PI3K
Os inibidores de PI3K são compostos que bloqueiam a atividade das fosfoinositídeo 3-quinases (PI3Ks), uma família de enzimas envolvidas em uma ampla gama de processos celulares, incluindo crescimento, proliferação, sobrevivência e metabolismo. A via PI3K/Akt/mTOR é frequentemente desregulada no câncer, tornando o PI3K um alvo-chave para a terapia do câncer. Os inibidores de PI3K são ferramentas essenciais para estudar a transdução de sinal, a biologia do câncer e o desenvolvimento de terapias direcionadas. Na CymitQuimica, oferecemos uma variedade de inibidores de PI3K para apoiar sua pesquisa em sinalização celular, oncologia e desenvolvimento terapêutico.
Foram encontrados 231 produtos para "PI3K".
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IITZ-01
CAS:IITZ-01 is potent autophagy inhibitor with single-agent anticancer activity ( IC50 of 2.62 μM for PI3Kγ.)Fórmula:C26H23FN8OPureza:99.31%Cor e Forma:SolidPeso molecular:482.51Lupiwighteone
CAS:Lupiwighteone has anti-angiogenesis potential, it also has anticancer and cancer preventive effects on SH-SY5Y cells.Fórmula:C20H18O5Pureza:98.92%Cor e Forma:SolidPeso molecular:338.35Leniolisib
CAS:Leniolisib (CDZ173) (CDZ173) is a potent and selective PI3Kδ inhibitor (IC50: 11 nM).Fórmula:C21H25F3N6O2Pureza:99.88%Cor e Forma:SolidPeso molecular:450.46Arnicolide D
CAS:Arnicolide D is a sesquiterpene lactone.Fórmula:C19H24O5Pureza:96.66% - 99.93%Cor e Forma:White SolidPeso molecular:332.39BGT226
CAS:BGT226 (NVP-BGT226) is a novel dual PI3K / mTOR inhibitor, it acts on PI3K α/β/γ with IC50 of 4 nM / 63 nM / 38 nM, respectively.Fórmula:C28H25F3N6O2Pureza:95.74% - 99.78%Cor e Forma:White SolidPeso molecular:534.53Ref: TM-T6072L
1mg47,00€2mg62,00€5mg92,00€1mL*10mM (DMSO)107,00€10mg147,00€25mg295,00€50mg485,00€100mg737,00€NIH-12848
CAS:NIH-12848 is a putative inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) with an IC50 of 1 μM.Fórmula:C20H14F3N3SPureza:99.87% - 99.9%Cor e Forma:SolidPeso molecular:385.41Ref: TM-T3556
2mg35,00€5mg51,00€1mL*10mM (DMSO)55,00€10mg75,00€25mg133,00€50mg225,00€100mg323,00€200mg447,00€GNE-493
CAS:GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM forFórmula:C17H20N6O2SPureza:98%Cor e Forma:SolidPeso molecular:372.44Rigosertib sodium
CAS:Rigosertib sodium (ON-01910), a non-ATP-competitive inhibitor of PLK1(IC50=9 nM), exhibits 30-fold higher specificity activity over Plk2 and no effect on Plk3.Fórmula:C21H24NNaO8SPureza:98% - 99.37%Cor e Forma:SolidPeso molecular:473.47Heterophyllin B
CAS:Heterophyllin B hinders esophageal cancer cell adhesion/invasion via PI3K/AKT/β-catenin and gene regulation.Fórmula:C40H58N8O8Pureza:98.77% - 99.85%Cor e Forma:White SolidPeso molecular:778.94AMG319
CAS:AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, >47-fold selectivity over other PI3Ks. Phase 2.Fórmula:C21H16FN7Pureza:98.9% - 99.24%Cor e Forma:Crystalline SolidPeso molecular:385.4P7C3-A20
CAS:P7C3-A20 is a derivative of P7C3 that has proneurogenic and neuroprotective activity.Fórmula:C22H19Br2FN2OPureza:96.83% - ≥98%Cor e Forma:White SolidPeso molecular:506.21Voxtalisib
CAS:Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.Fórmula:C13H14N6OPureza:98.21% - 99.69%Cor e Forma:SolidPeso molecular:270.29Ref: TM-T7014
1mg35,00€2mg50,00€5mg74,00€1mL*10mM (DMSO)74,00€10mg117,00€25mg226,00€50mg364,00€100mg532,00€Umbralisib
CAS:Umbralisib (TGR 1202) is a PI3Kδ inhibitor.Fórmula:C31H24F3N5O3Pureza:99.56% - 99.56%Cor e Forma:White SolidPeso molecular:571.55Ref: TM-T4976
1mg46,00€2mg62,00€5mg90,00€1mL*10mM (DMSO)114,00€10mg166,00€25mg324,00€50mg425,00€100mg623,00€AZD-8835
CAS:AZD-8835 is a mixed inhibitor of PI3Kα/δ (IC50: 6.2/5.7 nM), also with selectivity against PI3Kβ/γ (IC50: 431/90 nM).Fórmula:C22H31N9O3Pureza:98.22% - 99.88%Cor e Forma:SolidPeso molecular:469.54AS-604850
CAS:AS-604850: ATP-competitive PI3Kγ inhibitor, IC50 250 nM, 18x > PI3Kα, 80x > PI3Kδ/β.Fórmula:C11H5F2NO4SPureza:99.65%Cor e Forma:SolidPeso molecular:285.22PIK-93
CAS:PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.Fórmula:C14H16ClN3O4S2Pureza:97.72%Cor e Forma:SolidPeso molecular:389.88Ref: TM-T2616
1mg42,00€5mg85,00€1mL*10mM (DMSO)94,00€10mg105,00€25mg200,00€50mg305,00€100mg427,00€200mg613,00€CH5132799
CAS:CH5132799 has been used in trials studying the treatment of Solid Tumors.Fórmula:C15H19N7O3SPureza:99.41% - 99.87%Cor e Forma:SolidPeso molecular:377.42Ref: TM-T2619
1mg60,00€2mg92,00€5mg137,00€10mg215,00€25mg399,00€50mg590,00€100mg838,00€500mg1.693,00€Seletalisib
CAS:Seletalisib (UCB5857) (UCB5857) is a potent and specific PI3Kδ inhibitor (IC50: 12 nM).Fórmula:C23H14ClF3N6OPureza:99.81%Cor e Forma:SolidPeso molecular:482.85Ref: TM-TQ0044
1mg54,00€2mg77,00€5mg114,00€1mL*10mM (DMSO)119,00€10mg178,00€25mg313,00€50mg447,00€100mg625,00€α-Linolenic acid
CAS:α-Linolenic Acid (ALA) is an essential fatty acid. α-Linolenic acid improves memory, inhibits thrombosis, and lowers blood lipids. Cost-effective and quality-assured.Fórmula:C18H30O2Pureza:97.05% - 99.81%Cor e Forma:Transparent LiquidPeso molecular:278.43GSK2636771
CAS:GSK2636771, an effective, specific, orally bioavailable, PI3Kβ inhibitor, has been used in cancer, lymphoma, solid neoplasm, recurrent solid neoplasm, andFórmula:C22H22F3N3O3Pureza:98.58% - ≥95%Cor e Forma:SolidPeso molecular:433.42Ref: TM-T2073
1mg40,00€2mg54,00€5mg84,00€1mL*10mM (DMSO)84,00€10mg142,00€25mg240,00€50mg340,00€100mg518,00€Vps34-IN-1
CAS:Vps34-IN-1: potent, selective Vps34 inhibitor, 25 nM IC50, spares class I/II PI3Ks.Fórmula:C21H24ClN7OPureza:97.04%Cor e Forma:SolidPeso molecular:425.91Ref: TM-T7015
1mg43,00€2mg56,00€5mg88,00€1mL*10mM (DMSO)96,00€10mg124,00€25mg207,00€50mg333,00€100mg477,00€SAR405
CAS:SAR-405 inhibits PIK3C3/Vps34 (IC50: 1.2 nM, Kd: 1.5 nM), blocks autophagy, and enhances MTOR inhibitor effects on cancer cells.Fórmula:C19H21ClF3N5O2Pureza:99.42% - 99.99%Cor e Forma:SolidPeso molecular:443.85PIK-90
CAS:PIK-90, a DNA-PK and PI3K inhibitor, suppresses p110α( IC50=11 nM), p110γ(IC50=18 nM) and DNA-PK(IC50=13 nM) .Fórmula:C18H17N5O3Pureza:98.25% - ≥95%Cor e Forma:SolidPeso molecular:351.36A66
CAS:A66 is a specific and effective p110α inhibitor(IC50=32 nM).Fórmula:C17H23N5O2S2Pureza:99.51% - ≥95%Cor e Forma:SolidPeso molecular:393.53Ref: TM-T2418
2mg34,00€5mg52,00€1mL*10mM (DMSO)52,00€10mg79,00€25mg137,00€50mg234,00€100mg344,00€200mg485,00€Linperlisib
CAS:Linperlisib (PI3Kδ-IN-2) is a potent and selective inhibitor of PI3KδFórmula:C28H37FN6O5SPureza:99.01%Cor e Forma:SolidPeso molecular:588.69Ref: TM-T6330
1mg34,00€2mg46,00€5mg66,00€1mL*10mM (DMSO)87,00€10mg90,00€25mg192,00€50mg295,00€100mg462,00€Vps34-IN-4
CAS:VPS34 inhibitor 1 (Compound 19, PIK-III analogue) (PIK-III analogue) is a potent and selective inhibitor of VPS34( IC50 : 15 nM)Fórmula:C21H25N7OPureza:98.6%Cor e Forma:SolidPeso molecular:391.47Ref: TM-T7944
1mg63,00€5mg137,00€1mL*10mM (DMSO)150,00€10mg215,00€25mg378,00€50mg537,00€100mg713,00€200mg982,00€CAY10505
CAS:CAY10505, a form of dehydroxyl of AS-252424, is a PI3Kγ inhibitor (IC50: 33 nM).Fórmula:C14H8FNO3SPureza:99.69% - 99.74%Cor e Forma:SolidPeso molecular:289.28Ref: TM-T6433
10mg34,00€1mL*10mM (DMSO)38,00€25mg52,00€50mg96,00€100mg144,00€200mg205,00€500mg350,00€GDC-0326
CAS:GDC-0326 is a potent and selective inhibitor of α-Isoform of Phosphoinositide 3-Kinase (PI3Kalpha inhibitor).Fórmula:C19H22N6O3Pureza:99.35% - >99.99%Cor e Forma:SolidPeso molecular:382.42Ref: TM-T3985
1mg34,00€2mg50,00€1mL*10mM (DMSO)88,00€5mg90,00€10mg146,00€25mg241,00€50mg385,00€100mg560,00€AZD8186
CAS:AZD8186 is an effective and specific PI3Kβ/δ inhibitor (IC50: 4/12 nM).Fórmula:C24H25F2N3O4Pureza:99.89% - 99.91%Cor e Forma:SolidPeso molecular:457.47Ref: TM-T6773
2mg43,00€5mg63,00€1mL*10mM (DMSO)69,00€10mg94,00€25mg165,00€50mg289,00€100mg477,00€500mg1.063,00€Selective PI3Kδ Inhibitor 1
CAS:Selective PI3Kδ Inhibitor 1 is a PI3Kδ Inhibitor( IC50 = 0.9 nM).Fórmula:C23H20FN7OPureza:97.96%Cor e Forma:SolidPeso molecular:429.45Pilaralisib analogue
CAS:Pilaralisib analogue (XL147 analogue) is a selective and reversible class I PI3K inhibitor for PI3Kα/δ/γ.Fórmula:C21H16N6O2S2Pureza:99.3% - 99.72%Cor e Forma:SolidPeso molecular:448.52Ref: TM-T2377
2mg35,00€5mg52,00€1mL*10mM (DMSO)58,00€10mg84,00€25mg132,00€50mg205,00€100mg354,00€200mg460,00€AZD 6482
CAS:AZD 6482 (KIN-193) is a potent and selective inhibitor of p110β and PI3Kβ with IC50 values of 0.69nM and 10nM.Cost-effective and quality-assured.Fórmula:C22H24N4O4Pureza:99.87% - 99.95%Cor e Forma:SolidPeso molecular:408.45PIK-293
CAS:PIK-293 is a PI3K inhibitor, for PI3Kδ( IC50=0.24 μM), and less potent for PI3Kα/β/ γ.Fórmula:C22H19N7OPureza:99.65%Cor e Forma:SolidPeso molecular:397.43Ref: TM-T3348
1mg46,00€2mg62,00€5mg90,00€1mL*10mM (DMSO)100,00€10mg144,00€25mg260,00€50mg394,00€100mg572,00€ETP-45658
CAS:ETP-45658 (ETP45658) is a PI 3-kinase inhibitor (IC50 values are 22, 30, 129 and 710 nM for PI 3-Kα, PI 3-Kδ, PI 3-Kβ and PI 3-Kγ respectively).Fórmula:C16H17N5O2Pureza:99.14%Cor e Forma:White SolidPeso molecular:311.34Ref: TM-T25399
1mg50,00€5mg105,00€1mL*10mM (DMSO)117,00€10mg172,00€25mg299,00€50mg485,00€100mg708,00€Dactolisib
CAS:Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).Fórmula:C30H23N5OPureza:97.64% - 99.85%Cor e Forma:SolidPeso molecular:469.54Pectolinarin
CAS:Pectolinarin is a Cirsium isolate with anti-inflammatory activity.Fórmula:C29H34O15Pureza:98% - 99.79%Cor e Forma:SolidPeso molecular:622.57MTX-211
CAS:MTX-211, an inhibitor of EGFR and PI3K, is used for the therapy of cancer and other diseases.Fórmula:C20H14Cl2FN5O2SPureza:97.81% - >99.99%Cor e Forma:SolidPeso molecular:478.33Ref: TM-T4296
1mg60,00€2mg89,00€5mg167,00€1mL*10mM (DMSO)170,00€10mg260,00€25mg439,00€50mg605,00€100mg802,00€200mg1.099,00€Pictilisib
CAS:Pictilisib (GDC-0941) (GDC-0941) is a potent pan inhibitor of class I catalytic subunits of PI3K (IC50s: 3/33/3/75 nM for p110α/β/δ/γ).Fórmula:C23H27N7O3S2Pureza:98.69% - 99.97%Cor e Forma:White SolidPeso molecular:513.64Sincalide
CAS:Sincalide (CCK-8) is an injectable drug used to diagnose gallbladder and pancreas disorders; it's a cholecystokinin fragment.Fórmula:C49H62N10O16S3Pureza:98.32%Cor e Forma:White ViscousPeso molecular:1143.27IC-87114
CAS:IC-87114 is a specific PI3Kδ inhibitor(IC50=0.5 μM).Fórmula:C22H19N7OPureza:99.30% - >99.99%Cor e Forma:SolidPeso molecular:397.43Orobol
CAS:Orobol (3’,4’,5,7-tetrahydroxy-isoflavon) is an inhibitor of tyrosine-specific protein kinase and phosphatidylinositol turnover.Fórmula:C15H10O6Pureza:98% - 98%Cor e Forma:SolidPeso molecular:286.24Musk ketone
CAS:Musk ketone may suppress cancer cell growth, induce apoptosis, and boost glutathione S-transferase, potentially aiding cancer protection.Fórmula:C14H18N2O5Pureza:99.85%Cor e Forma:SolidPeso molecular:294.30AS-041164
CAS:AS-041164: Oral PI3Kγ inhibitor, IC50 70 nM; weaker on PI3Kα/β/δ; anti-inflammatory.Fórmula:C11H7NO4SPureza:99.45%Cor e Forma:SolidPeso molecular:249.24PQR530
CAS:PQR530, a potent dual PI3K/mTORC1/2 inhibitor, blocks PKB and pS6 phosphorylation (IC50: 0.07 μM) and has antitumor properties.Fórmula:C18H23F2N7O2Pureza:99.5%Cor e Forma:White SolidPeso molecular:407.42YM-201636
CAS:YM201636 (IC50=33 nM), a specific PIKfyve inhibitor, is less effective to p110α and insensitive to Fabl, which is yeast orthologue.Fórmula:C25H21N7O3Pureza:93.28% - 98.3%Cor e Forma:SolidPeso molecular:467.48Ref: TM-T6110
1mg46,00€2mg60,00€5mg90,00€1mL*10mM (DMSO)92,00€10mg170,00€25mg340,00€50mg532,00€100mg760,00€500mg1.558,00€Polygalasaponin F
CAS:Polygalasaponin F reduces neuroinflammation, blocks TNF-α/NO, and protects neurons by modulating NF-kB and NMDAR pathways.Fórmula:C53H86O23Pureza:98% - 99.83%Cor e Forma:White SolidPeso molecular:1091.24Isorhamnetin
CAS:Isorhamnetin (3-methylquercetin) is the methylated metabolite of quercetin.Fórmula:C16H12O7Pureza:99.20% - >99.99%Cor e Forma:Yellow SolidPeso molecular:316.26Ref: TM-T2836
1mg38,00€2mg49,00€5mg78,00€1mL*10mM (DMSO)81,00€10mg113,00€25mg222,00€50mg371,00€100mg532,00€Pilaralisib
CAS:Pilaralisib (XL-147) is an orally available small molecule that selectively inhibits the activity of phosphoinositide-3 kinase (PI3K).Fórmula:C25H25ClN6O4SPureza:98.51% - 99.61%Cor e Forma:Yellow SolidPeso molecular:541.02SF2523
CAS:SF2523 is a highly selective and potent inhibitor.Fórmula:C19H17NO5SPureza:99.1% - 99.51%Cor e Forma:Orange SolidPeso molecular:371.41Ref: TM-T3986
1mg34,00€5mg74,00€1mL*10mM (DMSO)82,00€10mg113,00€25mg260,00€50mg409,00€100mg605,00€500mg1.288,00€LY-294002 hydrochloride
CAS:LY-294002 HCl (NSC 697286) is a stable PI3K inhibitor (IC50: 0.5-0.97 µM) and prevents autophagosome formation.Fórmula:C19H17NO3·HClPureza:99.95% - 99.98%Cor e Forma:Purple LiquidPeso molecular:343.81
