gsk-3
Os inibidores da GSK-3 são compostos que alvo a Glicogênio Sintase Quinase 3 (GSK-3), uma enzima envolvida em numerosos processos celulares, incluindo o metabolismo do glicogênio, a transcrição genética e a proliferação celular. A GSK-3 está implicada em várias doenças, como diabetes, distúrbios neurodegenerativos e câncer. Os inibidores da GSK-3 são ferramentas importantes para explorar essas vias e desenvolver potenciais terapias. Na CymitQuimica, oferecemos inibidores da GSK-3 para apoiar sua pesquisa em doenças metabólicas, neurobiologia e oncologia.
Foram encontrados 109 produtos de "gsk-3"
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Cromolyn sodium
CAS:Cromolyn sodium (FPL-670) is a chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells.Fórmula:C23H14Na2O11Pureza:99.4% - 99.95%Cor e Forma:Colorless Crystals From Ethanol + Ether White Crystalline PowderPeso molecular:512.33Indazole
CAS:Indazole, a heterocyclic compound, offers diverse biological activities.Fórmula:C7H6N2Pureza:99.59% - 99.85%Cor e Forma:White Or Beige Crystalline PowderPeso molecular:118.14BRD0705
CAS:BRD0705: potent, selective GSK3α inhibitor, oral, IC50: 66 nM, 8x more selective than GSK3β.Fórmula:C20H23N3OPureza:99.01%Cor e Forma:SolidPeso molecular:321.429-ING-41
CAS:9-ING-41 is a glycogen synthase kinase-3 inhibitor.Fórmula:C22H13FN2O5Pureza:99.32%Cor e Forma:SolidPeso molecular:404.35Ref: TM-T14066
1mg50,00€2mg66,00€5mg94,00€1mL*10mM (DMSO)110,00€10mg155,00€25mg309,00€50mg447,00€100mg667,00€BMP agonist 1
BMP Agonist 1 (compound 2 b) is a small-molecule stimulator of bone morphogenic protein (BMP) signaling, crucial for the differentiation of C2C12 cells.Fórmula:C21H16N2O6Cor e Forma:SolidPeso molecular:392.36GSK-3β inhibitor 23
GSK-3β inhibitor23 (Compound 11726169) is an inhibitor of glycogen synthase kinase 3 (GSK-3), effectively inhibiting GSK-3β and GSK-3α with IC50 values of 12.1 nM and 18.8 nM, respectively. It demonstrates antiviral activity against HIV1 and exhibits good metabolic stability in mouse and human liver microsomes and plasma, although it has poor permeability in Caco-2 cells, indicating potentially low oral bioavailability.Fórmula:C18H13Cl2N5O2SCor e Forma:SolidPeso molecular:434.299GSK-3β inhibitor 24
GSK-3β inhibitor24 (Compound 41) is a potent GSK-3β inhibitor with an IC50 of 0.22 nM. It increases GSK-3β phosphorylation at the Ser9 site in a dose-dependent manner and inhibits tau protein hyperphosphorylation by reducing the abundance of p-tau-Ser396. The compound upregulates β-catenin and neurogenesis-related markers (GAP43 and MAP-2), demonstrating significant anti-Alzheimer's disease (AD) activity.Fórmula:C26H18N4O3Cor e Forma:SolidPeso molecular:434.446CHIR-98023
CAS:CHIR-98023 is a bio-active chemical.Fórmula:C20H16Cl2N8O2Cor e Forma:SolidPeso molecular:471.30GSK3β Inhibitor XI
CAS:GSK3β Inhibitor XI has GSK3β inhibitory effect.Fórmula:C18H15N5O3Cor e Forma:SolidPeso molecular:349.35GSK3a-IN-38
CAS:GSK3a-IN-38 is a novel small molecule compound that has inhibitory effects on GSK-3a.Fórmula:C18H20N4OPureza:99.75%Cor e Forma:SoildPeso molecular:308.38FRATide
CAS:FRATtide inhibits the phosphorylation of Axin and β-catenin, inhibits GSK-3 binding to Axin, and is a peptide derived from the GSK-3 binding protein.Fórmula:C55H102N2O2Cor e Forma:SolidPeso molecular:823.433GSK3β/mTOR modulator 1
GSK3β/mTOR modulator 1 (derivative 2) is an agent that modulates the GSK3β/mTOR signaling pathway. It is applicable in research related to acute lung injury (ALI) and inflammation.Fórmula:C19H28O5Cor e Forma:SolidPeso molecular:336.19367GSK-3β inhibitor 21
GSK-3β Inhibitor21 (compound 44) is an ATP-competitive inhibitor of GSK-3β with an IC50 value of 6.06 µM, characterized by its ability to inhibit tau phosphorylation and prevent amyloid protein aggregation. This compound is utilized in the research of Alzheimer's disease.Cor e Forma:Odour SolidWnt/β-catenin agonist 2
CAS:Wnt/β-catenin agonist 2 activates Wnt/β-catenin signaling and is an effective Wnt agonist.Fórmula:C13H12N4O3Pureza:99.35%Cor e Forma:SolidPeso molecular:272.26Ref: TM-T41094
1mg51,00€1mL*10mM (DMSO)105,00€5mg110,00€10mg177,00€25mg300,00€50mg424,00€100mg605,00€500mg1.198,00€GSK3-IN-1
CAS:GSK3-IN-1 is a GSK3B-glycogen synthase kinase-3 beta inhibitor.Fórmula:C14H10ClN3OSPureza:99.66%Cor e Forma:SolidPeso molecular:303.77Ref: TM-T9987
2mg42,00€5mg60,00€1mL*10mM (DMSO)73,00€10mg100,00€25mg215,00€50mg318,00€100mg455,00€200mg617,00€PROTAC GSK-3β Degrader-1
PROTACGSK-3β Degrader-1 (compound 1) is a degrader targeting GSK-3β with an IC50 of 833 nM. This compound consists of SB-216763 (a GSK-3β inhibitor), a PEG linker, and CRBN (E3 ligase ligand). It reduces neurotoxicity induced by Aβ25-35 peptide and CuSO4 and is applicable in Alzheimer's disease research.Fórmula:C43H42Cl2N6O9Peso molecular:856.239036-Me-ATP
CAS:6-Me-ATP, a modified ATP, binds well to GSK3 and donates phosphate for GSK3β phosphorylation.Fórmula:C11H18N5O13P3Cor e Forma:SolidPeso molecular:521.21GSK-3β inhibitor 22
CAS:GSK-3β inhibitor22 (compound 20o) is a GSK-3β inhibitor with an IC50 of 3.1 nM, showing potential for Alzheimer's disease research.Fórmula:C18H12F3N3O2S2Cor e Forma:SolidPeso molecular:423.432B-(SP)
CAS:Selective phosphopeptide substrate for glycogen synthase kinase-3 (GSK-3)Fórmula:C71H123N26O29PPureza:98%Cor e Forma:SolidPeso molecular:1835.87GSK-3β inhibitor 14
CAS:GSK-3β inhibitor 14 (1,5-Benzothiazepin-4(5H)-one, 2,3-dihydro-2-methyl-5-(phenylmethyl)-) is a weak GSK-3β inhibitor, IC50﹥ 100μM.Fórmula:C17H17NOSPureza:99.97%Cor e Forma:SolidPeso molecular:283.39GSK-3β inhibitor 1
CAS:GSK-3β inhibitor 1 is an inhibitor of GSK-3β( IC50 of 4.9 nM) and demonstrates high antidiabetic efficacy.Fórmula:C14H10N2OPureza:99.40%Cor e Forma:SolidPeso molecular:222.24Ref: TM-T11467
1mg60,00€5mg130,00€1mL*10mM (DMSO)142,00€10mg200,00€25mg356,00€50mg537,00€100mg737,00€200mg973,00€GSK3β inhibitor II
CAS:GSK3β inhibitor II is a GSK3β inhibitor. GSK3β inhibitor II exhibits the research potential of Alzheimer's disease (AD).Fórmula:C14H10IN3OSPureza:99.48%Cor e Forma:SolidPeso molecular:395.22GSK-3 inhibitor 3
CAS:GSK-3 inhibitor 3 is a selective, orally active, brain-permeable GSK-3 inhibitor that inhibits GSK-3α and GSK-3β with IC50s of 0.35 nM and 0.25 nM, respectivelyFórmula:C23H15FN6OPureza:99.89%Cor e Forma:SoildPeso molecular:410.4MeBIO
CAS:MeBIO is an agonist of aryl hydrocarbon receptor, with IC50 of 44 and 55 μM for GSK-3 and CDK1/CyclinB, respectively. MeBIO does not affect GSK-3β.Fórmula:C17H12BrN3O2Pureza:99.64%Cor e Forma:SolidPeso molecular:370.2Ref: TM-T21966
1mg39,00€5mg74,00€1mL*10mM (DMSO)86,00€10mg117,00€25mg220,00€50mg354,00€100mg520,00€500mg1.130,00€GSK-3 Inhibitor 5
CAS:4-Cyanophenacyl bromide, a ketone, used in drug-making and organic synthesis, blocks GSK-3.
Fórmula:C9H6BrNOPureza:99.58%Cor e Forma:Off-White To Light Yellow Crystalline PowderPeso molecular:224.05GSK-3β inhibitor 19
GSK-3β Inhibitor 19 (compound 36) is an inhibitor of GSK-3β with an IC50 value of 70 nM. It is applicable in research related to anti-inflammatory and Alzheimer's disease.Fórmula:C15H12N4O2SCor e Forma:SolidPeso molecular:312.35Kinase Inhibitor Library
A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;Cor e Forma:Odour SolidRef: TM-L1600
1mgA consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarGSK3-IN-4
CAS:GSK3-IN-4 is a GSK-3 inhibitor with IC50 of 0.101-1 μM of GSK-3α and GSK-3β in Calipe Assay.Fórmula:C18H20N4OPureza:98.33%Cor e Forma:SoildPeso molecular:308.38Ref: TM-T64366
1mg50,00€1mL*10mM (DMSO)102,00€5mg105,00€10mg154,00€25mg224,00€50mg314,00€100mg427,00€200mg575,00€Phospho-Glycogen Synthase Peptide-2(substrate)
CAS:Phospho-Glycogen Synthase Peptide-2 is a GSK-3 substrate, useful for serine kinase affinity purification.Fórmula:C123H191N40O48PCor e Forma:SolidPeso molecular:3029.087yGsy2p-IN-H23
CAS:yGsy2p-IN-H23 targets yeast GSY2 with IC50 of 875μM for hGYS1, for GSD research.Fórmula:C23H27N3O2Cor e Forma:SolidPeso molecular:377.488AR-A014418
CAS:AR-A014418 (GSK 3β inhibitor VIII) is an ATP-competitive, and selective GSK3β inhibitor.Fórmula:C12H12N4O4SPureza:>99.99% - ≥95%Cor e Forma:SolidPeso molecular:308.31R547
CAS:R547 (Ro 4584820) is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM.Fórmula:C18H21F2N5O4SPureza:90% - 99.64%Cor e Forma:SolidPeso molecular:441.45Ref: TM-T6312
1mg48,00€5mg96,00€1mL*10mM (DMSO)114,00€10mg140,00€25mg254,00€50mg487,00€100mg700,00€200mg973,00€5-Bromoindole
CAS:5-bromoindole is a potential inhibitor of glycogen synthase kinase 3 (GSK-3)and an important pharmaceutical chemical intermediate
Fórmula:C8H6BrNPureza:99.99%Cor e Forma:White To Beige Crystalline PowderPeso molecular:196.04AZD2858
CAS:AZD2858 is a selective GSK-3 inhibitor, inhibiting tau phosphorylation at the S396 site and activating Wnt signaling pathway.Fórmula:C21H23N7O3SPureza:98% - 99.25%Cor e Forma:SolidPeso molecular:453.52CHIR-99021
CAS:View and buy CHIR-99021 from TargetMol.CHIR-99021 is a GSK-3α/β inhibitor.Cited in 10 publications.Fórmula:C22H18Cl2N8Pureza:97.94% - ≥95%Cor e Forma:SolidPeso molecular:465.34Ref: TM-T2310
2mg40,00€5mg60,00€1mL*10mM (DMSO)66,00€10mg92,00€25mg152,00€50mg240,00€100mg384,00€200mg572,00€500mg888,00€Indirubin-3′-oxime
CAS:Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.Fórmula:C16H11N3O2Pureza:98.34%Cor e Forma:SolidPeso molecular:277.28Ref: TM-T9138
1mg44,00€1mL*10mM (DMSO)92,00€5mg93,00€10mg120,00€25mg236,00€50mg356,00€100mg532,00€200mg772,00€TBB
CAS:TBB (NSC-231634)(NSC-231634) is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2).
Fórmula:C6HBr4N3Pureza:98.51% - 99.45%Cor e Forma:Off-White SolidPeso molecular:434.71GSK3i XIII
CAS:GSK3i XIII (GSK3 inhibitor XIII) is a GSK-3 ATP-binding site inhibitor.Fórmula:C18H19N5Pureza:98.87%Cor e Forma:SolidPeso molecular:305.38Ref: TM-T24111
1mg63,00€5mg114,00€1mL*10mM (DMSO)128,00€10mg172,00€25mg279,00€50mg406,00€100mg572,00€TWS119
CAS:TWS119 is a GSK-3β inhibitor; capable of inducing neuronal differentiationFórmula:C18H14N4O2Pureza:98.14% - 99.63%Cor e Forma:SolidPeso molecular:318.33TDZD-8
CAS:TDZD-8 (NP 01139) is an inhibitor of GSK-3β, with an IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.Fórmula:C10H10N2O2SPureza:97.13% - 99.61%Cor e Forma:White SolidPeso molecular:222.26Bisindolylmaleimide I
CAS:Bisindolylmaleimide I (GF109203X) is a potent and highly selective protein kinase C (PKC) inhibitor with a Ki of 14 nM.Fórmula:C25H24N4O2Pureza:97.51% - 98.75%Cor e Forma:Orange SolidPeso molecular:412.48SB 216763
CAS:SB 216763 (SB216763) is an effective and specific GSK-3α/β inhibitor (IC50: 34.3 nM).Fórmula:C19H12Cl2N2O2Pureza:98.89% - 99.13%Cor e Forma:SolidPeso molecular:371.22Ref: TM-T3077
2mg37,00€5mg50,00€1mL*10mM (DMSO)50,00€10mg74,00€25mg124,00€50mg187,00€100mg315,00€500mg762,00€CP21R7
CAS:CP21 is a specific GSK3β inhibitor, used to activate stem cells for differentiation, often paired with BMP4 for mesodermal fate.Fórmula:C19H15N3O2Pureza:96.14% - 99.16%Cor e Forma:SolidPeso molecular:317.34Ref: TM-T3684
1mg38,00€2mg50,00€1mL*10mM (DMSO)77,00€5mg84,00€10mg120,00€25mg236,00€50mg356,00€100mg537,00€GSK 3 Inhibitor IX
CAS:GSK 3 Inhibitor IX (6-BIO) is a selective reversible, ATP-competitive inhibitor of GSK-3α/β and CDK1-cyclinB complex.Fórmula:C16H10BrN3O2Pureza:98% - 99.72%Cor e Forma:SolidPeso molecular:356.17Ref: TM-T1917
1mg42,00€2mg52,00€5mg78,00€1mL*10mM (DMSO)86,00€10mg96,00€25mg216,00€50mg389,00€100mg577,00€500mg1.234,00€Indirubin-3'-monoxime
CAS:Indirubin-3'-monoxime (Indirubin-3'-oxime) is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100/180/250 nM for Cdk5/p35, Cdk1/Fórmula:C16H11N3O2Pureza:99.55%Cor e Forma:Dark Red SolidPeso molecular:277.28PF-04802367
CAS:PF-04802367 is a highly selective GSK-3 inhibitor with an IC50 of 2.1 nM based on a recombinant human GSK-3β enzyme assay and 1.1 nM based on ADP-Glo assay.Fórmula:C16H16ClN5O3Pureza:98.76%Cor e Forma:SolidPeso molecular:361.78Ref: TM-T9611
1mg49,00€5mg100,00€1mL*10mM (DMSO)111,00€10mg152,00€25mg264,00€50mg399,00€100mg532,00€200mg705,00€KY19382
CAS:KY19382, a dual CXXC5-DVL and GSK3β inhibitor (IC50s: 19/10 nM), boosts Wnt/β-catenin signaling and may help in metabolic disease research.Fórmula:C17H11Cl2N3O2Pureza:98.06%Cor e Forma:SolidPeso molecular:360.19Ref: TM-T9025
1mg94,00€5mg187,00€1mL*10mM (DMSO)230,00€10mg333,00€25mg560,00€50mg797,00€100mg1.071,00€500mg2.187,00€IM-12
CAS:IM-12, an effective GSK-3β inhibitor(IC50=53 nM), regulates Wnt signalling.
Fórmula:C22H20FN3O2Pureza:99.42% - >99.99%Cor e Forma:SolidPeso molecular:377.41Tideglusib
CAS:Tideglusib (NP031112), a non-ATP competitive inhibitor of glycogen synthase kinase 3 (GSK-3), is with anti-inflammatory and neuroprotective activities.Fórmula:C19H14N2O2SPureza:98.40% - 99.35%Cor e Forma:SolidPeso molecular:334.39Ref: TM-T3067
10mg44,00€1mL*10mM (DMSO)48,00€25mg73,00€50mg107,00€100mg177,00€200mg268,00€500mg465,00€LY2090314
CAS:LY2090314, a potent GSK-3α/β blocker (IC50: 1.5/0.9 nM), could boost platinum chemo. Tested in leukemia and advanced cancers.Fórmula:C28H25FN6O3Pureza:99.21% - 99.91%Cor e Forma:SolidPeso molecular:512.53Ref: TM-T1755
1mg34,00€2mg50,00€5mg90,00€1mL*10mM (DMSO)92,00€10mg131,00€25mg225,00€50mg369,00€100mg545,00€200mg777,00€GS87
CAS:GS87 is a highly specific inhibitor of GSK3 (glycogen synthase kinase 3) that induces extensive differentiation of AML cells.Fórmula:C16H11N5O2SPureza:98.86%Cor e Forma:SolidPeso molecular:337.36Ref: TM-T8605
1mg84,00€5mg166,00€1mL*10mM (DMSO)170,00€10mg245,00€25mg404,00€50mg567,00€100mg767,00€200mg1.018,00€AZD1080
CAS:AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor.Fórmula:C19H18N4O2Pureza:97.72% - 99.75%Cor e Forma:SolidPeso molecular:334.37Ref: TM-T1741
1mg40,00€2mg52,00€1mL*10mM (DMSO)59,00€5mg80,00€10mg117,00€25mg207,00€50mg333,00€100mg406,00€BIO-acetoxime
CAS:BIO-acetoxime (GSK-3 Inhibitor X) is a potent dual GSK3α/β inhibitor with IC50 of 10 nM, >240-fold selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B.Fórmula:C18H12BrN3O3Pureza:97.15%Cor e Forma:SolidPeso molecular:398.21Ref: TM-T6787
1mg34,00€2mg46,00€5mg66,00€1mL*10mM (DMSO)73,00€10mg99,00€25mg177,00€50mg281,00€100mg439,00€Bikinin
CAS:Bikinin (Abrasin), a potent inhibitor of plant GSK-3/Shaggy-like kinase, activates BR signaling downstream of the BR receptor.
Fórmula:C9H9BrN2O3Pureza:99.86% - >99.99%Cor e Forma:SolidPeso molecular:273.08SB 415286
CAS:SB 415286 is a potent GSK3α inhibitor with IC50/Ki of 78 nM/31 nM with equally effective inhibition of GSK-3β.Fórmula:C16H10ClN3O5Pureza:99.55%Cor e Forma:SolidPeso molecular:359.72GSK-3β inhibitor 10
CAS:GSK-3β inhibitor 10 has skin-whitening, anti-oxidizing and PPAR activities.Fórmula:C12H12N2O3SPureza:98.06%Cor e Forma:SolidPeso molecular:264.3RGB-286638 free base
CAS:RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.Fórmula:C29H35N7O4Pureza:98% - 99.91%Cor e Forma:SolidPeso molecular:545.63GNF4877
CAS:GNF4877 inhibits DYRK1A/GSK3β (IC50: 6/16 nM), blocks NFATc export, and boosts β-cell growth.Fórmula:C25H27FN6O4Pureza:98.68% - 99.40%Cor e Forma:SolidPeso molecular:494.52(E/Z)-GSK-3β inhibitor 1
CAS:(E/Z)-GSK-3β inhibitor 1 is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy.Fórmula:C14H10N2OPureza:98.60%Cor e Forma:SolidPeso molecular:222.24Ref: TM-T9178
2mg35,00€5mg56,00€1mL*10mM (DMSO)63,00€10mg94,00€25mg154,00€50mg222,00€100mg318,00€200mg432,00€7BIO
CAS:7BIO triggers nonapoptotic death, blocks FLT3, DYRK1A/2, Aurora B/C kinases.
Fórmula:C16H10BrN3O2Pureza:99.67%Cor e Forma:SolidPeso molecular:356.174-Chloro-2'-bromoacetophenone
CAS:4-Chloro-2'-bromoacetophenone against glycogen synthase kinase-3 (GSK-3beta).Fórmula:C8H6BrClOPureza:98.34% - 99.41%Cor e Forma:White To Beige SolidPeso molecular:233.49KenPaullone
CAS:KenPaullone (9-Bromopaullone), a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation.Fórmula:C16H11BrN2OPureza:97.14% - 98.99%Cor e Forma:Tan SolidPeso molecular:327.18Ref: TM-T2247
1mg35,00€2mg50,00€5mg66,00€1mL*10mM (DMSO)71,00€10mg89,00€25mg178,00€50mg303,00€100mg449,00€500mg1.018,00€VP3.15 dihydrobromide
CAS:VP3.15 dihydrobromide: potent, oral, CNS-penetrant PDE7/GSK3 inhibitor; IC50s: PDE7- 1.59 μM, GSK- 0.88 μM.Fórmula:C20H24Br2N4OSPureza:99.67% - ≥95%Cor e Forma:SolidPeso molecular:528.3CHIR-98014
CAS:CHIR-98014 (CT98014) is a selective GSK3 inhibitor; potentiate insulin activation of glucose transport and utilization in vitro and in vivo.Fórmula:C20H17Cl2N9O2Pureza:97.25% - 99.59%Cor e Forma:SolidPeso molecular:486.31Ref: TM-T2608
1mL*10mM (DMSO)A consultar5mg71,00€10mg102,00€25mg205,00€50mg334,00€100mg537,00€500mg1.134,00€ALSTERPAULLONE
CAS:Alsterpaullone is a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells Through Apoptosis-Inducing EffecFórmula:C16H11N3O3Pureza:99.8%Cor e Forma:SolidPeso molecular:293.28Ref: TM-T7426
1mg55,00€1mL*10mM (DMSO)105,00€5mg110,00€10mg173,00€25mg296,00€50mg424,00€100mg587,00€200mg792,00€CHIR 98024
CAS:CHIR 98024: strong GSK-3α/β blocker, IC50 0.65/0.58 nM, selective over Cdc2/ERK2.Fórmula:C20H17Cl2N9O2Pureza:99.45%Cor e Forma:SolidPeso molecular:486.31Ref: TM-T3074
1mg42,00€2mg52,00€5mg90,00€1mL*10mM (DMSO)92,00€10mg144,00€25mg281,00€50mg462,00€100mg668,00€1-Azakenpaullone
CAS:1-Azakenpaullone (azakenpaullone) is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, >100-fold selectivity over CDK1/cyclin B and CDK5/p25.Fórmula:C15H10BrN3OPureza:99.73%Cor e Forma:Tan SolidPeso molecular:328.16Ref: TM-T6358
1mg74,00€5mg152,00€1mL*10mM (DMSO)177,00€10mg236,00€25mg439,00€50mg620,00€100mg888,00€200mg1.198,00€Dihydronarwedine
CAS:Dihydronarwedine is a metabolite of Galanthamine, an inhibitor of glycogen synthase kinase 3β (GSK3β)Fórmula:C17H21NO3Cor e Forma:SolidPeso molecular:287.35Cazpaullone
CAS:Cazpaullone inhibits GSK-3 and briefly boosts Pax4 mRNA expression.Fórmula:C16H10N4OCor e Forma:SolidPeso molecular:274.28VP3.15
CAS:VP3.15 is an orally bioavailable and CNS-penetrant dual inhibitor of phosphodiesterase (PDE)7- GSK3 (IC50s: 1.59 μM and 0.88 μM for PDE7 and GSK-3).Fórmula:C20H22N4OSPureza:98%Cor e Forma:SolidPeso molecular:366.48BRD1652
CAS:BRD1652 is a highly selective and potent GSK3 inhibitor.Fórmula:C20H20F3N3OPureza:98%Cor e Forma:SolidPeso molecular:375.39TWS-119
CAS:TWS-119 blocks GSK-3β, prompting neuronal formation in mouse stem cells.Fórmula:C22H16F6N4O6Cor e Forma:SolidPeso molecular:546.38PfGSK3/PfPK6-IN-2
CAS:PfGSK3/PfPK6-IN-2 inhibits Plasmodium falciparum GSK3/PK6 (IC50: 172 nM/11 nM) for Malaria research.Fórmula:C24H25Cl2N5OSCor e Forma:SolidPeso molecular:502.46PIMPC
CAS:PIMPC, a compound endowed with antioxidant and metal-chelating properties, acts as a novel inhibitor of glycogen synthase kinase 3 (GSK-3), and exhibitsFórmula:C21H19N5OPureza:98%Cor e Forma:SolidPeso molecular:357.413F8
CAS:3F8 is a selective GSK-3β inhibitor that can be used as a new tool and potential therapeutic candidate compound for GSK3-related diseases, and can be used inFórmula:C15H14N2O4Pureza:98.14% - 98.25%Cor e Forma:SolidPeso molecular:286.28ZDWX-25
CAS:ZDWX-25, a strong GSK-3β & DYRK1A inhibitor, kills SH-SY5Y/HL-7702 cells, may aid Alzheimer's research; IC50: 71 nM for GSK-3β.Fórmula:C17H15N3O3Cor e Forma:SolidPeso molecular:309.32TCS 2002
CAS:GSK-3β inhibitor 9b: potent, selective, oral, IC50=35 nM, good pharmacokinetics, BBB-permeable, researched for Alzheimer's.Fórmula:C18H14N2O3SCor e Forma:SolidPeso molecular:338.38GSK-3β inhibitor 12
CAS:GSK-3β inhibitor 12 is a selective GSK-3β inhibitor.GSK-3β inhibitor 12 inhibits 49.11% of 25 μM GSK-3β activity and 37.11% of 50 μM GSK-3β activity.GSK-3βFórmula:C14H13N3OSPureza:98.58%Cor e Forma:SolidPeso molecular:271.34MRT80
CAS:MRT80 is an inhibitor of GSK-3 in vitro. MRT80 de-stabilizes MDM2 and stabilizes p53 protein and E2F-1.Fórmula:C15H15N5OPureza:98%Cor e Forma:SolidPeso molecular:281.31BRD3731
CAS:BRD3731 selectively inhibits GSK3β with IC50 of 15 nM; it's promising for PTSD, psychiatric issues, diabetes, and neurodegeneration.Fórmula:C24H31N3OCor e Forma:SolidPeso molecular:377.52GSK3-IN-2
CAS:GSK3-IN-2 is a potent GSK3 inhibitor for the treatment of diabetes and neurodegenerative diseases.Fórmula:C17H19N3OSPureza:99.51%Cor e Forma:SolidPeso molecular:313.42BRD0209
CAS:BRD0209 is a highly selective and potent GSK3 inhibitor.
Fórmula:C22H25N3OPureza:99.92%Cor e Forma:SolidPeso molecular:347.4518BIOder
CAS:18BIOder is a neuroprotective inhibitor of GSK-3β, highly selectively inhibiting HIV-1. It is the second generation derivative of 6BIO.Fórmula:C9H7ClN2O2Pureza:98%Cor e Forma:SolidPeso molecular:210.62ABC1183
CAS:ABC1183, an oral diaminothiazole, inhibits GSK3α/β, CDK9, hinders cancer cell growth, induces G2/M arrest, and modulates phosphorylation.
Fórmula:C18H14N4OSPureza:98.92%Cor e Forma:SolidPeso molecular:334.39GSK-3β inhibitor 11
CAS:GSK-3β inhibitor 11 (compound 21) is a potent inhibitor of glycogen synthase kinase-3β (GSK-3β) with an inhibitory concentration (IC50) of 10.02 μM.
Fórmula:C20H15N3O4SPureza:97.33%Cor e Forma:SolidPeso molecular:393.42GSK-3 Inhibitor XIII
CAS:GSK-3 InhibitorXIII, an ATP-competitive GSK-3 inhibitor (Ki: 24 nM), can be used to study diabetes and obesity.Fórmula:C18H15N5Pureza:99.85% - 99.86%Cor e Forma:SolidPeso molecular:301.35Ref: TM-T78578
1mg101,00€5mg230,00€1mL*10mM (DMSO)239,00€10mg414,00€25mg884,00€50mg1.215,00€100mg1.639,00€200mg2.215,00€GSK-3β inhibitor 2
CAS:GSK-3β inhibitor 2 (5-Thiazolecarboxamide,2-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-4-methoxy-) is a BBB-crossing and selective inhibitor of GSK-3β (IC50
Fórmula:C14H14N4O3SPureza:99.08%Cor e Forma:SolidPeso molecular:318.35BIP-135
CAS:BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor.Fórmula:C21H13BrN2O3Pureza:99.93%Cor e Forma:SolidPeso molecular:421.24Ref: TM-T14613
1mg33,00€5mg75,00€1mL*10mM (DMSO)81,00€10mg110,00€25mg210,00€50mg313,00€100mg447,00€200mg617,00€BRD5648
CAS:BRD5648 ((R)-BRD0705) is an inactive (R)-enantiomer of BRD0705.Fórmula:C20H23N3OPureza:99.89%Cor e Forma:SolidPeso molecular:321.42PT-65
CAS:PT-65, a potent and selective GSK3 degrader, demonstrates the highest degradation capacity for GSK3α (DC50 = 28.3 nM) and GSK3β (DC50 = 34.2 nM) in SH-SY5Y cells, making it applicable for Alzheimer's disease research [1].Fórmula:C51H63N13O12SCor e Forma:SolidPeso molecular:1082.19Antitrypanosomal agent 14
CAS:Antitrypanosomal agent 14 (Compound 1), a potent T.Fórmula:C14H23N3OSPureza:98%Cor e Forma:SolidPeso molecular:281.42SAR502250
CAS:SAR502250: potent, selective GSK3 inhibitor, IC50=12nM, oral, brain-penetrant, potential for AD research, antidepressant-like properties.Fórmula:C19H18FN5O2Cor e Forma:SolidPeso molecular:367.38GSK-3β inhibitor 8
CAS:GSK-3β inhibitor 8 (GSK3β Inhibitor XVIII) is a potent and selective GSK-3β inhibitor with an IC50 value of 64 nM.GSK-3β inhibitor 8 is a thienopyrimidineFórmula:C20H20ClN5OSPureza:98.46%Cor e Forma:SolidPeso molecular:413.92(Rac)-BRD0705
CAS:(Rac)-BRD0705 is a less active racemate of BRD0705. BRD0705 is an effective and selective inhibitor of GSK3α.Fórmula:C20H23N3OPureza:99.7%Cor e Forma:SolidPeso molecular:321.42Ref: TM-T12664
1mg92,00€1mL*10mM (DMSO)146,00€5mg200,00€10mg299,00€25mg484,00€50mg658,00€100mg892,00€A 1070722
CAS:A 1070722: potent GSK-3 inhibitor, Ki = 0.6 nM for both α/β isoforms, crosses BBB, potential brain GSK-3 PET radiotracer.Fórmula:C17H13F3N4O2Pureza:99.9%Cor e Forma:SolidPeso molecular:362.31TCS 21311
CAS:TCS 21311 (NIBR3049) selectively inhibits JAK3 (IC50: 8 nM) and PKCα/θ & GSK3β; >100x selective over JAK1, JAK2, TYK2.Fórmula:C27H25F3N4O4Pureza:99.39% - ≥98%Cor e Forma:SolidPeso molecular:526.515-Iodo-indirubin-3'-monoxime
CAS:5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase (IC50sFórmula:C16H10IN3O2Cor e Forma:SolidPeso molecular:403.17GSK-3 inhibitor 1
CAS:GSK-3 inhibitor 1 is a GSK-3 inhibitor.Fórmula:C22H17ClFN5O2Pureza:98.42%Cor e Forma:SolidPeso molecular:437.85GSK3β-IN-1
CAS:GSK3β-IN-1 (compound 1) is an inhibitor of glycogen synthase kinase-3β (GSK-3β) with an IC50 value of 65 nM, and it is utilized in Alzheimer's disease research.Fórmula:C17H13FN2O4SCor e Forma:SolidPeso molecular:360.36
