Canal TRP/TRPV
Os canais TRP (Potencial do Receptor Transitório), incluindo a subfamília TRPV, são um grupo de canais iônicos envolvidos em vários processos sensoriais, como sensação de temperatura, percepção da dor e osmorregulação. Os canais TRP são amplamente expressos em diferentes tecidos e desempenham um papel nas respostas fisiológicas aos estímulos ambientais. Os canais TRPV, em particular, estão envolvidos na detecção de mudanças de temperatura e estão implicados em condições como dor crônica, inflamação e câncer. Na CymitQuimica, oferecemos uma gama abrangente de moduladores de canais TRP/TRPV para apoiar sua pesquisa em biologia sensorial, manejo da dor e transdução de sinais.
Foram encontrados 95 produtos de "Canal TRP/TRPV"
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IA-Alkyne
CAS:IA-Alkyne: TRPC agonist, cysteine-reactivity probe, potential in respiratory infection study.Fórmula:C8H12INOPureza:99.76%Cor e Forma:SolidPeso molecular:265.09TRPV4 agonist-1 free base
CAS:TRPV4 agonist-1 free base (OUN67600) is an agonist of transient receptor potential vanilloid 4 (TRPV4;EC50 of 60 nM, in the hTRPV4 Ca2+ assay).Fórmula:C25H22F2N4O2Pureza:99.79%Cor e Forma:SolidPeso molecular:448.46GFB-8438
CAS:GFB-8438 is a potent and subtype selective inhibitor of TRPC5(IC50s of 0.18 and 0.29 μM of hTRPC5 and hTRPC4, respectively).Fórmula:C16H14ClF3N4O2Pureza:99.58%Cor e Forma:SolidPeso molecular:386.76BI-749327
CAS:BI-749327 is a high selectivity and orally bioavailable antagonist of TRPC6 (IC50s: 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6).Fórmula:C23H21F3N4O2Pureza:99.68% - 99.84%Cor e Forma:SolidPeso molecular:442.43(Z)-Capsaicin
CAS:<p>(Z)-Capsaicin (Zucapsaicin) is a medication used to treat osteoarthritis of the knee and Others neuropathic pain.(Z)-Capsaicin is a synthetic cis isomer of</p>Fórmula:C18H27NO3Pureza:97.33% - 98.91%Cor e Forma:SolidPeso molecular:305.41Vocacapsaicin hydrochloride
CAS:<p>Vocacapsaicin hydrochloride (CA-008 hydrochloride) is a non-opioid TRPV1 agonist, a raw material for capsaicin, and is used for pain relief.</p>Fórmula:C26H42ClN3O4Pureza:99.66% - 99.80%Cor e Forma:SolidPeso molecular:496.08AP 18
CAS:<p>AP-18 is a potent and selective TRPA1 inhibitor.</p>Fórmula:C11H12ClNOPureza:99.85% - 99.96%Cor e Forma:SolidPeso molecular:209.67CBP-1008
CBP-1008 is a dual-ligand peptide-drug conjugate (PDC) with MMAE, targeting folate receptor (FRα) and TRPV6. It exhibits high binding affinity to FRα and low affinity to TRPV6. CBP-1008 shows antitumor activity and can be utilized for research in advanced solid tumors such as colorectal cancer, breast cancer, non-small cell lung cancer, ovarian cancer, adrenocortical carcinoma, and follicular dendritic cell sarcoma.Cor e Forma:Odour SolidNGD-8243
CAS:<p>NGD-8243 (N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]quinazolin-4-amine) is a TRPV1 inhibitor and can be used in studies for prevention</p>Fórmula:C21H12F6N4Pureza:95.26%Cor e Forma:SolidPeso molecular:434.34RN-1665
CAS:RN-1665 is a potent and selective TRPV4 receptor antagonist.Fórmula:C20H24F5N3O3S2Pureza:99.96%Cor e Forma:SoildPeso molecular:513.54(S)-ABT 102
CAS:N-[(1S)-1H-inden-1-yl]-N'-indazol-4-ylurea is a strong TRPV1 blocker with a 123 nM IC50 against capsaicin.Fórmula:C21H24N4OPureza:99.65% - 99.77%Cor e Forma:SoildPeso molecular:348.44TRPM8 antagonist 3
CAS:TRPM8 antagonist 3 is a blocker of TRPM8 (IC50 = 11 nM).Fórmula:C13H12N2O4SPureza:99.74%Cor e Forma:SolidPeso molecular:292.31PF-04745637
CAS:PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM[1].Fórmula:C27H32ClF3N2O2Pureza:98.88% - 99.3%Cor e Forma:SolidPeso molecular:509TRPA1-IN-2
CAS:<p>TRPA1-IN-2 is a potent and orally active TRPA1 inhibitor with an IC50 value of 0.04 µM.TRPA1-IN-2 has anti-inflammatory activity.</p>Fórmula:C24H25F3N4OPureza:98.05%Cor e Forma:SoildPeso molecular:442.48Resolvin D2
CAS:<p>Resolvin D2 (RvD2) is a TRPV1 inhibitor and pro-ablative mediator with anti-inflammatory, anti-infective and pro-ablative effects.</p>Fórmula:C22H32O5Pureza:98%Cor e Forma:SolidPeso molecular:376.49Cyclic ADP-Ribose (ammonium salt)
Cyclic ADP-Ribose (ammonium salt) (cADPR) is an NAD⁺ metabolite that triggers Ca²⁺ release from ER stores via ryanodine receptors, relevant to inflammation research.Fórmula:C15H21N5O13P2·xNH3Cor e Forma:SolidOleoyl Serotonin
CAS:<p>Oleoyl Serotonin is an antagonist of hTRPV1 with an IC50 of 2.57 μM.</p>Fórmula:C28H44N2O2Pureza:99.88%Cor e Forma:SolidPeso molecular:440.66L-R4W2
CAS:<p>Vanilloid TRPV1 (VR1) receptor antagonist peptide (IC50 ~ 0.1 μM); blocks Ca2+ currents in dorsal root ganglion neurons. Analgesic in vivo.</p>Fórmula:C46H71N21O6Pureza:98%Cor e Forma:SolidPeso molecular:1014.2GSK2798745
CAS:GSK2798745 is an orally active transient receptor potential vanilloid 4 (TRPV4) ion channel blocker (IC50s: 1.8 and 1.6 nM for hTRPV4 and rTRPV4).Fórmula:C25H28N6O3Cor e Forma:SolidPeso molecular:460.53Phenazopyridine
CAS:Phenazopyridine is an orally administered azo dye with local analgesic effects on urinary tract infections,. against SARM1 and TRPM8.Fórmula:C11H11N5Pureza:99.98%Cor e Forma:SolidPeso molecular:213.24
