CAS 122111-03-9

Gemcitabine Hydrochloride

Description:

Gemcitabine Hydrochloride is a nucleoside analog and an antineoplastic agent primarily used in cancer therapy. It is a white to off-white crystalline powder that is soluble in water, making it suitable for intravenous administration. The compound functions by inhibiting DNA synthesis, thereby interfering with the proliferation of cancer cells. Its mechanism of action involves incorporation into the DNA strand, leading to chain termination and apoptosis of the malignant cells. Gemcitabine is particularly effective against various solid tumors, including pancreatic, lung, and bladder cancers. The substance is typically administered in a clinical setting under strict medical supervision due to potential side effects, which may include myelosuppression, nausea, and fatigue. Additionally, its pharmacokinetics are characterized by rapid distribution and elimination, with a half-life that varies based on individual patient factors. As a chemotherapeutic agent, Gemcitabine Hydrochloride is often part of combination therapy regimens to enhance efficacy and overcome resistance in cancer treatment.

Formula: C₉H₁₂ClF₂N₃O₄

InChI: InChI=1/C9H11F2N3O4.ClH/c10-9(11)6(16)4(3-15)18-7(9)14-2-1-5(12)13-8(14)17;/h1-2,4,6-7,15-16H,3H2,(H2,12,13,17);1H

InChI key: InChIKey=OKKDEIYWILRZIA-OSZBKLCCSA-N

SMILES: FC1(F)[C@@H](O[C@H](CO)[C@H]1O)N2C(=O)N=C(N)C=C2.Cl

Synonyms:

• 2',2'-Difluoro-2'-deoxycytidine
• 2',2'-Difluoro-2'-deoxycytidine hydrochloride
• 2,2-Difluoro-2-deoxycytidine DDFC
• 2′-Deoxy-2′,2′-difluorocytidine monohydrochloride
• 4-Amino-1-[3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1H-pyrimidin-2-one hydrochloride
• 4-amino-1-(2-deoxy-2,2-difluoropentofuranosyl)pyrimidin-2(1H)-one
• 4-amino-1-(2-deoxy-2,2-difluoropentofuranosyl)pyrimidin-2(1H)-one hydrochloride (1:1)
• Cytidine, 2′-deoxy-2′,2′-difluoro-, hydrochloride (1:1)
• Cytidine, 2′-deoxy-2′,2′-difluoro-, monohydrochloride
• Gemcitabine HCl
• Gemcitabine hydrochlorid
• Gemcitera
• Gemoral
• Gemsar
• Gemzar
• LY 188011 hydrochloride
• Gemcitabine hydrochloride
• 2’-deoxy-2’,2’-difluorocytidinemonohydrochloride
• GEMCITABIN HYDROCHLORIDE
• GemcitabineHydrochloride&Int.
• DFDCYD
• 2’,2’-difluorodeoxycytidinemonohydrochloride
• GEMCITABINE HYDRECHLORIDE
• DFDC
• DDFC
• 2Deoxy-22difluorocytidine Hydrochloride, dFdC, dFdCyd,
• 2’-deoxy-2’,2’-difluoro-cytidinmonohydrochloride
• 2'-DEOXY-2',2'-DIFLUOROCYTIDINE HYDROCHLORIDE
• 2'-DEOXY-2',2'-DIFLUOROCYTIDINE
• ly188011

Gemcitabine

CAS: 122111-03-9, 95058-81-4

Formula: C₉H₁₁F₂N₃O₄

Purity: >98.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 263.20

Ref: 3B-G0544

Gemcitabine Hydrochloride

CAS: 122111-03-9, 95058-81-4

Formula: C₉H₁₁F₂N₃O₄·HCl

Purity: >98.0%(HPLC)(N)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 299.66

Ref: 3B-G0367

Gemcitabine Hydrochloride

CAS: 122111-03-9

Color and Shape: Neat

Ref: 61-FOR1257.00

GEMCITABINE HYDROCHLORIDE CRS

CAS: 122111-03-9

GEMCITABINE HYDROCHLORIDE CRS

Formula: C₉H₁₂ClF₂N₃O₄

Color and Shape: Added

Molecular weight: 299.6591

Ref: 41-Y0000675

Gemcitabine Hydrochloride

CAS: 122111-03-9

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₉H₁₁F₂N₃O₄·HCl

Color and Shape: White Off-White Powder

Molecular weight: 263.07176

Ref: 45-1288463

Gemcitabine Hydrochloride

CAS: 122111-03-9

Formula: C₉H₁₂ClF₂N₃O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 299.6591

Ref: IN-DA003QQQ

Gemcitabine hydrochloride

CAS: 122111-03-9

Gemcitabine hydrochloride

Purity: ≥98%

Molecular weight: 299.66g/mol

Ref: 54-BUP17839

Gemcitabine-13C-15N2 HCl

CAS: 122111-03-9

Formula: C₈₁₃CH₁₁F₂N₁₅N₂O₄·HCl

Color and Shape: White To Off-White Solid

Molecular weight: 266.18 36.46

Ref: 4Z-G-263

Gemcitabine hydrochloride

CAS: 122111-03-9

Formula: C₉H₁₁F₂N₃O₄·HCl

Purity: (HPLC) ≥ 97.5%

Color and Shape: White to off-white powder

Molecular weight: 299.66

Ref: 7W-GP8917

Gemcitabine Hydrochloride

CAS: 122111-03-9

Color and Shape: Neat

Ref: 86-MM1257.00

Gemcitabine Hydrochloride Salt

CAS: 122111-03-9

Gemcitabine Hydrochloride Salt

Formula: C₉H₁₁F₂N₃O₄·ClH

Purity: 98%

Color and Shape: white crystalline solid

Molecular weight: 299.66g/mol

Ref: 54-BIFK0024

Gemcitabine hydrochloride

CAS: 122111-03-9

Gemcitabine hydrochloride (LY 188011 hydrochloride) is a synthetic cytosine nucleoside derivative and an inhibitor of DNA synthesis.

Formula: C₉H₁₁F₂N₃O₄·HCl

Purity: 99.28% - 99.98%

Color and Shape: White Crystalline Granular Odorless

Molecular weight: 299.66

Ref: TM-T6069

Gemcitabine Hydrochloride

CAS: 122111-03-9

Applications An antineoplastic.
References Hertel, L.W., et al.: Cancer Res., 50, 4417 (1990), Abbruzzese, J.L., et al.: J. Clin. Oncol., 9, 491 (1991), Ruiz, V.W.T., et al.: Biochem. Pharmacol., 46, 762 (1993),

Formula: C₉H₁₁F₂N₃O₄·ClH

Color and Shape: Neat

Molecular weight: 299.66

Ref: TR-G305000

Gemcitabine HCl

CAS: 122111-03-9

Anticancer nucleoside; DNA synthesis interference

Formula: C₉H₁₁F₂N₃O₄·HCl

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 299.66 g/mol

Ref: 3D-ND09343

Gemcitabine hydrochloride - Bio-X ™

CAS: 122111-03-9

Gemcitabine is as a synthetic pyrimidine nucleoside prodrug. The hydrogen atoms on the 2' carbon of deoxycytidine are replaced by fluorine atoms. Gemcitabine works by being incorporated into the DNA of cancer cells during replication and inhibiting DNA synthesis. First gemcitabine is converted into its active form, gemcitabine triphosphate, by cellular enzymes including deoxycytidine kinase (DCK), after it is taken up by cancer cells. The gemcitabine triphosphate interferes with the normal functioning of the enzymes involved in replicating DNA, leading to the termination of DNA synthesis and ultimately, cell death. Gemcitabine is used as a chemotherapy drug used to treat various types of cancer, including pancreatic, lung, breast, and ovarian cancer.

Formula: C₉H₁₁F₂N₃O₄•HCl

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 299.66 g/mol

Ref: 3D-BG164501

Gemcitabine hydrochloride

CAS: 122111-03-9

Formula: C₉H₁₂ClF₂N₃O₄

Purity: 98%

Color and Shape: Solid, Powder or Crystalline Powder or Solid

Molecular weight: 299.66

Ref: 10-F079926