ATM/ATR
Os inibidores de ATM (Ataxia Telangiectasia Mutated) e ATR (ATM and Rad3-related) têm como alvo quinases chave envolvidas na resposta ao dano ao DNA (DDR) que são ativadas em resposta a quebras de fita dupla de DNA e estresse de replicação. Esses inibidores perturbam a capacidade dessas quinases de detectar e reparar danos no DNA, o que pode levar a um aumento da instabilidade genômica e morte celular, particularmente em células cancerígenas que dependem de mecanismos robustos de reparo do DNA para sobreviver. Os inibidores de ATM/ATR são ferramentas cruciais na pesquisa e terapia do câncer, especialmente em combinação com agentes que causam danos ao DNA. Na CymitQuimica, oferecemos uma ampla gama de inibidores de ATM/ATR de alta qualidade para apoiar sua pesquisa em resposta ao dano ao DNA, biologia do câncer e desenvolvimento terapêutico.
Foram encontrados 71 produtos de "ATM/ATR"
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FEN1-IN-1
CAS:<p>FEN1-IN-1 (LNT-1), a FEN1 active site inhibitor, partly works by coordinating Mg2+ ions.</p>Fórmula:C15H12N2O5SPureza:99.65% - 99.80%Cor e Forma:SolidPeso molecular:332.33Garcinone C
CAS:<p>Garcinone C, a xanthone from Garcinia oblongifolia, is anti-inflammatory, promotes healing, and may fight some cancers.</p>Fórmula:C23H26O7Pureza:99.13% - 99.92%Cor e Forma:SolidPeso molecular:414.45Elimusertib hydrochloride(1876467-74-1 free base)
<p>Elimusertib hydrochloride(1876467-74-1 free base) (BAY-1895344 hydrochloride) is a effective, orally available and selective ATR inhibitor with anti-tumor</p>Fórmula:C20H22ClN7OPureza:98.8% - 99.03%Cor e Forma:SolidPeso molecular:411.89GJ071 oxalate
CAS:<p>GJ071 oxalate is a Nonsense suppressor that induces readthrough by inserting amino acids at premature termination codons.</p>Fórmula:C20H29N3O7SPureza:99.97%Cor e Forma:SolidPeso molecular:455.53Antitumor agent-28
CAS:<p>Antitumor agent-28 inhibits ATM kinase, blocking ATM disease progression and showing anti-cancer effects.</p>Fórmula:C25H32N6O4SCor e Forma:SolidPeso molecular:512.63Abd110
CAS:<p>Abd110 (compound 42i), a Lenalidomide-based PROTAC ATR kinase degrader, selectively reduces levels of ATR and phospho-ATR while not impacting the related kinases ATM and DNA-PKcs [1].</p>Fórmula:C41H42N8O7SCor e Forma:SolidPeso molecular:790.89ATM Inhibitor-8
<p>ATM Inhibitor-8 (Compound 10r) is a potent, selective, and orally active inhibitor of ATM, exhibiting anti-tumor activity [1], characterized by an IC50 value of</p>Fórmula:C26H34N6O2Pureza:98%Cor e Forma:SolidPeso molecular:462.59ATM Inhibitor-9
<p>ATM Inhibitor-9 (Compd 7a) is a potent inhibitor of ATM kinase, exhibiting an IC50 value of 5 nM, and is utilized in cancer research [1].</p>Fórmula:C25H32N6O2Pureza:98%Cor e Forma:SolidPeso molecular:448.56Berzosertib
CAS:<p>Berzosertib (VE-822) is an ATR inhibitor (Ki<0.2 nM) that also inhibits ATM (Ki=34 nM). Berzosertib has antitumor activity. Cost-effective and quality-assured.</p>Fórmula:C24H25N5O3SPureza:97.34% - >99.99%Cor e Forma:SolidPeso molecular:463.55Hexapeptide-11
CAS:<p>Hexapeptide-11 is a novel proteostasis network modulator in human diploid fibroblasts.</p>Fórmula:C36H48N6O7Pureza:98%Cor e Forma:SolidPeso molecular:676.8CA-M11
CA-M11 (compound CA-M11) is capable of entering the liver's bile salt transport system to release Mirin.Fórmula:C34H46N2O6SCor e Forma:SolidPeso molecular:610.80Ceralasertib
CAS:<p>Ceralasertib (AZD6738) is an ATR kinase inhibitor (IC50=1 nM) with selective and oral activity. Ceralasertib has antitumor activity. Cost effective and quality assured.</p>Fórmula:C20H24N6O2SPureza:98% - 99.99%Cor e Forma:SolidPeso molecular:412.51AZD0156
CAS:<p>AZD0156 , an effective and specific inhibitors of ATM kinase, is potential antineoplastic activities and chemo-/radio-sensitizing.</p>Fórmula:C26H31N5O3Pureza:99.13% - 99.87%Cor e Forma:SolidPeso molecular:461.56PIK-93
CAS:PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.Fórmula:C14H16ClN3O4S2Pureza:97.72%Cor e Forma:SolidPeso molecular:389.88KU60019
CAS:<p>Ku-60019 is a potent, reversible inhibitor of ATM kinase (IC50: 6.3 nM). It is much less effective or without effect against a panel of 229 other kinases.</p>Fórmula:C30H33N3O5SPureza:95.9% - 99.36%Cor e Forma:SolidPeso molecular:547.67GJ103 sodium salt
CAS:<p>GJ103 sodium salt, a GJ072 analog, lowers surface tension, viscosity, and pH in aqueous solutions, aiding molecular movement.</p>Fórmula:C16H13N4NaO3SPureza:99.70% - 99.91%Cor e Forma:SolidPeso molecular:364.36NU6027
CAS:<p>NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-</p>Fórmula:C11H17N5O2Pureza:98.36%Cor e Forma:SolidPeso molecular:251.29KU-55933
CAS:<p>KU-55933 (ATM Kinase Inhibitor) is an ATM inhibitor that is selective and ATP-competitive. KU-55933 has antitumor effects. Cost-effective and quality-assured.</p>Fórmula:C21H17NO3S2Pureza:97.21% - >99.99%Cor e Forma:SolidPeso molecular:395.49AZD-7648
CAS:<p>AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.</p>Fórmula:C18H20N8O2Pureza:99.03% - 99.85%Cor e Forma:SolidPeso molecular:380.4AZ20
CAS:<p>AZ20 is an effective and specific inhibitor of ATR kinase (IC50: 5 nM, in a cell-free assay), 8-fold selectivity over mTOR.</p>Fórmula:C21H24N4O3SPureza:98% - 99.69%Cor e Forma:SolidPeso molecular:412.51
