PI3K
Os inibidores de PI3K são compostos que bloqueiam a atividade das fosfoinositídeo 3-quinases (PI3Ks), uma família de enzimas envolvidas em uma ampla gama de processos celulares, incluindo crescimento, proliferação, sobrevivência e metabolismo. A via PI3K/Akt/mTOR é frequentemente desregulada no câncer, tornando o PI3K um alvo-chave para a terapia do câncer. Os inibidores de PI3K são ferramentas essenciais para estudar a transdução de sinal, a biologia do câncer e o desenvolvimento de terapias direcionadas. Na CymitQuimica, oferecemos uma variedade de inibidores de PI3K para apoiar sua pesquisa em sinalização celular, oncologia e desenvolvimento terapêutico.
Foram encontrados 241 produtos de "PI3K"
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IITZ-01
CAS:<p>IITZ-01 is potent autophagy inhibitor with single-agent anticancer activity ( IC50 of 2.62 μM for PI3Kγ.)</p>Fórmula:C26H23FN8OPureza:99.31%Cor e Forma:SolidPeso molecular:482.51Lupiwighteone
CAS:<p>Lupiwighteone has anti-angiogenesis potential, it also has anticancer and cancer preventive effects on SH-SY5Y cells.</p>Fórmula:C20H18O5Pureza:98.92%Cor e Forma:SolidPeso molecular:338.35Leniolisib
CAS:<p>Leniolisib (CDZ173) (CDZ173) is a potent and selective PI3Kδ inhibitor (IC50: 11 nM).</p>Fórmula:C21H25F3N6O2Pureza:99.88%Cor e Forma:SolidPeso molecular:450.46Arnicolide D
CAS:<p>Arnicolide D is a sesquiterpene lactone.</p>Fórmula:C19H24O5Pureza:96.66%Cor e Forma:SolidPeso molecular:332.39BGT226
CAS:<p>BGT226 (NVP-BGT226) is a novel dual PI3K / mTOR inhibitor, it acts on PI3K α/β/γ with IC50 of 4 nM / 63 nM / 38 nM, respectively.</p>Fórmula:C28H25F3N6O2Pureza:95.74% - 99.51%Cor e Forma:SolidPeso molecular:534.53NIH-12848
CAS:<p>NIH-12848 is a putative inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) with an IC50 of 1 μM.</p>Fórmula:C20H14F3N3SPureza:99.84% - 99.9%Cor e Forma:SolidPeso molecular:385.41GNE-493
CAS:<p>GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for</p>Fórmula:C17H20N6O2SPureza:98%Cor e Forma:SolidPeso molecular:372.44Rigosertib sodium
CAS:<p>Rigosertib sodium (ON-01910), a non-ATP-competitive inhibitor of PLK1(IC50=9 nM), exhibits 30-fold higher specificity activity over Plk2 and no effect on Plk3.</p>Fórmula:C21H24NNaO8SPureza:98% - 99.37%Cor e Forma:SolidPeso molecular:473.47SKI V
CAS:<p>SKI V is a potent and noncompetitive non-lipid sphingosine kinase (SPHK; SK) inhibitor (GST-hSK,IC50 : 2 μM), and is a PI3K inhibitor(hPI3k,IC50 : 6 μM),</p>Fórmula:C15H10O4Pureza:98.78%Cor e Forma:SolidPeso molecular:254.24MOMIPP
CAS:<p>MOMIPP: PIKfyve inhibitor, spurs macropinocytosis, crosses blood-brain barrier, curbs glioblastoma growth.</p>Fórmula:C18H16N2O2Pureza:99.66%Cor e Forma:SolidPeso molecular:292.33(+)-Nortrachelogenin
CAS:<p>(+)-Nortrachelogenin is a lignan isolated from Wikstroemia indica C.A. Meyer (Thymelaeaceae). (+)-Nortrachelogenin possesses antileukemic activity.</p>Fórmula:C20H22O7Pureza:99.88%Cor e Forma:SolidPeso molecular:374.38Samotolisib
CAS:<p>Samotolisib (LY3023414) inhibits PI3K, DNA-PK, mTOR; tested for solid tumors including breast and colon cancer.</p>Fórmula:C23H26N4O3Pureza:98.41% - 99.69%Cor e Forma:SolidPeso molecular:406.48Heterophyllin B
CAS:<p>Heterophyllin B hinders esophageal cancer cell adhesion/invasion via PI3K/AKT/β-catenin and gene regulation.</p>Fórmula:C40H58N8O8Pureza:99.12% - 99.85%Cor e Forma:SolidPeso molecular:778.94AMG319
CAS:<p>AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, >47-fold selectivity over other PI3Ks. Phase 2.</p>Fórmula:C21H16FN7Pureza:98.9% - 99.24%Cor e Forma:Crystalline SolidPeso molecular:385.4P7C3-A20
CAS:<p>P7C3-A20 is a derivative of P7C3 that has proneurogenic and neuroprotective activity.</p>Fórmula:C22H19Br2FN2OPureza:96.83% - ≥98%Cor e Forma:SolidPeso molecular:506.21Voxtalisib
CAS:<p>Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.</p>Fórmula:C13H14N6OPureza:98.21% - 99.69%Cor e Forma:SolidPeso molecular:270.29Umbralisib
CAS:Umbralisib (TGR 1202) is a PI3Kδ inhibitor.Fórmula:C31H24F3N5O3Pureza:99.56% - 99.56%Cor e Forma:White SolidPeso molecular:571.55AZD-8835
CAS:<p>AZD-8835 is a mixed inhibitor of PI3Kα/δ (IC50: 6.2/5.7 nM), also with selectivity against PI3Kβ/γ (IC50: 431/90 nM).</p>Fórmula:C22H31N9O3Pureza:98.22% - 99.88%Cor e Forma:SolidPeso molecular:469.54AS-604850
CAS:<p>AS-604850: ATP-competitive PI3Kγ inhibitor, IC50 250 nM, 18x > PI3Kα, 80x > PI3Kδ/β.</p>Fórmula:C11H5F2NO4SPureza:99.65%Cor e Forma:SolidPeso molecular:285.22PIK-93
CAS:PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.Fórmula:C14H16ClN3O4S2Pureza:97.72%Cor e Forma:SolidPeso molecular:389.88CH5132799
CAS:<p>CH5132799 has been used in trials studying the treatment of Solid Tumors.</p>Fórmula:C15H19N7O3SPureza:99.41% - 99.87%Cor e Forma:SolidPeso molecular:377.42Seletalisib
CAS:Seletalisib (UCB5857) (UCB5857) is a potent and specific PI3Kδ inhibitor (IC50: 12 nM).Fórmula:C23H14ClF3N6OPureza:99.81%Cor e Forma:SolidPeso molecular:482.85α-Linolenic acid
CAS:<p>α-Linolenic Acid (ALA) is an essential fatty acid. α-Linolenic acid improves memory, inhibits thrombosis, and lowers blood lipids. Cost-effective and quality-assured.</p>Fórmula:C18H30O2Pureza:97.05% - 99.81%Cor e Forma:Physical Description Clear Colorless Liquid (Ntp 1992)Peso molecular:278.43GSK2636771
CAS:<p>GSK2636771, an effective, specific, orally bioavailable, PI3Kβ inhibitor, has been used in cancer, lymphoma, solid neoplasm, recurrent solid neoplasm, and</p>Fórmula:C22H22F3N3O3Pureza:98.58% - ≥95%Cor e Forma:SolidPeso molecular:433.42Vps34-IN-1
CAS:<p>Vps34-IN-1: potent, selective Vps34 inhibitor, 25 nM IC50, spares class I/II PI3Ks.</p>Fórmula:C21H24ClN7OPureza:97.04%Cor e Forma:SolidPeso molecular:425.91SAR405
CAS:<p>SAR-405 inhibits PIK3C3/Vps34 (IC50: 1.2 nM, Kd: 1.5 nM), blocks autophagy, and enhances MTOR inhibitor effects on cancer cells.</p>Fórmula:C19H21ClF3N5O2Pureza:99.42% - 99.79%Cor e Forma:SolidPeso molecular:443.85PIK-90
CAS:<p>PIK-90, a DNA-PK and PI3K inhibitor, suppresses p110α( IC50=11 nM), p110γ(IC50=18 nM) and DNA-PK(IC50=13 nM) .</p>Fórmula:C18H17N5O3Pureza:98.25% - ≥95%Cor e Forma:SolidPeso molecular:351.36A66
CAS:<p>A66 is a specific and effective p110α inhibitor(IC50=32 nM).</p>Fórmula:C17H23N5O2S2Pureza:99.51% - ≥95%Cor e Forma:SolidPeso molecular:393.53Linperlisib
CAS:<p>Linperlisib (PI3Kδ-IN-2) is a potent and selective inhibitor of PI3Kδ</p>Fórmula:C28H37FN6O5SPureza:99.01%Cor e Forma:SolidPeso molecular:588.69Vps34-IN-4
CAS:<p>VPS34 inhibitor 1 (Compound 19, PIK-III analogue) (PIK-III analogue) is a potent and selective inhibitor of VPS34( IC50 : 15 nM)</p>Fórmula:C21H25N7OPureza:98.6%Cor e Forma:SolidPeso molecular:391.47CAY10505
CAS:<p>CAY10505, a form of dehydroxyl of AS-252424, is a PI3Kγ inhibitor (IC50: 33 nM).</p>Fórmula:C14H8FNO3SPureza:99.69% - 99.74%Cor e Forma:SolidPeso molecular:289.28GDC-0326
CAS:<p>GDC-0326 is a potent and selective inhibitor of α-Isoform of Phosphoinositide 3-Kinase (PI3Kalpha inhibitor).</p>Fórmula:C19H22N6O3Pureza:99.35% - >99.99%Cor e Forma:SolidPeso molecular:382.42AZD8186
CAS:<p>AZD8186 is an effective and specific PI3Kβ/δ inhibitor (IC50: 4/12 nM).</p>Fórmula:C24H25F2N3O4Pureza:99.89% - 99.91%Cor e Forma:SolidPeso molecular:457.47Selective PI3Kδ Inhibitor 1
CAS:<p>Selective PI3Kδ Inhibitor 1 is a PI3Kδ Inhibitor( IC50 = 0.9 nM).</p>Fórmula:C23H20FN7OPureza:97.96%Cor e Forma:SolidPeso molecular:429.45Pilaralisib analogue
CAS:<p>Pilaralisib analogue (XL147 analogue) is a selective and reversible class I PI3K inhibitor for PI3Kα/δ/γ.</p>Fórmula:C21H16N6O2S2Pureza:99.3% - 99.72%Cor e Forma:SolidPeso molecular:448.52AZD 6482
CAS:<p>AZD 6482 (KIN-193) is a potent and selective inhibitor of p110β and PI3Kβ with IC50 values of 0.69nM and 10nM.Cost-effective and quality-assured.</p>Fórmula:C22H24N4O4Pureza:99.79% - 99.95%Cor e Forma:SolidPeso molecular:408.45PIK-293
CAS:<p>PIK-293 is a PI3K inhibitor, for PI3Kδ( IC50=0.24 μM), and less potent for PI3Kα/β/ γ.</p>Fórmula:C22H19N7OPureza:99.88%Cor e Forma:SolidPeso molecular:397.43ETP-45658
CAS:<p>ETP-45658 (ETP45658) is a PI 3-kinase inhibitor (IC50 values are 22, 30, 129 and 710 nM for PI 3-Kα, PI 3-Kδ, PI 3-Kβ and PI 3-Kγ respectively).</p>Fórmula:C16H17N5O2Pureza:99.14%Cor e Forma:SolidPeso molecular:311.34Dactolisib
CAS:<p>Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).</p>Fórmula:C30H23N5OPureza:97.64% - 99.85%Cor e Forma:SolidPeso molecular:469.54Pectolinarin
CAS:<p>Pectolinarin is a Cirsium isolate with anti-inflammatory activity.</p>Fórmula:C29H34O15Pureza:98% - 99.79%Cor e Forma:SolidPeso molecular:622.57GNE-317
CAS:<p>GNE-317, a PI3K/mTOR inhibitor, can pass through the blood-brain barrier (BBB).</p>Fórmula:C19H22N6O3SPureza:98.42% - 99.54%Cor e Forma:SolidPeso molecular:414.48Pictilisib
CAS:<p>Pictilisib (GDC-0941) (GDC-0941) is a potent pan inhibitor of class I catalytic subunits of PI3K (IC50s: 3/33/3/75 nM for p110α/β/δ/γ).</p>Fórmula:C23H27N7O3S2Pureza:98.69% - 99.97%Cor e Forma:SolidPeso molecular:513.64Sincalide
CAS:<p>Sincalide (CCK-8) is an injectable drug used to diagnose gallbladder and pancreas disorders; it's a cholecystokinin fragment.</p>Fórmula:C49H62N10O16S3Pureza:98.32%Cor e Forma:SolidPeso molecular:1143.27IC-87114
CAS:<p>IC-87114 is a specific PI3Kδ inhibitor(IC50=0.5 μM).</p>Fórmula:C22H19N7OPureza:99.30% - >99.99%Cor e Forma:SolidPeso molecular:397.43Orobol
CAS:<p>Orobol (3’,4’,5,7-tetrahydroxy-isoflavon) is an inhibitor of tyrosine-specific protein kinase and phosphatidylinositol turnover.</p>Fórmula:C15H10O6Pureza:98% - 98%Cor e Forma:SolidPeso molecular:286.24Musk ketone
CAS:<p>Musk ketone may suppress cancer cell growth, induce apoptosis, and boost glutathione S-transferase, potentially aiding cancer protection.</p>Fórmula:C14H18N2O5Pureza:99.85%Cor e Forma:Yellow Crystals Physical Description Light Yellow Crystalline Solid Insoluble In Water (Ntp 1992)Peso molecular:294.30AS-041164
CAS:<p>AS-041164: Oral PI3Kγ inhibitor, IC50 70 nM; weaker on PI3Kα/β/δ; anti-inflammatory.</p>Fórmula:C11H7NO4SPureza:99.45%Cor e Forma:SolidPeso molecular:249.24PQR530
CAS:<p>PQR530, a potent dual PI3K/mTORC1/2 inhibitor, blocks PKB and pS6 phosphorylation (IC50: 0.07 μM) and has antitumor properties.</p>Fórmula:C18H23F2N7O2Pureza:99.5%Cor e Forma:SolidPeso molecular:407.42YM-201636
CAS:<p>YM201636 (IC50=33 nM), a specific PIKfyve inhibitor, is less effective to p110α and insensitive to Fabl, which is yeast orthologue.</p>Fórmula:C25H21N7O3Pureza:93.28% - 98.3%Cor e Forma:SolidPeso molecular:467.48Polygalasaponin F
CAS:<p>Polygalasaponin F reduces neuroinflammation, blocks TNF-α/NO, and protects neurons by modulating NF-kB and NMDAR pathways.</p>Fórmula:C53H86O23Pureza:98% - 99.83%Cor e Forma:SolidPeso molecular:1091.24
