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CAS 144-83-2

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Sulfapyridine

Description:
Sulfapyridine is a sulfonamide antibiotic that belongs to the class of compounds known as sulfa drugs. It is characterized by its ability to inhibit bacterial growth by interfering with the synthesis of folic acid, which is essential for bacterial metabolism. The chemical structure of sulfapyridine includes a pyridine ring and a sulfonamide group, contributing to its pharmacological properties. It is typically used in the treatment of inflammatory bowel diseases, such as ulcerative colitis and Crohn's disease, due to its anti-inflammatory effects. Sulfapyridine is soluble in water and exhibits moderate stability under standard conditions. Its mechanism of action involves competitive inhibition of the enzyme dihydropteroate synthase, which is crucial for folate synthesis in bacteria. While effective, sulfapyridine can cause side effects, including allergic reactions and gastrointestinal disturbances. As with other sulfonamides, caution is advised in patients with a history of sulfa allergies. Overall, sulfapyridine remains an important therapeutic agent in specific clinical settings.
Formula:C11H11N3O2S
InChI:InChI=1S/C11H11N3O2S/c12-9-4-6-10(7-5-9)17(15,16)14-11-3-1-2-8-13-11/h1-8H,12H2,(H,13,14)
InChI key:InChIKey=GECHUMIMRBOMGK-UHFFFAOYSA-N
SMILES:S(NC1=CC=CC=N1)(=O)(=O)C2=CC=C(N)C=C2
Synonyms:
  • 2-Sulfanilamidopyridine
  • 2-Sulfapyridine
  • 4-Amino-N-2-pyridinylbenzenesulfonamide
  • 4-[(2-Pyridylamino)sulfonyl]aniline
  • A-499
  • Adiplon
  • Coccoclase
  • Dagenan
  • Eubasin
  • Eubasinum
  • See more synonyms
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