Transportador de Membranas/Canal Iónico
Os inibidores de transportadores de membrana e canais iônicos são compostos que bloqueiam a função de proteínas responsáveis pelo transporte de íons, nutrientes e outras moléculas através das membranas celulares. Esses inibidores são cruciais para o estudo da regulação da homeostase celular, transdução de sinais e neurotransmissão. Os inibidores de transportadores de membrana e canais iônicos também são importantes no desenvolvimento de tratamentos para distúrbios como epilepsia, doenças cardiovasculares e síndromes metabólicas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de alta qualidade de transportadores de membrana e canais iônicos para apoiar sua pesquisa em fisiologia, neurociência e farmacologia.
Subcategorias de "Transportador de Membranas/Canal Iónico"
- ABC(3 produtos)
- ATPase(93 produtos)
- Receptor de adiponectina(5 produtos)
- CFTR(64 produtos)
- Receptor CGRP(51 produtos)
- Canais de Cálcio(493 produtos)
- Canal de cloreto(49 produtos)
- Receptor GABA(336 produtos)
- Transportador de monoamina(23 produtos)
- Transportador de monocarboxilato(17 produtos)
- NKCC(2 produtos)
- NPC1L1(3 produtos)
- Cotransportador Na-K-Cl(8 produtos)
- OAT(27 produtos)
- OCT(7 produtos)
- P-gp(53 produtos)
- Canal de Potássio(276 produtos)
- Bomba de prótons(39 produtos)
- SGLT(30 produtos)
- Canal de Sódio(202 produtos)
- Canal TRP/TRPV(93 produtos)
Exibir 13 mais subcategorias
Foram encontrados 2277 produtos de "Transportador de Membranas/Canal Iónico"
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Sodium Channel inhibitor 4
CAS:<p>Sodium Channel Inhibitor 4 is a compound that functions as a sodium channel inhibitor [1].</p>Fórmula:C19H18ClN3O4S2Pureza:98%Cor e Forma:SolidPeso molecular:451.95URAT1 inhibitor 6
CAS:<p>URAT1 inhibitor 6 (Compound 1h), with an IC50 of 35 nM for hURAT1, demonstrates 200-fold and 8-fold greater potency compared to Lesinurad and Benzbromarone,</p>Fórmula:C9H7BrN3NaO2S2Cor e Forma:SolidPeso molecular:356.2Glibornuride
CAS:<p>Glibornuride is a blocker of ATP-sensitive K+ channel(pKi: 5.75).</p>Fórmula:C18H26N2O4SPureza:99.5%Cor e Forma:SolidPeso molecular:366.48NCS-382 sodium
CAS:<p>NCS-382 (sodium) is a potent antagonist of the GABA receptor, exhibiting anti-sedative and anti-hypnotic properties, with applications in neurological disease</p>Fórmula:C13H13NaO3Pureza:98%Cor e Forma:SolidPeso molecular:240.23PF-05241328
CAS:<p>PF-05241328 is an effective and selective inhibitor of human Nav1.7 voltage-dependent sodium channels (IC50: 31 nM).</p>Fórmula:C19H21ClN4O4SPureza:98%Cor e Forma:SolidPeso molecular:436.91ZM 260384
CAS:<p>ZM 260384 is a potassium channel opener.</p>Fórmula:C15H11F4N3O4Cor e Forma:SolidPeso molecular:373.26CGP 54626 hydrochloride
CAS:<p>CGP 54626 hydrochloride is a GABAB receptor antagonist.</p>Fórmula:C18H29Cl3NO3PPureza:98%Cor e Forma:SolidPeso molecular:444.76S-Pantoprazole sodium trihydrate
CAS:<p>S-Pantoprazole (sodium trihydrate), a variant of Pantoprazole, is pivotal in managing diseases associated with gastric acid secretion disorders, serving as a</p>Fórmula:C16H20F2N3NaO7SPureza:98%Cor e Forma:SolidPeso molecular:459.4TRPV2-selective blocker 1
CAS:<p>TRPV2-selective blocker 1 (compound IV2-1) is a selective inhibitor of the TRPV2 channel, exhibiting an IC50 value of 6.3 μM.</p>Fórmula:C15H18OS2Cor e Forma:SolidPeso molecular:278.43VMAT2-IN-I HCl
CAS:<p>VMAT2-IN-I HCl is an inhibitor of vesicular monoamine transporter-2. It also has 15- fold greater affinity than GZ- 793A.</p>Fórmula:C25H32ClF4NO4Pureza:98%Cor e Forma:SolidPeso molecular:521.97CE-224535
CAS:<p>CE-224535 (PF-04905428) is a selective antagonist of P2X7 receptor. CE-224535 can be used in disease-modifying antirheumatic studies.</p>Fórmula:C22H29ClN4O6Pureza:99.68%Cor e Forma:SolidPeso molecular:480.94C 101248
CAS:<p>C 101248 (KCNK13-IN-1) is a selective and potent tandem pore halogen inhibitor of K+ channel 1 (THIK-1) inhibitor and a human and mouse KCNK13 inhibitor.</p>Fórmula:C15H12N6OPureza:99.14% - 99.31%Cor e Forma:SolidPeso molecular:292.3Bupivacaine hydrochloride monohydrate
CAS:<p>Bupivacaine hydrochloride monohydrate is an NMDA receptor inhibitor that inhibits SCN5A channels and is commonly used in the study of chronic pain.</p>Fórmula:C18H31ClN2O2Pureza:99.91%Cor e Forma:SolidPeso molecular:342.9Reldesemtiv
CAS:<p>Reldesemtiv (CK-2127107) boosts exercise capacity, targeting fast muscle troponin, EC50 3.4 μM.</p>Fórmula:C19H18F2N6OPureza:97.27%Cor e Forma:SolidPeso molecular:384.38CFTR corrector 4
CAS:<p>Potent, oral CFTR corrector 4 targets cystic fibrosis, increasing cell surface CFTR levels.</p>Fórmula:C29H27F2NO7Pureza:99.32%Cor e Forma:SolidPeso molecular:539.52Funapide
CAS:<p>Funapide (TV 45070) is a potent Nav1.7 inhibitor, potentially treating inflammation and various pains.</p>Fórmula:C22H14F3NO5Pureza:99.91%Cor e Forma:SolidPeso molecular:429.35Aneratrigine hydrochloride
CAS:<p>Aneratrigine hydrochloride is a Nav 1.9 blocker that may be used to prevent or treat sodium channel blocker-related disorders.</p>Fórmula:C19H21Cl2F2N5O2S2Pureza:98.37% - 99.16%Cor e Forma:SolidPeso molecular:524.43Maralixibat Chloride
CAS:<p>Maralixibat Chloride (LUM001 chloride), an apical, sodium-dependent, bile acid transport inhibitor, prevents enterohepatic bile acid recirculation.</p>Fórmula:C40H56ClN3O4SPureza:99.19% - 99.65%Cor e Forma:SolidPeso molecular:710.41Kv3 modulator 1
CAS:<p>Kv3 modulator 1 is a voltage-gated potassium channel Kv3 modulator that can be used to study neurologic-level diseases.</p>Fórmula:C20H20N4O4Pureza:99.41%Cor e Forma:SolidPeso molecular:380.4LE135
CAS:<p>LE135: RARα/RARβ antagonist (Ki: 1.4 μM/220 nM), favors RARβ, selective vs RARγ/RXRs; also activates TRPV1/TRPA1 (EC50s: 2.5/20 μM).</p>Fórmula:C29H30N2O2Pureza:97.94%Cor e Forma:SolidPeso molecular:438.56Soraprazan
CAS:<p>BS3 Crosslinker (Bis(sulfosuccinimidyl)suberate) is an ADC linker that can be used to synthesize antibody-coupled active molecules.</p>Fórmula:C21H25N3O3Pureza:97.69% - 99.84%Cor e Forma:SolidPeso molecular:367.44EMD57033
CAS:<p>EMD57033 activates cardiac troponin C, enhances Ca2+ sensitivity to boost heart contraction.</p>Fórmula:C22H23N3O4SPureza:99.72% - >99.99%Cor e Forma:SolidPeso molecular:425.5MCT1-IN-3
CAS:<p>MCT1-IN-3 is a monocarboxylate transporter 1 (MCT1) inhibitor.</p>Fórmula:C22H19N3O4Pureza:99.35%Cor e Forma:SoildPeso molecular:389.4AMG-0347
CAS:<p>AMG-0347 inhibits TRPA1 ion channels in sensory neurons, blocking pain perception.</p>Fórmula:C24H26F3N3O2Pureza:99.93%Cor e Forma:SolidPeso molecular:445.48L-DABA hydrobromide
CAS:<p>L-DABA hydrobromide (L-2,4-Diaminobutyric acid hydrobromide) , GABA transaminase inhibitor with antitumor and anticonvulsant activity.</p>Fórmula:C4H11BrN2O2Pureza:99.11%Cor e Forma:SolidPeso molecular:199.05VGSCs-IN-1
CAS:<p>VGSCs-IN-1, a VGSC inhibitor and Riluzole analog, exhibits good blocking activity on Nav1.4 and can be used to study cellular excitability disorders.</p>Fórmula:C12H12F3N3OSPureza:99.88%Cor e Forma:SolidPeso molecular:303.3AMG2850
CAS:<p>AMG2850 is a potent, orally bioavailable, and selective antagonist of transient receptor potential melastatin 8 (TRPM8).</p>Fórmula:C19H17F6N3OPureza:99.84%Cor e Forma:SolidPeso molecular:417.35KCa2 channel modulator 2
<p>Compound 2q is a potent, subtype-selective K/Ca 2 modulator, effective on human K Ca 2.3 and rat K Ca 2.2a with EC50s of 0.60 μM and 0.64 μM.</p>Fórmula:C16H15ClFN5Cor e Forma:SolidPeso molecular:331.783-Methoxy PCE hydrochloride
CAS:<p>3-Methoxy PCE (3-MEO PCE) hydrochloride is an arylcyclohexylamine compound that functions as an NMDA receptor antagonist with a pKi value of 7.22.</p>Fórmula:C15H24ClNOCor e Forma:SolidPeso molecular:269.81Detajmium
CAS:<p>Detajmium is an anti-arrhythmia compound. It is an Na(+)-channel-blocking drug with an extremely long recovery from use-dependent sodium channel block.</p>Fórmula:C27H42N3O3Pureza:98%Cor e Forma:SolidPeso molecular:456.64Butein tetramethyl ether
CAS:<p>Butein tetramethyl ether (Compound 20) is a potent and selective inhibitor of breast cancer resistance protein / ATP-binding cassette sub-family G member 2 (BCRP/ABCG2). It inhibits MCF-7 MX and MDCKBCRP cells with IC50 values of 2.2 μM and 1.03 μM, respectively. Butein tetramethyl ether holds potential for cancer research.</p>Fórmula:C19H20O5Cor e Forma:SolidPeso molecular:328.359Leualacin
CAS:<p>Leualacin is a novel calcium blocker from Hapsidospora irregularis.</p>Fórmula:C31H47N3O7Pureza:98%Cor e Forma:SolidPeso molecular:573.72Tamitinol
CAS:<p>Tamitinol is a neurotropic drug. It has been found to help symptoms of obsessive rumination in conjunction with maprotiline.</p>Fórmula:C12H20N2OSPureza:98%Cor e Forma:SolidPeso molecular:240.37EF1502 free base
CAS:<p>EF1502 is a potent and selective GABA transporter inhibitor.</p>Fórmula:C22H26N2O2S2Pureza:98%Cor e Forma:SolidPeso molecular:414.58(R)-KMH-233
CAS:<p>(R)-KMH-233 is an isomer of KMH-233, which can serve as a reference compound in experiments. KMH-233 functions as a potent, reversible, and selective inhibitor of L-type amino acid transporter 1 (LAT1), effectively hindering the uptake of LAT1 substrate, l-leucine (IC50=18 μM), and also inhibiting cell growth. Even at a low concentration of 25 μM, KMH-233 significantly enhances the efficacy of Bestatin and cisplatin.</p>Fórmula:C32H25N7O5Peso molecular:587.58Caged MK801
CAS:<p>Caged MK801 (cMK801) is a selective, noncompetitive, and irreversible blocker of the NMDA receptor open channel. The NVOC cage is compatible in neuropharmacology and does not alter the intrinsic activity of the molecule.</p>Fórmula:C26H24N2O6Cor e Forma:SolidPeso molecular:460.48CFTR corrector 17
CAS:<p>CFTRcorrector 17 (example 17) is a regulator of the cystic fibrosis transmembrane conductance regulator (CFTR). It is utilized in the study of diseases mediated by CFTR.</p>Fórmula:C18H15FN2O2Cor e Forma:SolidPeso molecular:310.32BGT1-IN-1
CAS:<p>BGT1-IN-1 (compound 9) is an effective inhibitor of BGT1, demonstrating IC50 values of 13.9 µM for hBGT1 and 58.3 µM for GAT3. It exhibits no cytotoxic effects and possesses neuroprotective activity.</p>Fórmula:C6H9NO2Cor e Forma:SolidPeso molecular:127.14S9-A13
CAS:<p>S9-A13 is a potent and selective inhibitor of SLC26A9, exhibiting an IC50 of 90.9 nM without inhibiting other members of the SLC26 family, such as SLC26A3, SLC26A4, and SLC26A6. It also inhibits the SLC26A9 Cl- current in cells lacking CFTR expression.</p>Fórmula:C20H18ClN3O2SCor e Forma:SolidPeso molecular:399.89H052
CAS:<p>H052 is a selective inhibitor of Staphylococcus aureus α-hemolysin (Hla). It binds to the Hla monomer, disrupting its interaction with the host cell membrane, thereby blocking pore formation and inhibiting calcium influx, cytotoxicity, and inflammatory response. H052 exhibits inhibitory activity against Hla-induced calcium influx (EC50 = 30 nM in U937 cells) and holds potential for research into lung infections caused by S. aureus.</p>Fórmula:C21H15ClFN3O4SCor e Forma:SolidPeso molecular:459.88EU 1622-240
CAS:<p>EU 1622-240 is an allosteric modulator with a preference for GluN2B, GluN2C, and GluN2D, exhibiting EC50 values of 0.57, 0.82, and 1.1 μM, respectively. It possesses favorable physicochemical properties, along with in vitro stability and permeability.</p>Fórmula:C20H14BrF2N3O2SCor e Forma:SolidPeso molecular:478.31Cyproflanilide
CAS:<p>Cyproflanilide is a GABAR antagonist that exhibits high activity against a variety of pests, including those from the Lepidoptera, Coleoptera, and Thysanoptera orders.</p>Fórmula:C28H17BrF12N2O2Cor e Forma:SolidPeso molecular:721.33Vormatrigine
CAS:<p>Vormatrigine effectively inhibits sodium channels (sodium channel).</p>Fórmula:C16H12F6N4O2Cor e Forma:SolidPeso molecular:406.28Kv7.2/Kv7.3 agonist 1
CAS:<p>Kv7.2/Kv7.3 agonist 1 (Compound 16) is an orally effective agonist for the KV7.2/7.3 channels (KV7.2/7.3 channel/KCNQ2/3) with an EC50 of 1.03 μM. This compound demonstrates analgesic effects in mouse models of chronic constriction injury (CCI) and Streptozotocin-induced diabetic peripheral neuropathy (DPNP), with ED50 values of 12.02 mg/kg and 9.63 mg/kg, respectively.</p>Fórmula:C14H14FN3O2Cor e Forma:SolidPeso molecular:275.28NMD670
CAS:<p>NMD670 is an orally active, partial inhibitor of the skeletal muscle-specific chloride channel ClC-1. It enhances muscle excitability and neuromuscular transmission, restoring muscle function and mobility. NMD670 has a favorable safety profile and improves muscle function in rats, particularly in an MG rat model [1].</p>Fórmula:C12H10BrNO4Cor e Forma:SolidPeso molecular:312.12CRM1-IN-3
CAS:<p>CRM1-IN-3 (B28), a noncovalent inhibitor of CRM1, is utilized in the research of protein localization and tumor studies [1].</p>Fórmula:C26H26ClN3O3Cor e Forma:SolidPeso molecular:463.96Sp-8-Br-cGMPS
CAS:<p>Sp-8-Br-cGMPS, an analogue of cGMP, acts as an agonist for cGMP gated cation channels (CNG channels) with an EC50 of 106.5 μM. While Sp-8-Br-cGMPS can induce currents, it does not stabilize channel open states as effectively as a full agonist.</p>Fórmula:C10H11BrN5O6PSCor e Forma:SolidPeso molecular:440.17TRPV1 antagonist 10
CAS:<p>TRPV1 antagonist 10 is a potent, orally active TRPV1 antagonist with an IC50 of 33.06 nM and serves as a moderate to weak inhibitor of URAT1 (IC50 = 22.51 μM) and GLUT9 (inhibition of 60.25% at 50 μM). It exhibits analgesic and urate-lowering properties and is applicable for research in hyperuricemia and inflammatory pain.</p>Fórmula:C16H14N2O5Cor e Forma:SolidPeso molecular:314.293TRPA1 Antagonist 1
CAS:<p>TRPA1 Antagonist 1 is an antagonist of TRPA1(IC50: 8 nM) and is a methylene phosphate prodrug which converts to its active parent drug.</p>Fórmula:C24H20F6N5Na2O7PSPureza:98%Cor e Forma:SolidPeso molecular:713.45pan-HCN-IN-1
CAS:<p>Pan-HCN-IN-1 (Compound J&J12e) is an inhibitor of the hyperpolarization-activated and cyclic-nucleotide-gated 1 (HCN1) ion channel, with an IC50 of 58 nM. Pan-HCN-IN-1 reduces the voltage sag response and enhances EPSP summation in ex vivo rat brain slices [1].</p>Fórmula:C23H37N3O2Cor e Forma:SolidPeso molecular:387.56
