Aminopeptidase
As aminopeptidases são um grupo de enzimas que catalisam a clivagem de aminoácidos a partir do N-terminal de peptídeos e proteínas, desempenhando um papel crucial na maturação e degradação de proteínas. Essas enzimas estão envolvidas em vários processos fisiológicos, incluindo o processamento de antígenos, a regulação de hormônios peptídicos e a homeostase celular. Inibidores de aminopeptidases são de interesse no tratamento de doenças como câncer, inflamação e doenças infecciosas. Na CymitQuimica, oferecemos uma variedade de inibidores de aminopeptidases para apoiar sua pesquisa em proteômica, desenvolvimento de medicamentos e tratamento de doenças.
Foram encontrados 67 produtos de "Aminopeptidase"
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ERAP1-IN-1
CAS:<p>ERAP1-IN-1 inhibits and allosterically activates ERAP1, affecting fluorogenic, chromogenic, and nonamer peptide substrates.</p>Fórmula:C20H21F3N2O5SPureza:98.95%Cor e Forma:SolidPeso molecular:458.45Bufexamac
CAS:<p>Bufexamac (Bufexamic acid) is a COX inhibitor for IFN-α release with anti-inflammatory, analgesic, and antipyretic action.</p>Fórmula:C12H17NO3Pureza:99.73%Cor e Forma:Acicular CrystalPeso molecular:223.27Probestin
CAS:<p>Probestin is an aminopeptidase M inhibitor, isolated from Streptomyces azureus MH663-2F6.</p>Fórmula:C26H38N4O6Pureza:98%Cor e Forma:SolidPeso molecular:502.60Aminopeptidase N inhibitor 2
<p>AminopeptidaseN inhibitor 2 is an APN inhibitor (IC50: 4.3 μM) with antitumor properties.</p>Fórmula:C12H16F2N2O4SCor e Forma:SolidPeso molecular:322.07988BAY-277
<p>BAY-277 is a degrader of METAP2, with IC50 values of 5.8 nM for human METAP2 (hMETAP2) and 5.9 nM for mouse METAP2 (mMETAP2).</p>Fórmula:C44H52N8O5Cor e Forma:SolidPeso molecular:772.93LTA4H-IN-4
<p>LTA4H-IN-4 (compound 3) is an orally active inhibitor of LTA4H. It exhibits an IC50 value of 156 μM against hERG and is applicable for inflammation-related research.</p>Leuhistin
CAS:<p>Leuhistin is an aminopeptidases N inhibitor isolated from Bacillus laterosporus BMI156-14F1.</p>Fórmula:C11H19N3O3Pureza:98%Cor e Forma:White To Off-White SolidPeso molecular:241.29Matlystatin A
CAS:<p>Matlystatin A is an inhibitor of aminopeptidase. It shows multiple inhibitory activities against both aminopeptidase N and matrix metalloproteinases.</p>Fórmula:C27H47N5O8SCor e Forma:SolidPeso molecular:601.76SDUY817
<p>SDUY817 is a dual APN/NEP inhibitor with IC50 values of 0.29 μM for APN and 7.4 μM for NEP. It exhibits analgesic effects in a concentration- and time-dependent manner, making it a potential candidate for research in the field of neuropathic pain disorders.</p>Fórmula:C18H16IN3O3Cor e Forma:SolidPeso molecular:449.24CD13-IN-1
<p>CD13-IN-1 (Compound 5f) is a CD13 inhibitor with an IC50 value of 1.71 μM. It effectively suppresses the proliferation of various tumor cells, demonstrating antitumor activity.</p>Cor e Forma:Odour SolidAmastatin hydrochloride
CAS:<p>Amastatin HCl is an inhibitor of aminopeptidase. It also induces vasoconstriction.</p>Fórmula:C21H39ClN4O8Cor e Forma:White To Off-White PowderPeso molecular:511.01ecMetAP-IN-1
CAS:<p>ecMetAP-IN-1 可用作 QSAR 模型，以使用多元线性回归研究蛋氨酸氨基肽酶抑制剂作为抗癌剂。</p>Fórmula:C13H11N3Pureza:99.34%Cor e Forma:SolidPeso molecular:209.25NGR peptide
CAS:<p>Cell-penetrating peptide</p>Fórmula:C20H36N10O8S2Pureza:98%Cor e Forma:SolidPeso molecular:608.69JNJ-40929837 succinate
CAS:<p>JNJ-40929837 succinate is a selective, orally active inhibitor of LTA 4 H (leukotriene A 4 hydrolase). This compound effectively inhibits aminopeptidase activity, leading to the accumulation of Pro-Gly-Pro in serum, and can be utilized in asthma research [1].</p>Fórmula:C22H24N4O2S·xC4H6O4Cor e Forma:SolidBDM_92499
<p>BDM_92499 is a nanomolar, selective IRAP inhibitor with an IC50 of 3.4 nM. It also inhibits ERAP1 and ERAP2, with IC50 values of 0.46 μM and 4.2 μM, respectively.</p>Cor e Forma:Odour SolidAclimostat
CAS:<p>Aclimostat (ZGN-1061) is a MetAP2 inhibitor with strong preclinical results, improving obesity-related metrics and gene expression.</p>Fórmula:C26H42N2O6Cor e Forma:SolidPeso molecular:478.63Relzomostat
CAS:<p>Relzomostat inhibits MetAP2, with research potential for obesity and type 2 diabetes.</p>Fórmula:C24H36F2N2O5Cor e Forma:SolidPeso molecular:470.558SDUY816
<p>SDUY816 is an orally active dual APN/NEP inhibitor, with IC50 values of 0.68 μM for APN and 6.9 μM for NEP. It exhibits analgesic properties and demonstrates good safety and pharmacokinetic profiles, having an oral bioavailability of 27% and a half-life of 4.02 hours in rats (oral, 10 mg/kg). SDUY816 is applicable for research in the field of neuropathic pain disorders.</p>Fórmula:C18H16IN3O3Cor e Forma:SolidPeso molecular:449.24ERAP1-IN-3
<p>ERAP1-IN-3 (compound 13) is a potent inhibitor of endoplasmic reticulum aminopeptidase 1 (ERAP1), with a pIC50 value of 8.6. ERAP1-IN-3 shows potential for research in cancer immunotherapy and autoimmune disease studies.</p>Fórmula:C22H22N2O4SCor e Forma:SolidPeso molecular:410.49DG013A formate
<p>DG013A (formate) is a tripeptide-mimicking inhibitor of hypophosphorous acid. It exhibits IC50 values of 33 nM for ERAP1 and 11 nM for ERAP2. This compound can be utilized in research related to autoimmune diseases and cancer.</p>Fórmula:C27H37N4O4PCH2O2Cor e Forma:SolidPeso molecular:530.99
