CAS 1401031-39-7

6-Oxaspiro[4.5]decane-9-ethanamine, N-[(3-methoxy-2-thienyl)methyl]-9-(2-pyridinyl)-, hydrochloride (1:1), (9R)-

Description:

6-Oxaspiro[4.5]decane-9-ethanamine, N-[(3-methoxy-2-thienyl)methyl]-9-(2-pyridinyl)-, hydrochloride (1:1), (9R)- is a complex organic compound characterized by its spirocyclic structure, which includes a fused ring system that contributes to its unique three-dimensional conformation. The presence of an oxaspiro moiety indicates the incorporation of an oxygen atom within the spiro framework, enhancing its chemical reactivity and potential biological activity. The compound features an ethanamine functional group, which suggests it may exhibit amine-related properties, such as basicity and the ability to form hydrogen bonds. Additionally, the presence of a thienyl group and a pyridinyl group indicates potential interactions with biological targets, making it of interest in medicinal chemistry. The hydrochloride salt form enhances its solubility in aqueous environments, which is beneficial for pharmacological applications. Overall, this compound's structural complexity and functional groups suggest it may possess interesting pharmacological properties, warranting further investigation in drug development and related fields.

Formula: C₂₂H₃₀N₂O₂S·ClH

InChI: InChI=1S/C22H30N2O2S.ClH/c1-25-18-7-15-27-19(18)16-23-13-10-21(20-6-2-5-12-24-20)11-14-26-22(17-21)8-3-4-9-22;/h2,5-7,12,15,23H,3-4,8-11,13-14,16-17H2,1H3;1H/t21-;/m1./s1

InChI key: InChIKey=YIIWXYLJZRISQP-ZMBIFBSDSA-N

SMILES: C(CNCC1=C(OC)C=CS1)[C@@]2(CC3(OCC2)CCCC3)C4=CC=CC=N4.Cl

Synonyms:

• (9R)-N-[(3-Methoxy-2-thienyl)methyl]-9-(2-pyridinyl)-6-oxaspiro[4.5]decane-9-ethanamine hydrochloride (1:1)
• 6-Oxaspiro[4.5]decane-9-ethanamine, N-[(3-methoxy-2-thienyl)methyl]-9-(2-pyridinyl)-, hydrochloride (1:1), (9R)-

TRV-130 Hydrochloric Acid Salt

CAS: 1401031-39-7

Formula: C₂₂H₃₀N₂O₂S·HCl

Ref: TR-TRC-T895530

TRV-130 Hydrochloric Acid Salt

Controlled Product

CAS: 1401031-39-7

Applications TRV-130 is a μ-opioid receptor (MOR) G protein-biased ligand. It is potently analgesic while causing less gastrointestinal dysfunction and respiratory suppression than morphine at equianalgesic doses.
References DeWire, S., et al.: J. Pharm. Exper. Ther., 344, 708 (2013); Soergel, D., et al.: Pain, 155, 1829 (2014)

Formula: C₂₂H₃₀N₂O₂S·HCl

Color and Shape: Neat

Molecular weight: 423.01

Ref: TR-T895530

TRV-130·HCl

Controlled Product

CAS: 1401031-39-7

TRV-130·HCl is a mu-opioid receptor agonist that has been shown to produce antinociceptive effects in both acute and chronic pain models. It has also been shown to have potential therapeutic benefits in animal models of neuropathic pain, inflammatory pain, and visceral pain. TRV-130·HCl has a high binding affinity for the mu-opioid receptor and can be used as an analgesic drug candidate. This compound produces a profile that is similar to morphine, although it may lack some of the side effects common with this drug. TRV-130·HCl has not yet undergone any clinical trials for human use and there is no information on its safety or efficacy during pregnancy.

Formula: C₂₂H₃₀N₂O₂S·HCl

Purity: Min. 95%

Molecular weight: 423.01 g/mol

Ref: 3D-FT137730

TRV-130·HCl (racemic, 95%+)

Controlled Product

CAS: 1401031-39-7

TRV-130 is a mu-opioid agonist with nociceptive and antinociceptive properties. It has been shown to have a high affinity for the mu-opioid receptor, which is responsible for pain control. TRV-130 has also been found to be effective against inflammatory pain and neuropathic pain in animal models. TRV-130 has been shown to decrease the release of glutamate and substance P in animal models, which are neurotransmitters that play an important role in inflammatory and neuropathic pain. TRV-130 may also be used as a therapeutic strategy for the treatment of chronic pain.

Formula: C₂₂H₃₀N₂O₂S·HCl

Purity: Min. 95%

Molecular weight: 423.01 g/mol

Ref: 3D-FT137731

6-Oxaspiro[4.5]decane-9-ethanamine, N-[(3-methoxy-2-thienyl)methyl]-9-(2-pyridinyl)-, hydrochloride (1:1), (9R)-

CAS: 1401031-39-7

Formula: C₂₂H₃₁ClN₂O₂S

Color and Shape: Solid

Molecular weight: 423.0117

Ref: IN-DA001C0F