CAS 122111-03-9: Gemcitabine Hydrochloride
Description:Gemcitabine Hydrochloride is a nucleoside analog and an antineoplastic agent primarily used in cancer therapy. It is a white to off-white crystalline powder that is soluble in water, making it suitable for intravenous administration. The compound functions by inhibiting DNA synthesis, thereby interfering with the proliferation of cancer cells. Its mechanism of action involves incorporation into the DNA strand, leading to chain termination and apoptosis of the malignant cells. Gemcitabine is particularly effective against various solid tumors, including pancreatic, lung, and bladder cancers. The substance is typically administered in a clinical setting under strict medical supervision due to potential side effects, which may include myelosuppression, nausea, and fatigue. Additionally, its pharmacokinetics are characterized by rapid distribution and elimination, with a half-life that varies based on individual patient factors. As a chemotherapeutic agent, Gemcitabine Hydrochloride is often part of combination therapy regimens to enhance efficacy and overcome resistance in cancer treatment.
Formula:C9H11F2N3O4·ClH
InChI:InChI=1S/C9H11F2N3O4.ClH/c10-9(11)6(16)4(3-15)18-7(9)14-2-1-5(12)13-8(14)17;/h1-2,4,6-7,15-16H,3H2,(H2,12,13,17);1H/t4-,6-,7-;/m1./s1
InChI key:InChIKey=OKKDEIYWILRZIA-OSZBKLCCSA-N
SMILES:Cl.O=C1N=C(N)C=CN1C2OC(CO)C(O)C2(F)F
- Synonyms:
- 2',2'-Difluoro-2'-deoxycytidine
- 2',2'-Difluoro-2'-deoxycytidine hydrochloride
- 2,2-Difluoro-2-deoxycytidine DDFC
- 2′-Deoxy-2′,2′-difluorocytidine monohydrochloride
- 4-Amino-1-[3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1H-pyrimidin-2-one hydrochloride
- 4-amino-1-(2-deoxy-2,2-difluoropentofuranosyl)pyrimidin-2(1H)-one
- 4-amino-1-(2-deoxy-2,2-difluoropentofuranosyl)pyrimidin-2(1H)-one hydrochloride (1:1)
- Cytidine, 2′-deoxy-2′,2′-difluoro-, hydrochloride (1:1)
- Cytidine, 2′-deoxy-2′,2′-difluoro-, monohydrochloride
- Gemcitabine HCl
- See more synonyms
- Gemcitabine hydrochlorid
- Gemcitera
- Gemoral
- Gemsar
- Gemzar
- LY 188011 hydrochloride
- Gemcitabine hydrochloride
