Transportador de Membranas/Canal Iónico
Os inibidores de transportadores de membrana e canais iônicos são compostos que bloqueiam a função de proteínas responsáveis pelo transporte de íons, nutrientes e outras moléculas através das membranas celulares. Esses inibidores são cruciais para o estudo da regulação da homeostase celular, transdução de sinais e neurotransmissão. Os inibidores de transportadores de membrana e canais iônicos também são importantes no desenvolvimento de tratamentos para distúrbios como epilepsia, doenças cardiovasculares e síndromes metabólicas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de alta qualidade de transportadores de membrana e canais iônicos para apoiar sua pesquisa em fisiologia, neurociência e farmacologia.
Subcategorias de "Transportador de Membranas/Canal Iónico"
- ABC(3 produtos)
- ATPase(93 produtos)
- Receptor de adiponectina(5 produtos)
- CFTR(64 produtos)
- Receptor CGRP(51 produtos)
- Canais de Cálcio(493 produtos)
- Canal de cloreto(49 produtos)
- Receptor GABA(336 produtos)
- Transportador de monoamina(23 produtos)
- Transportador de monocarboxilato(17 produtos)
- NKCC(2 produtos)
- NPC1L1(3 produtos)
- Cotransportador Na-K-Cl(8 produtos)
- OAT(27 produtos)
- OCT(7 produtos)
- P-gp(53 produtos)
- Canal de Potássio(276 produtos)
- Bomba de prótons(39 produtos)
- SGLT(30 produtos)
- Canal de Sódio(202 produtos)
- Canal TRP/TRPV(93 produtos)
Exibir 13 mais subcategorias
Foram encontrados 2277 produtos de "Transportador de Membranas/Canal Iónico"
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CGP 64213
CAS:<p>CGP 64213 is a GABAb receptor agonist.</p>Fórmula:C26H36IN2O7PPureza:98%Cor e Forma:SolidPeso molecular:646.45AMPA receptor modulator-2
CAS:<p>AMPA receptor modulator-2 is a modulator of AMPA receptor. The pIC50 value for TARPγ2 dependent AMPA receptor is 10.1.</p>Fórmula:C15H6F6N4OSPureza:99.8%Cor e Forma:SolidPeso molecular:404.29PF-06456384
CAS:<p>PF-06456384 is a highly potent and selective NaV1.7 inhibitor with IC50 value of 0.01 nM.</p>Fórmula:C35H32F3N7O3S2Pureza:98%Cor e Forma:SolidPeso molecular:719.8VU6007477
CAS:<p>VU6007477: M1 PAM, EC50=230 nM, min. agonist activity, penetrates CNS, no seizure AEs.</p>Fórmula:C24H26N6O2Cor e Forma:SolidPeso molecular:430.5CRF1 receptor antagonist-1
CAS:<p>CRF1 Receptor Antagonist-1 (Compound 2), a CRF1 receptor antagonist, is utilized in research pertaining to congenital adrenal hyperplasia (CAH) [1].</p>Fórmula:C27H28ClFN2O2SPureza:98%Cor e Forma:SolidPeso molecular:499.04NPBA
CAS:<p>NPBA, a potassium K2P channel TASK-3 (KCNK9) agonist, concurrently functions as a blocker of the tandem pore domain weak inward rectifying K+ channel (TWIK2). This compound effectively inhibits NLRP3 inflammasome activation in macrophages [1].</p>Fórmula:C16H14F3N3O3Cor e Forma:SolidPeso molecular:353.3KCa1.1 channel activator-1
<p>A selective vascular KCa1.1 channel stimulator with CaV1.2 blocking ability and mild myorelaxant effects.</p>Fórmula:C25H16O10Cor e Forma:SolidPeso molecular:476.39GMA-839
CAS:<p>GMA-839 is a selective modulator of gamma-aminobutyric acid(A) receptors.</p>Fórmula:C21H31F3O3Pureza:98%Cor e Forma:SolidPeso molecular:388.46Piprofurol
CAS:<p>Piprofurol is used as a Calcium channel blocker.</p>Fórmula:C26H33NO6Pureza:98%Cor e Forma:SolidPeso molecular:455.54(Rac)-AMG8379
CAS:<p>(Rac)-AMG8379 ((Rac)-AMG8380) is a racemate of AMG8379 which is an orally active and selective sulfonamide NaV1.7 antagonist.</p>Fórmula:C25H16ClF2N3O5SPureza:99.6%Cor e Forma:SolidPeso molecular:543.93AGN-201904Z
CAS:<p>AGN-201904Z is a slow-release, acid-resistant pro-PPI that turns into omeprazole, offering extended acid suppression.</p>Fórmula:C25H25N3NaO8S2Pureza:98%Cor e Forma:SolidPeso molecular:582.6Nalanthalide
CAS:<p>Nalanthalide, serving as a voltage-gated potassium channel Kv1.3 blocker (IC50 = 3.9 µM) with potential immunosuppressive properties, is applicable in the research of inflammatory immune diseases including neuroinflammation [1] [2].</p>Fórmula:C30H44O5Cor e Forma:SolidPeso molecular:484.67RS 5773
CAS:<p>RS 5773 is a benzothiazepine derivative with antianginal effects.</p>Fórmula:C29H33ClN2O4SPureza:98%Cor e Forma:SolidPeso molecular:541.1AR-C141990
CAS:<p>AR-C141990 is a lactate transporters inhibitor.</p>Fórmula:C26H28N4O4SCor e Forma:SolidPeso molecular:492.59NaPi2b-IN-2
CAS:<p>NaPi2b-IN-2 (compound 5) serves as a potent inhibitor of the sodium-dependent transport protein 2b (SLC34A2, NaPi2b), exhibiting an IC50 of 38 nM against human</p>Fórmula:C41H47ClF3N5O5SPureza:98%Cor e Forma:SolidPeso molecular:814.36BTG 502
CAS:<p>BTG 502 is an alkylamide insecticide that binds to voltage-gated sodium channels, antagonising the activation of sodium channels by Batrachotoxin (BTX).</p>Fórmula:C21H24BrNOPureza:99.30%Cor e Forma:SolidPeso molecular:386.33Kv3 modulator 4
CAS:<p>Kv3 modulator 4 is a Kv3.1 (pEC50=5.45) and Kv3.2 modulator .Cyclobutyl structure.</p>Fórmula:C20H24N2O4Pureza:98%Cor e Forma:SolidPeso molecular:356.42TROX-1
CAS:<p>TROX-1 is the activation state-dependent Cav2 channel antagonist.</p>Fórmula:C22H16ClFN6OPureza:98%Cor e Forma:SolidPeso molecular:434.85JT010
CAS:<p>JT010 is an effective agonist of TRPA1 (EC50 = 0.65 nM).</p>Fórmula:C16H19ClN2O3SPureza:99.75%Cor e Forma:SolidPeso molecular:354.85SN40 hydrochloride
CAS:<p>SN40 hydrochloride is a potent inhibitor of amino acid transport (AAT), exhibiting inhibitory constants (Kis) of 7.29 μM, 2.42 μM, 2.94 μM, 5.55 μM, 24.43 μM, and 5.55 μM for rat ASCT2, human ASCT2, EAAT1, EAAT2, EAAC1, and EAAT5, respectively. It is utilized in cancer research. [1]</p>Fórmula:C18H21ClN2O2Cor e Forma:SolidPeso molecular:332.82TRPC3/6-IN-2
CAS:<p>TRPC3/6-IN-2 is a potent inhibitor of TRPC3 and TRPC6, exhibiting IC50 values of 16 nM for TRPC3 and 29.8 nM for TRPC6, respectively [1].</p>Fórmula:C18H23F2N5Cor e Forma:SolidPeso molecular:347.41Dimethylamiloride
CAS:<p>Dimethylamiloride is a specific inhibitor of antiporters [1].</p>Fórmula:C8H12ClN7OPureza:98%Cor e Forma:SolidPeso molecular:257.68Dasolampanel etibutil
CAS:<p>Dasolampanel etibutil is a novel selective antagonist of ionotropic glutamate receptor 5 (iGluR5).</p>Fórmula:C23H32ClN5O3Cor e Forma:SolidPeso molecular:461.98FGIN-1-27
CAS:<p>FGIN-1-27 is a high-affinity agonist of the translocator protein and a specific peripheral benzodiazepine receptor (PBR) ligand(Ki = 5.0 nM).</p>Fórmula:C28H37FN2OPureza:99.86%Cor e Forma:SolidPeso molecular:436.6VU0463271
CAS:<p>VU0463271: KCC2 antagonist, IC50 61 nM, >100x selective over NKCC1, inactive on other GPCRs, channels, transporters.</p>Fórmula:C19H18N4OS2Pureza:97.84% - 99.55%Cor e Forma:SolidPeso molecular:382.5COR659
CAS:<p>COR659: suppresses alcohol/chocolate intake in rats; enhances GABAB receptor, blocks CB1 receptor.</p>Fórmula:C16H16ClNO3SPureza:99.75%Cor e Forma:SolidPeso molecular:337.82(R)-3,4-DCPG
CAS:<p>AMPA receptor antagonist with weak activity at NMDA receptors and little activity at kainate receptors</p>Fórmula:C10H9NO6Pureza:98%Cor e Forma:SolidPeso molecular:239.18JM-1232
CAS:<p>JM-1232 is a sedative and hypnotic drug being researched as a potential anesthetic.</p>Fórmula:C24H27N3O2Cor e Forma:SolidPeso molecular:389.49Afizagabar
CAS:<p>Afizagabar, a first-in-class α5-GABAAR antagonist, IC50: 585 nM, Ki: 66 nM, may boost memory.</p>Fórmula:C19H12FN3O2SCor e Forma:SolidPeso molecular:365.38CGP-54626 free base
CAS:CGP-54626 is a selective antagonist of the GABAB receptor (IC50 = 4 nM ).Fórmula:C18H28Cl2NO3PPureza:98%Cor e Forma:SolidPeso molecular:408.3Nepaprazole
CAS:<p>Nepaprazole (TY-11345) is a potent proton pump inhibitor; IC50: 5.8µM at pH 6.0, 9.9µM at pH 7.4. Better inhibition in weak acid.</p>Fórmula:C18H19N3O2SPureza:98%Cor e Forma:SolidPeso molecular:341.43CFTR corrector 12
CAS:<p>CFTR corrector 12 is a CFTR corrector that rescues all mutant proteins except M760R ABCA3 and can be used to study cystic fibrosis.</p>Fórmula:C19H21ClN4O2S2Pureza:99.47%Cor e Forma:SolidPeso molecular:436.98Coelenterazine h
CAS:<p>Coelenterazine H, a Ca2+ sensitive synthetic derivative, is a luminescent biomolecule used to measure Ca2+ changes.</p>Fórmula:C26H21N3O2Pureza:99.49%Cor e Forma:Yellow To Brownish PowderPeso molecular:407.46M084 hydrochloride
CAS:<p>M084 hydrochloride, a TRPC4/5 channel blocker, exhibits IC50 values of 10.3 μM and 8.2 μM, respectively. This compound is noted for its antidepressant and anxiolytic effects [1] [2].</p>Fórmula:C11H16ClN3Cor e Forma:SolidPeso molecular:225.72PF-05105679
CAS:<p>PF-05105679 is a selective TRPM8 antagonist (IC50 = 103 nM). PF-05105679 can be used in research on cold-related pain.</p>Fórmula:C26H21FN2O3Pureza:99.84%Cor e Forma:SolidPeso molecular:428.45PPADS tetrasodium
CAS:<p>PPADS tetrasodiuma is a P2X receptor antagonist and an inhibitor of the inverse mode of Na/Ca²⁺ exchange in guinea pig airway smooth muscle.</p>Fórmula:C14H10N3Na4O12PS2Pureza:95% - ≥95%Cor e Forma:SolidPeso molecular:599.3Crobenetine hydrochloride
CAS:<p>Crobenetine hydrochloride, a sodium channel antagonist, is used potentially for the treatment of stroke.</p>Fórmula:C25H34ClNO2Cor e Forma:SolidPeso molecular:416Zelquistinel
CAS:<p>Zelquistinel, an NMDA receptor agonist, aids research on depression, anxiety, and psychiatric disorders.</p>Fórmula:C15H25N3O5Cor e Forma:SolidPeso molecular:327.38XR9051 Hydrochloride
CAS:<p>XR9051 Hydrochloride, a potent modulator of P-glycoprotein-mediated multidrug resistance (MDR), inhibits the binding of cytotoxics to P-glycoprotein.</p>Fórmula:C39H39ClN4O5Cor e Forma:SolidPeso molecular:679.21CGP 55845 hydrochloride
CAS:<p>CGP55845 hydrochloride is a potent and selective GABAB receptor antagonist with an IC 50 of 6 nM which can be used in neurological research [1] [2].</p>Fórmula:C18H23Cl3NO3PCor e Forma:SolidPeso molecular:438.71SCS
CAS:<p>SCS is a GABAA receptor antagonist.</p>Fórmula:C14H12N2O3Pureza:99.73%Cor e Forma:SolidPeso molecular:256.26L 691121
CAS:<p>L 691121 is a class III antiarrhythmic compound. It also blocks potassium currents.</p>Fórmula:C22H25ClN4O5SPureza:98%Cor e Forma:SolidPeso molecular:492.98α,β-Methylene ATP trisodium
CAS:<p>α,β-Methylene ATP trisodium is a ligand of P2X3 and P2X7 receptor.</p>Fórmula:C11H15N5Na3O12P3Pureza:99.66%Cor e Forma:SolidPeso molecular:571.15Etidocaine Hydrochloride
CAS:<p>Etidocaine Hydrochloride (W19053) is a long-acting anesthetic and a blocker of the voltage-gated sodium channel.</p>Fórmula:C17H29ClN2OPureza:99.86%Cor e Forma:SolidPeso molecular:312.88mGAT-IN-1
CAS:<p>mGAT-IN-1 is a potent, non-selective GAT inhibitor that inhibits mGAT3 activity well (IC50: 2.5 μM, pIC50: 5.61).</p>Fórmula:C28H34ClN3O2S2Cor e Forma:SolidPeso molecular:544.17Risevistinel
CAS:<p>Risevistinel (NYX-783), a positive allosteric modulator of the N-methyl-D-aspartate (NMDA) receptor, may mitigate cognitive deficits in neurodegenerative</p>Fórmula:C14H23N3O4Pureza:98%Cor e Forma:SolidPeso molecular:297.35α,β-Methylene-ATP
CAS:<p>α,β-Methylene ATP，一种ATP的膦酸酯类似物，充当P2X3和P2X7受体的配体。该化合物对P2X1和P2X3表现出高选择性激动剂活性，而在P2X2, 4, 7受体上无活性。</p>Fórmula:C11H18N5O12P3Cor e Forma:SolidPeso molecular:505.21LOE 908 hydrochloride
CAS:<p>Broad spectrum cation channel blocker</p>Fórmula:C41H49ClN2O9Pureza:98%Cor e Forma:SolidPeso molecular:749.29Piperidine-4-sulfonic acid
CAS:<p>Piperidine-4-sulfonic acid is a potent GABA agonist, demonstrating an IC50 value of 0.034 μM for the inhibition of H-GABA binding [1].</p>Fórmula:C5H11NO3SPureza:98%Cor e Forma:SolidPeso molecular:165.21NPEC-caged-(S)-AMPA
CAS:<p>AMPA receptor agonist</p>Fórmula:C16H17N3O8Pureza:98%Cor e Forma:SolidPeso molecular:379.32Sodium Channel inhibitor 4
CAS:<p>Sodium Channel Inhibitor 4 is a compound that functions as a sodium channel inhibitor [1].</p>Fórmula:C19H18ClN3O4S2Pureza:98%Cor e Forma:SolidPeso molecular:451.95URAT1 inhibitor 6
CAS:<p>URAT1 inhibitor 6 (Compound 1h), with an IC50 of 35 nM for hURAT1, demonstrates 200-fold and 8-fold greater potency compared to Lesinurad and Benzbromarone,</p>Fórmula:C9H7BrN3NaO2S2Cor e Forma:SolidPeso molecular:356.2Glibornuride
CAS:<p>Glibornuride is a blocker of ATP-sensitive K+ channel(pKi: 5.75).</p>Fórmula:C18H26N2O4SPureza:99.5%Cor e Forma:SolidPeso molecular:366.48NCS-382 sodium
CAS:<p>NCS-382 (sodium) is a potent antagonist of the GABA receptor, exhibiting anti-sedative and anti-hypnotic properties, with applications in neurological disease</p>Fórmula:C13H13NaO3Pureza:98%Cor e Forma:SolidPeso molecular:240.23PF-05241328
CAS:<p>PF-05241328 is an effective and selective inhibitor of human Nav1.7 voltage-dependent sodium channels (IC50: 31 nM).</p>Fórmula:C19H21ClN4O4SPureza:98%Cor e Forma:SolidPeso molecular:436.91ZM 260384
CAS:<p>ZM 260384 is a potassium channel opener.</p>Fórmula:C15H11F4N3O4Cor e Forma:SolidPeso molecular:373.26CGP 54626 hydrochloride
CAS:<p>CGP 54626 hydrochloride is a GABAB receptor antagonist.</p>Fórmula:C18H29Cl3NO3PPureza:98%Cor e Forma:SolidPeso molecular:444.76S-Pantoprazole sodium trihydrate
CAS:<p>S-Pantoprazole (sodium trihydrate), a variant of Pantoprazole, is pivotal in managing diseases associated with gastric acid secretion disorders, serving as a</p>Fórmula:C16H20F2N3NaO7SPureza:98%Cor e Forma:SolidPeso molecular:459.4TRPV2-selective blocker 1
CAS:<p>TRPV2-selective blocker 1 (compound IV2-1) is a selective inhibitor of the TRPV2 channel, exhibiting an IC50 value of 6.3 μM.</p>Fórmula:C15H18OS2Cor e Forma:SolidPeso molecular:278.43VMAT2-IN-I HCl
CAS:<p>VMAT2-IN-I HCl is an inhibitor of vesicular monoamine transporter-2. It also has 15- fold greater affinity than GZ- 793A.</p>Fórmula:C25H32ClF4NO4Pureza:98%Cor e Forma:SolidPeso molecular:521.97CE-224535
CAS:<p>CE-224535 (PF-04905428) is a selective antagonist of P2X7 receptor. CE-224535 can be used in disease-modifying antirheumatic studies.</p>Fórmula:C22H29ClN4O6Pureza:99.68%Cor e Forma:SolidPeso molecular:480.94C 101248
CAS:<p>C 101248 (KCNK13-IN-1) is a selective and potent tandem pore halogen inhibitor of K+ channel 1 (THIK-1) inhibitor and a human and mouse KCNK13 inhibitor.</p>Fórmula:C15H12N6OPureza:99.14% - 99.31%Cor e Forma:SolidPeso molecular:292.3Bupivacaine hydrochloride monohydrate
CAS:<p>Bupivacaine hydrochloride monohydrate is an NMDA receptor inhibitor that inhibits SCN5A channels and is commonly used in the study of chronic pain.</p>Fórmula:C18H31ClN2O2Pureza:99.91%Cor e Forma:SolidPeso molecular:342.9Reldesemtiv
CAS:<p>Reldesemtiv (CK-2127107) boosts exercise capacity, targeting fast muscle troponin, EC50 3.4 μM.</p>Fórmula:C19H18F2N6OPureza:97.27%Cor e Forma:SolidPeso molecular:384.38CFTR corrector 4
CAS:<p>Potent, oral CFTR corrector 4 targets cystic fibrosis, increasing cell surface CFTR levels.</p>Fórmula:C29H27F2NO7Pureza:99.32%Cor e Forma:SolidPeso molecular:539.52Funapide
CAS:<p>Funapide (TV 45070) is a potent Nav1.7 inhibitor, potentially treating inflammation and various pains.</p>Fórmula:C22H14F3NO5Pureza:99.91%Cor e Forma:SolidPeso molecular:429.35Aneratrigine hydrochloride
CAS:<p>Aneratrigine hydrochloride is a Nav 1.9 blocker that may be used to prevent or treat sodium channel blocker-related disorders.</p>Fórmula:C19H21Cl2F2N5O2S2Pureza:98.37% - 99.16%Cor e Forma:SolidPeso molecular:524.43Maralixibat Chloride
CAS:<p>Maralixibat Chloride (LUM001 chloride), an apical, sodium-dependent, bile acid transport inhibitor, prevents enterohepatic bile acid recirculation.</p>Fórmula:C40H56ClN3O4SPureza:99.19% - 99.65%Cor e Forma:SolidPeso molecular:710.41Kv3 modulator 1
CAS:<p>Kv3 modulator 1 is a voltage-gated potassium channel Kv3 modulator that can be used to study neurologic-level diseases.</p>Fórmula:C20H20N4O4Pureza:99.41%Cor e Forma:SolidPeso molecular:380.4LE135
CAS:<p>LE135: RARα/RARβ antagonist (Ki: 1.4 μM/220 nM), favors RARβ, selective vs RARγ/RXRs; also activates TRPV1/TRPA1 (EC50s: 2.5/20 μM).</p>Fórmula:C29H30N2O2Pureza:97.94%Cor e Forma:SolidPeso molecular:438.56Soraprazan
CAS:<p>BS3 Crosslinker (Bis(sulfosuccinimidyl)suberate) is an ADC linker that can be used to synthesize antibody-coupled active molecules.</p>Fórmula:C21H25N3O3Pureza:97.69% - 99.84%Cor e Forma:SolidPeso molecular:367.44EMD57033
CAS:<p>EMD57033 activates cardiac troponin C, enhances Ca2+ sensitivity to boost heart contraction.</p>Fórmula:C22H23N3O4SPureza:99.72% - >99.99%Cor e Forma:SolidPeso molecular:425.5MCT1-IN-3
CAS:<p>MCT1-IN-3 is a monocarboxylate transporter 1 (MCT1) inhibitor.</p>Fórmula:C22H19N3O4Pureza:99.35%Cor e Forma:SoildPeso molecular:389.4AMG-0347
CAS:<p>AMG-0347 inhibits TRPA1 ion channels in sensory neurons, blocking pain perception.</p>Fórmula:C24H26F3N3O2Pureza:99.93%Cor e Forma:SolidPeso molecular:445.48L-DABA hydrobromide
CAS:<p>L-DABA hydrobromide (L-2,4-Diaminobutyric acid hydrobromide) , GABA transaminase inhibitor with antitumor and anticonvulsant activity.</p>Fórmula:C4H11BrN2O2Pureza:99.11%Cor e Forma:SolidPeso molecular:199.05VGSCs-IN-1
CAS:<p>VGSCs-IN-1, a VGSC inhibitor and Riluzole analog, exhibits good blocking activity on Nav1.4 and can be used to study cellular excitability disorders.</p>Fórmula:C12H12F3N3OSPureza:99.88%Cor e Forma:SolidPeso molecular:303.3AMG2850
CAS:<p>AMG2850 is a potent, orally bioavailable, and selective antagonist of transient receptor potential melastatin 8 (TRPM8).</p>Fórmula:C19H17F6N3OPureza:99.84%Cor e Forma:SolidPeso molecular:417.35KCa2 channel modulator 2
<p>Compound 2q is a potent, subtype-selective K/Ca 2 modulator, effective on human K Ca 2.3 and rat K Ca 2.2a with EC50s of 0.60 μM and 0.64 μM.</p>Fórmula:C16H15ClFN5Cor e Forma:SolidPeso molecular:331.783-Methoxy PCE hydrochloride
CAS:<p>3-Methoxy PCE (3-MEO PCE) hydrochloride is an arylcyclohexylamine compound that functions as an NMDA receptor antagonist with a pKi value of 7.22.</p>Fórmula:C15H24ClNOCor e Forma:SolidPeso molecular:269.81Detajmium
CAS:<p>Detajmium is an anti-arrhythmia compound. It is an Na(+)-channel-blocking drug with an extremely long recovery from use-dependent sodium channel block.</p>Fórmula:C27H42N3O3Pureza:98%Cor e Forma:SolidPeso molecular:456.64Butein tetramethyl ether
CAS:<p>Butein tetramethyl ether (Compound 20) is a potent and selective inhibitor of breast cancer resistance protein / ATP-binding cassette sub-family G member 2 (BCRP/ABCG2). It inhibits MCF-7 MX and MDCKBCRP cells with IC50 values of 2.2 μM and 1.03 μM, respectively. Butein tetramethyl ether holds potential for cancer research.</p>Fórmula:C19H20O5Cor e Forma:SolidPeso molecular:328.359Leualacin
CAS:<p>Leualacin is a novel calcium blocker from Hapsidospora irregularis.</p>Fórmula:C31H47N3O7Pureza:98%Cor e Forma:SolidPeso molecular:573.72Tamitinol
CAS:<p>Tamitinol is a neurotropic drug. It has been found to help symptoms of obsessive rumination in conjunction with maprotiline.</p>Fórmula:C12H20N2OSPureza:98%Cor e Forma:SolidPeso molecular:240.37EF1502 free base
CAS:<p>EF1502 is a potent and selective GABA transporter inhibitor.</p>Fórmula:C22H26N2O2S2Pureza:98%Cor e Forma:SolidPeso molecular:414.58(R)-KMH-233
CAS:<p>(R)-KMH-233 is an isomer of KMH-233, which can serve as a reference compound in experiments. KMH-233 functions as a potent, reversible, and selective inhibitor of L-type amino acid transporter 1 (LAT1), effectively hindering the uptake of LAT1 substrate, l-leucine (IC50=18 μM), and also inhibiting cell growth. Even at a low concentration of 25 μM, KMH-233 significantly enhances the efficacy of Bestatin and cisplatin.</p>Fórmula:C32H25N7O5Peso molecular:587.58Caged MK801
CAS:<p>Caged MK801 (cMK801) is a selective, noncompetitive, and irreversible blocker of the NMDA receptor open channel. The NVOC cage is compatible in neuropharmacology and does not alter the intrinsic activity of the molecule.</p>Fórmula:C26H24N2O6Cor e Forma:SolidPeso molecular:460.48CFTR corrector 17
CAS:<p>CFTRcorrector 17 (example 17) is a regulator of the cystic fibrosis transmembrane conductance regulator (CFTR). It is utilized in the study of diseases mediated by CFTR.</p>Fórmula:C18H15FN2O2Cor e Forma:SolidPeso molecular:310.32BGT1-IN-1
CAS:<p>BGT1-IN-1 (compound 9) is an effective inhibitor of BGT1, demonstrating IC50 values of 13.9 µM for hBGT1 and 58.3 µM for GAT3. It exhibits no cytotoxic effects and possesses neuroprotective activity.</p>Fórmula:C6H9NO2Cor e Forma:SolidPeso molecular:127.14S9-A13
CAS:<p>S9-A13 is a potent and selective inhibitor of SLC26A9, exhibiting an IC50 of 90.9 nM without inhibiting other members of the SLC26 family, such as SLC26A3, SLC26A4, and SLC26A6. It also inhibits the SLC26A9 Cl- current in cells lacking CFTR expression.</p>Fórmula:C20H18ClN3O2SCor e Forma:SolidPeso molecular:399.89H052
CAS:<p>H052 is a selective inhibitor of Staphylococcus aureus α-hemolysin (Hla). It binds to the Hla monomer, disrupting its interaction with the host cell membrane, thereby blocking pore formation and inhibiting calcium influx, cytotoxicity, and inflammatory response. H052 exhibits inhibitory activity against Hla-induced calcium influx (EC50 = 30 nM in U937 cells) and holds potential for research into lung infections caused by S. aureus.</p>Fórmula:C21H15ClFN3O4SCor e Forma:SolidPeso molecular:459.88EU 1622-240
CAS:<p>EU 1622-240 is an allosteric modulator with a preference for GluN2B, GluN2C, and GluN2D, exhibiting EC50 values of 0.57, 0.82, and 1.1 μM, respectively. It possesses favorable physicochemical properties, along with in vitro stability and permeability.</p>Fórmula:C20H14BrF2N3O2SCor e Forma:SolidPeso molecular:478.31Cyproflanilide
CAS:<p>Cyproflanilide is a GABAR antagonist that exhibits high activity against a variety of pests, including those from the Lepidoptera, Coleoptera, and Thysanoptera orders.</p>Fórmula:C28H17BrF12N2O2Cor e Forma:SolidPeso molecular:721.33Vormatrigine
CAS:<p>Vormatrigine effectively inhibits sodium channels (sodium channel).</p>Fórmula:C16H12F6N4O2Cor e Forma:SolidPeso molecular:406.28Kv7.2/Kv7.3 agonist 1
CAS:<p>Kv7.2/Kv7.3 agonist 1 (Compound 16) is an orally effective agonist for the KV7.2/7.3 channels (KV7.2/7.3 channel/KCNQ2/3) with an EC50 of 1.03 μM. This compound demonstrates analgesic effects in mouse models of chronic constriction injury (CCI) and Streptozotocin-induced diabetic peripheral neuropathy (DPNP), with ED50 values of 12.02 mg/kg and 9.63 mg/kg, respectively.</p>Fórmula:C14H14FN3O2Cor e Forma:SolidPeso molecular:275.28NMD670
CAS:<p>NMD670 is an orally active, partial inhibitor of the skeletal muscle-specific chloride channel ClC-1. It enhances muscle excitability and neuromuscular transmission, restoring muscle function and mobility. NMD670 has a favorable safety profile and improves muscle function in rats, particularly in an MG rat model [1].</p>Fórmula:C12H10BrNO4Cor e Forma:SolidPeso molecular:312.12CRM1-IN-3
CAS:<p>CRM1-IN-3 (B28), a noncovalent inhibitor of CRM1, is utilized in the research of protein localization and tumor studies [1].</p>Fórmula:C26H26ClN3O3Cor e Forma:SolidPeso molecular:463.96Sp-8-Br-cGMPS
CAS:<p>Sp-8-Br-cGMPS, an analogue of cGMP, acts as an agonist for cGMP gated cation channels (CNG channels) with an EC50 of 106.5 μM. While Sp-8-Br-cGMPS can induce currents, it does not stabilize channel open states as effectively as a full agonist.</p>Fórmula:C10H11BrN5O6PSCor e Forma:SolidPeso molecular:440.17TRPV1 antagonist 10
CAS:<p>TRPV1 antagonist 10 is a potent, orally active TRPV1 antagonist with an IC50 of 33.06 nM and serves as a moderate to weak inhibitor of URAT1 (IC50 = 22.51 μM) and GLUT9 (inhibition of 60.25% at 50 μM). It exhibits analgesic and urate-lowering properties and is applicable for research in hyperuricemia and inflammatory pain.</p>Fórmula:C16H14N2O5Cor e Forma:SolidPeso molecular:314.293TRPA1 Antagonist 1
CAS:<p>TRPA1 Antagonist 1 is an antagonist of TRPA1(IC50: 8 nM) and is a methylene phosphate prodrug which converts to its active parent drug.</p>Fórmula:C24H20F6N5Na2O7PSPureza:98%Cor e Forma:SolidPeso molecular:713.45pan-HCN-IN-1
CAS:<p>Pan-HCN-IN-1 (Compound J&J12e) is an inhibitor of the hyperpolarization-activated and cyclic-nucleotide-gated 1 (HCN1) ion channel, with an IC50 of 58 nM. Pan-HCN-IN-1 reduces the voltage sag response and enhances EPSP summation in ex vivo rat brain slices [1].</p>Fórmula:C23H37N3O2Cor e Forma:SolidPeso molecular:387.56
