CAS 1134-47-0: Baclofen
Description:Baclofen is a pharmaceutical compound primarily used as a muscle relaxant and antispastic agent. It is classified as a gamma-aminobutyric acid (GABA) derivative, functioning as a GABA_B receptor agonist, which helps to inhibit excessive neuronal activity. This mechanism makes it effective in treating conditions such as multiple sclerosis and spinal cord injuries, where muscle spasticity is prevalent. Baclofen is typically administered orally or via intrathecal delivery for severe cases. The substance is characterized by its white to off-white crystalline powder form, with a relatively low solubility in water, which can influence its bioavailability. Its molecular formula is C10H12ClNO2, and it has a moderate molecular weight. Baclofen's pharmacokinetics involve absorption in the gastrointestinal tract, with peak plasma concentrations occurring within a few hours post-administration. Side effects may include drowsiness, dizziness, and potential withdrawal symptoms if discontinued abruptly. Overall, Baclofen is a vital medication in managing spasticity, with a well-established profile in clinical use.
Formula:C10H12ClNO2
InChI:InChI=1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)
InChI key:InChIKey=KPYSYYIEGFHWSV-UHFFFAOYSA-N
SMILES:O=C(O)CC(C1=CC=C(Cl)C=C1)CN
- Synonyms:
- (+/-)-beta(Aminomethyl)-4-chlorobenzenepropanoic acid, Lioresal
- (3S)-4-amino-3-(4-chlorophenyl)butanoic acid
- 4-Amino-3-(4-Chlorophenyl)Butanoic Acid
- 4-Amino-3-(4-Chlorophenyl)Butyric Acid
- 4-Amino-3-(p-chlorophenyl)butyric acid
- <span class="text-smallcaps">D</smallcap><smallcap>L</span>-4-Amino-3-p-chlorophenylbutanoic acid
- <span class="text-smallcaps">D</smallcap><smallcap>L</span>-Baclofen
- Atrofen
- Ba 34647
- Baclofene
- See more synonyms
- Baclofeno
- Baclon
- Benzenepropanoic acid, β-(aminomethyl)-4-chloro-
- Beta-(4-Chlorophenyl)-Gamma-Aminobutyric Acid
- Beta-(4-Chlorophenyl)Gaba
- Beta-(Aminomethyl)-4-Chlorobenzenepropanoic Acid
- Beta-(Aminomethyl)-P-Chlorohydrocinnamic Acid
- C 34647Ba
- CIBA Ba 34647
- Ciba 34,647-Ba
- DL-4-Amino-3-p-chlorophenylbutanoic acid
- Gamma-Amino-Beta-(P-Chlorophenyl)Butyric Acid
- Hydrocinnamic acid, β-(aminomethyl)-p-chloro-
- Lioresal
- dl-Baclofen
- β-(4-Chlorophenyl)-γ-aminobutyric acid
- β-(Aminomethyl)-4-chlorobenzenepropanoic acid
- β-(Aminomethyl)-p-chlorohydrocinnamic acid
- β-(p-Chlorophenyl)-γ-aminobutyric acid
- β-p-Chlorophenyl-GABA
