Sinalização PI3K/Akt/mTOR
Os inibidores da sinalização PI3K/Akt/mTOR são compostos que têm como alvo as vias da fosfoinositídeo 3-quinase (PI3K), da quinase Akt e do alvo da rapamicina em mamíferos (mTOR). Essas vias são reguladores críticos do crescimento celular, sobrevivência, metabolismo e autofagia, tornando-os alvos-chave na pesquisa de câncer e distúrbios metabólicos. A inibição dessas vias pode ajudar a controlar o crescimento e a proliferação tumoral, oferecendo estratégias terapêuticas potenciais para vários tipos de câncer e outras doenças caracterizadas por sinalização celular desregulada. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de alta qualidade de PI3K/Akt/mTOR para apoiar sua pesquisa em oncologia, sinalização celular e doenças metabólicas.
Subcategorias de "Sinalização PI3K/Akt/mTOR"
- AMPK(171 produtos)
- ATM/ATR(72 produtos)
- DNA-PK(48 produtos)
- EGFR(591 produtos)
- MELK(7 produtos)
- PDK(9 produtos)
- PI3K(231 produtos)
- S6 Quinase(8 produtos)
- gsk-3(110 produtos)
- mTOR(163 produtos)
Exibir 2 mais subcategorias
Foram encontrados 1006 produtos de "Sinalização PI3K/Akt/mTOR"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Barecetamab
CAS:Barecetamab (ISU-104) is a humanized monoclonal antibody against tyrosine protein kinase ErbB3 with anticancer activity.Pureza:97.1% (SDS-PAGE); 96.4% (SEC-HPLC) - 97.1% (SDS-PAGE); 96.4% (SEC-HPLC)Cor e Forma:LiquidSAR405 R enantiomer
CAS:SAR405 R enantiomer is the less active enantiomer of SAR405. SAR405 is an inhibitor of PIK3C3/Vps34.Fórmula:C19H21ClF3N5O2Pureza:98.04%Cor e Forma:SolidPeso molecular:443.85Ref: TM-T12831
1mg48,00€5mg92,00€10mg158,00€25mg261,00€50mg379,00€100mg530,00€200mg722,00€1mL*10mM (DMSO)89,00€LTURM34
CAS:LTURM34 is an inhibitor of DNA-PK with IC50 of 34 nM.Fórmula:C24H18N2O3SPureza:99.34%Cor e Forma:SolidPeso molecular:414.48Ref: TM-T15789
5mg46,00€10mg74,00€25mg145,00€50mg245,00€100mg364,00€200mg532,00€1mL*10mM (DMSO)49,00€BLU-945
CAS:<p>BLU-945 is a reversible, potent, highly selective, and orally available epidermal growth factor receptor tyrosine kinase inhibitor (TKIs).Cost-effective and quality-assured.</p>Fórmula:C28H37FN6O3SPureza:99.11% - 99.16%Cor e Forma:SolidPeso molecular:556.7O-Desmethyl gefitinib
CAS:O-Desmethyl gefitinib is an active EGFR inhibitor (IC50: 36 nM), a metabolite of Gefitinib, formed by CYP2D6.Fórmula:C21H22ClFN4O3Pureza:97.17%Cor e Forma:SolidPeso molecular:432.88Ref: TM-T16369
1mg56,00€5mg111,00€10mg170,00€25mg343,00€50mg547,00€100mg783,00€1mL*10mM (DMSO)120,00€NSC781406
CAS:NSC781406 is a highly effective inhibitor of PI3K and mTOR (IC50: 2 nM for PI3Kα).Fórmula:C29H27F2N5O5S2Pureza:99.58%Cor e Forma:SolidPeso molecular:627.68Ref: TM-T16355
2mg39,00€5mg60,00€10mg87,00€25mg159,00€50mg231,00€100mg355,00€200mg505,00€1mL*10mM (DMSO)84,00€Khellin
CAS:Khellin (Methafrone) is a vasodilator that also has bronchodilatory action.Fórmula:C14H12O5Pureza:99.89% - 99.95%Cor e Forma:Light Yellow CrystallinePeso molecular:260.24Lapatinib
CAS:Lapatinib (GW572016) is an inhibitor of ErbB2 and EGFR (IC50=9.2/10.8 nM) with oral activity.Fórmula:C29H26ClFN4O4SPureza:99.00% - 99.81%Cor e Forma:PowderPeso molecular:581.06Petosemtamab
CAS:<p>Petosemtamab (MCLA 158), a dual-action monoclonal antibody targets EGFR & LGR5, used in solid tumor research like HNSCC & CRC.</p>Pureza:> 95% - > 95%Cor e Forma:LiquidPeso molecular:145.97 kDaRociletinib
CAS:<p>Rociletinib (CNX-419) is an orally available small molecule, irreversible inhibitor of epidermal growth factor receptor (EGFR) with potential antineoplastic</p>Fórmula:C27H28F3N7O3Pureza:98.52% - 99.25%Cor e Forma:SolidPeso molecular:555.55Lapatinib ditosylate monohydrate
CAS:<p>Lapatinib ditosylate monohydrate: a drug for advanced breast cancer; may cause liver issues.</p>Fórmula:C29H26ClFN4O4S·2(C7H8O3S)·H2OPureza:98% - 99.41%Cor e Forma:Colourless To Light-Yellow CrystalPeso molecular:943.47Erlotinib hydrochloride
CAS:Erlotinib hydrochloride (NSC 718781) is an EGFR inhibitor (IC50: 2 nM). It is used for the treatment of non-small cell lung cancer.Fórmula:C22H23N3O4·HClPureza:99.78% - 99.85%Cor e Forma:White Or Off-White PowderPeso molecular:429.9Cyanoacetohydrazide
CAS:Cyanoacetohydrazide (Cyanoacetic hydrazide) is an anti-TB drug. It has also been used to derive compounds that may have antitumor properties.Fórmula:C3H5N3OPureza:99.78%Cor e Forma:Stout Prisms From Alcohol Slightly Brown PowderPeso molecular:99.09Tenalisib
CAS:Tenalisib (RP6530) (RP6530) is a potent and selective inhibitor of PI3Kδ and PI3Kγ(IC50 values of 25 and 33 nM, respectively.)Fórmula:C23H18FN5O2Pureza:99.71%Cor e Forma:SolidPeso molecular:415.42Ref: TM-T13119
1mg38,00€2mg49,00€5mg81,00€10mg111,00€25mg188,00€50mg304,00€100mg457,00€1mL*10mM (DMSO)88,00€Gancotamab
CAS:Gancotamab (MM-302) is a polyethylene glycolated liposome targeting HER2 with antitumor activity for the study of advanced HER2-positive breast cancer.Pureza:96.7% (SDS-PAGE); 98.4% (SEC-HPLC) - 96.7% (SDS-PAGE); 98.4% (SEC-HPLC)Cor e Forma:LiquidErlotinib
CAS:Erlotinib (NSC-718781) is an EGFR inhibitor (IC50: 2 nM). It is used for the treatment of non-small cell lung cancer.Fórmula:C22H23N3O4Pureza:98.19% - 99.98%Cor e Forma:White To Off-White PowderPeso molecular:393.44MELK-IN-1
CAS:MELK-IN-1 (MELK inhibitor 17) is a potent inhibitor of maternal embryonic leucine zipper kinase (MELK),(IC50:3nm;Ki:0.39 nM).Fórmula:C31H33N5O4Pureza:99.84%Cor e Forma:SolidPeso molecular:539.62Lapatinib Ditosylate
CAS:Lapatinib Ditosylate (Tykerb ditosylate) is an effective EGFR and ErbB2 inhibitor (IC50: 10.8/9.2 nM for EGFR/ErbB2).Fórmula:C29H26ClFN4O4S·2C7H8O3SPureza:99.41%Cor e Forma:Yellow SolidPeso molecular:925.46Intetumumab
CAS:Intetumumab (CNTO 95) is a fully humanized anti-α(v)-integrin monoclonal antibody that is a radiosensitizer for xenograft tumor-bearing mice.Pureza:97.6% (SDS-PAGE); 97.1% (SEC-HPLC) - 97.6% (SDS-PAGE); 97.1% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:145.6 (kDa)IPI-3063
CAS:IPI-3063 is an effective and selective inhibitor of PI3K p110δ (IC50: 2.5 ± 1.2 nM).Fórmula:C25H25N7O2Pureza:98.00%Cor e Forma:SolidPeso molecular:455.51Ref: TM-T15592
1mg47,00€2mg64,00€5mg104,00€10mg170,00€25mg340,00€50mg472,00€100mg645,00€1mL*10mM (DMSO)113,00€
