Transportador de Membranas/Canal Iónico
Os inibidores de transportadores de membrana e canais iônicos são compostos que bloqueiam a função de proteínas responsáveis pelo transporte de íons, nutrientes e outras moléculas através das membranas celulares. Esses inibidores são cruciais para o estudo da regulação da homeostase celular, transdução de sinais e neurotransmissão. Os inibidores de transportadores de membrana e canais iônicos também são importantes no desenvolvimento de tratamentos para distúrbios como epilepsia, doenças cardiovasculares e síndromes metabólicas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de alta qualidade de transportadores de membrana e canais iônicos para apoiar sua pesquisa em fisiologia, neurociência e farmacologia.
Subcategorias de "Transportador de Membranas/Canal Iónico"
- ABC(3 produtos)
- ATPase(93 produtos)
- Receptor de adiponectina(5 produtos)
- CFTR(64 produtos)
- Receptor CGRP(51 produtos)
- Canais de Cálcio(493 produtos)
- Canal de cloreto(49 produtos)
- Receptor GABA(336 produtos)
- Transportador de monoamina(23 produtos)
- Transportador de monocarboxilato(17 produtos)
- NKCC(2 produtos)
- NPC1L1(3 produtos)
- Cotransportador Na-K-Cl(8 produtos)
- OAT(27 produtos)
- OCT(7 produtos)
- P-gp(53 produtos)
- Canal de Potássio(276 produtos)
- Bomba de prótons(39 produtos)
- SGLT(30 produtos)
- Canal de Sódio(202 produtos)
- Canal TRP/TRPV(93 produtos)
Exibir 13 mais subcategorias
Foram encontrados 2277 produtos de "Transportador de Membranas/Canal Iónico"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
P2X4 antagonist-4
<p>P2X4 antagonist-4 (compound 64) is a potent P2X4R antagonist with an IC50 value of 8 µM. It can inhibit ATP-induced activation of the NLRP3 inflammasome and the subsequent release of IL-1β.</p>Fórmula:C27H22FN3O4SCor e Forma:SolidPeso molecular:503.545BKCa activator-1
<p>BKCa activator-1 (Compound 51b) is an orally active activator of BKCa calcium-activated potassium channels with an EC50 of 2.82 μM. It promotes K+ efflux, leading to cell membrane hyperpolarization and inhibition of smooth muscle contraction. In a spontaneous hypertensive rat (SHR) model, it alleviates urinary incontinence and exhibits antitussive effects in a guinea pig cough model.</p>Fórmula:C22H23F7N2O3Cor e Forma:SolidPeso molecular:496.418D-GsMTx4
<p>TRPC1/6 & Piezo2 inhibitor; mimics GsMTx4; blocks ~70% mechanosensitive currents; aids in mouse heart attack models; protease-resistant.</p>Cor e Forma:Soildω-Agatoxin IVA
CAS:<p>Selective blocker of P-type calcium channels (IC50 < 1 - 3 nM). Also inhibits N-type channels at micromolar concentrations.</p>Fórmula:C217H360N68O60S10Pureza:98%Cor e Forma:SolidPeso molecular:5202.25GX 201
CAS:<p>GX 201 is a selective NaV1.7 inhibitor, IC50 of < 3.2 nM for hNaV1.7.</p>Fórmula:C25H27ClF4N2O4SPureza:99.81%Cor e Forma:SolidPeso molecular:563ABCB1-IN-1
<p>ABCB1-IN-1 (compound 3) is a potent inhibitor of ABCB1 that promotes cell apoptosis.</p>Fórmula:C36H33F3FeN2O4PSCor e Forma:SolidPeso molecular:733.54α5-GABAA receptor modulator 1
<p>α5-GABAA receptor modulator 1 (Compound A-4) is a selective silent allosteric modulator (SAM) targeting the α5 subunit of GABAA receptors, useful for research into central nervous system (CNS) disorders.</p>Fórmula:C21H20FN3O4Cor e Forma:SolidPeso molecular:397.4Tacrine hydrochloride
CAS:<p>Tacrine: a cholinergic agonist, anticholinesterase; inhibits AChE/BChE with IC50s of 31/25.6 nM.</p>Fórmula:C13H15ClN2Pureza:98%Cor e Forma:SolidPeso molecular:234.73Agitoxin-2
CAS:Potent Shaker K+ channel blocker (Ki = 0.64 nM). Also inhibits Kv1.3, Kv1.6 and Kv1.1 K+ channels (Ki values are 4, 37 and 44 pM respectively).Fórmula:C169H278N54O48S8Pureza:98%Cor e Forma:SolidPeso molecular:4090.87Levamlodipine besylate Hemipentahydrate
CAS:<p>Levamlodipine besylate hemipentahydrate is the besylate hemipentahydrate salt form of Levamlodipine. It is an orally effective calcium channel blocker with antioxidative and vasodilatory properties. This compound can reduce serum malondialdehyde (MDA) levels, enhance the activity of superoxide dismutase (SOD), and alleviate oxidative stress. Levamlodipine besylate hemipentahydrate is relevant for research in vascular dementia, hypertension, and cerebrovascular diseases.</p>Fórmula:C20H25ClN2O5·C6H6O3SH2OCor e Forma:SolidPeso molecular:1224.18Ouabagenin
CAS:<p>Ouabagenin, a naturally occurring LXR ligand with selective agonist activity, functions as an EC 3.6.3.9 (Na(+)/K(+)-transport ATPase) inhibitor [1] [2].</p>Fórmula:C23H34O8Cor e Forma:SolidPeso molecular:438.51GS-9191 PM
<p>GS-9191 PM: novel antitumorviral bis-amide prodrug, inhibits MDR1/BCRP, has antiproliferative activity.</p>Fórmula:C11H16N6OPureza:99.79%Cor e Forma:SoildPeso molecular:248.28AQP3-IN-1
CAS:<p>AQP3-IN-1 (compounds 3), an AQP3 inhibitor, exhibits an IC 50 of 8.91 μM and effectively inhibits melanoma cell proliferation [1].</p>Fórmula:C11H9AuCl2N2Cor e Forma:SolidPeso molecular:437.08Anticonvulsant agent 9
<p>Anticonvulsant agent 9 (compound 4f) is an activator of the α1β2γ2GABA_A receptor, with an EC50 value of 1.24 μM. It inhibits the inactivation of Nav1.2 channels and exhibits significant anticonvulsant activity.</p>Fórmula:C22H24N4O2Cor e Forma:SolidPeso molecular:376.45PptT-IN-4
<p>PptT-IN-4 (Compound 3a) is a PptT inhibitor exhibiting an IC50 of 0.71 μM.</p>Fórmula:C17H23N3Pureza:98%Cor e Forma:SolidPeso molecular:269.38Elgodipine
CAS:<p>Elgodipine decreases angina severity, inhibits muscle growth, and is voltage-sensitive, showing promise for angina treatment.</p>Fórmula:C29H33FN2O6Pureza:98.95% - 99.50%Cor e Forma:SolidPeso molecular:524.585-Tridecanol
CAS:<p>5-Tridecanol blocks ion flux in sodium channels.</p>Fórmula:C13H28OPureza:97.87%Cor e Forma:SolidPeso molecular:200.3617(R)-Resolvin D1
CAS:<p>Resolvins are anti-inflammatory lipids from EPA and DHA. Resolvin D1, made from DHA, and its aspirin-triggered epimer 17(R)-RvD1, inhibit acute inflammation.</p>Fórmula:C22H32O5Cor e Forma:SolidPeso molecular:376.493P-gp inhibitor 15
<p>P-gp Inhibitor 15 (compound 7a), a nonsubstrate inhibitor of P-glycoprotein (Pgp), inhibits Pgp-ATPase activity and interferes with Pgp-mediated Rhodamine123</p>Fórmula:C35H60N2O4Cor e Forma:SolidPeso molecular:572.86Crofelemer
CAS:<p>Crofelemer (Provir) is an orally active antidiarrheal agent. It targets the cystic fibrosis transmembrane conductance regulator (CFTR) and calcium-activated chloride channels (CACC), which are responsible for chloride and fluid secretion in the gastrointestinal tract. Crofelemer is applicable for research in diarrhea-related conditions.</p>Cor e Forma:SolidAnalgesic/antidepressant agent-1
<p>Analgesic/antidepressant agent-1 (Compound k1) is an orally active N-acetylamino chloro ketone derivative capable of crossing the blood-brain barrier. It exhibits high affinity for NMDA receptors and demonstrates analgesic, anti-inflammatory, and antidepressant properties, with low psychotomimetic activity.</p>Fórmula:C22H25ClN2O2Cor e Forma:SolidPeso molecular:384.9AQP4 (201-220) TFA
<p>AQP4 (201-220) TFA is an encephalitogenic epitope of AQP-4. This compound can induce experimental autoimmune encephalomyelitis (EAE), characterized by midline brain lesions, retinal abnormalities, and lesions at the grey/white matter boundary of the spinal cord. AQP-4 is the target antigen in neuromyelitis optica.</p>Cor e Forma:Odour SolidCalcium Ionophore I
CAS:<p>Calcium Ionophore I has a wide range of applications in life science related research.</p>Fórmula:C38H72N2O8Cor e Forma:SolidPeso molecular:685.0Charybdotoxin
CAS:<p>Specific inhibitor of the big conductance Ca2+-activated K+ channel.</p>Fórmula:C176H277N57O55S7Pureza:98%Cor e Forma:SolidPeso molecular:4295.95ATP synthase inhibitor 2 TFA
<p>ATP Synthase Inhibitor 2 (Compound 22) TFA is a potent inhibitor of Pseudomonas aeruginosa ATP synthase with an IC50 value of 10 μg/mL.</p>Fórmula:C23H23F3N2O5SCor e Forma:SolidPeso molecular:496.5JAMI1001A
CAS:<p>JAMI1001A enhances AMPA receptor signaling, slows deactivation/desensitization for flip/flop isoforms.</p>Fórmula:C16H17F3N4O3SCor e Forma:SolidPeso molecular:402.39Phe-Met-Arg-Phe, amide
CAS:<p>Phe-Met-Arg-Phe amide activates K+ current in neurons (ED50=23 nM), co-localizes with neuropeptide Y in brain regions.</p>Fórmula:C29H42N8O4SPureza:98%Cor e Forma:SolidPeso molecular:598.76Tariquidar dimesylate
CAS:<p>Tariquidar, a non-competitive P-glycoprotein inhibitor, may help combat cancer drug resistance.</p>Fórmula:C80H94N8O25S4Pureza:98%Cor e Forma:SolidPeso molecular:1695.9L-Palmitoylcarnitine TFA
<p>L-Palmitoylcarnitine TFA: long-chain fat metabolite that disrupts membranes in ischaemia & inhibits KATP channels via Kir6.2 interaction.</p>Fórmula:C25H46F3NO6Cor e Forma:SolidPeso molecular:513.63Apamin acetate
<p>Apamin acetate: Selective Ca2+-activated K+ channel blocker, 18-amino acid bee venom peptide, promotes synapse repair, anti-inflammatory.</p>Pureza:96.97%Cor e Forma:SolidRoquefortine C
CAS:<p>Roquefortine C is a fungal cyclopeptide isolated from Penicillium roquefortii, activates P-gp and also inhibits P450-3A and other haemoproteins</p>Fórmula:C22H23N5O2Pureza:98%Cor e Forma:SolidPeso molecular:389.45SLC26A3-IN-2
CAS:<p>Vilobelimab (CaCP-29) is a human-mouse chimeric IgG antibody targeting human complement component 5a, a C5a inhibitor that inhibits neutrophil activation.</p>Fórmula:C19H13ClN2O2SPureza:99.86%Cor e Forma:SolidPeso molecular:368.84P-gp inhibitor 14
CAS:<p>Compound 8a, also known as P-gp inhibitor 14, demonstrates high affinity as a P-gp inhibitor and effectively reverses P-gp-mediated multidrug resistance (EC 50 = 48.74 nM). Additionally, this compound exhibits a weak inhibitory effect on CYP3A4 activity [1].</p>Fórmula:C37H38N2O8Cor e Forma:SolidPeso molecular:638.71MS7710
<p>MS7710 is a brain-penetrant inhibitor of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. It reduces Ih current by inhibiting HCN channels, thereby decreasing the activity of dopamine neurons in the ventral tegmental area (VTA). MS7710 effectively improves social interaction deficits and reward-related cognitive flexibility in mouse models of chronic social defeat stress (CSDS) and shows promise for depression research.</p>Cor e Forma:Odour SolidATP Synthesis-IN-2
<p>ATP Synthesis-IN-2 (Compound 5) serves as a potent inhibitor of ATP synthesis activity, displaying significant antibacterial properties with an IC50 value of 0.</p>Cor e Forma:Odour SolidWay 125971
CAS:<p>Way 125971 is a bioactive chemcial.</p>Fórmula:C22H28N4O5S2Cor e Forma:SolidPeso molecular:492.61Chlorotoxin TFA
<p>Chlorotoxin TFA, a scorpion venom peptide, blocks chloride channels and has anti-cancer properties.</p>Fórmula:C160H250F3N53O49S11Cor e Forma:SolidPeso molecular:4109.74AQP4 (205-215) TFA
<p>AQP4 (205-215) TFA is a fragment of the water channel protein-4 (AQP4). AQP4 acts as an autoimmune antigen in neuromyelitis optica, upregulating and presenting in B cells upon binding with CD40. AQP4 is associated with neuromyelitis optica (NMO), an autoimmune inflammatory disease of the central nervous system (CNS).</p>Cor e Forma:Odour SolidHomocarnosine
CAS:<p>Homocarnosine is an endogenous dipeptide in cerebral regions and cerebrospinal fluid.</p>Fórmula:C10H16N4O3Cor e Forma:SolidPeso molecular:240.26Quinine hemisulfate hydrate
CAS:<p>Quinine hemisulfate hydrate: anti-malaria, derived from cinchona bark, inhibits mouse Slo3 channels with IC50 169 μM.</p>Fórmula:C20H26N2O3H2O4S·H2OCor e Forma:SolidPeso molecular:391.47S-Sulfo-L-cysteine sodium salt
CAS:<p>S-Sulfo-L-cysteine sodium salt shows a weak affinity for mGluR1α and mGluR5a at high concentrations and has potential antioxidant activity.</p>Fórmula:C3H6NNaO5S2Pureza:99.88%Cor e Forma:SolidPeso molecular:223.2LY-466195
CAS:<p>LY-466195 is a competitive antagonist of GLUK5 receptor.</p>Fórmula:C16H24F2N2O4Cor e Forma:SolidPeso molecular:346.37Trans (2,3)-Dihydrotetrabenazine
CAS:<p>Trans (2,3)-Dihydrotetrabenazine is a Tetrabenazine metabolite, shows inhibition activity on vesicular monoamine transporter (VMAT2).</p>Fórmula:C19H29NO3Pureza:98%Cor e Forma:SolidPeso molecular:319.44MMK 1
CAS:<p>Potent hFPR2 agonist; EC50: 1 nM (mFPR2), 2 nM (hFPR2), >10,000 nM (hFPR1). Induces monocyte/neutrophil migration, boosts IL-1β/IL-6, activates NADPH-oxidase.</p>Fórmula:C75H123N19O18SPureza:98%Cor e Forma:SolidPeso molecular:1610.97TP-050
CAS:<p>TP-050: potent, selective NMDAR agonist, EC50 0.51 µM (GluN2A), 9.6 µM (GluN2D), BBB permeable, boosts hippocampal LTP.</p>Fórmula:C16H15ClF2N6OCor e Forma:SolidPeso molecular:380.78RuBi-GABA
CAS:<p>Ruthenium-bipyridine-triphenylphosphine caged GABA</p>Fórmula:C42H39F6N5O2P2RuPureza:98%Cor e Forma:SolidPeso molecular:922.8AHN-683
CAS:<p>AHN-683 is a fluorescent ligand. It was used for peripheral-type benzodiazepine receptors.</p>Fórmula:C42H32FN3O7Pureza:98%Cor e Forma:SolidPeso molecular:709.72NF864
CAS:<p>NF864, a suramin analog, is a P2X1 receptor inhibitor.</p>Fórmula:C57H28N6Na12O41S12Pureza:98%Cor e Forma:SolidPeso molecular:2113.5BeKm-1
CAS:<p>Potent, selective hERG (KV11.1) blocker; doesn't affect 14 other K+ channels; extends QTc in rabbit heart dose-dependently.</p>Fórmula:C174H261N51O52S6Pureza:98%Cor e Forma:SolidPeso molecular:4091.65Spongionellol A
<p>Spongionellol A inhibits MDR1, selectively kills prostate cancer through caspase-induced apoptosis, and aids cancer research.</p>Fórmula:C27H40O9Cor e Forma:SolidPeso molecular:508.6
