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Células - tronco e Derivados

Células - tronco e Derivados

Os inibidores de células-tronco são compostos que visam especificamente as vias de sinalização e proteínas envolvidas na manutenção, diferenciação e proliferação de células-tronco. Esses inibidores são cruciais para compreender a biologia das células-tronco e para desenvolver estratégias para manipular células-tronco para fins terapêuticos, como medicina regenerativa e tratamento do câncer. Ao controlar o destino das células-tronco, esses inibidores podem ajudar a orientar a diferenciação das células-tronco em tipos celulares específicos ou prevenir o crescimento celular indesejado. Na CymitQuimica, oferecemos uma seleção de inibidores de células-tronco de alta qualidade para apoiar sua pesquisa em biologia de células-tronco, biologia do desenvolvimento e medicina regenerativa.

Subcategorias de "Células - tronco e Derivados"

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Foram encontrados 695 produtos de "Células - tronco e Derivados"

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  • ROCK-IN-1
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    ROCK-IN-1

    CAS:
    <p>ROCK-IN-1 is a potent ROCK inhibitor that inhibits ROCK2-mediated signaling with an IC50 value of 1.2 nM.ROCK-IN-1 can be used in the study of neurological</p>
    Fórmula:C20H18FN3O
    Pureza:>99.99%
    Cor e Forma:Solid
    Peso molecular:335.37

    Ref: TM-T13419

  • JAK-IN-3
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    JAK-IN-3

    CAS:
    <p>JAK-IN-3 is a potent JAK inhibitor that inhibits JAK3, JAK1, TYK2, and JAK2, and can be used for the study of immune system disorders.</p>
    Fórmula:C18H20N4O3
    Pureza:98.04% - 98.19%
    Cor e Forma:Solid
    Peso molecular:340.38

    Ref: TM-T11704

  • GSK-3 inhibitor 1
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    GSK-3 inhibitor 1

    CAS:
    <p>GSK-3 inhibitor 1 is a GSK-3 inhibitor.</p>
    Fórmula:C22H17ClFN5O2
    Pureza:98.42%
    Cor e Forma:Solid
    Peso molecular:437.85

    Ref: TM-T11468

  • PT109
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    PT109

    CAS:
    <p>PT109 is a multikinase inhibitor that targets JNK and other kinases, playing a crucial role in anti-inflammatory, antioxidative, neurogenic, and synaptogenic processes. Specifically, PT109 inhibits JNK isoforms with the following IC50 values: JNK1 at 0.143 μM, JNK2 at 0.831 μM, and JNK3 at 0.285 μM. It also inhibits SGK isoforms (SGK1: IC50=1.34 μM; SGK2: IC50=5.6 μM; SGK3: IC50=26.4 μM) and ROCK2 (IC50=34 μM). Additionally, PT109 reprograms polymorphic glioblastoma multiforme (GBM) into oligodendroglia via the PTBP1/PKM1/2 pathway and alters the metabolic pattern of GBM to exhibit antiglioma activity.</p>
    Fórmula:C23H31N3OS2
    Cor e Forma:Solid
    Peso molecular:429.64

    Ref: TM-T201273

  • LNK01004
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    LNK01004

    CAS:
    <p>LNK01004 is a JAK inhibitor that exhibits potent inhibitory effects on JAK1 (IC50: 10 nM), JAK2 (IC50: ＜0.51 nM), and TYK2 (IC50: 1.0 nM). It can concurrently inhibit multiple cytokine-induced p-STAT signaling pathways and is applicable for research on diseases such as atopic dermatitis.</p>
    Fórmula:C26H31N7O2
    Cor e Forma:Solid
    Peso molecular:473.57

    Ref: TM-T205387

  • Milpecitinib
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    Milpecitinib

    CAS:
    <p>Milpecitinib (Compound 21a) is a potent and selective Janus tyrosine kinase (JAK) inhibitor with anti-inflammatory properties. It shows promise for research in cancer and inflammatory diseases.</p>
    Fórmula:C20H20N4O2S
    Cor e Forma:Solid
    Peso molecular:380.463

    Ref: TM-T205326

  • JAK3 covalent inhibitor-1
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    JAK3 covalent inhibitor-1

    CAS:
    <p>JAK3 Covalent Inhibitor-1 is a compound characterized by its potent and selective inhibition of Janus kinase 3 (JAK3), possessing an IC50 of 11 nM and</p>
    Fórmula:C22H17FN6O2S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:448.47

    Ref: TM-T11709

  • JAK3-IN-11
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    JAK3-IN-11

    CAS:
    <p>JAK3-IN-11: potent oral JAK3 inhibitor (IC50=1.7 nM), noncytotoxic, &gt;588-fold selectivity, blocks T-cell growth; useful in autoimmune research.</p>
    Fórmula:C23H23N5O2
    Cor e Forma:Solid
    Peso molecular:401.46

    Ref: TM-T9811

  • M3686
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    M3686

    CAS:
    <p>M3686 (Compound 29) is a potent and selective TEAD1 inhibitor with an IC50 value of 51 nM. It exhibits weaker binding activity toward TEAD3. M3686 significantly inhibits the cellular activity of YAP-dependent NCI-H226 cell lines, with an IC50 value of 0.06 μM, and demonstrates strong antitumor effects in the NCI-H226 xenograft model.</p>
    Fórmula:C21H18F3N5O2
    Cor e Forma:Solid
    Peso molecular:429.395

    Ref: TM-T205477

  • lirucitinib
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    lirucitinib

    CAS:
    <p>Lirucitinib is a JAK inhibitor known for its anti-inflammatory properties.</p>
    Fórmula:C16H25N5OS
    Cor e Forma:Solid
    Peso molecular:335.468

    Ref: TM-T205259

  • TEAD-IN-10
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    TEAD-IN-10

    CAS:
    <p>TEAD-IN-10 (compound 15), a covalent inhibitor, exhibits selective and potent inhibitory activity against TEAD1 (IC 50 =14 nM), TEAD2 (IC 50 =179 nM), and TEAD3 (IC 50 =4 nM). This compound is utilized in cancer research [1].</p>
    Fórmula:C15H14F3NO
    Cor e Forma:Solid
    Peso molecular:281.27

    Ref: TM-T87500

  • Tyk2-IN-15
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    Tyk2-IN-15

    CAS:
    <p>Tyk2-IN-15 (Compound 97) is a selective inhibitor of tyrosine kinase 2 (Tyk2) with an IC50 value ≤ 10 nM for Tyk2-JH2. It is utilized in the research of inflammatory and autoimmune diseases [1].</p>
    Fórmula:C21H25F2N7O
    Cor e Forma:Solid
    Peso molecular:429.47

    Ref: TM-T87584

  • TEAD-IN-1
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    TEAD-IN-1

    CAS:
    <p>TEAD-IN-1 (Compound 2) is an effective inhibitor of TEAD auto-palmitoylation with an IC50 of 603 nM. It enhances the interaction between TEAD and VGLL4, while diminishing the interaction between YAP and TEAD. TEAD-IN-1 is applicable for cancer research.</p>
    Fórmula:C15H20F2N2O3S
    Cor e Forma:Solid
    Peso molecular:346.393

    Ref: TM-T204883

  • YAP/TAZ inhibitor-3
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    YAP/TAZ inhibitor-3

    CAS:
    <p>YAP/TAZ inhibitor-3 (Compound 24) is a YAP/TAZ inhibitor applicable for relevant research within the life sciences field.</p>
    Fórmula:C21H18F3NO3
    Pureza:99.63%
    Cor e Forma:Solid
    Peso molecular:389.37

    Ref: TM-T87651

  • (3S,4R)-Tofacitinib
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    (3S,4R)-Tofacitinib

    CAS:
    <p>(3S,4R)-Tofacitinib is an less active enantiomer of Tofacitinib. Tofacitinib is a JAK3 inhibitor(IC50 : 1 nM).</p>
    Fórmula:C16H20N6O
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:312.37

    Ref: TM-T13427

  • Tyk2-IN-17
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    Tyk2-IN-17

    CAS:
    <p>Tyk2-IN-17 (compound 185) effectively inhibits TYK2 [1].</p>
    Fórmula:C20H20F2N8O
    Cor e Forma:Solid
    Peso molecular:426.42

    Ref: TM-T87586

  • Londamocitinib
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    Londamocitinib

    CAS:
    <p>Londamocitinib (JAK1-IN-7) is a selective and potent JAK1 inhibitor with anti-inflammatory activity.</p>
    Fórmula:C28H31F2N7O4S
    Pureza:98.64% - 99.56%
    Cor e Forma:Solid
    Peso molecular:599.65

    Ref: TM-T11706

  • CDK8-IN-11
    Targetmol
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    CDK8-IN-11

    CAS:
    <p>CDK8-IN-11 is a CDK8 inhibitor that demonstrates anti-proliferative activity against colon cancer cell lines and inhibits the activation of WNT/β-catenin.</p>
    Fórmula:C19H15F3N4O2
    Pureza:99.74%
    Cor e Forma:Solid
    Peso molecular:388.34

    Ref: TM-T61742

  • JAK3-IN-7
    Targetmol
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    JAK3-IN-7

    CAS:
    <p>JAK3-IN-7 is a potent and selective JAK3 inhibitor (IC50&lt;0.01 μM) for the treatment of rejection in organ transplantation, graft-versus-host reaction after</p>
    Fórmula:C17H20N6O
    Pureza:98.81%
    Cor e Forma:Solid
    Peso molecular:324.38

    Ref: TM-T10009

  • Tyk2-IN-3
    Targetmol
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    Tyk2-IN-3

    CAS:
    <p>Tyk2-IN-3 is an inhibitor of Tyk2 pseudokinase (IC50: 485 nM).</p>
    Fórmula:C25H24N6O3S2
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:520.63

    Ref: TM-T13233