Imunologia e Inflamação
Os inibidores de imunologia e inflamação são compostos que modulam a resposta imunológica e os processos inflamatórios. Esses inibidores são cruciais para estudar os mecanismos de regulação imunológica, autoimunidade e inflamação crônica, bem como para desenvolver tratamentos para doenças inflamatórias, alergias e distúrbios relacionados ao sistema imunológico. Ao direcionar vias-chave no sistema imunológico, esses inibidores podem ajudar a reduzir respostas imunológicas excessivas ou inadequadas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de alta qualidade para apoiar sua pesquisa em imunologia, inflamação e desenvolvimento terapêutico.
Subcategorias de "Imunologia e Inflamação"
- CCR(136 produtos)
- CXCR(149 produtos)
- Parede celular(5 produtos)
- Receptor IL(112 produtos)
- IκB/IKK(59 produtos)
- LTR(3 produtos)
- MALT(23 produtos)
- MRP(6 produtos)
- NADPH-oxidase(1 produtos)
- NF-κB(443 produtos)
- NOD(18 produtos)
- NOS(63 produtos)
- Nrf2(78 produtos)
- PGE Sintase(31 produtos)
- ROS(69 produtos)
- TGF-beta/Smad(58 produtos)
- TLR(66 produtos)
- Tiorredoxina(12 produtos)
- gp120/CD4(4 produtos)
Exibir 11 mais subcategorias
Foram encontrados 3054 produtos de "Imunologia e Inflamação"
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RS 09 TFA
<p>RS 09 TFA is a TLR4 agonist and LPS peptide analogue, promotes NF-κB nuclear translocation, induces inflammatory cytokine secretion in RAW264.7 macrophages.</p>Fórmula:C33H50F3N9O11Pureza:99.78%Cor e Forma:SolidPeso molecular:805.8BTA-188
CAS:<p>BTA-188, a potent synthetic benzoxazole/thiazole, exhibits strong oral anti-rhinovirus effects.</p>Fórmula:C21H28N4O2Pureza:98.1% - 99.77%Cor e Forma:SolidPeso molecular:368.47TJ-M2010-5
CAS:TJ-M2010-5 is a MyD88 inhibitor that binds to the TIR domain to interfere with its homodimerization and suppress MyD88 signaling.Fórmula:C23H26N4OSPureza:99.63%Cor e Forma:SolidPeso molecular:406.54PMX 205 Trifluoroacetate
<p>PMX 205 Trifluoroacetate is a potent complement C5a receptor ( C5aR ; CD88 ) antagonist.</p>Fórmula:C47H63F3N10O8Cor e Forma:SolidPeso molecular:953.06Nω-Propyl-L-arginine
CAS:<p>Nω-Propyl-L-arginine, a powerful and specific inhibitor of neuronal nitric oxide synthase (nNOS), effectively inhibits nNOS with a Ki of 57 nM.</p>Fórmula:C9H20N4O2Cor e Forma:SolidPeso molecular:216.28TLR8 agonist 2
CAS:<p>TLR8 agonist 2 activates human TLR8 (EC50=3nM), less effective on TLR7 (EC50=33.33μM).</p>Fórmula:C16H22N8Cor e Forma:SolidPeso molecular:326.408β-Interleukin II (44-56)
β-Interleukin II is a peptide with the sequence NH2-ILE-LEU-ASN-GLY-ILE-ASN-ASN-TYR-LYS-ASN-PRO-LYS-LEU-COOH.Fórmula:C68H113N19O19Pureza:98%Cor e Forma:SolidPeso molecular:1500.743-O-(2'E,4'Z-Decadienoyl)ingenol
<p>3-O-(2'E,4'Z-Decadienoyl)ingenol is a useful organic compound for research related to life sciences and the catalog number is T124104.</p>Fórmula:C30H42O6Cor e Forma:SolidPeso molecular:498.663D-Monophosphoryl Lipid (12,16) free acid
CAS:3D-Monophosphoryl Lipid (12,16) (3D-MPL (12,16)) free acid is a TLR agonist that serves as a vaccine adjuvant to boost the immunogenicity of vaccines.Fórmula:C96H181N2O21PCor e Forma:SolidPeso molecular:1730.44Guignardone L
CAS:<p>Guignardone L, a metabolite extracted from the endophytic fungus Guignardia mangiferae, possesses toll-like receptor 3 (TLR3) regulating activity [1].</p>Fórmula:C17H24O4Cor e Forma:SolidPeso molecular:292.37FITC-labeled ODN 2395 sodium
<p>FITC-labeled ODN 2395 (sodium), a class C oligodeoxynucleotide and TLR9 agonist, facilitates the assessment of CpG ODN cellular uptake and localization through</p>Cor e Forma:Odour Solid(±)-Phrymarolin II
CAS:<p>(±)-Phrymarolin II is a promising class of inhibitors that targets the tobacco mosaic virus, representing a novel approach in plant virus suppression.</p>Fórmula:C23H22O10Cor e Forma:SolidPeso molecular:458.419STING agonist-31
CAS:<p>STING agonist-31, a potent STING agonist, exhibits EC50 values of 0.24 μM and 39.51 μM for human STING (h-STING) and murine STING (m-STING), respectively,</p>Fórmula:C43H51N15O6Cor e Forma:SolidPeso molecular:873.96FITC-labeled ODN 1668 sodium
<p>FITC-labeled ODN 1668 (sodium), a class B CpG oligodeoxynucleotide (ODN), functions as a TLR9 agonist.</p>Cor e Forma:Odour SolidBCOR(498-514), biotinylated
BCOR(498-514), biotinylated, is the smallest BCL6 binding domain with a KD of 1.32 µM. It can block BCL6-mediated transcriptional repression and induce cell death in lymphoma cells.Fórmula:C98H155N25O29SPeso molecular:2178.11433R-HP210
<p>R-HP210 blocks LPS-triggered IL-1β, IL-6, COX-2 gene transcription and has a 3.80 μM IC50 for NF-κB inhibition without activating GCs.</p>Fórmula:C22H19N3O2S2Cor e Forma:SolidPeso molecular:421.54Inbakicept
CAS:<p>Inbakicept (ALT 803) is a fusion protein of the IL-15 receptor 伪-sushi binding domain IL-15R伪Su and immunoglobulin G1 (human Fc fragment).</p>Pureza:98.94%Cor e Forma:LiquidCIB-1476
<p>CIB-1476, a caspase-1 inhibitor, effectively reduces joint swelling in mouse models of arthritis and demonstrates lasting anti-inflammatory effects. This compound achieves its benefits by blocking IL-1β production, NF-κB activation, and GSDMD-mediated pyroptosis, all of which are triggered by the NLRP3 inflammasome.</p>Fórmula:C28H28N2O6SCor e Forma:SolidPeso molecular:520.6APF
CAS:<p>APF, a low-fluorescence probe, turns bright (490/515 nm) when oxidized by specific radicals; not affected by NO or H2O2.</p>Fórmula:C26H17NO5Cor e Forma:SolidPeso molecular:423.42Avatrombopag hydrochloride
CAS:<p>Avatrombopag (AKR-501) - oral, nonpeptide TPO receptor agonist, EC50 3.3 nM, boosts platelet production, CYP2C9 and CYP3A substrate.</p>Cor e Forma:SolidPratensein
CAS:<p>Pratensein as a novel transcriptional up-regulator of scavenger receptor class B type I in HepG2 cells.</p>Fórmula:C16H12O6Pureza:99.90%Cor e Forma:SolidPeso molecular:300.26MUC1, mucin core
CAS:<p>MUC1: Type I transmembrane glycoprotein, overexpressed and abnormally glycosylated in cancer, binds ICAM-1 domain 1.</p>Fórmula:C61H101N19O24Cor e Forma:SolidPeso molecular:1484.588(±)19(20)-EDP Ethanolamide
CAS:<p>(±)19(20)-EDP ethanolamide is an ω-3 endocannabinoid epoxide and cannabinoid (CB) receptor agonist (EC50s = 108 and 280 nM for CB1 and CB2, respectively).</p>Fórmula:C24H37NO3Cor e Forma:SolidPeso molecular:387.564Ac-LDEETGEFL-NH2
CAS:<p>Ac-LDEETGEFL-NH2 is a fluorescent molecule designed to target the interaction between the Kelch-like ECH-associated protein 1 (Keap1) and nuclear factor</p>Fórmula:C48H72N10O19Cor e Forma:SolidPeso molecular:1093.14STING modulator-5
CAS:<p>STING modulator-5: pIC50 9.5, antagonizes PBMC (pIC50 8.1), THP-1 cell antagonist, for immunology research.</p>Fórmula:C43H45F4N11O5Cor e Forma:SolidPeso molecular:871.88CD19 CAR circRNA
<p>CD19 CAR circRNA expresses a CD19 car protein for CAR-T immunotherapy targeting B-cell antigens.</p>Cor e Forma:SolidNLRP3-IN-73
<p>NLRP3-IN-73 (W16) is an orally bioavailable inhibitor that disrupts the assembly of the NLRP3 inflammasome, exhibiting an IC50 value of 0.18 μM for the NLRP3/IL-1β pathway.</p>Cor e Forma:Odour SolidSTING agonist-28
CAS:<p>STING agonist-28 (CF510), a non-nucleotide, boosts STING, TBK1, IRF3 phosphorylation, and cytokines; active against SARS-CoV.</p>Fórmula:C39H46N14O6Cor e Forma:SolidPeso molecular:806.87Nrf2 activator-8
<p>Nrf2 Activator-8 (Compound 10e), with an EC50 of 37.9 nM, is a potent Nrf2 activator that demonstrates significant antioxidant and anti-inflammatory properties</p>Fórmula:C13H11ClN2O3SCor e Forma:SolidPeso molecular:310.76Redaporfin
CAS:<p>Redaporfin (F-2BMet, LUZ-11) is a PDT cancer photosensitizer; 83% of mice had tumor regression with 1.5 mg/kg and 74 J/cm² light.</p>Fórmula:C48H38F8N8O8S4Cor e Forma:SolidPeso molecular:1135.11diABZI-V/C-DBCO
<p>Compound 3 (diABZI-V/C-DBCO) functions as an efficient STING agonist. This compound acts by releasing diABZI-amine under the action of cathepsin B to activate STING, thereby inducing the production of interferon and other immune-activating molecules, which enhances the immune system's response to tumors. In THP1-Dual cells, the EC50 values for STING activation by diABZI-V/C-DBCO and diABZI-amine are 1.47 nM and 0.144 nM, respectively, and in primary mouse splenic cells, the EC50 values are 7.7 µM and 0.17 µM, respectively. diABZI-V/C-DBCO is useful for research in the field of cancer immunotherapy.</p>Fórmula:C78H89N19O13Cor e Forma:SolidPeso molecular:1500.66XJB-5-131
CAS:<p>XJB-5-131: synthetic, bi-functional antioxidant; targets mitochondria, scavenges ROS/electrons, protects CB MNCs from irradiation.</p>Fórmula:C53H80N7O9Cor e Forma:SolidPeso molecular:959.263Z-VRPR-FMK TFA
<p>Z-VRPR-FMK (TFA), a tetrapeptide, irreversibly inhibits MALT1, protecting against influenza A.</p>Fórmula:C33H50F4N10O8Cor e Forma:SolidPeso molecular:790.81CDD-3290
<p>CDD-3290 (Compound 20) is an inhibitor of prostate-specific antigen (PSA) with a Ki value of 216 nM. This compound also exhibits inhibitory effects on α-chymotrypsin and elastase.</p>Cor e Forma:Odour SolidAra-F-NAD+ sodium
<p>Ara-F-NAD+ sodium, an arabino analogue of NAD+, serves as a potent, reversible, and slow-binding inhibitor of the CD38 NADase [1] [2].</p>Fórmula:C21H25FN7NaO13P2Cor e Forma:SolidPeso molecular:687.4Eramkafusp Alfa
<p>Eramkafusp alfa is a human IgG1 antibody that targets the murine B lymphocyte antigen CD20, also known as MS4A1 [1].</p>Cor e Forma:Odour LiquidIACS-8803 diammonium
<p>IACS-8803 diammonium, a potent cyclic dinucleotide STING agonist, demonstrates robust systemic antitumor efficacy [1].</p>Fórmula:C20H29FN12O9P2S2Cor e Forma:SolidPeso molecular:726.6ROS-ERS inducer 1
<p>Type II ICD agent, ROS-ERS inducer 1, is a Pt(II)-NHC from 4,5-diarylimidazole, boosting ER stress, ROS, and DAMPs in HCC, outperforming Cisplatin.</p>Fórmula:C24H23F2I2N3PtCor e Forma:SolidPeso molecular:840.35NLRP3-IN-45
<p>NLRP3-IN-45 (D6) serves as an inhibitor specifically targeting the NLRP3 inflammasome, demonstrated through its ability to curb the activity of IL-1β (IC 50 = 41.79 nM). It effectively prevents the activation of the NLRP3 inflammasome while sparing the initial stages of its activation process. Furthermore, NLRP3-IN-45 has been shown to selectively inhibit NLRP3 inflammasome activation in the LPS-induced acute lung injury (ALI) mouse model.</p>Fórmula:C27H30FNO6Cor e Forma:SolidPeso molecular:483.53Pegaldesleukin
CAS:<p>Pegaldesleukin, a PEG-IL2 conjugate, exhibits antiviral properties, potentially slowing HIV progression, preserving immune function.</p>Cor e Forma:LiquidPOT-4 acetate
<p>POT-4 acetate inhibits Complement C3 activation. POT-4 acetate can be used for studies about age-related macular degeneration.</p>Fórmula:C74H106N22O20S2Pureza:98%Cor e Forma:SolidPeso molecular:1687.9AB-680 ammonium
<p>AB-680: potent, reversible CD73 inhibitor, Ki=4.9 pM, >10,000-fold selectivity vs CD39, anti-tumor.</p>Fórmula:C20H30ClFN6O9P2Cor e Forma:SolidPeso molecular:614.893-Hydroxykynurenamine
CAS:<p>3-Hydroxykynurenamine (3-HKA) is a tryptophan metabolite with anti-inflammatory effects, reducing cytokines and aiding in models of psoriasis and nephritis.</p>Fórmula:C9H12N2O2Cor e Forma:SolidPeso molecular:180.2ADU-S100 disodium salt
CAS:<p>ADU-S100 (MIW815) disodium salt is an activator of stimulator of interferon genes (STING).</p>Fórmula:C20H22N10Na2O10P2S2Pureza:98%Cor e Forma:SolidPeso molecular:734.51α-Guanidinoglutaric Acid
CAS:<p>α-Guanidinoglutaric Acid is found in cobalt-induced epileptogenic focus tissue in the cerebral cortex of cats.</p>Fórmula:C6H11N3O4Pureza:99.73%Cor e Forma:SolidPeso molecular:189.17RDR 02308
CAS:<p>RDR 02308 is a TLR4-MyD88 binding inhibitor that inhibits full-length β-lactamase [1] .</p>Fórmula:C19H15N3O3Cor e Forma:SolidPeso molecular:333.34H-Lys-Trp-Lys-OH acetate
<p>H-Lys-Trp-Lys-OH acetate is a peptide with antibacterial and antiviral activities.</p>Fórmula:C25H40N6O6Pureza:99.50%Cor e Forma:SolidPeso molecular:520.62Englumafusp alfa
<p>Englumafusp alfa (CD19-4-1BBL; RO7227166) is a fusion protein combining a CD19-specific antibody domain with trimerized extracellular domains of human 4-1BBL,</p>Cor e Forma:Odour LiquidMitoquinol
CAS:<p>Mitoquinol is a mitochondria-targeted antioxidant used in the study of cardiovascular disease by modulating the mitochondrial antioxidant defense system.</p>Fórmula:C38H49O7PSPureza:98%Cor e Forma:SolidPeso molecular:680.83HNGF6A
CAS:<p>increases glucose stimulated insulin secretion and glucose metabolism</p>Fórmula:C112H198N34O31S2Pureza:98%Cor e Forma:SolidPeso molecular:2581.11
