CAS 144675-97-8: Pixantrone maleate
Description:Pixantrone maleate is a synthetic anthracenedione derivative primarily used in the treatment of certain types of cancer, particularly non-Hodgkin lymphoma. It exhibits a mechanism of action similar to that of other anthracyclines, functioning as an intercalating agent that disrupts DNA replication and transcription, ultimately leading to apoptosis in cancer cells. The maleate salt form enhances its solubility and stability, facilitating its administration. Pixantrone is characterized by its unique chemical structure, which includes a planar aromatic system that allows for effective interaction with DNA. It is known for having a lower cardiotoxicity profile compared to traditional anthracyclines, making it a valuable option in chemotherapy regimens. The substance is typically administered intravenously and is subject to specific dosage guidelines based on patient factors and treatment protocols. As with many chemotherapeutic agents, monitoring for side effects and managing potential toxicities is crucial during treatment. Overall, Pixantrone maleate represents an important advancement in targeted cancer therapy.
Formula:C17H19N5O2·2C4H4O4
InChI:InChI=1S/C17H19N5O2.C4H4O4/c18-4-7-21-12-1-2-13(22-8-5-19)15-14(12)16(23)10-3-6-20-9-11(10)17(15)24;5-3(6)1-2-4(7)8/h1-3,6,9,21-22H,4-5,7-8,18-19H2;1-2H,(H,5,6)(H,7,8)/b;2-1-
InChI key:InChIKey=GORZTPPEWDXGBU-BTJKTKAUSA-N
SMILES:O=C(O)C=CC(=O)O.O=C1C=2C=NC=CC2C(=O)C=3C(=CC=C(NCCN)C13)NCCN
- Synonyms:
- 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione di[(2E)-but-2-enedioate]
- Bbr 2778
- Benz[g]isoquinoline-5,10-dione, 6,9-bis[(2-aminoethyl)amino]-, (Z)-2-butenedioate (1:2)
- Pixantrone dimaleate
- Pixantrone maleate
- Pixolti
- Pixuvri
- Unii-P0R64C4Cr9
- Benz[g]isoquinoline-5,10-dione, 6,9-bis[(2-aminoethyl)amino]-, (2Z)-2-butenedioate (1:2)
![Benz[g]isoquinoline-5,10-dione, 6,9-bis[(2-aminoethyl)amino]-, (2Z)-2-butenedioate (1:2)](https://static.cymitquimica.com/products/IN/thumb/DA001JYV.jpg)
