gsk-3
Os inibidores da GSK-3 são compostos que alvo a Glicogênio Sintase Quinase 3 (GSK-3), uma enzima envolvida em numerosos processos celulares, incluindo o metabolismo do glicogênio, a transcrição genética e a proliferação celular. A GSK-3 está implicada em várias doenças, como diabetes, distúrbios neurodegenerativos e câncer. Os inibidores da GSK-3 são ferramentas importantes para explorar essas vias e desenvolver potenciais terapias. Na CymitQuimica, oferecemos inibidores da GSK-3 para apoiar sua pesquisa em doenças metabólicas, neurobiologia e oncologia.
Foram encontrados 109 produtos de "gsk-3"
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BRD0705
CAS:BRD0705: potent, selective GSK3α inhibitor, oral, IC50: 66 nM, 8x more selective than GSK3β.Fórmula:C20H23N3OPureza:99.01%Cor e Forma:SolidPeso molecular:321.42Indazole
CAS:Indazole, a heterocyclic compound, offers diverse biological activities.Fórmula:C7H6N2Pureza:99.59% - 99.85%Cor e Forma:White Or Beige Crystalline PowderPeso molecular:118.14Cromolyn sodium
CAS:Cromolyn sodium (FPL-670) is a chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells.Fórmula:C23H14Na2O11Pureza:99.4% - 99.95%Cor e Forma:Colorless Crystals From Ethanol + Ether White Crystalline PowderPeso molecular:512.339-ING-41
CAS:9-ING-41 is a glycogen synthase kinase-3 inhibitor.Fórmula:C22H13FN2O5Pureza:99.32%Cor e Forma:SolidPeso molecular:404.35Ref: TM-T14066
1mg50,00€2mg66,00€5mg94,00€1mL*10mM (DMSO)110,00€10mg155,00€25mg309,00€50mg447,00€100mg667,00€GSK-3 inhibitor 3
CAS:GSK-3 inhibitor 3 is a selective, orally active, brain-permeable GSK-3 inhibitor that inhibits GSK-3α and GSK-3β with IC50s of 0.35 nM and 0.25 nM, respectivelyFórmula:C23H15FN6OPureza:99.89%Cor e Forma:SoildPeso molecular:410.4GSK3-IN-1
CAS:GSK3-IN-1 is a GSK3B-glycogen synthase kinase-3 beta inhibitor.Fórmula:C14H10ClN3OSPureza:99.66%Cor e Forma:SolidPeso molecular:303.77Ref: TM-T9987
2mg42,00€5mg60,00€1mL*10mM (DMSO)73,00€10mg100,00€25mg215,00€50mg318,00€100mg455,00€200mg617,00€MeBIO
CAS:MeBIO is an agonist of aryl hydrocarbon receptor, with IC50 of 44 and 55 μM for GSK-3 and CDK1/CyclinB, respectively. MeBIO does not affect GSK-3β.Fórmula:C17H12BrN3O2Pureza:99.64%Cor e Forma:SolidPeso molecular:370.2Ref: TM-T21966
1mg39,00€5mg74,00€1mL*10mM (DMSO)86,00€10mg117,00€25mg220,00€50mg354,00€100mg520,00€500mg1.130,00€GSK3β/mTOR modulator 1
GSK3β/mTOR modulator 1 (derivative 2) is an agent that modulates the GSK3β/mTOR signaling pathway. It is applicable in research related to acute lung injury (ALI) and inflammation.Fórmula:C19H28O5Cor e Forma:SolidPeso molecular:336.193676-Me-ATP
CAS:6-Me-ATP, a modified ATP, binds well to GSK3 and donates phosphate for GSK3β phosphorylation.Fórmula:C11H18N5O13P3Cor e Forma:SolidPeso molecular:521.21FRATide
CAS:FRATtide inhibits the phosphorylation of Axin and β-catenin, inhibits GSK-3 binding to Axin, and is a peptide derived from the GSK-3 binding protein.Fórmula:C55H102N2O2Cor e Forma:SolidPeso molecular:823.433GSK-3β inhibitor 24
GSK-3β inhibitor24 (Compound 41) is a potent GSK-3β inhibitor with an IC50 of 0.22 nM. It increases GSK-3β phosphorylation at the Ser9 site in a dose-dependent manner and inhibits tau protein hyperphosphorylation by reducing the abundance of p-tau-Ser396. The compound upregulates β-catenin and neurogenesis-related markers (GAP43 and MAP-2), demonstrating significant anti-Alzheimer's disease (AD) activity.Fórmula:C26H18N4O3Cor e Forma:SolidPeso molecular:434.446GSK3a-IN-38
CAS:GSK3a-IN-38 is a novel small molecule compound that has inhibitory effects on GSK-3a.Fórmula:C18H20N4OPureza:99.75%Cor e Forma:SoildPeso molecular:308.38GSK3-IN-4
CAS:GSK3-IN-4 is a GSK-3 inhibitor with IC50 of 0.101-1 μM of GSK-3α and GSK-3β in Calipe Assay.Fórmula:C18H20N4OPureza:98.33%Cor e Forma:SoildPeso molecular:308.38Ref: TM-T64366
1mg50,00€1mL*10mM (DMSO)102,00€5mg105,00€10mg154,00€25mg224,00€50mg314,00€100mg427,00€200mg575,00€GSK-3β inhibitor 1
CAS:GSK-3β inhibitor 1 is an inhibitor of GSK-3β( IC50 of 4.9 nM) and demonstrates high antidiabetic efficacy.Fórmula:C14H10N2OPureza:99.40%Cor e Forma:SolidPeso molecular:222.24Ref: TM-T11467
1mg60,00€5mg130,00€1mL*10mM (DMSO)142,00€10mg200,00€25mg356,00€50mg537,00€100mg737,00€200mg973,00€GSK-3 Inhibitor 5
CAS:4-Cyanophenacyl bromide, a ketone, used in drug-making and organic synthesis, blocks GSK-3.
Fórmula:C9H6BrNOPureza:99.58%Cor e Forma:Off-White To Light Yellow Crystalline PowderPeso molecular:224.05GSK-3β inhibitor 22
CAS:GSK-3β inhibitor22 (compound 20o) is a GSK-3β inhibitor with an IC50 of 3.1 nM, showing potential for Alzheimer's disease research.Fórmula:C18H12F3N3O2S2Cor e Forma:SolidPeso molecular:423.43GSK3β inhibitor II
CAS:GSK3β inhibitor II is a GSK3β inhibitor. GSK3β inhibitor II exhibits the research potential of Alzheimer's disease (AD).Fórmula:C14H10IN3OSPureza:99.48%Cor e Forma:SolidPeso molecular:395.22Phospho-Glycogen Synthase Peptide-2(substrate)
CAS:Phospho-Glycogen Synthase Peptide-2 is a GSK-3 substrate, useful for serine kinase affinity purification.Fórmula:C123H191N40O48PCor e Forma:SolidPeso molecular:3029.087PROTAC GSK-3β Degrader-1
PROTACGSK-3β Degrader-1 (compound 1) is a degrader targeting GSK-3β with an IC50 of 833 nM. This compound consists of SB-216763 (a GSK-3β inhibitor), a PEG linker, and CRBN (E3 ligase ligand). It reduces neurotoxicity induced by Aβ25-35 peptide and CuSO4 and is applicable in Alzheimer's disease research.Fórmula:C43H42Cl2N6O9Peso molecular:856.23903BMP agonist 1
BMP Agonist 1 (compound 2 b) is a small-molecule stimulator of bone morphogenic protein (BMP) signaling, crucial for the differentiation of C2C12 cells.Fórmula:C21H16N2O6Cor e Forma:SolidPeso molecular:392.36Kinase Inhibitor Library
A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;Cor e Forma:Odour SolidRef: TM-L1600
1mgA consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultar2B-(SP)
CAS:Selective phosphopeptide substrate for glycogen synthase kinase-3 (GSK-3)Fórmula:C71H123N26O29PPureza:98%Cor e Forma:SolidPeso molecular:1835.87GSK3β Inhibitor XI
CAS:GSK3β Inhibitor XI has GSK3β inhibitory effect.Fórmula:C18H15N5O3Cor e Forma:SolidPeso molecular:349.35Wnt/β-catenin agonist 2
CAS:Wnt/β-catenin agonist 2 activates Wnt/β-catenin signaling and is an effective Wnt agonist.Fórmula:C13H12N4O3Pureza:99.35%Cor e Forma:SolidPeso molecular:272.26Ref: TM-T41094
1mg51,00€1mL*10mM (DMSO)105,00€5mg110,00€10mg177,00€25mg300,00€50mg424,00€100mg605,00€500mg1.198,00€GSK-3β inhibitor 14
CAS:GSK-3β inhibitor 14 (1,5-Benzothiazepin-4(5H)-one, 2,3-dihydro-2-methyl-5-(phenylmethyl)-) is a weak GSK-3β inhibitor, IC50﹥ 100μM.Fórmula:C17H17NOSPureza:99.97%Cor e Forma:SolidPeso molecular:283.39GSK-3β inhibitor 23
GSK-3β inhibitor23 (Compound 11726169) is an inhibitor of glycogen synthase kinase 3 (GSK-3), effectively inhibiting GSK-3β and GSK-3α with IC50 values of 12.1 nM and 18.8 nM, respectively. It demonstrates antiviral activity against HIV1 and exhibits good metabolic stability in mouse and human liver microsomes and plasma, although it has poor permeability in Caco-2 cells, indicating potentially low oral bioavailability.Fórmula:C18H13Cl2N5O2SCor e Forma:SolidPeso molecular:434.299GSK-3β inhibitor 19
GSK-3β Inhibitor 19 (compound 36) is an inhibitor of GSK-3β with an IC50 value of 70 nM. It is applicable in research related to anti-inflammatory and Alzheimer's disease.Fórmula:C15H12N4O2SCor e Forma:SolidPeso molecular:312.35CHIR-98023
CAS:CHIR-98023 is a bio-active chemical.Fórmula:C20H16Cl2N8O2Cor e Forma:SolidPeso molecular:471.30GSK-3β inhibitor 21
GSK-3β Inhibitor21 (compound 44) is an ATP-competitive inhibitor of GSK-3β with an IC50 value of 6.06 µM, characterized by its ability to inhibit tau phosphorylation and prevent amyloid protein aggregation. This compound is utilized in the research of Alzheimer's disease.Cor e Forma:Odour SolidyGsy2p-IN-H23
CAS:yGsy2p-IN-H23 targets yeast GSY2 with IC50 of 875μM for hGYS1, for GSD research.Fórmula:C23H27N3O2Cor e Forma:SolidPeso molecular:377.488LY2090314
CAS:LY2090314, a potent GSK-3α/β blocker (IC50: 1.5/0.9 nM), could boost platinum chemo. Tested in leukemia and advanced cancers.Fórmula:C28H25FN6O3Pureza:99.21% - 99.91%Cor e Forma:SolidPeso molecular:512.53Ref: TM-T1755
1mg34,00€2mg50,00€5mg90,00€1mL*10mM (DMSO)92,00€10mg131,00€25mg225,00€50mg369,00€100mg545,00€200mg777,00€GS87
CAS:GS87 is a highly specific inhibitor of GSK3 (glycogen synthase kinase 3) that induces extensive differentiation of AML cells.Fórmula:C16H11N5O2SPureza:98.86%Cor e Forma:SolidPeso molecular:337.36Ref: TM-T8605
1mg84,00€5mg166,00€1mL*10mM (DMSO)170,00€10mg245,00€25mg404,00€50mg567,00€100mg767,00€200mg1.018,00€Tideglusib
CAS:Tideglusib (NP031112), a non-ATP competitive inhibitor of glycogen synthase kinase 3 (GSK-3), is with anti-inflammatory and neuroprotective activities.Fórmula:C19H14N2O2SPureza:98.40% - 99.35%Cor e Forma:SolidPeso molecular:334.39Ref: TM-T3067
10mg44,00€1mL*10mM (DMSO)48,00€25mg73,00€50mg107,00€100mg177,00€200mg268,00€500mg465,00€VP3.15 dihydrobromide
CAS:VP3.15 dihydrobromide: potent, oral, CNS-penetrant PDE7/GSK3 inhibitor; IC50s: PDE7- 1.59 μM, GSK- 0.88 μM.Fórmula:C20H24Br2N4OSPureza:99.67% - ≥95%Cor e Forma:SolidPeso molecular:528.3(E/Z)-GSK-3β inhibitor 1
CAS:(E/Z)-GSK-3β inhibitor 1 is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy.Fórmula:C14H10N2OPureza:98.60%Cor e Forma:SolidPeso molecular:222.24Ref: TM-T9178
2mg35,00€5mg56,00€1mL*10mM (DMSO)63,00€10mg94,00€25mg154,00€50mg222,00€100mg318,00€200mg432,00€BIO-acetoxime
CAS:BIO-acetoxime (GSK-3 Inhibitor X) is a potent dual GSK3α/β inhibitor with IC50 of 10 nM, >240-fold selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B.Fórmula:C18H12BrN3O3Pureza:97.15%Cor e Forma:SolidPeso molecular:398.21Ref: TM-T6787
1mg34,00€2mg46,00€5mg66,00€1mL*10mM (DMSO)73,00€10mg99,00€25mg177,00€50mg281,00€100mg439,00€Indirubin-3′-oxime
CAS:Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.Fórmula:C16H11N3O2Pureza:98.34%Cor e Forma:SolidPeso molecular:277.28Ref: TM-T9138
1mg44,00€1mL*10mM (DMSO)92,00€5mg93,00€10mg120,00€25mg236,00€50mg356,00€100mg532,00€200mg772,00€GNF4877
CAS:GNF4877 inhibits DYRK1A/GSK3β (IC50: 6/16 nM), blocks NFATc export, and boosts β-cell growth.Fórmula:C25H27FN6O4Pureza:98.68% - 99.40%Cor e Forma:SolidPeso molecular:494.527BIO
CAS:7BIO triggers nonapoptotic death, blocks FLT3, DYRK1A/2, Aurora B/C kinases.
Fórmula:C16H10BrN3O2Pureza:99.67%Cor e Forma:SolidPeso molecular:356.174-Chloro-2'-bromoacetophenone
CAS:4-Chloro-2'-bromoacetophenone against glycogen synthase kinase-3 (GSK-3beta).Fórmula:C8H6BrClOPureza:98.34% - 99.41%Cor e Forma:White To Beige SolidPeso molecular:233.49CHIR-99021
CAS:View and buy CHIR-99021 from TargetMol.CHIR-99021 is a GSK-3α/β inhibitor.Cited in 10 publications.Fórmula:C22H18Cl2N8Pureza:97.94% - ≥95%Cor e Forma:SolidPeso molecular:465.34Ref: TM-T2310
2mg40,00€5mg60,00€1mL*10mM (DMSO)66,00€10mg92,00€25mg152,00€50mg240,00€100mg384,00€200mg572,00€500mg888,00€CP21R7
CAS:CP21 is a specific GSK3β inhibitor, used to activate stem cells for differentiation, often paired with BMP4 for mesodermal fate.Fórmula:C19H15N3O2Pureza:96.14% - 99.16%Cor e Forma:SolidPeso molecular:317.34Ref: TM-T3684
1mg38,00€2mg50,00€1mL*10mM (DMSO)77,00€5mg84,00€10mg120,00€25mg236,00€50mg356,00€100mg537,00€KY19382
CAS:KY19382, a dual CXXC5-DVL and GSK3β inhibitor (IC50s: 19/10 nM), boosts Wnt/β-catenin signaling and may help in metabolic disease research.Fórmula:C17H11Cl2N3O2Pureza:98.06%Cor e Forma:SolidPeso molecular:360.19Ref: TM-T9025
1mg94,00€5mg187,00€1mL*10mM (DMSO)230,00€10mg333,00€25mg560,00€50mg797,00€100mg1.071,00€500mg2.187,00€AZD2858
CAS:AZD2858 is a selective GSK-3 inhibitor, inhibiting tau phosphorylation at the S396 site and activating Wnt signaling pathway.Fórmula:C21H23N7O3SPureza:98% - 99.25%Cor e Forma:SolidPeso molecular:453.52SB 415286
CAS:SB 415286 is a potent GSK3α inhibitor with IC50/Ki of 78 nM/31 nM with equally effective inhibition of GSK-3β.Fórmula:C16H10ClN3O5Pureza:99.55%Cor e Forma:SolidPeso molecular:359.72AZD1080
CAS:AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor.Fórmula:C19H18N4O2Pureza:97.72% - 99.75%Cor e Forma:SolidPeso molecular:334.37Ref: TM-T1741
1mg40,00€2mg52,00€1mL*10mM (DMSO)59,00€5mg80,00€10mg117,00€25mg207,00€50mg333,00€100mg406,00€GSK-3β inhibitor 10
CAS:GSK-3β inhibitor 10 has skin-whitening, anti-oxidizing and PPAR activities.Fórmula:C12H12N2O3SPureza:98.06%Cor e Forma:SolidPeso molecular:264.3Indirubin-3'-monoxime
CAS:Indirubin-3'-monoxime (Indirubin-3'-oxime) is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100/180/250 nM for Cdk5/p35, Cdk1/Fórmula:C16H11N3O2Pureza:99.55%Cor e Forma:Dark Red SolidPeso molecular:277.28TDZD-8
CAS:TDZD-8 (NP 01139) is an inhibitor of GSK-3β, with an IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.Fórmula:C10H10N2O2SPureza:97.13% - 99.61%Cor e Forma:White SolidPeso molecular:222.26IM-12
CAS:IM-12, an effective GSK-3β inhibitor(IC50=53 nM), regulates Wnt signalling.
Fórmula:C22H20FN3O2Pureza:99.42% - >99.99%Cor e Forma:SolidPeso molecular:377.41
