Transportador de Membranas/Canal Iónico
Os inibidores de transportadores de membrana e canais iônicos são compostos que bloqueiam a função de proteínas responsáveis pelo transporte de íons, nutrientes e outras moléculas através das membranas celulares. Esses inibidores são cruciais para o estudo da regulação da homeostase celular, transdução de sinais e neurotransmissão. Os inibidores de transportadores de membrana e canais iônicos também são importantes no desenvolvimento de tratamentos para distúrbios como epilepsia, doenças cardiovasculares e síndromes metabólicas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de alta qualidade de transportadores de membrana e canais iônicos para apoiar sua pesquisa em fisiologia, neurociência e farmacologia.
Subcategorias de "Transportador de Membranas/Canal Iónico"
- ABC(3 produtos)
- ATPase(93 produtos)
- Receptor de adiponectina(5 produtos)
- CFTR(64 produtos)
- Receptor CGRP(51 produtos)
- Canais de Cálcio(493 produtos)
- Canal de cloreto(49 produtos)
- Receptor GABA(336 produtos)
- Transportador de monoamina(23 produtos)
- Transportador de monocarboxilato(17 produtos)
- NKCC(2 produtos)
- NPC1L1(3 produtos)
- Cotransportador Na-K-Cl(8 produtos)
- OAT(27 produtos)
- OCT(7 produtos)
- P-gp(53 produtos)
- Canal de Potássio(276 produtos)
- Bomba de prótons(39 produtos)
- SGLT(30 produtos)
- Canal de Sódio(202 produtos)
- Canal TRP/TRPV(93 produtos)
Exibir 13 mais subcategorias
Foram encontrados 2277 produtos de "Transportador de Membranas/Canal Iónico"
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Cav 2.2/3.2 blocker 1
<p>Compound 9e is a Cav 2.2/3.2 blocker; IC50: 1.22 μM & 80 μM, respectively; penetrates CNS.</p>Fórmula:C28H30N2O3Cor e Forma:SolidPeso molecular:442.55Ro-51
CAS:<p>dual P2X3 and P2X2/3 antagonist</p>Fórmula:C17H23IN4O4Pureza:98%Cor e Forma:SolidPeso molecular:474.29Quinacainol dihydrochloride
CAS:<p>Quinacainol dihydrochloride (PK 10139 dihydrochloride) is the bis(2 hydrochloride) salt form of Quinacainol. It acts as an inhibitor of the sodium current, with an EC50 of 95 µM. This compound displays antiarrhythmic activity by modulating the electrophysiological properties of the heart.</p>Fórmula:C21H32Cl2N2OCor e Forma:SolidPeso molecular:399.398IAB15
CAS:<p>IAB15 is a potent inhibitor of T-type calcium channel that can be used in the research of epilepsy [1].</p>Fórmula:C15H14F3NO2Cor e Forma:SolidPeso molecular:297.27SGE-516
CAS:<p>SGE516: neuroactive steroid, enhances GABAA, lowers neuronal activity, protects from seizures.</p>Fórmula:C23H35N3O2Pureza:98%Cor e Forma:SolidPeso molecular:385.54TTA-P1
CAS:<p>TTA-P1: potent T-type calcium channel inhibitor; impacts neuron firing, hormone secretion, cell growth; potential in absence epilepsy research.</p>Fórmula:C19H27Cl2FN2OCor e Forma:SolidPeso molecular:389.33YY-23
CAS:<p>YY-23 is a selective NMDAR (containing GluN2C or GluN2D) inhibitor. By inhibiting NMDARs with GluN2D on GABAergic interneurons in the prefrontal cortex, YY-23 suppresses GABAergic neurotransmission and enhances excitatory transmission. YY-23 exhibits antidepressant activity and is useful for neurological disease research.</p>Fórmula:C33H54O8Cor e Forma:SolidPeso molecular:578.777LY3130481
CAS:<p>LY3130481: TARP γ-8 dependent AMPA receptor blocker; selectively targets AMPA/TARP γ-8 with 65 nM IC50.</p>Fórmula:C19H18N4O3SCor e Forma:SolidPeso molecular:382.44Cav 3.2 inhibitor 2
<p>Cav 3.2 inhibitor 2 blocks T-type Ca2+ channels (IC50=0.09339 μM) and reduces mouse somatic/visceral pain. Used for intractable pain studies.</p>Fórmula:C32H37F2N3OCor e Forma:SolidPeso molecular:517.65MSK-195
CAS:<p>MSK-195 is an effective TRPV1 agonist.</p>Fórmula:C28H40N2O5Pureza:98%Cor e Forma:SolidPeso molecular:484.63Kv7.2/Kv7.3 modulator-1
CAS:<p>Kv7.2/Kv7.3 modulator-1 (compound 6a) acts as a modulator for Kv7.2/Kv7.3 channels, with a pEC50 value of 7.96 for opening these channels. Kv7.2/Kv7.3 modulator-1 is applicable in research related to epilepsy, depression, brain injury, and pain.</p>Fórmula:C20H21F4N3O3Cor e Forma:SolidPeso molecular:427.393SR 33805 oxalate
CAS:<p>Ca2+ channel antagonist</p>Fórmula:C34H42N2O9SPureza:98%Cor e Forma:SolidPeso molecular:654.77T-Type calcium channel inhibitor 2
<p>Compound 6g inhibits T-type Ca channels (IC50: Cav3.1-31μM, Cav3.2-83μM), cytotoxic to A549 (IC50: 5μM) & HCT-116 cells (IC50: 6.4μM).</p>Fórmula:C36H39FN4OSCor e Forma:SolidPeso molecular:594.78ATP synthase inhibitor 2
CAS:<p>ATP synthase inhibitor 2 blocks P. aeruginosa ATP synthase; IC50=10 μg/mL, fully inhibits at 128 μg/mL.</p>Fórmula:C21H22N2O3SCor e Forma:SolidPeso molecular:382.48264W94
CAS:<p>264W94 robustly inhibits IBAT, induces CYP7A1, and significantly reduces cholesterol.</p>Fórmula:C23H31NO4SPureza:98%Cor e Forma:SolidPeso molecular:417.56CFTR corrector 18
CAS:<p>CFTRcorrector 18 (Compound I-99) acts as a modulator of the cystic fibrosis transmembrane conductance regulator (CFTR). It enhances the processing and trafficking of CFTR, thereby increasing the amount of CFTR present on the cell surface. CFTRcorrector 18 holds potential for research in cystic fibrosis (CF).</p>Fórmula:C38H40N6O5SCor e Forma:SolidPeso molecular:692.826P2X4-IN-1
CAS:<p>P2X4-IN-1 is an orally active P2X4 inhibitor. P2X4-IN-1 is applicable in research focused on disease prevention.</p>Fórmula:C18H14ClN5O3SCor e Forma:SolidPeso molecular:415.85ML-SI1
CAS:<p>ML-SI1, a racemic mixture of diastereoisomers, is a TRPML inhibitor and acts on TRPML1 (IC50: 15 μM).</p>Fórmula:C23H26Cl2N2O3Cor e Forma:SolidPeso molecular:449.373-Bromoamphetamine hydrochloride
CAS:<p>3-Bromoamphetamine hydrochloride is a para-substituted amphetamine that functions as a monoamine releaser.</p>Fórmula:C9H13BrClNCor e Forma:SolidPeso molecular:250.563PF-06305591 dihydrate
<p>PF-06305591 dihydrate is a potent and highly selective voltage gated sodium channel NaV1.8 blocker (IC 50 = 15 nM) with an excellent preclinical in vitro ADME</p>Fórmula:C15H26N4O3Cor e Forma:SolidPeso molecular:310.39Mibefradil dihydrochloride hydrate
CAS:<p>Mibefradil dihydrochloride hydrate is a long-acting antihypertensive blocking high-voltage L calcium channels.</p>Fórmula:C29H42Cl2FN3O4Cor e Forma:SolidPeso molecular:586.57LY 235959
CAS:<p>LY 235959 is a NMDA receptor antagonist.</p>Fórmula:C11H20NO5PPureza:98%Cor e Forma:SolidPeso molecular:277.25CRM1 degrader 1
<p>CRM1 degrader 1 (1l) is a low-toxic CRM1 degrader that induces apoptosis in gastric carcinoma and selectively inhibits the proliferation of gastric cancer[1].</p>Fórmula:C16H20O3Cor e Forma:SolidPeso molecular:260.33PDE2 inhibitor 6
CAS:<p>PDE2 inhibitor6 (Compound 1) is an orally active phosphodiesterase (PDE) inhibitor, effectively inhibiting PDE2A, PDE3B, and PDE10A2 with IC50 values of 0.95 nM, 6.17 μM (pIC50=5.21), and 87.1 nM (pIC50=7.06), respectively. It modulates AMPA receptor activity, enhances synaptic plasticity, and improves learning and memory in rat models. Furthermore, PDE2 inhibitor6 possesses blood-brain barrier permeability.</p>Fórmula:C20H22F2N6OCor e Forma:SolidPeso molecular:400.425Metaphit methylsulfate
CAS:<p>Metaphit methylsulfate is a specific PCP antagonist and an acylating agent for the [3H] phencyclidine binding site in rat brain homogenate. It inhibits PCP-induced motor activity through a presynaptic mechanism.</p>Fórmula:C19H28N2O3S2Cor e Forma:SolidPeso molecular:396.567URAT1 inhibitor 3
<p>URAT1 inhibitor 3: potent oral URAT1 blocker, IC50=0.8 nM, for gout/hyperuricemia study.</p>Fórmula:C14H8Cl2N2O2Cor e Forma:SolidPeso molecular:307.13Unoprostone
CAS:<p>Unoprostone is a prostaglandin F2α analogs (PGAs), and reduces intraocular pressure and is used topically for glaucoma or ocular hypertension.</p>Fórmula:C22H38O5Pureza:98%Cor e Forma:SolidPeso molecular:382.53S-8510 phosphate
CAS:<p>S-8510 phosphate is an agonist of inverse Benzodiazepine (BDZ) receptor(Kis of 34.6 nM, 36.2 nM for –GABA and +GABA respectively).</p>Fórmula:C12H13N4O6PPureza:98%Cor e Forma:SolidPeso molecular:340.23Gabaculine HCl
CAS:<p>Gabaculine, an irreversible GABA-T inhibitor (Ki: 2.9 μM), impacts plastid development and affects DPOR/GluTR levels.</p>Fórmula:C7H10ClNO2Cor e Forma:SolidPeso molecular:175.61EMD-95885
CAS:<p>EMD-95885 is a selective antagonist of NMDA receptors containing NR2B subunits, with an IC50 of 3.9 nM. It does not interact with other sites on the NMDA receptor.</p>Fórmula:C22H23FN2O3Cor e Forma:SolidPeso molecular:382.428RO-275
CAS:<p>RO-275 is an HCN1 inhibitor that also inhibits HCN2, HCN3, and HCN4, improving working memory deficits and being used in research on cognitive disorders.</p>Fórmula:C18H14ClN5OPureza:98.12% - 98.3%Cor e Forma:SolidPeso molecular:351.79Olorigliflozin
CAS:<p>Olorigliflozin is a sodium glucose co-transporter (SGLT) inhibitor with antihyperglycemic properties.</p>Fórmula:C23H27ClO7Cor e Forma:SolidPeso molecular:450.909ARN23765
CAS:<p>ARN23765 is an F508del-CFTR corrector with an EC50 of 38 pM in human bronchial epithelial cells. It enhances the maturation and function of F508del-CFTR at the cell membrane, influencing ion transport and secretion, thereby addressing the pathological mechanisms of cystic fibrosis (CF).</p>Fórmula:C30H22F5N3O6Cor e Forma:SolidPeso molecular:615.504Pyrimidinone 8
CAS:<p>Pyrimidinone 8 is a reversible, linear non-competitive inhibitor of divalent metal transporter 1 (DMT1) with a Ki of 20 μM (hDMT1). It does not affect the surface expression of hDMT1 and is not influenced by extracellular pH. Pyrimidinone 8 inhibits hDMT1-mediated iron uptake, with an IC50 of 13.8 μM.</p>Fórmula:C10H12N4OCor e Forma:SolidPeso molecular:204.229GABA-IN-4
CAS:<p>GABA-IN-4 (Compound 17) is a derivative of N-(indol-3-ylglyoxylyl)benzylamine. It exhibits high affinity for the benzodiazepine receptor (BzR), the binding site within the GABAA receptor complex, with a Ki value of 67 nM. Benzodiazepines are widely used as anxiolytic, sedative-hypnotic, and anticonvulsant agents.</p>Fórmula:C17H13ClN2O2Cor e Forma:SolidPeso molecular:312.75Zilvetrigine
CAS:<p>Zilvetrigine is a sodium channel (sodium channel) blocker. It can be used as an analgesic.</p>Fórmula:C20H20ClN3O2Cor e Forma:SolidPeso molecular:369.845NMDA agonist 1
CAS:<p>NMDA agonist 1 (compound 42d) is a potent NMDA agonist with a Ki value of 96 nM. It acts as a partial agonist of the GluN1/GluN2B complex, exhibiting an EC50 value of 78 nM.</p>Fórmula:C12H13N3O3SCor e Forma:SolidPeso molecular:279.315Antidepressant agent 9
CAS:<p>Antidepressant agent 9 (Compound 24) is an orally active inhibitor of NMDAR and SERT, with IC50 values of 3.50 μM and 1044 nM, respectively. It exhibits good metabolic stability and plasma exposure, and demonstrates antidepressant-like effects in the forced swim test in mice.</p>Fórmula:C17H24N2Cor e Forma:SolidPeso molecular:256.386SGC-CAMKK2-1
CAS:<p>SGC-CAMKK2-1 is a selective inhibitor of calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) with an IC50 of 30 nM. It effectively inhibits AMPK phosphorylation in C4-2 cells, exhibiting an IC50 value of 1.6 µM.</p>Fórmula:C26H23NO3Cor e Forma:SolidPeso molecular:397.466Antidepressant agent 8
CAS:<p>Antidepressant agent 8 (Compound 1f) acts as a selective antagonist for the NMDA receptor GluN1/2A (NMDA receptorGluN1/2A), with an IC50 of 2.94 μmol/L. In a hydrocortisone-induced zebrafish depression model, it demonstrates antidepressant-like effects and shows good blood-brain barrier penetration.</p>Fórmula:C18H23FN4OS2Cor e Forma:SolidPeso molecular:394.53O4I4
CAS:<p>O4I4 is an OCT4-inducing compound capable of activating endogenous OCT4 and its associated signaling pathways, shown anti-aging effects.</p>Fórmula:C15H20N2SPureza:99.74%Cor e Forma:SolidPeso molecular:260.4LY503430
CAS:<p>LY503430: Oral AMPA enhancer with nootropic, neuroprotective properties, mitigates 6-OHDA/MPTP brain damage.</p>Fórmula:C20H25FN2O3SPureza:98%Cor e Forma:SolidPeso molecular:392.49Antimalarial agent 7
<p>Antimalarial agent 7 is a potent and effective inhibitor of PfATP4. Antimalarial agent 7 has potential for the study of the human plasmodium falciparum.</p>Fórmula:C23H22F2N4O3Cor e Forma:SolidPeso molecular:440.44Olisutrigine bromide
CAS:<p>Olisutrigine bromide is a sodium channel blocker used as an analgesic.</p>Fórmula:C25H35BrN2Cor e Forma:SolidPeso molecular:443.463ErSO-TFPy
CAS:<p>ErSO-TFPy activates the sodium ion channel TRPM4, resulting in an imbalance of intracellular calcium and sodium ions. It exhibits low nanomolar-level cytotoxicity (IC50 = 5-25 nM) by inducing necrosis in ERα+ breast cancer cell lines. Additionally, ErSO-TFPy shows antitumor activity in mouse models.</p>Fórmula:C19H13F7N2O2Cor e Forma:SolidPeso molecular:434.307Moxetomidate
CAS:<p>Moxetomidate is a GABAA receptor (GABAA receptor) agonist with hypnotic properties.</p>Fórmula:C15H18N2O3Cor e Forma:SolidPeso molecular:274.315Crinecerfont tosylate
CAS:<p>Crinecerfont tosylate is an effective oral CRF1 receptor antagonist. It is applicable to studies involving congenital adrenal hyperplasia (CAH).</p>Fórmula:C34H36ClFN2O4S2Cor e Forma:SolidPeso molecular:655.242(3S,6R)-NML
CAS:<p>(3S,6R)-NML is an NMDA receptor antagonist with pIC50 values of 4.8 [GluN1-GluN2A], 4.6 [GluN1-GluN2B], 5.0 [GluN1-GluN2C], and 5.0 [GluN1-GluN2D]. It is applicable in the study of depression.</p>Fórmula:C20H27NOCor e Forma:SolidPeso molecular:297.435URAT1 inhibitor 2
<p>URAT1 inhibitor 2: oral URAT1/CYP blocker, IC50 of 1.36μM (URAT1), 16.97μM (CYP1A2), 5.22μM (CYP2C9); potential gout treatment.</p>Fórmula:C21H18BrN3O2SCor e Forma:SolidPeso molecular:456.36Insecticidal agent 21
CAS:<p>Insecticidal agent 21 (Compound 6) is an insecticide targeting Culex pipiens larvae with an LC50 of 0.4 μg/mL. It achieves multi-target neurotoxicity by inhibiting acetylcholinesterase (AChE) and simultaneously targeting other neural receptors, including nicotinic acetylcholine receptors (nAChR), voltage-gated sodium channels (VGSC), and γ-aminobutyric acid receptors (GABAAR). Insecticidal agent 21 shows potent insecticidal activity and can be utilized in the development of new insecticides to combat mosquito resistance to conventional agents.</p>Fórmula:C37H40ClN3O2Cor e Forma:SolidPeso molecular:594.185
