CAS 144675-97-8

Pixantrone maleate

Description:

Pixantrone maleate is a synthetic anthracenedione derivative primarily used in the treatment of certain types of cancer, particularly non-Hodgkin lymphoma. It exhibits a mechanism of action similar to that of other anthracyclines, functioning as an intercalating agent that disrupts DNA replication and transcription, ultimately leading to apoptosis in cancer cells. The maleate salt form enhances its solubility and stability, facilitating its administration. Pixantrone is characterized by its unique chemical structure, which includes a planar aromatic system that allows for effective interaction with DNA. It is known for having a lower cardiotoxicity profile compared to traditional anthracyclines, making it a valuable option in chemotherapy regimens. The substance is typically administered intravenously and is subject to specific dosage guidelines based on patient factors and treatment protocols. As with many chemotherapeutic agents, monitoring for side effects and managing potential toxicities is crucial during treatment. Overall, Pixantrone maleate represents an important advancement in targeted cancer therapy.

Formula: C₁₇H₁₉N₅O₂·2C₄H₄O₄

InChI: InChI=1S/C17H19N5O2.C4H4O4/c18-4-7-21-12-1-2-13(22-8-5-19)15-14(12)16(23)10-3-6-20-9-11(10)17(15)24;5-3(6)1-2-4(7)8/h1-3,6,9,21-22H,4-5,7-8,18-19H2;1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI key: InChIKey=GORZTPPEWDXGBU-BTJKTKAUSA-N

SMILES: N(CCN)C1=C2C(=C(NCCN)C=C1)C(=O)C=3C(C2=O)=CC=NC3.C(=C\C(O)=O)\C(O)=O

Synonyms:

• 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione di[(2E)-but-2-enedioate]
• Bbr 2778
• Benz[g]isoquinoline-5,10-dione, 6,9-bis[(2-aminoethyl)amino]-, (Z)-2-butenedioate (1:2)
• Pixantrone dimaleate
• Pixantrone maleate
• Pixolti
• Pixuvri
• Unii-P0R64C4Cr9
• Benz[g]isoquinoline-5,10-dione, 6,9-bis[(2-aminoethyl)amino]-, (2Z)-2-butenedioate (1:2)

Benz[g]isoquinoline-5,10-dione, 6,9-bis[(2-aminoethyl)amino]-, (2Z)-2-butenedioate (1:2)

CAS: 144675-97-8

Formula: C₂₅H₂₇N₅O₁₀

Purity: 98%

Color and Shape: Solid

Molecular weight: 557.5094

Ref: IN-DA001JYV

Pixantrone Dimaleate

CAS: 144675-97-8

Formula: C₁₇H₁₉N₅O₂·2C₄H₄O₄

Color and Shape: Black Blue Solid

Molecular weight: 325.37 2 116.07

Ref: 4Z-P-193001

Pixantrone dimaleate

CAS: 144675-97-8

Pixantrone dimaleate

Purity: ≥98%

Molecular weight: 557.21g/mol

Ref: 54-BUP13394

Pixantrone dimaleate

CAS: 144675-97-8

Pixantrone dimaleate (Pixantrone Maleate) (BBR 2778 dimaleate) is an experimental antineoplastic drug.

Formula: C₂₅H₂₇N₅O₁₀

Purity: 98.70% - 99.11%

Color and Shape: Solid

Molecular weight: 557.21

Ref: TM-T2394

Pixantrone Dimaleate

Controlled Product

CAS: 144675-97-8

Applications Pixantrone is an antineoplastic drug belonging to group of antitumor antibiotics. Pixantrone is an anlogue of Mitoxantrone (M373425) and is just as potent in the treatment of multiple sclerosis with fewer toxic effects on cardiac tissue. Studies suggest that Pixantrone significantly reduces amyloid beta (A beta(1-42)) neurotoxicity, a mechanism implicated in Alzheimer's disease.
References Cavalletti, E. et al.: Invest. New Drugs, 25, 187 (2007); Gonsette, R.E. et al.: J. Neurol. Sci., 223, 81 (2004); Colombo, R. et al.: Electrophoresis, 30, 1418 (2009)

Formula: C₁₇H₁₉N₅O₂·2C₄H₄O₄

Color and Shape: Neat

Molecular weight: 557.51

Ref: TR-P552500

Pixatrone dimaleate

CAS: 144675-97-8

Inhibitor of topoisomerase TOP2

Formula: C₁₇H₁₉N₅O₂·2C₄H₄O₄

Purity: Min. 95%

Color and Shape: Purple Powder

Molecular weight: 557.51 g/mol

Ref: 3D-BP164036