Imunologia e Inflamação
Os inibidores de imunologia e inflamação são compostos que modulam a resposta imunológica e os processos inflamatórios. Esses inibidores são cruciais para estudar os mecanismos de regulação imunológica, autoimunidade e inflamação crônica, bem como para desenvolver tratamentos para doenças inflamatórias, alergias e distúrbios relacionados ao sistema imunológico. Ao direcionar vias-chave no sistema imunológico, esses inibidores podem ajudar a reduzir respostas imunológicas excessivas ou inadequadas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de alta qualidade para apoiar sua pesquisa em imunologia, inflamação e desenvolvimento terapêutico.
Subcategorias de "Imunologia e Inflamação"
- CCR(136 produtos)
- CXCR(149 produtos)
- Parede celular(5 produtos)
- Receptor IL(112 produtos)
- IκB/IKK(59 produtos)
- LTR(3 produtos)
- MALT(23 produtos)
- MRP(6 produtos)
- NADPH-oxidase(1 produtos)
- NF-κB(443 produtos)
- NOD(18 produtos)
- NOS(63 produtos)
- Nrf2(78 produtos)
- PGE Sintase(31 produtos)
- ROS(69 produtos)
- TGF-beta/Smad(58 produtos)
- TLR(66 produtos)
- Tiorredoxina(12 produtos)
- gp120/CD4(4 produtos)
Exibir 11 mais subcategorias
Foram encontrados 3054 produtos de "Imunologia e Inflamação"
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W-54011
CAS:<p>W-54011: potent non-peptide C5a receptor blocker; binds 125I-C5a (Ki=2.2nM); stops Ca2+ movement, chemotaxis, ROS in neutrophils (IC50=1.6-3.1nM).</p>Fórmula:C30H37ClN2O2Pureza:96.8%Cor e Forma:SolidPeso molecular:493.08TLR4 agonist-1
CAS:<p>TLR4 agonist-1 (compound 17a) serves as a potent activator of Toll-like Receptor 4 (TLR4) and stimulates the production of MIP-1β in RAW 264.7 and MM6 cells [1</p>Fórmula:C81H158N3O15PCor e Forma:SolidPeso molecular:1445.11IMD-vanillin
CAS:<p>IMD-vanillin is a novel compound characterized as an imidazoquinolinone-derived dimer with NF-κB immunomodulatory properties.</p>Fórmula:C37H45N7O4Pureza:98%Cor e Forma:SolidPeso molecular:651.8IRAK4-IN-28
CAS:<p>IRAK4-IN-28 (compound 42), an orally-active IRAK4 inhibitor (IC50=8.9 nM), exhibits strong binding affinity with a Kd of 0.58 nM for the target enzyme.</p>Fórmula:C27H31N9O3Pureza:98%Cor e Forma:SolidPeso molecular:529.59C5aR-IN-1
CAS:<p>C5aR-IN-1, a potent C5aR inhibitor, may aid in researching autoimmune and inflammatory diseases.</p>Fórmula:C36H39F4N3O2Cor e Forma:SolidPeso molecular:621.71TBK1-IN-1
CAS:<p>TBK1-IN-1 is a TANK-binding kinase 1 inhibitor with anticancer activity.TBK1-IN-1 inhibits the expression of TBK1 downstream target genes, cxcl10 and ifnβ.</p>Fórmula:C27H37N7O2Pureza:>99.99%Cor e Forma:SolidPeso molecular:491.63Keap1-Nrf2-IN-16
CAS:<p>Keap1-Nrf2-IN-16 is a biologically active peptide with KEAP1 binding activity.</p>Fórmula:C73H114N16O26Cor e Forma:SolidPeso molecular:1631.78Galectin-3 antagonist 2
CAS:<p>Galectin-3: a lectin aiding BCP-ALL cell migration & drug resistance.</p>Fórmula:C22H23NO10Pureza:98%Cor e Forma:SolidPeso molecular:461.42RIPK2-IN-3
CAS:<p>RIPK2-IN-3 (FCG806791773) is a RIPK2 inhibitor with anti-inflammatory and anticancer activities, useful for research on immune diseases and cancer.</p>Fórmula:C25H22N4O2Pureza:99.57%Cor e Forma:SolidPeso molecular:410.47Cergutuzumab amunaleukin
CAS:<p>Cergutuzumab amunaleukin (CEA-IL2v) is a CEA-targeted IL-2 variant immunocytokine for combination cancer immunotherapy with anti-tumor activity.</p>Pureza:98% (SDS-PAGE); 99.7% (SEC-HPLC) - 98% (SDS-PAGE); 99.7% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:162.05 kDaPF-184
<p>PF-184: potent IKK-2 inhibitor, selective over 30+ kinases; useful for asthma & COPD research. IC50: 37 nM.</p>Fórmula:C32H32ClFN6O4Cor e Forma:SolidPeso molecular:619.09Benoxaprofen
CAS:<p>Benoxaprofen (NSC-299582) is a non-steroidal anti-inflammatory drug.</p>Fórmula:C16H12ClNO3Pureza:98.87%Cor e Forma:SolidPeso molecular:301.72Keap1-Nrf2-IN-6
<p>Keap1-Nrf2-IN-6 is a potent, selective inhibitor of the Keap1-Nrf2 protein−protein interaction (PPI), demonstrating an inhibitory concentration (IC50) of 41 nM</p>Fórmula:C30H34N4O8SCor e Forma:SolidPeso molecular:610.68STING agonist-10
CAS:<p>STING agonist-10 is a potent activator of the STING small molecule cyclic urea class (EC50: 2600 nM).STING activation is a highly promising immunotherapy.</p>Fórmula:C25H20ClF4N3O2Cor e Forma:SolidPeso molecular:505.89Vipoglanstat
CAS:<p>Vipoglanstat: inhibits prostaglandin E synthase, anti-inflammatory, reduces leukocyte infiltration and lung injury from endotoxin/sepsis.</p>Fórmula:C30H34Cl2F5N5O3Cor e Forma:SolidPeso molecular:678.52TMV-IN-3
CAS:<p>TMV-IN-3 is a chalcone derivative that inhibits TMV with a 120.3 μg/mL EC50, used in research on infection and cancer.</p>Fórmula:C28H26O4Cor e Forma:SolidPeso molecular:426.5IR-Crizotinib
CAS:<p>IR-Crizotinib is a conjugate of the near-infrared dye IR-786 and Crizotinib, an NF-κB-inducing kinase (NIK) inhibitor, with an IC50 of 3.381 μM for intracranial</p>Fórmula:C53H57Cl2FIN7OPureza:98%Cor e Forma:SolidPeso molecular:1024.88Trovafloxacin mesylate
CAS:<p>Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).</p>Fórmula:C21H19F3N4O6SPureza:99.18%Cor e Forma:SolidPeso molecular:512.46Antitumor agent-114
CAS:<p>Antitumor Agent-114, a potent STING (stimulator of interferon genes) agonist, activates immune responses and diminishes tumor size in mouse breast cancer models</p>Fórmula:C39H50F2N10O13P2Pureza:98%Cor e Forma:SolidPeso molecular:966.82RIPK1-IN-16
CAS:<p>RIPK1-IN-16 is an orally active, potent RIPK1 inhibitor that mitigates excessive inflammation via inhibition of RIPK1-mediated necroptosis in vivo.</p>Fórmula:C20H19N5O2SPureza:98%Cor e Forma:SolidPeso molecular:393.46NF-κB-IN-13
CAS:<p>NF-κB-IN-13 (compound 12) markedly suppresses LPS-induced NF-κB activation and NO synthesis in RAW264.7 macrophages, exhibiting anti-inflammatory properties [1</p>Fórmula:C20H20O5Pureza:98%Cor e Forma:SolidPeso molecular:340.37BDW568
CAS:<p>BDW568, a prodrug of BDW-OH, serves as a stimulator of interferon genes (STING) agonist.</p>Fórmula:C12H12N4O2S2Cor e Forma:SolidPeso molecular:308.38TLR8 agonist 5
CAS:<p>TLR8 Agonist 5, exhibiting potent efficacy as a TLR8 agonist, demonstrates an EC50 of 20 nM in HEK-Blue hTLR8, effectively activating the immune response.</p>Fórmula:C31H40N6O5Cor e Forma:SolidPeso molecular:576.69BI 7446
CAS:<p>BI 7446 is a potent and selective cyclic dinucleotide (CDN)-based stimulator of interferon genes (STING) agonist capable of activating all five STING variants</p>Fórmula:C20H22FN9O10P2S2Pureza:98%Cor e Forma:SolidPeso molecular:693.52Dimethoxycurcumin
CAS:Dimethoxycurcumin is a stable curcumin analog causing epigenetic shifts in leukemia cells, affecting gene expression.Fórmula:C23H24O6Pureza:99.87%Cor e Forma:SolidPeso molecular:396.43IKK-IN-4
CAS:<p>IKK-IN-4 is a potent and selective inhibitor of IkappaB kinase 2 with IC 50 values of 45 and 650 nM against IKKβ and IKKα, respectively [1].</p>Fórmula:C18H19N5SCor e Forma:SolidPeso molecular:337.44Stobadine
CAS:<p>Stobadine, a potent antioxidant, safeguards endoplasmic reticulum (ER) membrane fluidity against free radical-induced changes.</p>Fórmula:C13H18N2Pureza:98%Cor e Forma:SolidPeso molecular:202.3HBF-0259
CAS:HBF-0259 is an inhibitors of hepatitis B virus surface antigen (HBsAg) secretion with an EC50 of 11.3 μM and a CC50 value of >50 μM in HepG2.2.15 cells.Fórmula:C16H12Cl2FN5Pureza:98.07% - 99.42%Cor e Forma:SolidPeso molecular:364.2Glabrescone C
CAS:<p>Glabrescone C exhibits strong anti-inflammatory properties through direct binding to IKKα/β.</p>Fórmula:C19H22O7Cor e Forma:SolidPeso molecular:362.37NLRP3-IN-18
CAS:<p>NLRP3-IN-18, also known as compound 13, is a potent inhibitor of NLRP3, demonstrating an IC50 value of ≤1.0 µM [1].</p>Fórmula:C19H18ClN3OPureza:98%Cor e Forma:SolidPeso molecular:339.82Friluglanstat
CAS:<p>Friluglanstat is an inhibitor of the enzyme prostaglandin E synthase (mPGES-1) and exhibits anti-inflammatory activity [1].</p>Fórmula:C25H20ClF3N4O3Pureza:98%Cor e Forma:SolidPeso molecular:516.9TLR7/8 agonist 9
CAS:<p>TLR7/8 agonist 9 (Compound 25a), exhibiting EC50 values of 40 nM and 23 nM for hTLR7 and hTLR8 respectively, demonstrates anti-tumor properties and enhances the</p>Fórmula:C20H26N6OCor e Forma:SolidPeso molecular:366.46NLRP3-IN-22
CAS:<p>NLRP3-IN-22 (Compound II-4) is an inhibitor of NLRP3, exhibiting a 67% inhibition rate at a concentration of 10 μM [1].</p>Fórmula:C19H12F3NO4SPureza:98%Cor e Forma:SolidPeso molecular:407.36OATD-02
CAS:<p>OATD-02 is an orally active, competitive, reversible, noncovalent inhibitor with slow offset kinetics that targets both Arginase1 and 2, exhibiting inhibitory</p>Fórmula:C12H25BN2O4Pureza:98%Cor e Forma:SolidPeso molecular:272.15MAPK-IN-1
CAS:<p>MAPK-IN-1 inhibits MAPK for Alzheimer's research with anti-inflammatory effects, IC50 of 23.84 μM against AChE.</p>Fórmula:C19H18O4Cor e Forma:SolidPeso molecular:310.34Lipid peroxidation inhibitor 1
CAS:<p>Lipid peroxidation inhibitor 1 is an inhibitor of lipid peroxidation (IC50: 0.07 μM).</p>Fórmula:C24H32N2OPureza:98%Cor e Forma:SolidPeso molecular:364.52JT002
CAS:<p>JT002 is an orally active NLRP3 inflammasome inhibitor that decreases the production of NLRP3-dependent proinflammatory cytokines (such as IL-1β, IL-1α, IL-18)</p>Fórmula:C20H24N4O5SPureza:98%Cor e Forma:SolidPeso molecular:432.49Nitric oxide production-IN-1
CAS:<p>Nitric oxide production-IN-1 (Compound 1) is an inhibitor of nitric oxide (NO) production extracted from Tupistra chinensis.</p>Fórmula:C33H52O15Pureza:98%Cor e Forma:SolidPeso molecular:688.76Dapsone hydroxylamine
CAS:<p>Dapsone hydroxylamine (DDS-NOH) promotes methemoglobinemia, impedes catalase (CAT) activity, and suppresses the generation of reactive oxygen species, while</p>Fórmula:C12H12N2O3SPureza:98%Cor e Forma:SolidPeso molecular:264.3BW 755C
CAS:BW 755C is a dual inhibitor of 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathways.Fórmula:C10H10F3N3Pureza:96.52%Cor e Forma:SolidPeso molecular:229.2GSK840
CAS:<p>GSK840 (GSK'840) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds the RIP3 kinase domain (IC50: 0.9 nM), and inhibits kinase</p>Fórmula:C21H23N3O3Pureza:99.7%Cor e Forma:SolidPeso molecular:365.43Caspase-3 activator 1
<p>Caspase-3 activator 1 (compound 4b), a Ru(III) metal complex, effectively inhibits gastric tumor growth and metastasis by mediating caspase-3 cleavage.</p>Fórmula:C28H27N6O2RuS2Pureza:98%Cor e Forma:SolidPeso molecular:644.75STING agonist-11
CAS:<p>STING agonist-11 is a potent activator of the small molecule cyclic urea class of STING (EC50: 18 nM).STING activation is a highly promising immunotherapy.</p>Fórmula:C25H20ClF4N3O2Cor e Forma:SolidPeso molecular:505.89CD73-IN-4
CAS:<p>CD73-IN-4 is a potent and selective methylenephosphonic acid CD73 inhibitor</p>Fórmula:C16H23ClN5O7PPureza:98.61%Cor e Forma:SolidPeso molecular:463.81PK68
CAS:<p>PK68 selectively inhibits RIPK1 (IC50=90nM), potentially useful in inflammation and cancer metastasis studies.</p>Fórmula:C22H24N4O3SPureza:98.09% - 99.64%Cor e Forma:SolidPeso molecular:424.52α-Pyridoin
CAS:<p>α-Pyridoin (α-pyridoin) is an enediol (enediol) compound that acts as a unique antioxidant.</p>Fórmula:C12H12N2O2Cor e Forma:SolidPeso molecular:216.24JNJ-67856633
CAS:<p>JNJ-67856633 is an orally active, first-in-class, potent, selective and allosteric inhibitor of MALT1 protease .</p>Fórmula:C20H11F6N5O2Pureza:99.87%Cor e Forma:SolidPeso molecular:467.32MALT1-IN-9
CAS:<p>MALT1-IN-9: potent MALT1 protease inhibitor, IC50 <500 nM in Raji cells, significant anticancer effects.</p>Fórmula:C16H12ClF3N6OCor e Forma:SolidPeso molecular:396.75FEN1-IN-5
CAS:<p>FEN1-IN-5 (compound 12A) is a potent Flap endonuclease-1 (FEN1) inhibitor with an IC50 value of 12 nM, playing a role in DNA repair mechanisms [1].</p>Fórmula:C21H17N3O4SPureza:98%Cor e Forma:SolidPeso molecular:407.44Keap1-Nrf2-IN-15
CAS:<p>Keap1-Nrf2-IN-15 (Compound 24a) is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, displaying IC50 values of 77 nM in a fluorescence</p>Fórmula:C39H35N3O12S2Cor e Forma:SolidPeso molecular:801.84
