Sinalização JAK/STAT
Os inibidores da sinalização JAK/STAT são compostos que interrompem a via da Janus quinase (JAK) e do transdutor e ativador da transcrição (STAT), que está envolvida na sinalização de citocinas, crescimento celular e resposta imunológica. Esses inibidores são ferramentas importantes para estudar a regulação dessa via e seu papel em diversas doenças, incluindo cânceres, distúrbios imunológicos e condições inflamatórias. Os inibidores de JAK/STAT também estão sendo desenvolvidos como terapias direcionadas para essas doenças. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de sinalização JAK/STAT de alta qualidade para apoiar sua pesquisa em biologia molecular, oncologia e imunologia.
Subcategorias de "Sinalização JAK/STAT"
Foram encontrados 362 produtos de "Sinalização JAK/STAT"
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Tyk2-IN-7
CAS:Tyk2-IN-7 is an inhibitor of TYK2 JH2, binds to the TYK2 JH2 domain (IC50: 0.00053 μM; Ki.app: 0.00007 μM).Fórmula:C18H15D3N6O3SPureza:98%Cor e Forma:SolidPeso molecular:401.46MS-1020
CAS:MS-1020 inhibits JAK3/STAT3, blocks active JAK3, suppresses JAK3/STAT5 signaling, and targets STAT3 in certain cells.Fórmula:C21H18N2O3Pureza:98%Cor e Forma:SolidPeso molecular:346.381,2,3,4,5,6-Hexabromocyclohexane
CAS:Inhibits JAK2 autophosphorylation; non-cytotoxic at 100μM; 1μM reduces activity by 50%, 50μM nearly abolishes it.Fórmula:C6H6Br6Pureza:98%Cor e Forma:SolidPeso molecular:557.54OICR-0547
CAS:OICR-0547 is an inactive derivative of OICR-9429 and is commonly used as a negative control for OICR-9429.Fórmula:C28H29F3N4O4Pureza:98%Cor e Forma:SolidPeso molecular:542.55JAK3-IN-9
CAS:JAK3-IN-9, potent JAK3 inhibitor, IC50 of 1.7 nM, highly selective, low toxicity, orally bioavailable, shows anti-arthritis activity.Fórmula:C17H23N5O4SCor e Forma:SolidPeso molecular:393.46EP009
CAS:EP009, a novel, selective, and orally active inhibitor of JAK3, induces therapeutic response in T-cell malignancies.Fórmula:C14H24O2Cor e Forma:SolidPeso molecular:224.34INCB16562
CAS:INCB16562: oral JAK1/2 inhibitor, halts IL-6/STAT3 in myeloma cells, boosts drug efficacy, stunts myeloma in mice.Fórmula:C19H11Cl2N5Cor e Forma:SolidPeso molecular:380.23BP-5-087
CAS:BP-5-087 is a STAT3 inhibitor, combining with BCR-ABL1 inhibition to overcome kinase-independent resistance in chronic myeloid leukemia.Fórmula:C36H30F8N2O6SCor e Forma:SolidPeso molecular:770.69Galiellalactone
CAS:inhibits IL-6-mediated JAK/STAT signal transductionFórmula:C11H14O3Pureza:98%Cor e Forma:SolidPeso molecular:194.23CP-690550A
CAS:Cp-690550a is a novel JAK3 inhibitor, which is used to treat rheumatoid arthritis, graft rejection, psoriasis, and other immune-mediated diseases.Fórmula:C15H21N5O2Cor e Forma:SolidPeso molecular:303.36GDC-4379
CAS:GDC-4379 is a JAK1 inhibitor that can be used to study asthma.Fórmula:C21H18ClF2N7O3Cor e Forma:SolidPeso molecular:489.86Peficitinib hydrobromide
CAS:Peficitinib hydrobromide is used in the treatment of Psoriasis and Rheumatoid Arthritis.Fórmula:C18H23BrN4O2Cor e Forma:SolidPeso molecular:407.312Povorcitinib
CAS:Povorcitinib is a highly potent and selective JAK1 inhibitor with significant potential for the investigation of cutaneous lupus erythematosus (CLE) and Lichen planus (LP).Fórmula:C23H22F5N7OCor e Forma:SolidPeso molecular:507.469(2R,5S)-Ritlecitinib
CAS:(2R,5S)-Ritlecitinib ((2R,5S)-PF-06651600) is a potent and selective inhibitor of JAK3 with IC 50 of 144.8 nM[1].Fórmula:C15H19N5OCor e Forma:SolidPeso molecular:285.34YM-341619
CAS:YM-341619 (AS1617612), potent STAT6 inhibitor; IC50: 0.70 nM; hinders IL-4-induced Th2 in mice; may aid allergic disease research.Fórmula:C22H21F3N6O2Cor e Forma:SolidPeso molecular:458.44TUL01101
CAS:TUL01101, a selective oral JAK1 inhibitor (IC50: 3 nM), also targets JAK2, JAK3, TYK2; for rheumatoid arthritis research.Fórmula:C22H25F2N5O2Cor e Forma:SolidPeso molecular:429.46Stafia-1-dipivaloyloxymethyl ester
CAS:Stafia-1 suppresses pSTAT5a in a dose-dependent manner (0-200 μM) without affecting pSTAT5b.Fórmula:C37H48FO13PCor e Forma:SolidPeso molecular:750.74MM-206
CAS:MM-206, a cell-permeable, non-cytotoxic naphthalene sulfonamide compound, it effectively inhibits STAT3 DNA-binding activity.Fórmula:C22H12F5NO3S2Cor e Forma:SolidPeso molecular:497.46MC0704
MC0704: STAT3 inhibitor, IC50=2.13μM, promotes apoptosis & cell arrest, anti-breast cancer, for mTNBC research.Fórmula:C29H21BrN4O2Cor e Forma:SolidPeso molecular:537.41STAT3-IN-15
STAT3-IN-15: Potent, oral STAT3 inhibitor for IPF, blocks STAT3 phosphorylation, cell migration, and EMT.Fórmula:C20H17F3N2O3SCor e Forma:SolidPeso molecular:422.42
