CAS 1000025-07-9

N-[[5-(3-Chlorophenyl)-3-hydroxy-2-pyridinyl]carbonyl]glycine

Description:

N-[[5-(3-Chlorophenyl)-3-hydroxy-2-pyridinyl]carbonyl]glycine, identified by its CAS number 1000025-07-9, is a chemical compound characterized by its complex structure, which includes a pyridine ring, a chlorophenyl group, and a glycine moiety. This compound typically exhibits properties associated with both aromatic and heterocyclic compounds, contributing to its potential biological activity. The presence of the hydroxyl group on the pyridine ring may enhance its solubility in polar solvents and influence its interaction with biological targets. Additionally, the chlorophenyl substituent can impart specific electronic properties, potentially affecting the compound's reactivity and binding affinity in biochemical contexts. Such characteristics suggest that this compound may have applications in medicinal chemistry, particularly in the development of pharmaceuticals targeting specific pathways or receptors. However, detailed studies on its pharmacokinetics, toxicity, and efficacy would be necessary to fully understand its potential uses and safety profile.

Formula: C₁₄H₁₁ClN₂O₄

InChI: InChI=1S/C14H11ClN2O4/c15-10-3-1-2-8(4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)

InChI key: InChIKey=JGRXMPYUTJLTKT-UHFFFAOYSA-N

SMILES: OC1=CC(=CN=C1C(NCC(O)=O)=O)C2=CC(Cl)=CC=C2

Synonyms:

• AKB 6548
• Glycine, N-[[5-(3-chlorophenyl)-3-hydroxy-2-pyridinyl]carbonyl]-
• PG 1016548
• Vadadustat
• N-[[5-(3-Chlorophenyl)-3-hydroxy-2-pyridinyl]carbonyl]glycine

Vadadustat

CAS: 1000025-07-9

Vadadustat is a novel, titratable, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor in development for the treatment of anemia.

Formula: C₁₄H₁₁ClN₂O₄

Purity: 99.02% - 99.80%

Color and Shape: Solid

Molecular weight: 306.7

Ref: TM-T4651

Vadadustat (AKB-6548)

CAS: 1000025-07-9

Formula: C₁₄H₁₁ClN₂O₄

Color and Shape: White To Off-White Solid

Molecular weight: 306.71

Ref: 4Z-V-059001

Vadadustat

CAS: 1000025-07-9

Vadadustat

Purity: ≥98%

Molecular weight: 306.7g/mol

Ref: 54-BUP01360

Vadadustat

CAS: 1000025-07-9

Applications Vadadustat is a novel HIF (Hypoxia-inducible factor) stabilizer. It provides an effective anemia treatment in nondialysis-dependent chronic kidney disease.
References Pergola, P., et al.: Kidney Int., 90, 1115 (2016);

Formula: C₁₄H₁₁ClN₂O₄

Color and Shape: Beige

Molecular weight: 306.70

Ref: TR-V849530

Vadadustat

Controlled Product

CAS: 1000025-07-9

Vadadustat is an orally administered hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI), which is a synthetic small molecule. Its mode of action involves the inhibition of prolyl hydroxylase enzymes, which normally facilitate the degradation of hypoxia-inducible factor (HIF) under normal oxygen conditions. By stabilizing HIF, vadadustat effectively mimics a hypoxic response, leading to increased endogenous production of erythropoietin (EPO), a key hormone in red blood cell production.

Formula: C₁₄H₁₁ClN₂O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 306.7 g/mol

Ref: 3D-FV168206

VADADUSTAT

CAS: 1000025-07-9

Purity: 97%

Molecular weight: 306.7000122

Ref: 10-F826348

Vadadustat-13C2,D2,15N

Controlled Product

CAS: 1000025-07-9

Formula: C₂C₁₂D₂H₉Cl₁₅NNO₄

Color and Shape: Neat

Molecular weight: 311.692

Ref: TR-V849532

Glycine, N-[[5-(3-chlorophenyl)-3-hydroxy-2-pyridinyl]carbonyl]-

CAS: 1000025-07-9

Formula: C₁₄H₁₁ClN₂O₄

Purity: 97%

Color and Shape: Solid

Molecular weight: 306.7011

Ref: IN-DA00008T