Imunologia e Inflamação
Os inibidores de imunologia e inflamação são compostos que modulam a resposta imunológica e os processos inflamatórios. Esses inibidores são cruciais para estudar os mecanismos de regulação imunológica, autoimunidade e inflamação crônica, bem como para desenvolver tratamentos para doenças inflamatórias, alergias e distúrbios relacionados ao sistema imunológico. Ao direcionar vias-chave no sistema imunológico, esses inibidores podem ajudar a reduzir respostas imunológicas excessivas ou inadequadas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de alta qualidade para apoiar sua pesquisa em imunologia, inflamação e desenvolvimento terapêutico.
Subcategorias de "Imunologia e Inflamação"
- CCR(136 produtos)
- CXCR(148 produtos)
- Parede celular(5 produtos)
- Receptor IL(112 produtos)
- IκB/IKK(60 produtos)
- LTR(3 produtos)
- MALT(23 produtos)
- MRP(6 produtos)
- NADPH-oxidase(1 produtos)
- NF-κB(444 produtos)
- NOD(17 produtos)
- NOS(63 produtos)
- Nrf2(79 produtos)
- PGE Sintase(31 produtos)
- ROS(69 produtos)
- TGF-beta/Smad(58 produtos)
- TLR(66 produtos)
- Tiorredoxina(12 produtos)
- gp120/CD4(4 produtos)
Exibir 11 mais subcategorias
Foram encontrados 3045 produtos de "Imunologia e Inflamação"
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Glabrescone C
CAS:<p>Glabrescone C exhibits strong anti-inflammatory properties through direct binding to IKKα/β.</p>Fórmula:C19H22O7Cor e Forma:SolidPeso molecular:362.37(R)-IL-17 modulator 4
CAS:<p>(R)-IL-17 modulator 4, an R-isomer prodrug of IL-17 modulator 1, is potent and taken orally.</p>Fórmula:C27H34N6O2Cor e Forma:SolidPeso molecular:474.6Glu-urea-Glu-NHS ester
CAS:<p>Compound 21, Glu-urea-Glu-NHS ester, an activated N-hydroxysuccinamide (NHS) ester derivative of Glu-urea-Glu, serves as a pharmacophore for conjugation to prostate specific membrane antigen (PSMA) inhibitors [1].</p>Fórmula:C27H43N3O11Cor e Forma:SolidPeso molecular:585.64TLR7 agonist 14
CAS:<p>Compound 17b, a TLR7 agonist also known as TLR7 agonist 14, exhibits high potency with an EC50 of 18 nM.</p>Fórmula:C29H36N6O3Cor e Forma:SolidPeso molecular:516.63FCE-27164
CAS:<p>FCE-27164 inhibits PDGF-β and IL-7 receptor binding, potentially modulating inflammatory and immune responses for therapeutic applications.</p>Fórmula:C45H34N10Na6O23S6Pureza:96.04%Cor e Forma:SolidPeso molecular:1413.11DNA polymerase-IN-1
CAS:<p>DNA polymerase-IN-1 exhibits antiproliferative activity against tumor cells and inhibits Taq DNA polymerase as a DNA polymerase inhibitor.</p>Fórmula:C10H7ClO4Pureza:99.16%Cor e Forma:SolidPeso molecular:226.61CAY10464
CAS:<p>CAY10464 (AHR antagonist 7) is an AHR antagonist for the study of cancer and metabolic diseases.</p>Fórmula:C15H12Cl2OPureza:99.96%Cor e Forma:SolidPeso molecular:279.16TLR7 agonist 15
CAS:<p>TLR7 agonist 15 (compound 16b) is a potent activator of mouse macrophages and hPBMCs, demonstrating an EC50 of 18 nM.</p>Fórmula:C26H31N5OCor e Forma:SolidPeso molecular:429.56Tyrosinase-IN-22
CAS:<p>Tyrosinase-IN-22 (compound 4) serves as a potent inhibitor for tyrosinase substrates, namely L-tyrosine and L-dopa, exhibiting inhibitory concentrations (IC50s) of 60 nM and 30 nM, respectively. Additionally, it demonstrates significant antioxidant and anti-melanogenic properties, making it suitable for related research endeavors [1].</p>Fórmula:C7H5ClN2SCor e Forma:SolidPeso molecular:184.64GSK840
CAS:<p>GSK840 (GSK'840) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds the RIP3 kinase domain (IC50: 0.9 nM), and inhibits kinase</p>Fórmula:C21H23N3O3Pureza:99.7%Cor e Forma:SolidPeso molecular:365.43TLR7 agonist 16
CAS:<p>TLR7 agonist 16 (compound 16d) is a potent activator of TLR7 with an EC50 value of 18 nM.</p>Fórmula:C25H29N5O2Cor e Forma:SolidPeso molecular:431.53AVP-13358
CAS:<p>AVP-13358: a CD23/IgE inhibitor for treating immune, infection, and ENT disorders.</p>Fórmula:C30H29N5O2Pureza:98.42%Cor e Forma:SolidPeso molecular:491.58ERDRP-0519
CAS:<p>ERDRP-0519 is an oral measles polymerase inhibitor, preventing disease in monkeys, with potent nanomolar efficacy against morbilliviruses.</p>Fórmula:C23H30F3N5O4SPureza:98.64% - 98.71%Cor e Forma:SolidPeso molecular:529.58LTβR-IN-1
CAS:<p>LTβR-IN-1 is a potent and selective lymphin β receptor (LTβR) inhibitor.</p>Fórmula:C18H16N4O2Pureza:98.93%Cor e Forma:SolidPeso molecular:320.35GW274150
CAS:<p>GW274150: selective oral iNOS inhibitor (Kd=40 nM), low activity on eNOS/nNOS, protective in acute lung injury.</p>Fórmula:C8H17N3O2SPureza:96.43%Cor e Forma:SolidPeso molecular:219.3Netakimab
CAS:<p>Netakimab (BCD 085) is a monoclonal antibody targeting interleukin-17A and can be used to study spondyloarthritis.</p>Pureza:95%Cor e Forma:LiquidPeso molecular:145.74 kDaIL-17 modulator 4
CAS:<p>IL-17 modulator 4 is a prodrug of IL-17 modulator 1, which acts as a potent modulator of IL-17.Cost-effective and quality-assured.</p>Fórmula:C27H34N6O2Pureza:99.59%Cor e Forma:SolidPeso molecular:474.6ADS032
CAS:<p>ADS032 (BT-032) is an NLRP1 and NLRP3 inhibitor with anti-inflammatory activity for the study of respiratory inflammation or infection.</p>Fórmula:C22H29NO4SPureza:98.37%Cor e Forma:SolidPeso molecular:403.54Usnoflast
CAS:<p>Usnoflast (ZYIL1) is an NLRP3 inhibitor, inhibiting NLRP3 inflammasome activation, used in neurological disease research.</p>Fórmula:C21H29N3O3SPureza:98.79%Cor e Forma:SolidPeso molecular:403.54Sembragiline
CAS:<p>Sembragiline (EVT-302) is a selective MAO-B inhibitor for the study of Alzheimer's disease (AD).</p>Fórmula:C19H19FN2O3Pureza:99.49% - 99.49%Cor e Forma:SolidPeso molecular:342.36Iptacopan
CAS:<p>Iptacopan (LNP023) is an inhibitor with high affinity to factor B, with a KD value of 7.9 nM and an IC50 value of 10 nM. Cost-effective and quality-assured.</p>Fórmula:C25H30N2O4Pureza:99.07% - >99.99%Cor e Forma:SolidPeso molecular:422.52Oditrasertib
CAS:<p>Oditrasertib, a RIPK1 inhibitor characterized by an IC50 value below 100 nM, is employed in inflammation research.</p>Fórmula:C14H15F2N3O2Pureza:98.65% - 99.65%Cor e Forma:SolidPeso molecular:295.28Supercinnamaldehyde
CAS:<p>Supercinnamaldehyde is a potent activator of transient receptor potential ankyrin 1 (TRPA1), exhibiting an EC50 of 0.8 μM, and induces activation of TRPA1 ion</p>Fórmula:C12H11NO2Pureza:98.89%Cor e Forma:SolidPeso molecular:201.22Antiviral agent 34
CAS:<p>Antiviral Agent 34 is an antiviral compound that inhibits influenza virus and inhibits the proliferation of influenza virus by modulating RNA polymerase.</p>Fórmula:C29H33N3O2SPureza:99.51%Cor e Forma:SoildPeso molecular:487.66CU-CPD107
CAS:<p>CU-CPD107 selectively activates TLR8 and ssRNA, inhibits TLR8 with R848 (IC50=13.7 μM), and coactivates with ssRNA.</p>Fórmula:C16H21IN2O2Pureza:98%Cor e Forma:SolidPeso molecular:400.25Xanthine oxidase-IN-10
CAS:<p>Xanthine oxidase-IN-10 (XO8 analog) is a xanthine oxidase (XO) inhibitor for the study of gout.</p>Fórmula:C10H8N2OSPureza:99.16%Cor e Forma:SolidPeso molecular:204.25Piflufolastat
CAS:<p>Piflufolastat (DCFPYL) is a PET imaging agent for prostate cancer PSMA.</p>Fórmula:C18H23FN4O8Pureza:98.98%Cor e Forma:SolidPeso molecular:442.4Nrf2-IN-3
CAS:<p>Nrf2-IN-3 is an NRF2 inhibitor that selectively sensitizes xenografts of mouse mKEAP1 cancer cells to cisplatin.</p>Fórmula:C22H26N4O4SPureza:98.07%Cor e Forma:SolidPeso molecular:442.53(±)-CPSI-1306
CAS:<p>(±)-CPSI-1306 (2-(3-(2,4-Difluorophenyl)-4,5-dihydroisoxazol-5-yl)-1-morpholinoethan-1-one) is a macrophage migration inhibitory factor (MIF) antagonist and can</p>Fórmula:C15H16F2N2O3Pureza:97.46%Cor e Forma:SolidPeso molecular:310.3GB1107
CAS:<p>GB1107 is an effective and selective Galectin-3 inhibitor with a Kd of 37 nM.</p>Fórmula:C20H16Cl2F3N3O4SPureza:98.33% - 99.87%Cor e Forma:SolidPeso molecular:522.32ABR-238901
CAS:<p>ABR-238901 is an oral, active S100A8/A9 blocker that inhibits the interaction of S100A8/A9 with its receptors RAGE(receptor for advanced glycation end products</p>Fórmula:C11H9BrClN3O4SPureza:98.63% - 98.71%Cor e Forma:SolidPeso molecular:394.63RIPK1-IN-4
CAS:<p>RIPK1-IN-4 is a potent and selective type II kinase receptor interacting protein 1 (RIP1) kinase inhibitor and binds to a DLG-out inactive form of RIP1 (IC50s</p>Fórmula:C23H23N5O2Pureza:99.94%Cor e Forma:SolidPeso molecular:401.46cGAS-IN-4
CAS:<p>cGAS-IN-4 (Compound 36) is an orally active inhibitor of cyclic GMP-AMP synthase (cGAS) with IC50 values of 32 nM for human cGAS (h-cGAS) and 5.8 nM for mouse cGAS (m-cGAS). In THP-1 cells, cGAS-IN-4 inhibits cGAMP with an IC50 of 60 nM, enhancing cellular potency. Additionally, cGAS-IN-4 exhibits anti-inflammatory effects in a mouse model of Concanavalin A-induced acute liver injury.</p>Fórmula:C19H18Cl2N4O3Cor e Forma:SolidPeso molecular:421.277IRAK4-IN-15
CAS:<p>IRAK4-IN-15: selective IRAK4 inhibitor, IC50 0.002 μM, good PK, low clearance, synergizes with Acalabrutinib in MyD88/CD79 mutant ABC-DLBCL.</p>Fórmula:C25H29FN10Cor e Forma:SolidPeso molecular:488.56Creatine ethyl ester
CAS:<p>Creatine ethyl ester (CEE) is a readily available form of creatine commonly used in supplements. It can upregulate TLRs (TLR2, 3, 4, and TLR7) over a short period.</p>Fórmula:C6H13N3O2Cor e Forma:SolidPeso molecular:159.186DPP4-In hydrochloride
CAS:<p>DPP4-In (hydrochloride) is an inhibitor of dipeptidyl peptidase 4 (DPP4) that effectively reduces the expression of DPP4.</p>Fórmula:C14H21ClN4O2Cor e Forma:SolidPeso molecular:312.8Cyclic-di-GMP sodium
<p>c-di-GMP sodium: STING activator, regulates bacteria biofilm, motility, virulence.</p>Fórmula:C20H24N10NaO14P2Cor e Forma:SolidPeso molecular:713.08464EGR-1-IN-3
CAS:<p>EGR-1-IN-3 (Compound 36) is an inhibitor of early growth response 1 (EGR-1) binding to DNA. It effectively suppresses the binding of EGR-1 to DNA and the expression of inflammation-related genes (such as TSLP, IL-31, IL-6, and CCL2) induced by TNFα. This compound is applicable to the study of inflammatory diseases.</p>Fórmula:C31H31N3O6SCor e Forma:SolidPeso molecular:573.659FAPI-74
CAS:<p>FAPI-74 is a PET (positron emission tomography) tracer involved in early FAPI-PET imaging.FAPI-74 can be used to study cancer tumors and degenerative diseases.</p>Fórmula:C36H49N9O8Cor e Forma:SolidPeso molecular:735.83Amilo-5MER
CAS:<p>Amilo-5MER (5-MP) is an orally active and selective inhibitor of serum amyloid A (SAA). It specifically suppresses the release of pro-inflammatory cytokines IL-6 and IL-1β in SAA-activated cells. Amilo-5MER reduces chronic inflammation and alleviates symptoms of diseases such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and multiple sclerosis (MS). It holds potential for research in autoimmune and chronic inflammatory diseases.</p>Fórmula:C23H40N6O9SCor e Forma:SolidPeso molecular:576.664Ocadusertib
CAS:<p>Ocadusertib is an effective inhibitor of the serine/threonine kinase receptor-interacting protein kinase 1 (RIPK1).</p>Fórmula:C25H25N5O4Cor e Forma:SolidPeso molecular:459.50AhR agonist 8
CAS:<p>Compound 9, also known as AhR agonist 8, effectively activates the Aryl Hydrocarbon Receptor (AhR) with an EC50 of 0.154 nM. This compound is utilized in researching psoriasis and atopic dermatitis.</p>Fórmula:C17H15FN4OCor e Forma:SolidPeso molecular:310.33TNFα activity modulator 3
CAS:<p>TNFα Activity Modulator 3 (example 6) is a molecule that regulates TNF activity by inhibiting TNFα-induced NF-κB activation, making it applicable for related research.</p>Fórmula:C27H24F2N6O2Cor e Forma:SolidPeso molecular:502.52NLRP3-IN-44
CAS:<p>NLRP3-IN-44 (compound P33), an orally active (approximately 62%) and potent inhibitor of NLRP3, exhibits a dissociation constant (K D) of 17.5 nM. This compound is crucial in the research of diseases mediated by the NLRP3 inflammasome.</p>Fórmula:C25H30N4O3Cor e Forma:SolidPeso molecular:434.53GTCpFE
CAS:GTCpFE, a compound synthesized from Dimethyl fumarate (DMF) and Aspirin (ASA), inhibits IKKα/β in the NF-κB pathway, exhibiting anti-inflammatory activity by preventing p65 from entering the nucleus. It selectively inhibits cancer stem cell (CSC) activity by reducing the growth of mammospheres and the expression of the CD44+CD24- immune phenotype. Furthermore, GTCpFE targets breast cancer stem cells, crucial in aggressive cancer phenotypes that depend on NFκB and PGE2.Fórmula:C22H20O8Cor e Forma:SolidPeso molecular:412.39Panaxcerol B
CAS:<p>Panaxcerol B, a monogalactosyl monoacylglycerol, exhibits an IC50 value of 59.4 μM against NO production in LPS-stimulated RAW264.7 cells.</p>Fórmula:C27H46O9Cor e Forma:SolidPeso molecular:514.65SBI-0640726
CAS:<p>SBI-0640726, an eIF4G1 inhibitor, exhibits antiproliferative activity against melanoma. It disrupts the eIF4F translation initiation complex by inhibiting the AKT and NF-kB signaling pathways. Additionally, SBI-0640726 inhibits the growth of melanoma with NRAS and BRAF mutations in vitro.</p>Fórmula:C23H15ClN2O2Cor e Forma:SolidPeso molecular:386.83LD03-DEX
CAS:LD03-DEX is a precursor compound of dexamethasone, characterized by its immunosuppressive activity.Fórmula:C44H65FO8Peso molecular:740.98Indeno[1,2,3-cd]pyrene
CAS:<p>Indeno[1,2,3-cd]pyrene, a polycyclic aromatic hydrocarbon, exhibits moderate cytotoxicity to human alveolar epithelial cells (HPAEpiC). Additionally, it enhances allergic pulmonary inflammation responses through the activation of the aryl hydrocarbon receptor.</p>Fórmula:C22H12Cor e Forma:SolidPeso molecular:276.33UM-3006
CAS:UM-3006 is a potent TLR7/8 agonist that enhances immune responses by activating the TLR signaling pathway. This compound holds significant research and application potential in the fields of vaccine adjuvants and immune diseases.Fórmula:C20H34N6O2Peso molecular:390.52
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