Células - tronco e Derivados
Os inibidores de células-tronco são compostos que visam especificamente as vias de sinalização e proteínas envolvidas na manutenção, diferenciação e proliferação de células-tronco. Esses inibidores são cruciais para compreender a biologia das células-tronco e para desenvolver estratégias para manipular células-tronco para fins terapêuticos, como medicina regenerativa e tratamento do câncer. Ao controlar o destino das células-tronco, esses inibidores podem ajudar a orientar a diferenciação das células-tronco em tipos celulares específicos ou prevenir o crescimento celular indesejado. Na CymitQuimica, oferecemos uma seleção de inibidores de células-tronco de alta qualidade para apoiar sua pesquisa em biologia de células-tronco, biologia do desenvolvimento e medicina regenerativa.
Subcategorias de "Células - tronco e Derivados"
- Gama-secretase(68 produtos)
- Hedgehog/Smoothened(49 produtos)
- Via Hippo(7 produtos)
- JAK(246 produtos)
- Porcupine(8 produtos)
- ROCK(61 produtos)
- STAT(104 produtos)
- Células - tronco(129 produtos)
- TGF-beta/Smad(70 produtos)
- Wnt/beta-catenina(65 produtos)
Exibir 2 mais subcategorias
Foram encontrados 437 produtos para "Células - tronco e Derivados".
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GDC-9918
CAS:GDC-9918 (compound GDC-9918) is an inhibitor of Janus kinases.Fórmula:C20H18F2N6O5SCor e Forma:SolidPeso molecular:492.46Tyk2-IN-15
CAS:Tyk2-IN-15 (Compound 97) is a selective inhibitor of tyrosine kinase 2 (Tyk2) with an IC50 value ≤ 10 nM for Tyk2-JH2. It is utilized in the research of inflammatory and autoimmune diseases [1].Fórmula:C21H25F2N7OCor e Forma:SolidPeso molecular:429.47Tyk2-IN-17
CAS:Tyk2-IN-17 (compound 185) effectively inhibits TYK2 [1].Fórmula:C20H20F2N8OCor e Forma:SolidPeso molecular:426.42CDD-1431
CAS:CDD-1431 is a highly selective BMPR2 kinase inhibitor with a Kiapp of 20.6 nM. It inhibits BRE reporter gene activity, exhibiting an IC50 of 4.87 μM. BMPs regulate cellular processes across various tissue types such as the kidneys, skeletal muscle, heart, and reproductive organs, and can induce ectopic bone formation.Fórmula:C33H38N8O5SCor e Forma:SolidPeso molecular:658.77Yhhu-3792
CAS:Yhhu-3792 activates Notch, boosts Hes3/Hes5, enhances NSC renewal, expands NSC pool, and may improve memory.Fórmula:C24H24N4O2Pureza:99.72%Cor e Forma:SolidPeso molecular:400.47JAK1/TYK2-IN-4
CAS:JAK1/TYK2-IN-4 serves as a dual inhibitor targeting both JAK and TYK2, displaying IC50 values of 39 nM and 21 nM, respectively. It is also orally bioavailable [1].Fórmula:C17H23N7OCor e Forma:SolidPeso molecular:341.41CEE321
CAS:CEE321 is an effective pan-JAK inhibitor with an IC50 of 54 nM. It effectively inhibits biomarkers associated with atopic dermatitis.Fórmula:C18H16ClN5OCor e Forma:SolidPeso molecular:353.806TEAD-IN-10
CAS:TEAD-IN-10 (compound 15), a covalent inhibitor, exhibits selective and potent inhibitory activity against TEAD1 (IC 50 =14 nM), TEAD2 (IC 50 =179 nM), and TEAD3 (IC 50 =4 nM). This compound is utilized in cancer research [1].Fórmula:C15H14F3NOCor e Forma:SolidPeso molecular:281.27JAK1-IN-19
CAS:JAK1-IN-19 (Compound 18) is a potent JAK1 inhibitor with IC50 values of 0.02 nM for JAK1, 0.5 nM for JAK2, 91 nM for JAK3, and 0.2 nM for TYK2. It demonstrates a higher intrinsic clearance in both rats and humans. JAK1-IN-19 is applicable for research into atopic dermatitis and other autoimmune diseases.Fórmula:C20H21N7O2Peso molecular:391.44TEAD-IN-22
CAS:TEAD-IN-22 (compound I) is a TEAD inhibitor with potential applications in cancer and fibrosis research.Fórmula:C22H20F3N3O3Peso molecular:431.42JAK1/TYK2-IN-3
JAK1/TYK2-IN-3, orally active, selectively inhibits TYK2 (IC50: 6 nM), JAK1 (37 nM), JAK2 (140 nM), JAK3 (362 nM), and has anti-inflammatory effects.Cor e Forma:SolidTyk2-IN-14
CAS:Tyk2-IN-14, a small molecule inhibitor of TYK2, is significant in treating inflammatory diseases and conditions linked to hypersecretion of IFNa and interferons [1].Fórmula:C22H21N9O2Cor e Forma:SolidPeso molecular:443.46Kartogenin sodium
CAS:Kartogenin (KGN) sodium acts as an inducer of chondrogenic tissue formation (EC 50: 100 nM). It promotes chondrogenesis by binding to fibrin A, disrupting its interaction with the transcription factor core binding factor beta subunit (CBFβ), and modulating the CBFβ-RUNX1 transcriptional program. Additionally, Kartogenin sodium aids tendon-bone junction (TBJ) wound healing by stimulating collagen synthesis. It is extensively utilized in cell-free therapies for cartilage regeneration and protection, tendon-bone healing, wound healing, and limb development. The compound is also vital for cartilage repair, coordinating limb development, and osteoarthritis (OA) research [1] [2] [3] [4].Fórmula:C20H14NNaO3Cor e Forma:SolidPeso molecular:339.32Tyk2-IN-10
CAS:Tyk2-IN-10 acts as an inhibitor of the Tyrosine Kinase 2 (Tyk2)-mediated signaling pathway, which plays a role in inflammation regulation.Fórmula:C25H27N5O3Cor e Forma:SolidPeso molecular:445.51Aβ42-IN-1
CAS:Aβ42-IN-1, compound 1v, is a novel, potent and orally active γ-secretase modulator (GSM).Fórmula:C29H27ClN4O2Pureza:98%Cor e Forma:SolidPeso molecular:499JAK1-IN-9
CAS:JAK1-IN-9 (compound 23a) is a potent, selective inhibitor of JAK1, demonstrating an IC50 of 72 nM.Fórmula:C16H13IN6Cor e Forma:SolidPeso molecular:416.22PF-06442609
CAS:PF-06442609 is an orally active γ-secretase modulator with an IC50 value of 6 nM for Aβ42. It exhibits good CNS permeability.Fórmula:C24H24F4N4O3Cor e Forma:SolidPeso molecular:492.47Londamocitinib
CAS:Londamocitinib (JAK1-IN-7) is a selective and potent JAK1 inhibitor with anti-inflammatory activity.Fórmula:C28H31F2N7O4SPureza:98.64% - 99.56%Cor e Forma:SolidPeso molecular:599.65Ref: TM-T11706
10mgA consultar25mgA consultar50mgA consultar100mgA consultar1mg170,00€5mg416,00€1mL*10mM (DMSO)537,00€TYK2 ligand 2
CAS:TYK2ligand 2 is the TYK2 ligand of PROTACTYD-68. TYD-68 is a highly potent and selective CRBN-recruiting TYK2 PROTAC degrader with a DC50 value of 0.42 nM.Fórmula:C24H20FN7O4Cor e Forma:SolidPeso molecular:489.458TEAD-IN-20
CAS:TEAD-IN-20 is a TEAD inhibitor with IC50 values of 0.021 μM in TEAD4 FRET and 0.044 μM in TEAD4 MCF7-Tead cell lines. It has potential applications in cancer research.Fórmula:C20H19F3N4O3Cor e Forma:SolidPeso molecular:420.39
