Imunologia e Inflamação
Os inibidores de imunologia e inflamação são compostos que modulam a resposta imunológica e os processos inflamatórios. Esses inibidores são cruciais para estudar os mecanismos de regulação imunológica, autoimunidade e inflamação crônica, bem como para desenvolver tratamentos para doenças inflamatórias, alergias e distúrbios relacionados ao sistema imunológico. Ao direcionar vias-chave no sistema imunológico, esses inibidores podem ajudar a reduzir respostas imunológicas excessivas ou inadequadas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de alta qualidade para apoiar sua pesquisa em imunologia, inflamação e desenvolvimento terapêutico.
Subcategorias de "Imunologia e Inflamação"
- CCR(136 produtos)
- CXCR(149 produtos)
- Parede celular(5 produtos)
- Receptor IL(112 produtos)
- IκB/IKK(59 produtos)
- LTR(3 produtos)
- MALT(23 produtos)
- MRP(6 produtos)
- NADPH-oxidase(1 produtos)
- NF-κB(443 produtos)
- NOD(18 produtos)
- NOS(62 produtos)
- Nrf2(78 produtos)
- PGE Sintase(31 produtos)
- ROS(69 produtos)
- TGF-beta/Smad(58 produtos)
- TLR(66 produtos)
- Tiorredoxina(12 produtos)
- gp120/CD4(4 produtos)
Exibir 11 mais subcategorias
Foram encontrados 3055 produtos de "Imunologia e Inflamação"
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NG-Hydroxy-L-arginine acetate
CAS:NG-Hydroxy-L-arginine acetate (NOHA acetate) acts as a crucial physiological inhibitor of arginase, playing a vital role in the conversion of arginine to nitric oxide and citrulline via nitric oxide synthase.Fórmula:C6H14N4O3xC2H4O2Cor e Forma:SolidPeso molecular:190.20（free base）(Rac)-γ-Tocopherol
CAS:<p>(Rac)-γ-Tocopherol (DMPBQ) is an isoform of Vitamin E that undergoes conversion to γ-Tocopherol through the action of tocopherol cyclase.</p>Fórmula:C28H48O2Cor e Forma:SolidPeso molecular:416.68TSR-033
CAS:<p>TSR-033 is a human IgG4 antibody with high affinity for LAG-3 (lymphocyte activation gene-3), a co-receptor linked to diminished T cell activity, frequently co-</p>Cor e Forma:LiquidAnti-inflammatory agent 93
<p>Compound 2g (Anti-inflammatory agent 93) is an active compound that exhibits analgesic activity.</p>Fórmula:C27H17Cl2N3O2Cor e Forma:SolidPeso molecular:486.35OVA Peptide(257-264)
CAS:<p>OVA Peptide(257-264) is an ovalbumin octamer Peptide expressed by class I MHC molecule h-2kb.</p>Fórmula:C45H74N10O13Pureza:99.53%Cor e Forma:SolidPeso molecular:963.132-Iminobiotin
CAS:2-Iminobiotin inhibits iNOS/nNOS; Ki: 21.8 μM (mouse iNOS), 37.5 μM (rat nNOS).Fórmula:C10H17N3O2SPureza:98%Cor e Forma:SolidPeso molecular:243.33Antifungal agent 123
<p>Antifungalagent 123 (Compound 4b) demonstrates strong affinity for the oxidoreductase of Staphylococcus aureus or membrane proteins of Candida albicans, exhibiting both antibacterial and antifungal properties. Additionally, it is capable of scavenging free radicals, showcasing antioxidant effects. Antifungalagent 123 also inhibits the TLR signaling pathway and possesses anti-inflammatory activity.</p>Fórmula:C21H20N4O3Cor e Forma:SolidPeso molecular:376.409Multinoside A
CAS:Multinoside A is a useful organic compound for research related to life sciences. The catalog number is T124593 and the CAS number is 59262-54-3.Fórmula:C27H30O16Cor e Forma:SolidPeso molecular:610.521Pelgifatamab
CAS:<p>Pelgifatamab (BAY-2315497) is a prostate-specific membrane antigen (PSMA) antibody with potential anticancer activity that can be used to study prostate cancer.</p>Pureza:97.9% (SDS-PAGE); 95.1% (SEC-HPLC) - 97.9% (SDS-PAGE); 95.1% (SEC-HPLC)Cor e Forma:LiquidCarboxy-PTIO
CAS:<p>Carboxy-PTIO rapidly scavenges NO, forming NO2, key in preventing hypotension and shock in rats.</p>Fórmula:C14H17N2O4Cor e Forma:SolidPeso molecular:277.3Anti-Human MSLN Antibody (Clone HN1)
<p>Anti-Human MSLN Antibody (Clone HN1) is a humanised monoclonal antibody targeting MSLN (Mesothelin), , blocks the interaction between MSLN and CA125, cancer .</p>Pureza:95%Cor e Forma:Odour LiquidiNOs-IN-6
<p>iNOs-IN-6 is an anti-inflammatory agent known for inhibiting the expression of NF-κB, iNOS, and MAPK with an IC50 ranging from 0.2 to 0.62 μM. Additionally, it decreases the levels of pro-inflammatory mediators, such as IL-6, TNF-α, and IL-1β, with an IC50 ranging from 0.4 to 0.69 μM.</p>Cor e Forma:Odour SolidPepinh-MYD
CAS:<p>Pepinh-MYD, a MyD88 inhibitor, incorporates both a domain sequence from MyD88 TIR and a protein transduction sequence to facilitate cell membrane penetration. This compound disrupts MyD88-mediated TLR signaling pathways, effectively inhibiting associated immune responses. Its design is particularly useful for investigating MyD88's function in viral infections.</p>Fórmula:C151H248N50O35S2Cor e Forma:SolidPeso molecular:3388.03CRX-526
CAS:<p>CRX-526, a TLR4 antagonist, protects against advanced diabetic nephropathy.</p>Fórmula:C69H127N2O19PPureza:98%Cor e Forma:SolidPeso molecular:1319.72TPNA10168
CAS:<p>Compound Fr13590, with CAS No. 957942-34-6, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound Fr13590 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>Fórmula:C9H9ClO2S2Cor e Forma:SolidPeso molecular:248.75Dithianon
CAS:Dithianon: broad-spectrum anthraquinone fungicide; sticks to leaves/fruits; controls various fungi in some produce.Fórmula:C14H4N2O2S2Pureza:98%Cor e Forma:SolidPeso molecular:296.32Vadastuximab
<p>Vadastuximab (Anti-Human CD33 Recombinant Antibody) is a humanized anti-CD33 monoclonal antibody for the study of acute myeloid leukemia (AML).</p>Pureza:98.5% (SDS-PAGE); 97.3% (SEC-HPLC) - 98.5% (SDS-PAGE); 97.3% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:145.5 kDaSomantadine
CAS:<p>Somantadine has antiviral activities and can be used for research on preventing and treating coronavirus-related diseases.</p>Fórmula:C14H25NPureza:99.9%Cor e Forma:SolidPeso molecular:207.35QKY-613
CAS:<p>QKY-613 is a prodrug designed to enhance immune surveillance by targeting nucleic acid modification pathways. It selectively facilitates the incorporation of 6mdA (N6-methyl-deoxyadenosine) into viral DNA, boosting the DNA's phase separation potential and subsequently increasing cGAS activation levels to strengthen host immune surveillance. In mouse models of viral infection, QKY-613 significantly reduced mortality in aged mice. This compound holds promise for studying immune surveillance mechanisms based on nucleic acid modifications.</p>Fórmula:C27H31N6O7PCor e Forma:SolidPeso molecular:582.55Englumafusp alfa
<p>Englumafusp alfa (CD19-4-1BBL; RO7227166) is a fusion protein combining a CD19-specific antibody domain with trimerized extracellular domains of human 4-1BBL,</p>Cor e Forma:Odour LiquidPirenoxine
CAS:<p>Pirenoxine is an agent with anti-cataractogenesis activity by interacting with calcium ions or selenite which could lead to the formation of lens cataract.</p>Fórmula:C16H8N2O5Cor e Forma:SolidPeso molecular:308.25IL-6-IN-1
IL-6-IN-1 (Compound 22) inhibits the release of IL-6 with an IC50 of 1.065 μM and demonstrates anti-inflammatory activity in LPS-induced acute lung injury in mice.Fórmula:C16H12N2OSCor e Forma:SolidPeso molecular:280.34PSMα3
CAS:<p>PSMα3 is a peptide compound that can be utilized to induce tolerance in dendritic cells (DCs) for DC vaccination strategies.</p>Fórmula:C128H192N28O30SCor e Forma:SolidPeso molecular:2635.17ZL-1102
<p>ZL-1102 is a humanized monoclonal antibody inhibitor targeting interleukin-17A (IL-17A). SCH-900117 is being investigated for its potential use in the treatment of autoimmune diseases such as psoriasis and rheumatoid arthritis.</p>Cor e Forma:Odour LiquidUNC8900
UNC8900 is a VHL-recruiting STINGPROTAC degrader with a DC50 of 0.924 μM. It is applicable for the study of bacterial and viral infections.Fórmula:C75H99N17O15SPeso molecular:1509.72273Keap1-Nrf2-IN-3
CAS:<p>Keap1-Nrf2-IN-3 is a KEAP1:NRF2 protein protein interaction inhibitor, and with a K d value of 2.5 nM for KEAP1 protein.</p>Fórmula:C31H34N6O3Cor e Forma:SolidPeso molecular:538.652SN50
CAS:<p>SN50 is a cell-permeable inhibitor of NF-κB nuclear translocation that protects against ventilator-induced acute lung injury in rats.</p>Fórmula:C129H230N36O29SPureza:99.91%Cor e Forma:SolidPeso molecular:2781.5LL-37 GKE acetate
<p>LL-37 GKE acetate, a peptide and active structural domain of LL-37, inhibits lps-induced vascular nitric oxide production,less toxic,antimicrobial，sepsis.</p>Fórmula:C121H206N38O30Pureza:99.88%Cor e Forma:SolidPeso molecular:2673.17TLR4-IN-C34-C2-amide-C6-OH
<p>TLR4-IN-C34-C2-amide-C6-OH: a linker with TLR4-IN-C34 that curbs TLR4 and inflammation in mice.</p>Fórmula:C25H42N2O11Cor e Forma:SolidPeso molecular:546.61Antiviral agent 61
<p>Antiviralagent 61 (compound Z40) serves as an effective antiviral agent with activity against Tomato Spotted Wilt Virus (TSWV), exhibiting an EC50 value of 252 µg/mL. It increases the RNA expression of Ndufb9, COX6B, 7.1.2.2, E, COX5B, Ndufs4, and SDHB, while reducing the expression of Ndufb7, Ndufa5, and G.</p>Fórmula:C22H23N5O4SCor e Forma:SolidPeso molecular:453.51NLRP3-IN-15
CAS:<p>NLRP3-IN-15: potent, selective NLRP3 inflammasome inhibitor; IC50 0.114 μM for IL-1β; for inflammation research.</p>Fórmula:C22H19NO4Cor e Forma:SolidPeso molecular:361.39Numidargistat dihydrochloride
<p>Numidargistat dihydrochloride is an ARG1 inhibitor and an immuno-oncology agent that inhibits TGF-β2-induced pre-lens cataract formation.</p>Fórmula:C11H24BCl2N3O5Pureza:99.49%Cor e Forma:SolidPeso molecular:360.04ABX-IL8
<p>ABX-IL8 is a humanized antibody targeting IL-8, capable of interfering with tube formation in human umbilical vein endothelial cells.</p>Pureza:>95%Cor e Forma:LiquidPeso molecular:145.5 kDadiABZI STING agonist-1 trihydrochloride
CAS:<p>diABZI STING agonist-1 (trihydrochloride) is stimulator of interferon genes (STING) receptor agonist.</p>Fórmula:C42H54Cl3N13O7Pureza:95.33% - 99.55%Cor e Forma:SolidPeso molecular:959.32Tri(TLR4-IN-C34-PEG2-amide-PEG1)-amide-C3-COOH
<p>Tri(TLR4-IN-C34-PEG2/PEG1)-amide-C3-COOH is a TLR4 inhibiting linker, reducing inflammation in endotoxemia and enterocolitis mouse models.</p>Fórmula:C78H125N7O42Cor e Forma:SolidPeso molecular:1832.85Axinelline A
CAS:<p>Axinelline A: COX inhibitor, IC50 of 2.22 μM (COX-2) & 8.89 μM (COX-1), anti-inflammatory.</p>Fórmula:C12H15NO6Cor e Forma:SolidPeso molecular:269.25β-Interleukin II (44-56)
β-Interleukin II is a peptide with the sequence NH2-ILE-LEU-ASN-GLY-ILE-ASN-ASN-TYR-LYS-ASN-PRO-LYS-LEU-COOH.Fórmula:C68H113N19O19Pureza:98%Cor e Forma:SolidPeso molecular:1500.74Fentiazac
CAS:<p>Fentiazac (BR-700) is an oral NSAID for pain, inflammation, fever, studied for arthritis and tendonitis.</p>Fórmula:C17H12ClNO2SPureza:99.83%Cor e Forma:SolidPeso molecular:329.8FITC-labeled ODN 2395 sodium
<p>FITC-labeled ODN 2395 (sodium), a class C oligodeoxynucleotide and TLR9 agonist, facilitates the assessment of CpG ODN cellular uptake and localization through</p>Cor e Forma:Odour SolidPegaldesleukin
CAS:<p>Pegaldesleukin, a PEG-IL2 conjugate, exhibits antiviral properties, potentially slowing HIV progression, preserving immune function.</p>Cor e Forma:LiquidSartorypyrone D
CAS:<p>Sartorypyrone D, from N. fischeri, inhibits NFRD (1.7 μM) and NADH oxidase (3 μM), and fights Gram-positive bacteria.</p>Fórmula:C26H38O4Cor e Forma:SolidPeso molecular:414.586Aβ-IN-6
<p>Aβ-IN-6 is an orally active compound exhibiting anti-inflammatory, antioxidant, and anti-oligomeric activities, with significant implications for Alzheimer's</p>Fórmula:C28H31N3O4Cor e Forma:SolidPeso molecular:473.56CHBO4
CAS:<p>CHBO4 is an hMAO-B inhibitor that is potent, reversible, competitive and selective.The IC50 value of CHBO4 against hMAO-B in the CHBO assay was 0.031 μM, and</p>Fórmula:C15H10BrFOPureza:98.14%Cor e Forma:SolidPeso molecular:305.14IL-17-IN-3
<p>IL-17-IN-3 (compound 11) is an IL-17A inhibitor with an IC50 value of 35 nM. In a rat tolerance study, it showed no adverse reactions when administered at doses up to 300 mg/kg/day for four consecutive days.</p>Fórmula:C22H25F6N5O3SCor e Forma:SolidPeso molecular:553.521IACS-8803 disodium
CAS:<p>IACS-8803 Disodium, a potent cyclic dinucleotide STING agonist, exhibits strong systemic antitumor efficacy [1].</p>Fórmula:C20H21FN10Na2O9P2S2Cor e Forma:SolidPeso molecular:736.50R-HP210
<p>R-HP210 blocks LPS-triggered IL-1β, IL-6, COX-2 gene transcription and has a 3.80 μM IC50 for NF-κB inhibition without activating GCs.</p>Fórmula:C22H19N3O2S2Cor e Forma:SolidPeso molecular:421.54CIB-1476
<p>CIB-1476, a caspase-1 inhibitor, effectively reduces joint swelling in mouse models of arthritis and demonstrates lasting anti-inflammatory effects. This compound achieves its benefits by blocking IL-1β production, NF-κB activation, and GSDMD-mediated pyroptosis, all of which are triggered by the NLRP3 inflammasome.</p>Fórmula:C28H28N2O6SCor e Forma:SolidPeso molecular:520.6Damnacanthol
<p>Damnacanthol is a useful organic compound for research related to life sciences and the catalog number is T131609.</p>Fórmula:C16H12O5Cor e Forma:SolidPeso molecular:284.267Nrf2 activator 18
<p>Nrf2 activator 18 (Compound 11a) is an orally active activator of the Keap1/Nrf2/HO-1 signaling pathway, promoting Nrf2 nuclear translocation and enhancing antioxidant effects. It inhibits IL-6 release with an IC50 of 4.816 μM. In a mouse model of PM2.5-induced lung injury, Nrf2 activator 18 demonstrates anti-inflammatory activity.</p>Fórmula:C23H24FN3OCor e Forma:SolidPeso molecular:377.45IACS-8803 diammonium
<p>IACS-8803 diammonium, a potent cyclic dinucleotide STING agonist, demonstrates robust systemic antitumor efficacy [1].</p>Fórmula:C20H29FN12O9P2S2Cor e Forma:SolidPeso molecular:726.6
