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Sinalização PI3K/Akt/mTOR

Sinalização PI3K/Akt/mTOR

Os inibidores da sinalização PI3K/Akt/mTOR são compostos que têm como alvo as vias da fosfoinositídeo 3-quinase (PI3K), da quinase Akt e do alvo da rapamicina em mamíferos (mTOR). Essas vias são reguladores críticos do crescimento celular, sobrevivência, metabolismo e autofagia, tornando-os alvos-chave na pesquisa de câncer e distúrbios metabólicos. A inibição dessas vias pode ajudar a controlar o crescimento e a proliferação tumoral, oferecendo estratégias terapêuticas potenciais para vários tipos de câncer e outras doenças caracterizadas por sinalização celular desregulada. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de alta qualidade de PI3K/Akt/mTOR para apoiar sua pesquisa em oncologia, sinalização celular e doenças metabólicas.

Subcategorias de "Sinalização PI3K/Akt/mTOR"

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Foram encontrados 1038 produtos de "Sinalização PI3K/Akt/mTOR"

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  • PI3Kγ inhibitor 2
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    PI3Kγ inhibitor 2

    CAS:
    <p>PI3Kγ inhibitor 2 is an orally bioavailable inhibitor of PI3Kγ(Ki of 4 nM).</p>
    Fórmula:C20H18F3N5O3
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:433.38

    Ref: TM-T12465

  • BX-320
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    BX-320

    CAS:
    <p>BX-320, a PDK1 inhibitor (IC50=30nM), selectively blocks Akt/p70S6K1 phosphorylation, induces apoptosis, and inhibits cancer cell growth.</p>
    Fórmula:C23H31BrN8O3
    Cor e Forma:Solid
    Peso molecular:547.45

    Ref: TM-T37561

  • BEBT-109
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    BEBT-109

    CAS:
    <p>BEBT-109 is a selective epidermal growth factor receptor (EGFR) inhibitor that shows anti-tumor activity in EGFR-mutant non-small cell lung cancer.</p>
    Fórmula:C27H32N8O3
    Pureza:97.26%
    Cor e Forma:Solid
    Peso molecular:516.6

    Ref: TM-T80643

  • Simotinib
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    Simotinib

    CAS:
    <p>Simotinib (AL-6802) is an EGFR tyrosine kinase inhibitor (IC50 : 19.9 nM) with antitumour activity for the study of non-small cell lung cancer.</p>
    Fórmula:C25H26ClFN4O4
    Pureza:99.7%
    Cor e Forma:Solid
    Peso molecular:500.95

    Ref: TM-T35916

  • EGFR-IN-61
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    EGFR-IN-61

    CAS:
    <p>EGFR-IN-61 inhibits EGFR kinase (IC50: 42 nM L858R/T790M, 137 nM L858R/T790M/C797S, 743 nM WT) and slows A549 &amp; H1975 cell growth (IC50: 2.14 &amp; 1.82 μM).</p>
    Fórmula:C33H37ClN8O3
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:629.15

    Ref: TM-T73128

  • EGFR-IN-85
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    EGFR-IN-85

    CAS:
    <p>EGFR-IN-85 (Compound 1), an EGFR inhibitor, exhibits potent activity with an IC50 of 0.19 μM against EGFRvⅢ phosphorylation and can suppress intratumoral EGFR</p>
    Fórmula:C26H30N8O2
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:486.57

    Ref: TM-T78574

  • JGK-068S
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    JGK-068S

    CAS:
    <p>Compound I (JGK-068S) is a potent inhibitor of the epidermal growth factor receptor (EGFR) [1].</p>
    Fórmula:C22H23BrFN5O2
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:488.35

    Ref: TM-T79124

  • PI3K/mTOR Inhibitor-12
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    PI3K/mTOR Inhibitor-12

    CAS:
    <p>PI3K/mTOR Inhibitor-12: oral, potent, selective; IC50: PI3Kα 0.06 nM, mTOR 3.12 nM; strong antitumor; less liver toxicity.</p>
    Fórmula:C27H27F2N9O4S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:611.62

    Ref: TM-T72374

  • PI3Kδ-IN-17
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    PI3Kδ-IN-17

    CAS:
    <p>PI3Kδ-IN-17 (Compound S5) is a potent PI3K δ inhibitor, exhibiting an IC50 value of 2.82 nM and demonstrates significant efficacy in suppressing the</p>
    Fórmula:C23H24F3N7O2
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:487.48

    Ref: TM-T81468

  • Logotipo do CymitQuimica
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    EGFR/CSC-IN-1

    CAS:
    <p>EGFR/CSC-IN-1 is a dual inhibitor targeting both the epidermal growth factor receptor (EGFR [IC50 10.52 nM]) and cancer stem cells (CSC), with potential</p>
    Fórmula:C54H54Cl2FN7O7S2
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:1067.08

    Ref: TM-T73995

  • 2′-Thioadenosine
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    2′-Thioadenosine

    CAS:
    <p>2'-Thioadenosine (PD157432) serves as a selective and irreversible inhibitor of ErbB-1 and ErbB-2 tyrosine kinases, demonstrating an IC50 value of 45 µM against</p>
    Fórmula:C10H13N5O3S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:283.31

    Ref: TM-T78634

  • DZD1516
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    DZD1516

    CAS:
    <p>DZD1516, a potent and selective HER2 inhibitor (IC50 = 0.56 nM), demonstrates good blood-brain barrier permeability and exhibits antitumor activity in both</p>
    Fórmula:C28H27F2N7O3
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:547.56

    Ref: TM-T79297

  • EGFR mutant-IN-1
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    EGFR mutant-IN-1

    <p>EGFR mutant-in-1, a 5-methylpyrimidopyridone, selectively inhibits EGFRL858R/T790M/C797S mutants with an IC50 of 27.5 nM, lessening EGFRWT impact.</p>
    Fórmula:C34H39ClFN7O2
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:632.17

    Ref: TM-T11164

  • GSK-3β inhibitor 8
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    GSK-3β inhibitor 8

    CAS:
    <p>GSK-3β inhibitor 8 (GSK3β Inhibitor XVIII) is a potent and selective GSK-3β inhibitor with an IC50 value of 64 nM.GSK-3β inhibitor 8 is a thienopyrimidine</p>
    Fórmula:C20H20ClN5OS
    Pureza:98.46%
    Cor e Forma:Solid
    Peso molecular:413.92

    Ref: TM-T35556

  • EGFR-IN-36
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    EGFR-IN-36

    CAS:
    <p>EGFR-IN-36 inhibits EGFR, HER2, &amp; mutants with IC50s: 19.09 nM (EGFR WT), 120.01 nM (HER2 WT), 2.35 nM (HER2 mutant).</p>
    Fórmula:C26H25ClN6O2
    Cor e Forma:Solid
    Peso molecular:488.97

    Ref: TM-T63265

  • AMPK-α1β1γ1 activator 1
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    AMPK-α1β1γ1 activator 1

    CAS:
    <p>AMPK-α1β1γ1 activator 1 (M1), an acyl glucuronide metabolite derived from an Indole-3-carboxylic Acid-based AMPK activator, selectively activates the β1</p>
    Fórmula:C25H24ClNO9
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:517.91

    Ref: TM-T83125

  • PI3K/mTOR Inhibitor-7
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    PI3K/mTOR Inhibitor-7

    CAS:
    <p>Potent PI3K/mTOR inhibitor, 4.7x stronger than gedatolisib; IC50: 1.4 μM (PI3K), 0.3 μM (mTOR); impacts PI3K/Akt/mTOR pathway; research in cancer.</p>
    Fórmula:C29H33N9O4
    Cor e Forma:Solid
    Peso molecular:571.63

    Ref: TM-T64041

  • EGFR/ErbB-2 inhibitor-1
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    EGFR/ErbB-2 inhibitor-1

    CAS:
    <p>EGFR/ErbB-2 inhibitor-1 is a selective ErbB2/HER2 inhibitor that effectively blocks ErbB2 and HER2 signaling.</p>
    Fórmula:C23H15ClFN3OS2
    Pureza:98.93%
    Cor e Forma:Solid
    Peso molecular:467.97

    Ref: TM-T79861

  • PI3K-IN-54
    Targetmol
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    PI3K-IN-54

    CAS:
    <p>Compound 10w, a substituted pyrazolo[1,5-a]pyrimidinamide compound, is a ZSTK474 analog that shows anticancer activity against HeLa cells.</p>
    Fórmula:C20H24F2N8O3
    Pureza:98.15%
    Cor e Forma:Solid
    Peso molecular:462.45

    Ref: TM-T77771

  • Sevabertinib
    Targetmol
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    Sevabertinib

    CAS:
    <p>Sevabertinib (BAY 2927088) is an EGFR tyrosine kinase inhibitor, with anticancer activity, used in research on non-small cell lung cancer.</p>
    Fórmula:C24H25ClN4O5
    Pureza:99.81%
    Cor e Forma:Solid
    Peso molecular:484.93

    Ref: TM-T200964