CAS 129-46-4

Suramin sodium

Description:

Suramin sodium is a complex organic compound primarily known for its use as an antiparasitic agent, particularly in the treatment of African sleeping sickness and certain other parasitic infections. It is a polysulfonated naphthylurea derivative, characterized by its large molecular structure and multiple sulfonate groups, which contribute to its solubility in water. Suramin functions by inhibiting various enzymes and disrupting metabolic processes in parasites, making it effective against Trypanosoma brucei, the causative agent of sleeping sickness. The compound is typically administered intravenously due to its poor oral bioavailability. Suramin sodium is also noted for its potential use in research, particularly in studies related to cancer and viral infections, as it can modulate immune responses. However, it is associated with a range of side effects, including allergic reactions and nephrotoxicity, necessitating careful monitoring during treatment. Overall, Suramin sodium is a significant therapeutic agent with a complex profile of biological activity and safety considerations.

Formula: C₅₁H₃₄N₆Na₆O₂₃S₆

InChI: InChI=1/C51H40N6O23S6.6Na/c1-25-9-11-29(49(60)54-37-13-15-41(83(69,70)71)35-21-33(81(63,64)65)23-43(45(35)37)85(75,76)77)19-39(25)56-47(58)27-5-3-7-31(17-27)52-51(62)53-32-8-4-6-28(18-32)48(59)57-40-20-30(12-10-26(40)2)50(61)55-38-14-16-42(84(72,73)74)36-22-34(82(66,67)68)24-44(46(36)38)86(78,79)80;;;;;;/h3-24H,1-2H3,(H,54,60)(H,55,61)(H,56,58)(H,57,59)(H2,52,53,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80);;;;;;/q;6*+1/p-6

InChI key: InChIKey=CAUQVVHSBBABOW-UHFFFAOYSA-N

SMILES: N(C(=O)C1=CC(NC(=O)C2=CC(NC(NC3=CC(C(NC4=CC(C(NC=5C6=C(C(S(=O)(=O)O)=CC5)C=C(S(=O)(=O)O)C=C6S(=O)(=O)O)=O)=CC=C4C)=O)=CC=C3)=O)=CC=C2)=C(C)C=C1)C=7C8=C(C(S(=O)(=O)O)=CC7)C=C(S(=O)(=O)O)C=C8S(=O)(=O)O.[Na]

Synonyms:

• 309F
• 1,3,5-Naphthalenetrisulfonic acid, 8,8′-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-, hexasodium salt
• 1,3,5-Naphthalenetrisulfonic acid, 8,8′-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-, sodium salt (1:6)
• 1,3,5-Naphthalenetrisulfonic acid, 8,8′-[ureylenebis[m-phenylenecarbonylimino(4-methyl-m-phenylene)carbonylimino]]di-, hexasodium salt
• Bayer 205
• SURAMIN SODIUM SALT
• 8-[[4-Methyl-3-[[3-[[3-[[2-methyl-5-[(4,6,8-trisulfonaphthalen-1-yl)carbamoyl]phenyl]carbamoyl]phenyl]carbamoylamino]benzoyl]amino]benzoyl]amino]naphthalene-1,3,5-trisulfonic acid
• SURAMINE SODIUM SALT
• 1,3,5-naphthylenetrisulfonicacid,8,8’-(ureylenebis(m-phenylenecarbonylimino(4
• SURAMIN HEXASODIUM SALT
• 1,3,5-Naphthalenetrisulfonicacid,8,8'-[carbonylbis[iMino-3,1-phenylenecarbonyliMino(4-Methyl-3,1-phenylene)carbonyliMino]]bis-,sodiuM salt (1:6)
• reasodiumsalt
• naganine
• Naganol
• 1,3,5-NAPHTHYLENETRISULFONIC ACID, 8,8'-[UREYLENEBIS[M-PHENYLENE-CARBONYLIMINO(4-METHYL-M-PHENYLENE)-CARBONYLIMINO]] DI- HEXASODIUM SALT
• sodiumsuramin
• 8,8'-CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]BIS-1,3,5-NAPHTHALENETRISULFONIC ACID HEXASODIUM
• fourneau309
• Suppressor
• 1-(3-benzamido-4-methylbenzamido)naphthalene-4,6,8-trisulfonicacidsym-3’’-u
• 8,8'-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFONIC ACID HEXASODIUM SALT
• SURAMIN
• suraminesodium
• antrypol
• SURAMIN SODIUM, 98+%
• naphuridesodium
• bay205
• F-309
• SURAMIN SODIUM
• SuraMin hexasodiuM salt, 98% 50MG
• 8,8'-carbonylbisimino-3,1-phenylenecarbonylimino-(4-methyl-3,1-phenylene)carbonyliminobis-1,3,5-naphthalenetrisulfonic acid hexasodium
• Suramin hexasodium salt,98%
• bayer205
• 8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfoni
• nf060
• naganin
• germanin

Suramin hexasodium salt, 98+%

CAS: 129-46-4

Suramin hexasodium salt, 129-46-4, is the salt form of suramin, a naphthylurea which shows antineoplastic activity through inhibition of several growth factors. Learn more.

Formula: C₅₁H₃₄N₆Na₆O₂₃S₆

Purity: 98+%

Molecular weight: 1429.16

Ref: 02-J61707

Suramin hexasodium salt

CAS: 129-46-4

Formula: C₅₁H₃₄N₆Na₆O₂₃S₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 1429.1707

Ref: IN-DA003UH6

Suramin Sodium Salt

CAS: 129-46-4

Suramin Sodium Salt

Purity: ≥95%

Molecular weight: 1429.15g/mol

Ref: 54-BUP00626

Suramin sodium salt

CAS: 129-46-4

Formula: C₅₁H₃₄N₆Na₆O₂₃S₆

Purity: ≥ 98%

Color and Shape: White to off-white powder

Molecular weight: 1429.16

Ref: 7W-GP0138

Suramin Sodium Salt

CAS: 129-46-4

Formula: C₅₁H₃₄N₆O₂₃S₆·6Na

Molecular weight: 1291.22 6*22.99

Ref: 4Z-S-233001

Suramin-d12 Sodium Salt

CAS: 129-46-4

Formula: C₅₁H₂₂D₁₂N₆O₂₃S₆·6Na

Molecular weight: 1303.29 6*22.99

Ref: 4Z-S-233002

Suramin Sodium Salt

CAS: 129-46-4

Suramin Sodium Salt (BAY-205) is a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors.

Formula: C₅₁H₃₄N₆Na₆O₂₃S₆

Purity: 97.47% - 99.97%

Color and Shape: White

Molecular weight: 1429.15

Ref: TM-T2160

Suramin (Sodium Salt)

Controlled Product

CAS: 129-46-4

Stability Hygroscopic
Applications Sodium salt of Suramin, a hepatitis C virus NS3 helicase inhibitor. Also used in the treatment of arthritis due to problematic collagen.
References Mukherjee, S. et al.: Nucl. Acids Res., 40, 8607 (2012); Sahu, D. et al.: Int. Immunopharmacol., 12, 288 (2012);

Formula: C₅₁H₃₄N₆O₂₃S₆·6Na

Color and Shape: Neat

Molecular weight: 1429.17

Ref: TR-S860000

Suramin hexasodium salt hydrate

CAS: 129-46-4

Treatment of trypanosomiasis in heamolytic stage

Formula: C₅₁H₃₄N₆O₂₃S₆·6Na·13H₂O

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 1,663.38 g/mol

Ref: 3D-FS35303