Ubiquitinação
Os inibidores de ubiquitinação são compostos que interferem no processo de ubiquitinação, onde as proteínas são marcadas com moléculas de ubiquitina para degradação pelo proteassoma. Esses inibidores são críticos para o estudo da renovação de proteínas, transdução de sinais e regulação de vários processos celulares. A ubiquitinação desempenha um papel fundamental em muitas doenças, incluindo câncer, distúrbios neurodegenerativos e disfunções do sistema imunológico. Ao modular a ubiquitinação, esses inibidores podem fornecer insights sobre os mecanismos das doenças e abrir novas vias para intervenções terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de ubiquitinação de alta qualidade para apoiar sua pesquisa em biologia celular, proteômica e descoberta de medicamentos.
Subcategorias de "Ubiquitinação"
Foram encontrados 106 produtos de "Ubiquitinação"
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ICCB-19 hydrochloride
CAS:<p>ICCB-19 hydrochloride (ICCB-19 HCl) is an inhibitor of TRADD (TNFRSF1A Associated Via Death Domain). It binds to a pocket on the TRADD-N.</p>Fórmula:C12H22ClN3OSPureza:99.3%Cor e Forma:SolidPeso molecular:291.84Subasumstat
CAS:<p>Subasumstat (TAK-981) is a selective the SUMOylation enzymatic cascade inhibitor, has potential immune-activating and antineoplastic activities.</p>Fórmula:C25H28ClN5O5S2Pureza:97.02% - 98.22%Cor e Forma:SolidPeso molecular:578.1BI8626
CAS:BI8626 is a ubiquitin ligase inhibitor with protective effects against spontaneous dry syndrome in NOD/ShiLtj mice and inhibits the proliferation of CD4 T cellsFórmula:C25H28N8Pureza:98.66%Cor e Forma:SolidPeso molecular:440.54USP1-IN-2
CAS:<p>USP1-IN-2 is a potent USP1 inhibitor with potential anti-tumor activity for the study of cancer.</p>Fórmula:C26H22F4N6OPureza:99.69% - 99.88%Cor e Forma:SolidPeso molecular:510.486FT827
CAS:<p>FT827 is a covalent inhibitor of USP7 that targets the catalytic center of the autoinhibitory apolipoprotein form of USP7 for cancer research.</p>Fórmula:C27H28N6O5SPureza:98.76%Cor e Forma:SolidPeso molecular:548.61I-138
CAS:<p>I-138 is an orally active and reversible inhibitor of USP1-UAF1.I-138 induces mono-ubiquitination of FANCD2 and PCNA and inhibits USP1 auto-cleavage in cells.</p>Fórmula:C26H23F3N6OPureza:99.41%Cor e Forma:SolidPeso molecular:492.5USP28-IN-4
CAS:USP28-IN-4 is a USP28 inhibitor with anticancer activity that dose-dependently down-regulates cellular levels of c-Myc via the ubiquitin-proteasome system.Fórmula:C22H18Cl2N2O3SPureza:98.48%Cor e Forma:SolidPeso molecular:461.36Smurf1-IN-1
CAS:<p>Smurf1-IN-1, a selective E3 ubiquitin protein ligase 1 (SMURF1) inhibitor, exhibits oral activity with an IC50 of 92 nM and demonstrates considerable efficacy</p>Fórmula:C24H29ClN6O2Pureza:98%Cor e Forma:SolidPeso molecular:468.98USP28-IN-3
CAS:USP28-IN-3 is a USP28 inhibitor with anticancer activity that dose-dependently down-regulates cellular levels of c-Myc via the ubiquitin-proteasome system.Fórmula:C23H20Cl2N2O3SPureza:99.92%Cor e Forma:SolidPeso molecular:475.39DT204
CAS:<p>DT204 is an SCFSkp2 inhibitor that reduces the binding of Skp2 to Cullin-1 and Commd1. It can be used to study multiple myeloma.</p>Fórmula:C19H13BrClNO5SPureza:99.17%Cor e Forma:SolidPeso molecular:482.73OTUB1/USP8-IN-1
CAS:OTUB1/USP8-IN-1 is an OTUB1/USP8 inhibitor with anticancer activity for the study of non-small cell lung cancer.Fórmula:C22H16ClFN2O4Pureza:98.59%Cor e Forma:SoildPeso molecular:426.83CB-5339
CAS:<p>p97-IN-1 is a potent inhibitor of p97 with an IC 50 <30 nM [1].</p>Fórmula:C24H24N6OPureza:97.66%Cor e Forma:SoildPeso molecular:412.49GSK2643943A
CAS:<p>GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor, with an IC 50 of 160 nM for USP20/Ub-Rho. GSK2643943A has anti-tumor efficacy.</p>Fórmula:C17H12FN3Pureza:97.09%Cor e Forma:SolidPeso molecular:277.3SJB3-019A
CAS:SJB3-019A is a potent, potent and novel ubiquitin-specific protease 1 (USP1) inhibitor, which promotes ID1 degradation and cytotoxicity in K562 cells 5 timesFórmula:C16H8N2O3Pureza:99.72%Cor e Forma:SolidPeso molecular:276.25NAcM-OPT
CAS:<p>NAcM-OPT is a specific, reversible inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 （IC50: 79 nM).</p>Fórmula:C23H29Cl2N3OPureza:99.93%Cor e Forma:SolidPeso molecular:434.4USP30 inhibitor 11
CAS:<p>USP30 inhibitor 11 (USP30-IN-11) is a USP30 inhibitor that inhibits SVA and can be used in studies of cancer, mitochondrial dysfunction and Parkinson's.</p>Fórmula:C17H16N6O2SPureza:98.84% - 99.59%Cor e Forma:SolidPeso molecular:368.41P22074
CAS:<p>P22074 is a USP7 inhibitor. It is not an active antagonist like its halogenated related compounds. p22074 has antitumour activity.</p>Fórmula:C12H9NO3S2Pureza:>99.99%Cor e Forma:SolidPeso molecular:279.33USP22-IN-1
CAS:<p>USP22-IN-1 is a ubiquitin-specific peptidase 22 (USP22) inhibitor that can be used to treat proliferative diseases or cancer.</p>Fórmula:C22H18N4Pureza:98.2%Cor e Forma:SolidPeso molecular:338.41Ubiquitination-IN-1
CAS:<p>Ubiquitination-IN-1 is an inhibitor of ubiquitination and Cksl-Skp2 protein-protein interaction (IC50: 0.17 μM).</p>Fórmula:C21H14F3N3O2SPureza:98.396% - 99.88%Cor e Forma:SolidPeso molecular:429.42USP30 inhibitor 18
CAS:<p>USP30 inhibitor 18 is a selective inhibitor of USP30 (IC50 = 0.02 μM). USP30 inhibitor 18 is able to accelerate mitophagy and increase protein ubiquitination.</p>Fórmula:C26H28FN3O4SPureza:99.85%Cor e Forma:SolidPeso molecular:497.58
