Description:TGR5, also known as G-protein coupled receptor 19 (GPCR19), is a receptor that plays a significant role in various physiological processes, particularly in metabolism and energy homeostasis. It is primarily activated by bile acids, which are important for digestion and absorption of fats. TGR5 is expressed in various tissues, including the gastrointestinal tract, immune cells, and brown adipose tissue, where it influences metabolic pathways. Activation of TGR5 has been associated with increased energy expenditure, improved insulin sensitivity, and modulation of inflammation. This receptor is of interest in the context of metabolic disorders, such as obesity and type 2 diabetes, as well as in liver diseases. Research into TGR5 is ongoing, with potential therapeutic applications being explored, particularly in the development of drugs targeting metabolic diseases. Its unique role in mediating the effects of bile acids makes it a valuable target for understanding and potentially treating metabolic dysregulation.
We use cookies to enhance your visit. We do not include advertising.
Please see our Cookies Policy for more details or adjust your preferences in "Settings".
This is the advanced settings system for our own and third-party cookies. Here you can modify parameters that will directly affect your browsing experience on this website. If you wish you may check the list of Cookie types.
Please note that disabling cookies can cause failures in the normal operation of the web.
