Células - tronco e Derivados

Os inibidores de células-tronco são compostos que visam especificamente as vias de sinalização e proteínas envolvidas na manutenção, diferenciação e proliferação de células-tronco. Esses inibidores são cruciais para compreender a biologia das células-tronco e para desenvolver estratégias para manipular células-tronco para fins terapêuticos, como medicina regenerativa e tratamento do câncer. Ao controlar o destino das células-tronco, esses inibidores podem ajudar a orientar a diferenciação das células-tronco em tipos celulares específicos ou prevenir o crescimento celular indesejado. Na CymitQuimica, oferecemos uma seleção de inibidores de células-tronco de alta qualidade para apoiar sua pesquisa em biologia de células-tronco, biologia do desenvolvimento e medicina regenerativa.

Subcategorias de "Células - tronco e Derivados"

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Foram encontrados 692 produtos de "Células - tronco e Derivados"

Pureza (%)

100

produtos por página.

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Ritlecitinib tosylate
CAS:
- 2192215-81-7
Ritlecitinib (PF-06651600) is a potent, selective JAK3 inhibitor with proven in vivo efficacy, low clearance, and has undergone clinical trials.
Fórmula:C₂₂H₂₇N₅O₄S
Cor e Forma:Solid
Peso molecular:457.549
Ref: TM-T69822
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IHR-1
CAS:
- 548779-60-8
IHR-1, a Smo inhibitor (IC50 7.6 nM), blocks Hedgehog pathway, not Wnt/Notch, and prevents Smo in primary cilium.
Fórmula:C₂₀H₁₂Cl₄N₂O₂
Pureza:97.02%
Cor e Forma:Solid
Peso molecular:454.13
Ref: TM-T24159
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Tofacitinib Citrate
CAS:
- 540737-29-9
Tofacitinib Citrate (CP-690550 citrate) is a a potent, cell-permeable inhibitor of JAK1/2/3 (IC50s: 1/20/112 nM).
Fórmula:C₂₂H₂₈N₆O₈
Pureza:99.19% - 99.75%
Cor e Forma:Solid
Peso molecular:504.49
Ref: TM-T2398
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Deucravacitinib
CAS:
- 1609392-27-9
Deucravacitinib (BMS-986165) is a highly selective, orally bioavailable, allosteric TYK2 inhibitor.Cost-effective and quality-assured.
Fórmula:C₂₀H₁₉D₃N₈O₃
Pureza:98.52% - >99.99%
Cor e Forma:Solid
Peso molecular:425.46
Ref: TM-T14687
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Silmitasertib
CAS:
- 1009820-21-6
Silmitasertib (CX-4945) is a potent, orally bioavailable inhibitor of casein kinase 2 (CK2; Ki: 0.38 nM).
Fórmula:C₁₉H₁₂ClN₃O₂
Pureza:98% - 99.90%
Cor e Forma:Solid
Peso molecular:349.77
Ref: TM-T2259
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Fedratinib
CAS:
- 936091-26-8
Fedratinib (TG-101348) (TG101348) is an ATP-competitive inhibitor of JAK2 (IC50: 3 nM) with significantly less potent activity against JAK3.
Fórmula:C₂₇H₃₆N₆O₃S
Pureza:97.31% - 99.96%
Cor e Forma:Solid
Peso molecular:524.68
Ref: TM-T1995
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CP21R7
CAS:
- 125314-13-8
CP21 is a specific GSK3β inhibitor, used to activate stem cells for differentiation, often paired with BMP4 for mesodermal fate.
Fórmula:C₁₉H₁₅N₃O₂
Pureza:96.14% - 99.16%
Cor e Forma:Solid
Peso molecular:317.34
Ref: TM-T3684
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SH5-07
CAS:
- 1456632-41-9
SH5-07 is a hydroxamic acid-based Stat3 inhibitor (IC50: 3.9 μM).
Fórmula:C₂₉H₂₈F₅N₃O₅S
Pureza:95.54%
Cor e Forma:Solid
Peso molecular:625.61
Ref: TM-TQ0052
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Brevilin A
CAS:
- 16503-32-5
Brevilin A, a sesquiterpene from Centipeda minima, hinders JAK and blocks STAT3 (IC50=10.6μM), inducing apoptosis and autophagy in cancer cells.
Fórmula:C₂₀H₂₆O₅
Pureza:99.97% - >99.99%
Cor e Forma:Solid
Peso molecular:346.42
Ref: TM-T4672
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(E/Z)-GO289
CAS:
- 694522-87-7
(E/Z)-GO289, which strongly lengthened circadian period, is a potent and selective inhibitor of CK2.
Fórmula:C₁₇H₁₅BrN₄O₂S
Pureza:98.1%
Cor e Forma:Solid
Peso molecular:419.3
Ref: TM-T9356
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RO8191
CAS:
- 691868-88-9
RO8191 (CDM-3008) (CDM-3008) is an agonist of interferon (IFN) receptor.
Fórmula:C₁₄H₅F₆N₅O
Pureza:98% - 98.85%
Cor e Forma:Solid
Peso molecular:373.21
Ref: TM-T22142
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AZD2858
CAS:
- 486424-20-8
AZD2858 is a selective GSK-3 inhibitor, inhibiting tau phosphorylation at the S396 site and activating Wnt signaling pathway.
Fórmula:C₂₁H₂₃N₇O₃S
Pureza:98% - 99.25%
Cor e Forma:Solid
Peso molecular:453.52
Ref: TM-T1957
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Momelotinib
CAS:
- 1056634-68-4
Momelotinib (LM-1149), an oral JAK1/2 inhibitor with IC50s 11/18 nM, blocks ATP binding, disrupting JAK-STAT pathway and reducing tumor growth.
Fórmula:C₂₃H₂₂N₆O₂
Pureza:97.47% - 99.56%
Cor e Forma:Solid
Peso molecular:414.46
Ref: TM-T1849
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SC99
CAS:
- 882290-02-0
SC99 inhibits JAK2-STAT3, reducing STAT3 genes, platelet activity, and has anti-myeloma, anti-thrombotic effects.
Fórmula:C₁₅H₈Cl₂FN₃O
Pureza:99.56%
Cor e Forma:Solid
Peso molecular:336.15
Ref: TM-T8719
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2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide
CAS:
- 1258292-64-6
2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide (GDC046), a potent lead analog, has good kinase selectivity and physicochemical properties.
Fórmula:C₁₆H₁₃Cl₂N₃O₂
Pureza:98.77%
Cor e Forma:Solid
Peso molecular:350.2
Ref: TM-T22338
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Epiblastin A
CAS:
- 16470-02-3
Epiblastin A inhibits CK1, targets its isoenzymes, and converts EpiSCs to cESCs.
Fórmula:C₁₂H₁₀ClN₇
Pureza:99.45%
Cor e Forma:Solid
Peso molecular:287.71
Ref: TM-T8987
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BMS986260
CAS:
- 2001559-19-7
BMS-986260 is a selective, and orally bioavailable TGFβR1 inhibitor(IC50 = 1.6 nM).
Fórmula:C₁₈H₁₂ClFN₆O
Pureza:97.67%
Cor e Forma:Solid
Peso molecular:382.78
Ref: TM-T8730
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AS-252424
CAS:
- 900515-16-4
AS-252424 is a potent and selective inhibitor of PI3Kγ with IC50 of 33 nM; >10 fold selectivity for PI3Kγ versus PI3Kα.
Fórmula:C₁₄H₈FNO₄S
Pureza:99.06% - 99.09%
Cor e Forma:Solid
Peso molecular:305.28
Ref: TM-T6208
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Pacritinib hydrochloride
CAS:
- 1228923-43-0
Pacritinib HCl: strong JAK2/Wild-type & JAK2V617F inhibitor (IC50: 23/19 nM), used in AML & MF research.
Fórmula:C₂₈H₃₂N₄O₃·xClH
Cor e Forma:Solid
Ref: TM-T64283
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KY02111
CAS:
- 1118807-13-8
KY02111 facilitates differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, maybe affect downstream of GSK3β and APC.
Fórmula:C₁₈H₁₇ClN₂O₃S
Pureza:97.71% - 98.3%
Cor e Forma:Solid
Peso molecular:376.86
Ref: TM-T2052