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Sinalização PI3K/Akt/mTOR

Sinalização PI3K/Akt/mTOR

Os inibidores da sinalização PI3K/Akt/mTOR são compostos que têm como alvo as vias da fosfoinositídeo 3-quinase (PI3K), da quinase Akt e do alvo da rapamicina em mamíferos (mTOR). Essas vias são reguladores críticos do crescimento celular, sobrevivência, metabolismo e autofagia, tornando-os alvos-chave na pesquisa de câncer e distúrbios metabólicos. A inibição dessas vias pode ajudar a controlar o crescimento e a proliferação tumoral, oferecendo estratégias terapêuticas potenciais para vários tipos de câncer e outras doenças caracterizadas por sinalização celular desregulada. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de alta qualidade de PI3K/Akt/mTOR para apoiar sua pesquisa em oncologia, sinalização celular e doenças metabólicas.

Subcategorias de "Sinalização PI3K/Akt/mTOR"

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Foram encontrados 1038 produtos de "Sinalização PI3K/Akt/mTOR"

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  • EGFR-IN-1 hydrochloride
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    EGFR-IN-1 hydrochloride

    CAS:
    <p>EGFR-IN-1 HCl targets L858R/T790M EGFR mutants over wild-type; IC50: 4 nM in H1975, 28 nM in mutant HCC827 cells.</p>
    Fórmula:C28H31ClN6O4
    Pureza:99.16%
    Cor e Forma:Solid
    Peso molecular:551.04

    Ref: TM-T11157L

  • EGFR/ErbB-2 inhibitor-1
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    EGFR/ErbB-2 inhibitor-1

    CAS:
    <p>EGFR/ErbB-2 inhibitor-1 is a selective ErbB2/HER2 inhibitor that effectively blocks ErbB2 and HER2 signaling.</p>
    Fórmula:C23H15ClFN3OS2
    Pureza:98.93%
    Cor e Forma:Solid
    Peso molecular:467.97

    Ref: TM-T79861

  • EGFR-IN-87
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    EGFR-IN-87

    CAS:
    <p>EGFR-IN-87 is an EGFR tyrosine kinase inhibitor with potent inhibitory activity, exhibiting IC50 values of 3.1 nM, 1.3 nM, and 7.1 nM against EGFR_d746-750,</p>
    Fórmula:C28H33N7O2
    Pureza:98.64%
    Cor e Forma:Solid
    Peso molecular:499.61

    Ref: TM-T79888

  • Sevabertinib
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    Sevabertinib

    CAS:
    <p>Sevabertinib (BAY 2927088) is an EGFR tyrosine kinase inhibitor, with anticancer activity, used in research on non-small cell lung cancer.</p>
    Fórmula:C24H25ClN4O5
    Pureza:99.81%
    Cor e Forma:Solid
    Peso molecular:484.93

    Ref: TM-T200964

  • GDC-0349
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    GDC-0349

    CAS:
    <p>GDC-0349 (RG-7603) is a potent and selective ATP-competitive inhibitor of mTOR, 790-fold inhibitory effect against PI3Kα and other 266 kinases. Phase 1.</p>
    Fórmula:C24H32N6O3
    Pureza:96.00% - 98.17%
    Cor e Forma:Solid
    Peso molecular:452.55

    Ref: TM-T6510

  • EGFR-IN-8
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    EGFR-IN-8

    CAS:
    <p>EGFR-IN-8, a dual inhibitor targeting both EGFR and c-Met, shows potential as a promising candidate for further development in treating EGFR TKI-resistant NSCLC</p>
    Fórmula:C32H23ClF3N7O4
    Pureza:99.51%
    Cor e Forma:Solid
    Peso molecular:662.02

    Ref: TM-T11162

  • PKI-402
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    PKI-402

    CAS:
    <p>PKI-402 is a potent PI3K and mTOR inhibitor. PKI-402 inhibits PI3Kα, mTOR, PI3Kβ, PI3Kδ and PI3Kγ with IC50s of 2, 3, 7, 14 and 16 nM, respectively.</p>
    Fórmula:C29H34N10O3
    Pureza:99.94%
    Cor e Forma:Solid
    Peso molecular:570.65

    Ref: TM-T3656

  • PF-04979064
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    PF-04979064

    CAS:
    <p>PF-04979064 is a potent and selective PI3K and mTOR dual kinase inhibitor(Ki of 0.13 nM and 1.42 nM,respectively).</p>
    Fórmula:C24H26N6O3
    Pureza:98.20% - ≥98%
    Cor e Forma:Solid
    Peso molecular:446.5

    Ref: TM-T7343

  • GSK-F1
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    GSK-F1

    CAS:
    <p>GSK-F1 (PI4KA inhibitor-F1) is a novel potent PI4KA inhibitor.</p>
    Fórmula:C27H18F5N5O4S
    Pureza:97.03%
    Cor e Forma:Solid
    Peso molecular:603.52

    Ref: TM-T19840

  • GSK-3 inhibitor 1
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    GSK-3 inhibitor 1

    CAS:
    <p>GSK-3 inhibitor 1 is a GSK-3 inhibitor.</p>
    Fórmula:C22H17ClFN5O2
    Pureza:98.42%
    Cor e Forma:Solid
    Peso molecular:437.85

    Ref: TM-T11468

  • DNA-PK-IN-15
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    DNA-PK-IN-15

    CAS:
    <p>DNA-PK-IN-15 (compound 6) acts as an inhibitor of DNA-PK, exhibiting an IC50 value of 0.08 nM.</p>
    Fórmula:C23H23N9O
    Cor e Forma:Solid
    Peso molecular:441.49

    Ref: TM-T201160

  • Andamertinib
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    Andamertinib

    CAS:
    <p>Andamertinib is an EGFR inhibitor with antitumor activity.</p>
    Fórmula:C31H36N8O3
    Cor e Forma:Solid
    Peso molecular:568.669

    Ref: TM-T206579

  • HER2-IN-7
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    HER2-IN-7

    CAS:
    <p>HER2-IN-7 is a potent HER2 inhibitor with potential for researching ErbB-related diseases, especially cancer.</p>
    Fórmula:C28H26F3N7O3
    Cor e Forma:Solid
    Peso molecular:565.55

    Ref: TM-T64003

  • EGFR-IN-139
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    EGFR-IN-139

    CAS:
    <p>EGFR-IN-139 (compound PD 18) is an EGFR inhibitor with IC50 values of 12.88 nM (wild type), 10.84 nM (L858R/T790M), and 42.68 nM (L858R/T790M/C797S). It demonstrates significant anticancer activity against the A549 and H1975 cancer cell lines, which express high levels of EGFR. EGFR-IN-139 exhibits strong selectivity for cancer cells and can be utilized in research on non-small cell lung cancer (NSCLC).</p>
    Fórmula:C27H25ClN2O4
    Cor e Forma:Solid
    Peso molecular:476.951

    Ref: TM-T204772

  • LAS195319
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    LAS195319

    CAS:
    <p>LAS195319 is a potent and selective inhaled PI3Kδ Inhibitor (IC50 = 0.5 nM) for the Treatment of Respiratory Diseases.</p>
    Fórmula:C29H26N10O3S
    Cor e Forma:Solid
    Peso molecular:594.65

    Ref: TM-T70402

  • EGFR-IN-135
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    EGFR-IN-135

    <p>EGFR-IN-135 (compound 3d) is an EGFR inhibitor with an IC50 value of 0.086 µM. It inhibits cell growth and arrests the cell cycle in the S phase in breast cancer cell lines.</p>
    Fórmula:C12H14N4OS2
    Cor e Forma:Solid
    Peso molecular:294.4

    Ref: TM-T201484

  • PF-5177624
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    PF-5177624

    CAS:
    <p>PF-5177624 is a selective and potent PDK1 inhibitor inducing anti-tumor activity in breast cancer cells.</p>
    Fórmula:C25H25FN8O2
    Cor e Forma:Solid
    Peso molecular:488.52

    Ref: TM-T70911

  • Logotipo do CymitQuimica
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    EGFR-IN-24

    <p>EGFR-IN-24 is a potent inhibitor of EGFR and inhibits EGFR (del19/T790M/C797S) and EGFR (L858R/T790M/C797S).</p>
    Fórmula:C30H35FN6O3
    Cor e Forma:Solid
    Peso molecular:546.64

    Ref: TM-T63857

  • GLPG3312
    Targetmol
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    GLPG3312

    CAS:
    <p>GLPG3312 is a selective and potent pan-SIK inhibitor with the advantage of oral activity, for SIK1, SIK2 and SIK3, anti-inflammatory and immunomodulatory .</p>
    Fórmula:C23H21F2N5O3
    Pureza:98.53%
    Cor e Forma:Solid
    Peso molecular:453.44

    Ref: TM-T86509

  • EGFR/VEGFR2-IN-2
    Targetmol
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    EGFR/VEGFR2-IN-2

    <p>EGFR/VEGFR2-IN-2 (compound 4b) serves as a dual inhibitor of VEGFR-2 and EGFR.</p>
    Fórmula:C24H15FO3
    Cor e Forma:Solid
    Peso molecular:370.37

    Ref: TM-T201505