Fórmula:C14H15NO3S2Pureza:99.62%Cor e Forma:SolidPeso molecular:309.4Siegesbeckialide I
<p>Siegesbeckialide I effectively suppresses LPS-induced NO production in RAW264.7 murine macrophages by directly interacting with IKKα/β.</p>Fórmula:C20H28O6Cor e Forma:SolidPeso molecular:364.43R-HP210
<p>R-HP210 blocks LPS-triggered IL-1β, IL-6, COX-2 gene transcription and has a 3.80 μM IC50 for NF-κB inhibition without activating GCs.</p>Fórmula:C22H19N3O2S2Cor e Forma:SolidPeso molecular:421.54UNC8900
UNC8900 is a VHL-recruiting STINGPROTAC degrader with a DC50 of 0.924 μM. It is applicable for the study of bacterial and viral infections.Fórmula:C75H99N17O15SPeso molecular:1509.72273ODN D-SL03
CAS:<p>ODN D-SL03, a C class CpG oligonucleotide, stimulates PBMCs, activating B cells, NK cells & monocytes, and can inhibit tumor growth.</p>Cor e Forma:SolidPeso molecular:9345STING modulator-5
CAS:<p>STING modulator-5: pIC50 9.5, antagonizes PBMC (pIC50 8.1), THP-1 cell antagonist, for immunology research.</p>Fórmula:C43H45F4N11O5Cor e Forma:SolidPeso molecular:871.88EC1169
CAS:<p>EC1169 is a targeted PSMA ligand that acts to inhibit the proliferation of cells expressing PSMA.</p>Fórmula:C78H112N14O28S3Cor e Forma:SolidPeso molecular:1790.00Chitoheptaose heptahydrochloride
CAS:<p>Chitoheptaose heptahydrochloride, a chitosan derivative, enhances wheat growth and photosynthesis, with health-protective traits.</p>Fórmula:C42H80ClN7O29Cor e Forma:SolidPeso molecular:1182.57ROS-ERS inducer 1
<p>Type II ICD agent, ROS-ERS inducer 1, is a Pt(II)-NHC from 4,5-diarylimidazole, boosting ER stress, ROS, and DAMPs in HCC, outperforming Cisplatin.</p>Fórmula:C24H23F2I2N3PtCor e Forma:SolidPeso molecular:840.35cGAS-IN-3
<p>cGAS-IN-3 (compound 30d-S) is an orally active inhibitor of cyclic GMP-AMP synthase (cGAS) that exhibits excellent plasma exposure and low clearance rate. It demonstrates anti-inflammatory properties, significantly reducing pulmonary inflammation in rats.</p>Fórmula:C21H20Cl2F2N4O2Peso molecular:468.09314Porphyra 334
CAS:<p>Porphyra 334 is a mycosporine-like amino acid.</p>Fórmula:C14H22N2O8Cor e Forma:SolidPeso molecular:346.336Human Immunoglobulin M
<p>Human Immunoglobulin M (IgM) is an antibody secreted by the adaptive immune system in response to foreign antigens. It is a primary type of immunoglobulin released into circulation during the early stages of the primary antibody response. Human Immunoglobulin M forms a pentamer comprising five IgG equivalents, with 10 Fab fragments, allowing for 10 antigen binding sites. Additionally, Human Immunoglobulin M acts as a complement (complement) activator.</p>Cor e Forma:Odour SolidEnglumafusp alfa
<p>Englumafusp alfa (CD19-4-1BBL; RO7227166) is a fusion protein combining a CD19-specific antibody domain with trimerized extracellular domains of human 4-1BBL,</p>Cor e Forma:Odour LiquidMitoquinol
CAS:Mitoquinol is a mitochondria-targeted antioxidant used in the study of cardiovascular disease by modulating the mitochondrial antioxidant defense system.Fórmula:C38H49O7PSPureza:98%Cor e Forma:SolidPeso molecular:680.83(±)-Phrymarolin II
CAS:<p>(±)-Phrymarolin II is a promising class of inhibitors that targets the tobacco mosaic virus, representing a novel approach in plant virus suppression.</p>Fórmula:C23H22O10Cor e Forma:SolidPeso molecular:458.419Biotin-labeled ODN 1668 sodium
<p>Biotin-labeled ODN 1668 (sodium), a class B CpG oligodeoxynucleotide (ODN) and TLR9 agonist, facilitates the assessment of cellular uptake and localization of</p>Cor e Forma:Odour Solid(R)-(-)-Ibuprofen
CAS:(R)-(-)-Ibuprofen ((R)-Ibuprofen) is the R enantiomer of Ibuprofen and inhibits NF-κB activation.Fórmula:C13H18O2Pureza:99.86%Cor e Forma:SolidPeso molecular:206.28
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