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Sinalização PI3K/Akt/mTOR

Sinalização PI3K/Akt/mTOR

Os inibidores da sinalização PI3K/Akt/mTOR são compostos que têm como alvo as vias da fosfoinositídeo 3-quinase (PI3K), da quinase Akt e do alvo da rapamicina em mamíferos (mTOR). Essas vias são reguladores críticos do crescimento celular, sobrevivência, metabolismo e autofagia, tornando-os alvos-chave na pesquisa de câncer e distúrbios metabólicos. A inibição dessas vias pode ajudar a controlar o crescimento e a proliferação tumoral, oferecendo estratégias terapêuticas potenciais para vários tipos de câncer e outras doenças caracterizadas por sinalização celular desregulada. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de alta qualidade de PI3K/Akt/mTOR para apoiar sua pesquisa em oncologia, sinalização celular e doenças metabólicas.

Subcategorias de "Sinalização PI3K/Akt/mTOR"

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Foram encontrados 1037 produtos de "Sinalização PI3K/Akt/mTOR"

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  • (Rac)-BRD0705
    Targetmol
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    (Rac)-BRD0705

    CAS:
    <p>(Rac)-BRD0705 is a less active racemate of BRD0705. BRD0705 is an effective and selective inhibitor of GSK3α.</p>
    Fórmula:C20H23N3O
    Pureza:99.7%
    Cor e Forma:Solid
    Peso molecular:321.42

    Ref: TM-T12664

  • LDHA/PDKs-IN-1
    Targetmol
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    LDHA/PDKs-IN-1

    CAS:
    <p>Compound 20e inhibits PDKs (IC50: 0.8 μM) &amp; LDHA (IC50: 0.15 μM), halts A549 cell growth, lowers lactate, boosts oxygen use.</p>
    Fórmula:C19H21FN2O4
    Cor e Forma:Solid
    Peso molecular:360.38

    Ref: TM-T61339

  • PI3K/mTOR Inhibitor-6
    Targetmol
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    PI3K/mTOR Inhibitor-6

    CAS:
    <p>Potent, stable PI3K/mTOR Inhibitor-6 surpasses gedatolisib in gastric fluid; 10 μM hinders PI3K/Akt/mTOR pathway, aids cancer research.</p>
    Fórmula:C30H34N10O4
    Cor e Forma:Solid
    Peso molecular:598.66

    Ref: TM-T64219

  • HKI-357
    Targetmol
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    HKI-357

    CAS:
    <p>HKI-357 irreversibly inhibits EGFR/ERBB2 (IC50: 34/33 nM), blocks EGFR Y1068 autophosphorylation, and AKT/MAPK phosphorylation.</p>
    Fórmula:C31H29ClFN5O3
    Pureza:99.91%
    Cor e Forma:Solid
    Peso molecular:574.05

    Ref: TM-T11569

  • Labuxtinib
    Targetmol
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    Labuxtinib

    CAS:
    <p>Labutinib is a selective inhibitor of the c-kit tyrosine kinase [1].</p>
    Fórmula:C20H16FN5O2
    Pureza:99.77%
    Cor e Forma:Solid
    Peso molecular:377.37

    Ref: TM-T79851

  • T-00127_HEV1
    Targetmol
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    T-00127_HEV1

    CAS:
    <p>T-00127_HEV1 is an inhibitor of phosphatidylinositol 4-kinase III beta(PI4KIIIβ, IC50 = 60 nM).</p>
    Fórmula:C22H29N5O3
    Pureza:99.89%
    Cor e Forma:Solid
    Peso molecular:411.5

    Ref: TM-T16967

  • mTOR inhibitor 9d
    Targetmol
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    mTOR inhibitor 9d

    CAS:
    <p>mTOR inhibitor 9d is a dual inhibitor of the protein kinases mTOR and PI3K with an mTOR IC50 value of 0.31 nm, and can be used for the treatment of leukemia,</p>
    Fórmula:C21H23N5O3S
    Pureza:99.08%
    Cor e Forma:Soild
    Peso molecular:425.5

    Ref: TM-T67702

  • WYE-23
    Targetmol
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    WYE-23

    CAS:
    <p>WYE-23 is an inhibitor of mammalian target of rapamycin (mTOR).</p>
    Fórmula:C26H32N8O4
    Cor e Forma:Solid
    Peso molecular:520.58

    Ref: TM-T71514

  • EGFR-IN-74
    Targetmol
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    EGFR-IN-74

    <p>EGFR-IN-74 is a potent inhibitor targeting EGFR, specifically effective against the L858R/T790M mutations, exhibiting an IC50 value of 138 nM.</p>
    Fórmula:C32H28BrF3N6O4S
    Cor e Forma:Solid
    Peso molecular:729.57

    Ref: TM-T73170

  • mTOR inhibitor 9b
    Targetmol
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    mTOR inhibitor 9b

    CAS:
    <p>mTOR inhibitor 9b is an enzyme inhibitor of protein kinase mTOR he phosphatidylinositol 3-kinase PIK3CA with IC50s of 0.76 nm and 1.262 µM, respectively.mTOR</p>
    Fórmula:C21H23N5O2S
    Pureza:99.52%
    Cor e Forma:Soild
    Peso molecular:409.5

    Ref: TM-T67703

  • Dezapelisib
    Targetmol
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    Dezapelisib

    CAS:
    <p>Dezapelisib, an oral delta PI3K inhibitor, blocks PIP3 production and PI3K/AKT pathway, hindering tumor cell growth and survival.</p>
    Fórmula:C20H16FN7OS
    Cor e Forma:Solid
    Peso molecular:421.45

    Ref: TM-T27157

  • SU-11752
    Targetmol
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    SU-11752

    CAS:
    <p>SU-11752 selectively inhibits DNA-PK by competing with ATP, enhances ionizing radiation sensitivity without affecting cell cycle or ATM activity.</p>
    Fórmula:C26H27N3O5S
    Cor e Forma:Solid
    Peso molecular:493.57

    Ref: TM-T68870

  • PAT-505
    Targetmol
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    PAT-505

    CAS:
    <p>PAT-505 is an autologous epidermal growth factor inhibitor.</p>
    Fórmula:C23H18ClF2N3O2S
    Pureza:98.84%
    Cor e Forma:Solid
    Peso molecular:473.92

    Ref: TM-T12372

  • BMS-599626 Hydrochloride
    Targetmol
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    BMS-599626 Hydrochloride

    CAS:
    <p>BMS-599626 HCl (AC480 HCl) is an oral inhibitor of HER1, HER2, HER4 kinases, potentially blocking tumor growth. IC50: 22/32/190 nM.</p>
    Fórmula:C27H28ClFN8O3
    Pureza:99.98%
    Cor e Forma:Solid
    Peso molecular:567.01

    Ref: TM-T5390

  • PI3K/mTOR Inhibitor-1
    Targetmol
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    PI3K/mTOR Inhibitor-1

    CAS:
    PI3K/mTOR Inhibitor-1 is a potent, orally bioavailable dual inhibitor of PI3K/mTOR (PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ/mTOR with IC50s of 20/376/204/46/186 nM)
    Fórmula:C18H22FN5O3S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:407.46

    Ref: TM-T12460

  • PF-06459988
    Targetmol
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    PF-06459988

    CAS:
    <p>PF-06459988 is a novel, effective, orally active, irreversible, and selective epidermal growth factor receptor (EGFR) mutant inhibitor.</p>
    Fórmula:C19H22ClN7O3
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:431.88

    Ref: TM-T16492

  • mTOR inhibitor-3
    Targetmol
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    mTOR inhibitor-3

    CAS:
    <p>mTOR inhibitor-3 is a selective mTOR inhibitor (Ki= 1.5 nM). mTOR inhibitor-3 inhibits mTORC1 and mTORC2 in cellular and in vivo experiments.</p>
    Fórmula:C25H30N8O2
    Pureza:99% - 99.64%
    Cor e Forma:Solid
    Peso molecular:474.56

    Ref: TM-T12123

  • SAR-260301
    Targetmol
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    SAR-260301

    CAS:
    <p>SAR-260301 is an orally available and selective inhibitor of PI3Kβ (IC50: 23 nM).</p>
    Fórmula:C19H22N4O3
    Pureza:99.74%
    Cor e Forma:Solid
    Peso molecular:354.4

    Ref: TM-T16841

  • Zandelisib
    Targetmol
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    Zandelisib

    CAS:
    <p>Zandelisib is an inhibitor of phosphatidylinositol 3-kinase (PI3K)(p110δ, IC50 of 3.5 nM), and with antineoplastic activity.</p>
    Fórmula:C31H38F2N8O
    Pureza:99.88%
    Cor e Forma:Solid
    Peso molecular:576.68

    Ref: TM-T13386

  • Alpelisib hydrochloride
    Targetmol
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    Alpelisib hydrochloride

    CAS:
    <p>Alpelisib hydrochloride (BYL-719) is an oral, selective PI3Kα inhibitor with anticancer properties.</p>
    Fórmula:C19H23ClF3N5O2S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:477.93

    Ref: TM-T14191