Sinalização JAK/STAT
Os inibidores da sinalização JAK/STAT são compostos que interrompem a via da Janus quinase (JAK) e do transdutor e ativador da transcrição (STAT), que está envolvida na sinalização de citocinas, crescimento celular e resposta imunológica. Esses inibidores são ferramentas importantes para estudar a regulação dessa via e seu papel em diversas doenças, incluindo cânceres, distúrbios imunológicos e condições inflamatórias. Os inibidores de JAK/STAT também estão sendo desenvolvidos como terapias direcionadas para essas doenças. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de sinalização JAK/STAT de alta qualidade para apoiar sua pesquisa em biologia molecular, oncologia e imunologia.
Subcategorias de "Sinalização JAK/STAT"
Foram encontrados 362 produtos de "Sinalização JAK/STAT"
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Thi-DPPY
CAS:Thi-DPPY: Potent JAK3/BTK inhibitor (IC50: 1.38/62.4 nM), anti-proliferative, anti-inflammatory, potential in IPF research.Fórmula:C28H28ClN5O4SCor e Forma:SolidPeso molecular:566.07HJC0149
CAS:HJC0149 is a potent orally bioavailable signal transducer and activator of transcription 3 inhibitor.Fórmula:C15H10ClNO4SCor e Forma:SolidPeso molecular:335.76TYK2-IN-11
CAS:TYK2-IN-11 (5B) selectively inhibits TYK2 (IC50: 0.016 nM) and JAK1 (IC50: 0.31 nM), aiding autoimmune and inflammatory disease research.Fórmula:C18H17N5O3SCor e Forma:SolidPeso molecular:383.42SYK/JAK-IN-1
CAS:SYK/JAK-IN-1 is a dual SYK/JAK inhibitor with IC50 values of less than 5 nM for both SYK and JAK2.Fórmula:C24H26N8O3Cor e Forma:SolidPeso molecular:474.52PF-00956980
CAS:PF-00956980: reversible JAK inhibitor, IC50: JAK1 (2.2μM), JAK2 (23.1μM), JAK3 (59.9μM), for lung/skin inflammation research.Fórmula:C18H26N6OCor e Forma:SolidPeso molecular:342.44LLL12
CAS:LLL12 inhibits STAT3 phosphorylation, boosting Cisplatin and Paclitaxel effects against ovarian cancer cell activities.Fórmula:C14H9NO5SCor e Forma:SolidPeso molecular:303.29JAK-IN-10
CAS:JAK-IN-10 is a JAK inhibitor. JAK-IN-10 can be used for the research of dry eye disorders.Fórmula:C20H18FN5O3SPureza:99.53%Cor e Forma:SolidPeso molecular:427.45Ref: TM-T13571
1mg82,00€5mg167,00€10mg246,00€25mg405,00€50mg572,00€100mg772,00€500mg1.539,00€1mL*10mM (DMSO)178,00€JAK3-IN-1
CAS:JAK3-IN-1 is an orally active, selective and potent JAK3 inhibitor for the study of immune system disorders.Fórmula:C26H30ClN7O2Cor e Forma:SolidPeso molecular:508.02JMS-053
CAS:JMS-053 is a phosphatase DUSP3 inhibitor that inhibits CDC25B and prevents VEGF from disrupting the microvascular endothelial barrier.Fórmula:C13H8N2O2SPureza:≥98.0%Cor e Forma:SolidPeso molecular:256.28TP-5801
CAS:TP-5801 is an orally active non-receptor tyrosine kinase (TNK1) inhibitor with an IC50 value of 1.40 nM and antitumor effects.Fórmula:C24H31BrN8OCor e Forma:SolidPeso molecular:527.46AC430
CAS:AC430, a specific JAK2 inhibitor for cancer and autoimmune therapy, excels in preclinical trials with low doses. Developed by Ambit.Fórmula:C19H16FN5OCor e Forma:SolidPeso molecular:349.36CAY10784
CAS:CAY10784(STAT3-IN-17) is a STAT3 inhibitor with antiproliferative and antitumor activities. CAY10784 showed antibacterial activity against Clostridium difficileFórmula:C11H6F3N3O3SPureza:99.74%Cor e Forma:SolidPeso molecular:317.24JAK-IN-21
CAS:JAK-IN-21 is a selective and potent JAK inhibitor that inhibits JAK1, JAK2, J2V617F and TYK2 with IC50 values of 1.73, 2.04, 109 and 62.9 nM, respectively.Fórmula:C19H16N8OPureza:99.87%Cor e Forma:SolidPeso molecular:372.38inS3-54-A26
CAS:inS3-54-A26 is an inhibitor of the DNA-binding domain of STAT3. inS3-54-A26 suppresses tumor growth, metastasis and the gene expression of STAT3.Fórmula:C25H19ClN2O2Pureza:99.57%Cor e Forma:SolidPeso molecular:414.88Ref: TM-T27613
1mg109,00€2mg163,00€5mg241,00€10mg355,00€25mg532,00€50mg745,00€100mg1.018,00€500mgA consultarJAK-IN-30
CAS:JAK-IN-30 (compound 31) is a water-soluble inhibitor of Janus kinases (JAKs), demonstrating inhibitory potency with half-maximal inhibitory concentration (IC50Fórmula:C19H26N8SPureza:98%Cor e Forma:SolidPeso molecular:398.53JAK-IN-28
CAS:JAK-IN-28 (Compound 111) is a Janus kinase (JAK) inhibitor potentially applicable in the research of cancer and inflammatory diseases [1].Fórmula:C20H18ClN7OPureza:98%Cor e Forma:SolidPeso molecular:407.86AZD-1897
CAS:AZD-1897 is a highly efficient ATP-competitive pan-PIM inhibitor with anti-cancer and anti-leukemia activity, used in multiple myeloma research.Fórmula:C18H23N3O3SPureza:99.49%Cor e Forma:SolidPeso molecular:361.46M-110
CAS:M-110 selectively targets PIM kinases, best at PIM-3 (IC50=47nM), and inhibits prostate cancer cell growth (IC50=0.6-0.9μM).Fórmula:C22H28ClN5O3Pureza:99.55%Cor e Forma:SolidPeso molecular:445.94JAK1-IN-4
CAS:JAK1-IN-4 selectively blocks JAK1 (IC50 = 85 nM) over JAK2/JAK3 and halts STAT3 phosphorylation in NCI-H 1975 cells (IC50 = 227 nM).Fórmula:C26H32FN9O2Pureza:98%Cor e Forma:SolidPeso molecular:521.59JAK3/BTK-IN-2
CAS:JAK3/ BTk-in-2 is a potent JAK3/BTK inhibitor.
Fórmula:C25H32N8O2Pureza:99.64% - 99.87%Cor e Forma:SolidPeso molecular:476.57
