Sinalização PI3K/Akt/mTOR
Os inibidores da sinalização PI3K/Akt/mTOR são compostos que têm como alvo as vias da fosfoinositídeo 3-quinase (PI3K), da quinase Akt e do alvo da rapamicina em mamíferos (mTOR). Essas vias são reguladores críticos do crescimento celular, sobrevivência, metabolismo e autofagia, tornando-os alvos-chave na pesquisa de câncer e distúrbios metabólicos. A inibição dessas vias pode ajudar a controlar o crescimento e a proliferação tumoral, oferecendo estratégias terapêuticas potenciais para vários tipos de câncer e outras doenças caracterizadas por sinalização celular desregulada. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de alta qualidade de PI3K/Akt/mTOR para apoiar sua pesquisa em oncologia, sinalização celular e doenças metabólicas.
Subcategorias de "Sinalização PI3K/Akt/mTOR"
- AMPK(158 produtos)
- ATM/ATR(71 produtos)
- DNA-PK(51 produtos)
- EGFR(572 produtos)
- MELK(7 produtos)
- PDK(9 produtos)
- PI3K(242 produtos)
- S6 Quinase(9 produtos)
- gsk-3(112 produtos)
- mTOR(144 produtos)
Exibir 2 mais subcategorias
Foram encontrados 1038 produtos de "Sinalização PI3K/Akt/mTOR"
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Buformin hydrochloride
CAS:<p>Buformin hydrochloride, an oral biguanide antidiabetic, activates AMPK, enhances insulin sensitivity, and inhibits hepatic glucose production.</p>Fórmula:C6H16ClN5Pureza:97.83%Cor e Forma:SolidPeso molecular:193.68FIIN-3
CAS:<p>FIIN-3 is an irreversible inhibitor of FGFR.</p>Fórmula:C34H36Cl2N8O4Pureza:97.63% - 98.92%Cor e Forma:SolidPeso molecular:691.61WZ8040
CAS:<p>WZ8040 is a novel mutant-selective irreversible EGFRT790M inhibitor, does not inhibit ERBB2 phosphorylation (T798I).</p>Fórmula:C24H25ClN6OSPureza:97.42% - 99.785%Cor e Forma:SolidPeso molecular:481.01PD153035 hydrochloride
CAS:<p>PD153035 hydrochloride (ZM 252868) is a effective and selective inhibitor of EGFR; few influence against FGFR, PGDFR, InsR, CSF-1, and Src.</p>Fórmula:C16H15BrClN3O2Pureza:99.39% - ≥95%Cor e Forma:SolidPeso molecular:396.67Eganelisib
CAS:<p>Eganelisib (IPI-549) is an inhibitor of PI3Kγ (IC50 = 16, 3,200, 3,500, and >8,400 nM for PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ, respectively)</p>Fórmula:C30H24N8O2Pureza:99.04% - 99.28%Cor e Forma:SolidPeso molecular:528.56AMG 511
CAS:<p>AMG 511: oral class I PI3K inhibitor (α, β, δ, γ Kis: 4, 6, 2, 1 nM), anti-tumor in mouse glioblastoma model, reduces p-Akt (Ser473).</p>Fórmula:C22H28FN9O3SPureza:≥98%Cor e Forma:SolidPeso molecular:517.58ZM39923 hydrochloride
CAS:<p>ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor, almost no activity to JAK2 and modestly potent to EGFR; also is sensitive to transglutaminase.</p>Fórmula:C23H25NO·HClPureza:98.05%Cor e Forma:SolidPeso molecular:367.91SB 216763
CAS:<p>SB 216763 (SB216763) is an effective and specific GSK-3α/β inhibitor (IC50: 34.3 nM).</p>Fórmula:C19H12Cl2N2O2Pureza:98.9% - 99.13%Cor e Forma:SolidPeso molecular:371.22WZ4003
CAS:<p>WZ4003, a highly selective NUAK kinase inhibitor, is with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2, respectively.</p>Fórmula:C25H29ClN6O3Pureza:99.65% - >99.99%Cor e Forma:SolidPeso molecular:496.99SU5214
CAS:<p>SU5214 is a modulator of tyrosine kinase signal transduction.</p>Fórmula:C16H13NO2Pureza:99.45% - 99.55%Cor e Forma:SolidPeso molecular:251.28EAI045
CAS:<p>EAI045, an allosteric inhibitor, targets towards drug-resistant EGFR mutants but avoids the wild-type receptor.</p>Fórmula:C19H14FN3O3SPureza:98.00% - 99.12%Cor e Forma:SolidPeso molecular:383.4iMDK
CAS:<p>iMDK quarterhydrate, a PI3K inhibitor, blocks MDK growth factor and enhances NSCLC treatment with MEK inhibitors, sparing normal cells.</p>Fórmula:C21H13FN2O2SPureza:99.99%Cor e Forma:SolidPeso molecular:376.4Vps34-PIK-III
CAS:<p>Vps34-PIK-III (VPS34-IN2), a selective inhibitor of VPS34 enzymatic activity, inhibits autophagy and results in the stabilization of autophagy substrates.</p>Fórmula:C17H17N7Pureza:98.39% - 98.43%Cor e Forma:SolidPeso molecular:319.36Chrysophanol
CAS:<p>Chrysophanol (Turkey Rhubarb) is an EGFR/mTOR pathway inhibitor, which can be found in rhubarb, and sorrel.</p>Fórmula:C15H10O4Pureza:99.44% - 99.91%Cor e Forma:Physical Description Golden Yellow Plates Or Brown Powder Melting Point 196°CPeso molecular:254.24Indirubin-3'-monoxime
CAS:<p>Indirubin-3'-monoxime (Indirubin-3'-oxime) is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100/180/250 nM for Cdk5/p35, Cdk1/</p>Fórmula:C16H11N3O2Pureza:99.55%Cor e Forma:Dark Red SolidPeso molecular:277.28MK-3903
CAS:<p>MK-3903 is a potent and selective AMPK activator (EC50: 8 nM).</p>Fórmula:C27H19ClN2O3Pureza:98.63% - 99.75%Cor e Forma:SolidPeso molecular:454.9SYR127063
CAS:<p>SYR127063 (BDBM-92454) (BDBM92454) is a potent and selective HER2 inhibitor, binds to HER2 in a reactive conformation.</p>Fórmula:C23H20ClF3N4O3Pureza:98.57%Cor e Forma:SolidPeso molecular:492.88CP-724714
CAS:<p>CP-724714 (CP724714) is an effective and selective HER2/ErbB2 inhibitor (IC50: 10 nM), >640-fold selectivity against EGFR, Abl, InsR, PDGFR, IRG-1R, Src, VEGFR2</p>Fórmula:C27H27N5O3Pureza:97.1% - 98.82%Cor e Forma:SolidPeso molecular:469.54CP21R7
CAS:<p>CP21 is a specific GSK3β inhibitor, used to activate stem cells for differentiation, often paired with BMP4 for mesodermal fate.</p>Fórmula:C19H15N3O2Pureza:96.14% - 99.16%Cor e Forma:SolidPeso molecular:317.34AZ7550
CAS:<p>AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).</p>Fórmula:C27H31N7O2Pureza:97.07% - 99.75%Cor e Forma:SolidPeso molecular:485.58GNE-477
CAS:<p>GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor.</p>Fórmula:C21H28N8O3S2Pureza:98.88% - 99.55%Cor e Forma:SolidPeso molecular:504.63O-304
CAS:<p>O-304 is a pan-activator of AMP-activated protein kinase (AMPK).</p>Fórmula:C16H11Cl2N3O2SPureza:99.84% - ≥98%Cor e Forma:SolidPeso molecular:380.25TG 100713
CAS:<p>TG 100713 is a pan-PI3K inhibitor against PI3Kγ, PI3Kδ, PI3Kα and PI3Kβ with IC50 of 50 nM, 24 nM, 165 nM and 215 nM, respectively.</p>Fórmula:C12H10N6OPureza:98.17%Cor e Forma:SolidPeso molecular:254.25BEBT-908
CAS:<p>BEBT-908 (PI3Kα inhibitor 1) is a selective PI3Kα inhibitor (IC50 <0.1 μM). BEBT-908 also inhibits HDAC (0.1 μM≤IC50≤1 μM).</p>Fórmula:C23H25N9O3SPureza:99.67%Cor e Forma:SolidPeso molecular:507.57PI3K-IN-1
CAS:<p>PI3K-IN-1 (Voxtalisib Analogue) is a dual inhibitor of mTOR/PI3K, mostly for p110γ , also inhibits DNA-PK and mTOR.</p>Fórmula:C31H29N5O6SPureza:97.03% - 98%Cor e Forma:SolidPeso molecular:599.66Dorsomorphin dihydrochloride
CAS:<p>Dorsomorphin dihydrochloride (BML-275 2HCl) is a potent, selective and ATP-competitive AMPK inhibitor (Ki: 109 nM) and does not exhibit significant activity on</p>Fórmula:C24H25N5O·2HClPureza:97.74% - 99.89%Cor e Forma:SolidPeso molecular:472.41VP3.15 dihydrobromide
CAS:<p>VP3.15 dihydrobromide: potent, oral, CNS-penetrant PDE7/GSK3 inhibitor; IC50s: PDE7- 1.59 μM, GSK- 0.88 μM.</p>Fórmula:C20H24Br2N4OSPureza:99.67% - ≥95%Cor e Forma:SolidPeso molecular:528.3MHY1485
CAS:<p>MHY1485 is an mTOR activator that is cell-permeable. MHY1485 inhibits autophagosome and lysosome fusion, thereby inhibiting autophagy. Cost-effective and quality-assured.</p>Fórmula:C17H21N7O4Pureza:97.74% - >99.99%Cor e Forma:SolidPeso molecular:387.39PS 48
CAS:<p>PS 48 has been shown to be a PKB Kinase (PDK1) activator (Kd: 10.3 μM). This compound selectively binds to the PIF-binding pocket of PKB Kinase (PDK1).</p>Fórmula:C17H15ClO2Pureza:99.96% - ≥95%Cor e Forma:SolidPeso molecular:286.75mTOR inhibitor-1
CAS:<p>C-4 is a potential ATP-competitive inhibitor of mTOR. C-4 could inhibit cell growth and proliferation.</p>Fórmula:C16H15BrN2O3Pureza:99.43%Cor e Forma:SolidPeso molecular:363.21Epidermal Growth Factor
CAS:<p>EGF binds EGFR, promotes cell growth & heals diabetic foot ulcers.</p>Fórmula:C270H401N73O83S7Pureza:97.17%Cor e Forma:SolidPeso molecular:6222lavendustin C
CAS:<p>lavendustin C (NSC 666251) is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase.</p>Fórmula:C14H13NO5Pureza:98.06%Cor e Forma:Yellow To Tan PowderPeso molecular:275.26Canertinib
CAS:<p>Canertinib (CI-1033), a pan-erbB inhibitor, effectively targets esophageal cancer in vitro/vivo, altering metabolism and reducing growth and hypoxia.</p>Fórmula:C24H25ClFN5O3Pureza:98% - >99.99%Cor e Forma:White Or Similar To White Crystalline PowderPeso molecular:485.94Tyrphostin 23
CAS:<p>Tyrphostin 23 (AG18) inhibits EGFR with IC50 of 35 μM.</p>Fórmula:C10H6N2O2Pureza:99.7% - 99.86%Cor e Forma:Yellow-Tan SolidPeso molecular:186.17AS-605240
CAS:<p>AS-605240 is an effective and specific inhibitor of PI3Kγ (IC50/Ki: 87.8 nM).</p>Fórmula:C12H7N3O2SPureza:97% - 99.91%Cor e Forma:SolidPeso molecular:257.27Tyrphostin AG 879
CAS:<p>Tyrphostin AG 879 (AG 879) effectively inhibits HER2/ErbB2 (IC50: 1 μM), 100- and 500-fold higher selective to ErbB2 than EGFR and PDGFR.</p>Fórmula:C18H24N2OSPureza:99.05%Cor e Forma:SolidPeso molecular:316.46EGFR-IN-12
CAS:<p>EGFR-IN-12 (EGFR Inhibitor) is a cell permeable and selective inhibitor of EGFR kinase (IC50: 21 nM) and blocks receptor autophosphorylation in cells.</p>Fórmula:C21H18F3N5OPureza:98.3% - 99.76%Cor e Forma:SolidPeso molecular:413.4Serabelisib
CAS:<p>Serabelisib (INK1117) is a p110α/β/γ/δ inhibitor (IC50: 15/4.5/1.9/13.39 μM).</p>Fórmula:C19H17N5O3Pureza:98.41% - 99.5%Cor e Forma:SolidPeso molecular:363.37PS210
CAS:<p>PS210 selectively activates PDK1 (Kd: 3 μM), doesn't affect PDK1 downstream kinases. Prodrug PS423 inhibits PDK1-mediated S6K phosphorylation.</p>Fórmula:C19H15F3O5Pureza:99.78%Cor e Forma:SolidPeso molecular:380.31PD168393
CAS:<p>PD168393 is an irreversible EGFR inhibitor (IC50: 0.70 nM), irreversibly alkylate Cys-773; inactive against PKC, FGFR, PDGFR, and insulin.</p>Fórmula:C17H13BrN4OPureza:99.13% - 99.83%Cor e Forma:SolidPeso molecular:369.22TG100-115
CAS:<p>TG100-115 is a PI3Kγ/δ inhibitor (IC50: 83/235 nM), with fewer effects on PI3Kα/β.</p>Fórmula:C18H14N6O2Pureza:99.22% - 99.26%Cor e Forma:SolidPeso molecular:346.34NS309
CAS:<p>NS309 activates SK/KCa2, IK/KCa3.1 (0.12-1.2 μM EC50, 10-90 nM EC50), and Kv11.1 channels; doesn't affect BK/KCa1.1; modulates neuronal firing.</p>Fórmula:C8H4Cl2N2O2Pureza:97.55%Cor e Forma:SolidPeso molecular:231.04Cetuximab
CAS:<p>Cetuximab (C225) is a monoclonal antibody that is an inhibitor of human epidermal growth factor receptor (EGFR) (Kd=0.201 nM).</p>Fórmula:C107H179N35O36S7Pureza:95 - 98.60%Cor e Forma:LiquidPeso molecular:152 kDaONO-7475
CAS:<p>ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinase</p>Fórmula:C32H26N4O6Pureza:98.74%Cor e Forma:SolidPeso molecular:562.57WH-4-025
CAS:<p>WH-4-025 is a Salt-inducible kinase (SIK) inhibitor.</p>Fórmula:C39H38F3N7O5Pureza:99.41%Cor e Forma:SolidPeso molecular:741.76Methyl 2,5-dihydroxycinnamate
CAS:<p>Methyl 2,5-dihydroxycinnamate is an EGF receptor-associated tyrosine kinases inhibitor.</p>Fórmula:C10H10O4Pureza:99.60%Cor e Forma:CrystallinePeso molecular:194.18PS47
CAS:<p>PS-47(PS 47) is an inactive E-isomer of PS48. PS48 is an activator of PDK1.</p>Fórmula:C17H15ClO2Pureza:99.09%Cor e Forma:SolidPeso molecular:286.75PIK-293
CAS:<p>PIK-293 is a PI3K inhibitor, for PI3Kδ( IC50=0.24 μM), and less potent for PI3Kα/β/ γ.</p>Fórmula:C22H19N7OPureza:99.88%Cor e Forma:SolidPeso molecular:397.43ALK-IN-1
CAS:<p>ALK-IN-1 is a potent ALK inhibitor, demonstrating the ability to overcome Crizotinib resistance mediated by an L1196M mutation.</p>Fórmula:C26H34ClN6O2PPureza:99.74% - 99.80%Cor e Forma:SolidPeso molecular:529.01ETP-45658
CAS:<p>ETP-45658 (ETP45658) is a PI 3-kinase inhibitor (IC50 values are 22, 30, 129 and 710 nM for PI 3-Kα, PI 3-Kδ, PI 3-Kβ and PI 3-Kγ respectively).</p>Fórmula:C16H17N5O2Pureza:99.14%Cor e Forma:SolidPeso molecular:311.34
