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Transportador de Membranas/Canal Iónico

Transportador de Membranas/Canal Iónico

Os inibidores de transportadores de membrana e canais iônicos são compostos que bloqueiam a função de proteínas responsáveis pelo transporte de íons, nutrientes e outras moléculas através das membranas celulares. Esses inibidores são cruciais para o estudo da regulação da homeostase celular, transdução de sinais e neurotransmissão. Os inibidores de transportadores de membrana e canais iônicos também são importantes no desenvolvimento de tratamentos para distúrbios como epilepsia, doenças cardiovasculares e síndromes metabólicas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de alta qualidade de transportadores de membrana e canais iônicos para apoiar sua pesquisa em fisiologia, neurociência e farmacologia.

Subcategorias de "Transportador de Membranas/Canal Iónico"

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Foram encontrados 2293 produtos de "Transportador de Membranas/Canal Iónico"

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  • CFTR corrector 18
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    CFTR corrector 18

    CAS:
    <p>CFTRcorrector 18 (Compound I-99) acts as a modulator of the cystic fibrosis transmembrane conductance regulator (CFTR). It enhances the processing and trafficking of CFTR, thereby increasing the amount of CFTR present on the cell surface. CFTRcorrector 18 holds potential for research in cystic fibrosis (CF).</p>
    Fórmula:C38H40N6O5S
    Cor e Forma:Solid
    Peso molecular:692.826

    Ref: TM-T206874

  • S-8510 phosphate
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    S-8510 phosphate

    CAS:
    S-8510 phosphate is an agonist of inverse Benzodiazepine (BDZ) receptor(Kis of 34.6 nM, 36.2 nM for –GABA and +GABA respectively).
    Fórmula:C12H13N4O6P
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:340.23

    Ref: TM-T12792

  • 264W94
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    264W94

    CAS:
    264W94 robustly inhibits IBAT, induces CYP7A1, and significantly reduces cholesterol.
    Fórmula:C23H31NO4S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:417.56

    Ref: TM-T10090

  • ATP synthase inhibitor 2
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    ATP synthase inhibitor 2

    CAS:
    <p>ATP synthase inhibitor 2 blocks P. aeruginosa ATP synthase; IC50=10 μg/mL, fully inhibits at 128 μg/mL.</p>
    Fórmula:C21H22N2O3S
    Cor e Forma:Solid
    Peso molecular:382.48

    Ref: TM-T61649

  • Logotipo do CymitQuimica
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    T-Type calcium channel inhibitor 2

    <p>Compound 6g inhibits T-type Ca channels (IC50: Cav3.1-31μM, Cav3.2-83μM), cytotoxic to A549 (IC50: 5μM) &amp; HCT-116 cells (IC50: 6.4μM).</p>
    Fórmula:C36H39FN4OS
    Cor e Forma:Solid
    Peso molecular:594.78

    Ref: TM-T64203

  • Gabaculine HCl
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    Gabaculine HCl

    CAS:
    <p>Gabaculine, an irreversible GABA-T inhibitor (Ki: 2.9 μM), impacts plastid development and affects DPOR/GluTR levels.</p>
    Fórmula:C7H10ClNO2
    Cor e Forma:Solid
    Peso molecular:175.61

    Ref: TM-T24080

  • SR 33805 oxalate
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    SR 33805 oxalate

    CAS:
    <p>Ca2+ channel antagonist</p>
    Fórmula:C34H42N2O9S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:654.77

    Ref: TM-T23391

  • Kv7.2/Kv7.3 modulator-1
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    Kv7.2/Kv7.3 modulator-1

    CAS:
    <p>Kv7.2/Kv7.3 modulator-1 (compound 6a) acts as a modulator for Kv7.2/Kv7.3 channels, with a pEC50 value of 7.96 for opening these channels. Kv7.2/Kv7.3 modulator-1 is applicable in research related to epilepsy, depression, brain injury, and pain.</p>
    Fórmula:C20H21F4N3O3
    Cor e Forma:Solid
    Peso molecular:427.393

    Ref: TM-T206950

  • RO-275
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    RO-275

    CAS:
    <p>RO-275 is an HCN1 inhibitor that also inhibits HCN2, HCN3, and HCN4, improving working memory deficits and being used in research on cognitive disorders.</p>
    Fórmula:C18H14ClN5O
    Pureza:98.12% - 98.3%
    Cor e Forma:Solid
    Peso molecular:351.79

    Ref: TM-T87339

  • EMD-95885
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    EMD-95885

    CAS:
    <p>EMD-95885 is a selective antagonist of NMDA receptors containing NR2B subunits, with an IC50 of 3.9 nM. It does not interact with other sites on the NMDA receptor.</p>
    Fórmula:C22H23FN2O3
    Cor e Forma:Solid
    Peso molecular:382.428

    Ref: TM-T205291

  • MSK-195
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    MSK-195

    CAS:
    <p>MSK-195 is an effective TRPV1 agonist.</p>
    Fórmula:C28H40N2O5
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:484.63

    Ref: TM-T24504

  • Olorigliflozin
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    Olorigliflozin

    CAS:
    <p>Olorigliflozin is a sodium glucose co-transporter (SGLT) inhibitor with antihyperglycemic properties.</p>
    Fórmula:C23H27ClO7
    Cor e Forma:Solid
    Peso molecular:450.909

    Ref: TM-T205428

  • Logotipo do CymitQuimica
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    Cav 3.2 inhibitor 2

    <p>Cav 3.2 inhibitor 2 blocks T-type Ca2+ channels (IC50=0.09339 μM) and reduces mouse somatic/visceral pain. Used for intractable pain studies.</p>
    Fórmula:C32H37F2N3O
    Cor e Forma:Solid
    Peso molecular:517.65

    Ref: TM-T63606

  • ARN23765
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    ARN23765

    CAS:
    <p>ARN23765 is an F508del-CFTR corrector with an EC50 of 38 pM in human bronchial epithelial cells. It enhances the maturation and function of F508del-CFTR at the cell membrane, influencing ion transport and secretion, thereby addressing the pathological mechanisms of cystic fibrosis (CF).</p>
    Fórmula:C30H22F5N3O6
    Cor e Forma:Solid
    Peso molecular:615.504

    Ref: TM-T205032

  • Pyrimidinone 8
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    Pyrimidinone 8

    CAS:
    <p>Pyrimidinone 8 is a reversible, linear non-competitive inhibitor of divalent metal transporter 1 (DMT1) with a Ki of 20 μM (hDMT1). It does not affect the surface expression of hDMT1 and is not influenced by extracellular pH. Pyrimidinone 8 inhibits hDMT1-mediated iron uptake, with an IC50 of 13.8 μM.</p>
    Fórmula:C10H12N4O
    Cor e Forma:Solid
    Peso molecular:204.229

    Ref: TM-T205042

  • GABA-IN-4
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    GABA-IN-4

    CAS:
    <p>GABA-IN-4 (Compound 17) is a derivative of N-(indol-3-ylglyoxylyl)benzylamine. It exhibits high affinity for the benzodiazepine receptor (BzR), the binding site within the GABAA receptor complex, with a Ki value of 67 nM. Benzodiazepines are widely used as anxiolytic, sedative-hypnotic, and anticonvulsant agents.</p>
    Fórmula:C17H13ClN2O2
    Cor e Forma:Solid
    Peso molecular:312.75

    Ref: TM-T205501

  • Zilvetrigine
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    Zilvetrigine

    CAS:
    <p>Zilvetrigine is a sodium channel (sodium channel) blocker. It can be used as an analgesic.</p>
    Fórmula:C20H20ClN3O2
    Cor e Forma:Solid
    Peso molecular:369.845

    Ref: TM-T205304

  • NMDA agonist 1
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    NMDA agonist 1

    CAS:
    <p>NMDA agonist 1 (compound 42d) is a potent NMDA agonist with a Ki value of 96 nM. It acts as a partial agonist of the GluN1/GluN2B complex, exhibiting an EC50 value of 78 nM.</p>
    Fórmula:C12H13N3O3S
    Cor e Forma:Solid
    Peso molecular:279.315

    Ref: TM-T204880

  • Antidepressant agent 9
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    Antidepressant agent 9

    CAS:
    <p>Antidepressant agent 9 (Compound 24) is an orally active inhibitor of NMDAR and SERT, with IC50 values of 3.50 μM and 1044 nM, respectively. It exhibits good metabolic stability and plasma exposure, and demonstrates antidepressant-like effects in the forced swim test in mice.</p>
    Fórmula:C17H24N2
    Cor e Forma:Solid
    Peso molecular:256.386

    Ref: TM-T205640

  • SGC-CAMKK2-1
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    SGC-CAMKK2-1

    CAS:
    <p>SGC-CAMKK2-1 is a selective inhibitor of calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) with an IC50 of 30 nM. It effectively inhibits AMPK phosphorylation in C4-2 cells, exhibiting an IC50 value of 1.6 µM.</p>
    Fórmula:C26H23NO3
    Cor e Forma:Solid
    Peso molecular:397.466

    Ref: TM-T205037